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Paul M. Burkat
4fAssociate Professor of Clinical Psychiatry
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Medical Co-Director Outpatient Psychiatry Center, University of Pennsylvania Perelman School of Medicine
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Department: Psychiatry
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Contact information
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3535 Market Street
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 2155734849
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30 Fax: 2155735668
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Education:
21 9 B.S. 19 (Neuroscience) c
30 University of Rochester, 1995.
21 a Ph.D. 28 (Pharmacology and Physiology) c
51 University of Rochester School of Medicine and Dentistry, 2001.
21 9 M.D. c
51 University of Rochester School of Medicine and Dentistry, 2003.
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21 9 B.S. 19 (Neuroscience) c
30 University of Rochester, 1995.
21 a Ph.D. 28 (Pharmacology and Physiology) c
51 University of Rochester School of Medicine and Dentistry, 2001.
21 9 M.D. c
51 University of Rochester School of Medicine and Dentistry, 2003.
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Post-Graduate Training
24 53 Intern, University of Wisconsin Hospitals and Clinics, 2003-2004.
24 5a Resident in Anesthesiology, Milton S. Hershey Medical Center, 2004-2004.
24 82 Postdoctoral Researcher, Department of Anesthesiology, University of Wisconsin Hospitals and Clinics, 2004-2006.
24 5c Resident in Psychiatry, University of Rochester Medical Center, 2006-2010.
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Permanent link24 53 Intern, University of Wisconsin Hospitals and Clinics, 2003-2004.
24 5a Resident in Anesthesiology, Milton S. Hershey Medical Center, 2004-2004.
24 82 Postdoctoral Researcher, Department of Anesthesiology, University of Wisconsin Hospitals and Clinics, 2004-2006.
24 5c Resident in Psychiatry, University of Rochester Medical Center, 2006-2010.
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122 Burkat, PM. : Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Diazepam: Unbound Interstitial Brain Concentrations Correspond to Clinical End Points. J Clin Pharmacol. 62(10): 1297-1309, Oct 2022.
149 Burkat PM, Lor C, Perouansky M, Pearce RA. : Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation. Anesth Analg 119(6): 1277-1284, Dec 2014.
e2 Gingrich KJ, Burkat PM, Roberts WA. : Pentobarbital produces activation and block of alpha1beta2gamma2S GABA(A) receptors in rapidly perfused whole cells and membrane patches: 79 divergent results can be explained by pharmacokinetics. J Gen Physiol 133(2): 171-188, Feb 2009.
f6 Burkat PM, Yang J, Gingrich KJ. : Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis. J Neurosci. 21(18): 7026-7036, Sep 2001.
fc Gingrich KJ, Burkat PM.: Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit. J Physiol 506: 609-25, Feb 1998.
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Selected Publications
101 Burkat, PM: Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Alprazolam: Implications for Anxiety and Addiction. Br J Clin Pharmacol 89(8): 2569-2581, August 2023.122 Burkat, PM. : Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Diazepam: Unbound Interstitial Brain Concentrations Correspond to Clinical End Points. J Clin Pharmacol. 62(10): 1297-1309, Oct 2022.
149 Burkat PM, Lor C, Perouansky M, Pearce RA. : Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation. Anesth Analg 119(6): 1277-1284, Dec 2014.
e2 Gingrich KJ, Burkat PM, Roberts WA. : Pentobarbital produces activation and block of alpha1beta2gamma2S GABA(A) receptors in rapidly perfused whole cells and membrane patches: 79 divergent results can be explained by pharmacokinetics. J Gen Physiol 133(2): 171-188, Feb 2009.
f6 Burkat PM, Yang J, Gingrich KJ. : Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis. J Neurosci. 21(18): 7026-7036, Sep 2001.
fc Gingrich KJ, Burkat PM.: Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit. J Physiol 506: 609-25, Feb 1998.
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