Stewart A Anderson
Professor of Psychiatry
Research Director, Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA
Department: Psychiatry
Graduate Group Affiliations
Contact information
3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147
Abramson Research Center
Room 517
Philadelphia, PA 19147
Office: 215-590-6527
Fax: 215-590-3709
Fax: 215-590-3709
Email:
andersons3@email.chop.edu
andersons3@email.chop.edu
Education
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
MD (Medicine)
University of Connecticut, Storrs, CT, 1989.
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
MD (Medicine)
University of Connecticut, Storrs, CT, 1989.
Post-Graduate Training
Resident, Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, 1990-1994.
Postdoctoral Fellow, Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA, 1994-1998.
Permanent linkResident, Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, 1990-1994.
Postdoctoral Fellow, Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA, 1994-1998.
Description of Clinical Expertise
I am a psychiatrist who worked mainly with treatment-resistant outpatients suffering from schizophrenia. Since moving in July, 2012 from Cornell Medical College to UPenn/The Children's Hospital of Philadelphia, I am not seeing patients as I focus on laboratory research into the causes of neuropsychiatric illnesses.Description of Research Expertise
I am a Children's Hospital of Philadelphia-based faculty in the Department of Psychiatry at UPenn.The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination of subclasses of GABAergic interneurons implicated in the neuropathology of autism and schizophrenia. In addition, we are using mouse and human stem cell-derived interneurons in animal models of cell-based therapies for seizures, psychosis, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease. Additional projects include the study of mitochondria in stem cell derived neurons derived from people with the 22q11.2 deletion syndrome and schizophrenia, and the study of human stem cell derived microglia infected with HIV.
For more information, please visit the Anderson lab website at:
https://stewandersonlab.research.chop.edu/
Selected Publications
Tran HA, Greenblatt ZL, Min A, Yee M, Law A, Wu A, Doyle E, O’Keefe O, Fausak ED, Krovvidy M, Anderson SA, Giulivi C.: Mitochondrial Bioenergetics in Schizophrenia: A Systematic Review, Meta-analysis, and GRADE-Based Certainty Assessment. Schizophrenia Bulletin. In press. in press, 2026.Brosius SN, Manley W, Harvey K, Galanaugh J, Rahocek D, Anderson SA*, De Raedt T*. *co-corresponding authors: Glioblastoma chemoattract migratory interneuron precursors modified to deliver therapeutic proteins . Nature Neuroscience 2026.
Choi K, Henderson NT, Feierman ER, Louzon S, Galanaugh J, Davatolhagh F, Bhandaru I, Tischfield DJ, Anderson SA, Korb E, Fuccillo MV : Control of striatal circuit development by the chromatin regulator Zswim6. Science Advances 11(3):eadq6663, 2025.
Crockett A, Vélez Colόn MC, Kebir H, Smith FM, Iascone DM, Cielieski B, Koshkin S, Patterson AD, Rossano AJ, Sehgal A, Anderson SA*, Alvarez JI* *co-corresponding authors.: Targeting Mitochondrial Dysfunction and BBB Disruption with Bezafibrate Improves Social Deficits in Models of 22q11.2 Deletion Syndrome. Science Translational Medicine 17: (812):eads2116, 2025.
Crockett, A. M., Kebir, H., Anderson, S. A., Jyonouchi, S., Romberg, N., Alvarez, J. I.: 22q11.2 Deletion-Associated Blood-Brain Barrier Permeability Potentiates Systemic Capillary Leak Syndrome Neurologic Features. J Clin Immunol 44(4): 87, 2024.
Littleton, S. H., Trang, K. B., Volpe, C. M., Cook, K., DeBruyne, N., Maguire, J. A., Weidekamp, M. A., Hodge, K. M., Boehm, K., Lu, S., Chesi, A., Bradfield, J. P., Pippin, J. A., Anderson, S. A., Wells, A. D., Pahl, M. C., Grant, S. F. A.: Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3'' UTR of FAIM2. Cell Genom 4(5): 100556, 2024.
Iascone, D. M., Zhang, X., Brafford, P., Mesaros, C., Sela, Y., Hofbauer, S., Zhang, S. L., Madhwal, S., Cook, K., Pivarshev, P., Stanger, B. Z., Anderson, S., Dang, C. V., Sehgal, A.: Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells. Proc Natl Acad Sci U S A 121(30): e2319782121, 2024.
Qu, G., Merchant, J. P., Clatot, J., DeFlitch, L. M., Frederick, D. J., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S. A., Goldberg, E. M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, 2024.
Crockett AM, Kebir. H, Benallegue, Adelman P, Gur RE, Sullivan S, Anderson SA, Alvarez JI : Immune status of the murine 22q11.2 deletion syndrome model European Journal of Immunology 53(1): https://doi.org/10.1002/eji.202249840, January 2023.
Lu, Y., Lee, J., Li, J., Allu, S. R., Wang, J., Kim, H., Bullaughey, K. L., Fisher, S. A., Nordgren, C. E., Rosario, J. G., Anderson, S. A., Ulyanova, A. V., Brem, S., Chen, H. I., Wolf, J. A., Grady, M. S., Vinogradov, S. A., Kim, J., Eberwine, J.: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential. Nat Commun 14(1): 7346, 2023.