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Paul M. Burkat

Associate Professor of Clinical Psychiatry
Associate Medical Director Outpatient Psychiatry for APP and Nursing Services, University of Pennsylvania Perelman School of Medicine
Department: Psychiatry

Contact information
3535 Market Street
Philadelphia, PA 19104
Education:
B.S. (Neuroscience)
University of Rochester, 1995.
Ph.D. (Pharmacology and Physiology)
University of Rochester School of Medicine and Dentistry, 2001.
M.D.
University of Rochester School of Medicine and Dentistry, 2003.
Post-Graduate Training
Intern, University of Wisconsin Hospitals and Clinics, 2003-2004.
Resident in Anesthesiology, Milton S. Hershey Medical Center, 2004-2004.
Postdoctoral Researcher, Department of Anesthesiology, University of Wisconsin Hospitals and Clinics, 2004-2006.
Resident in Psychiatry, University of Rochester Medical Center, 2006-2010.
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Selected Publications

Burkat, PM: Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Alprazolam: Implications for Anxiety and Addiction. Br J Clin Pharmacol 89(8): 2569-2581, August 2023.

Burkat, PM. : Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Diazepam: Unbound Interstitial Brain Concentrations Correspond to Clinical End Points. J Clin Pharmacol. 62(10): 1297-1309, Oct 2022.

Burkat PM, Lor C, Perouansky M, Pearce RA. : Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation. Anesth Analg 119(6): 1277-1284, Dec 2014.

Gingrich KJ, Burkat PM, Roberts WA. : Pentobarbital produces activation and block of alpha1beta2gamma2S GABA(A) receptors in rapidly perfused whole cells and membrane patches: divergent results can be explained by pharmacokinetics. J Gen Physiol 133(2): 171-188, Feb 2009.

Burkat PM, Yang J, Gingrich KJ. : Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis. J Neurosci. 21(18): 7026-7036, Sep 2001.

Gingrich KJ, Burkat PM.: Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit. J Physiol 506: 609-25, Feb 1998.

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Last updated: 07/19/2023
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