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Richard K. Assoian, Ph.D.

Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Department of Systems Pharmacology and Translational Therapeutics
421 Curie Blvd.
Rm 805(office)/833 (lab)
Philadelphia, PA 19104-6160
Office: (215) 898-7157
Fax: (215) 573-5656
Lab: (215) 898-7265
Education:
B.A. (Natural Science)
Johns Hopkins University, 1975.
Ph.D. (Biochemistry)
University of Chicago, 1981.
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Selected Publications

Liu SL, Bajpai A, Hawthorne EA, Bae Y, Castagnino P, Monslow J, Puré E, Spiller KL, Assoian RK. : Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12. JCI Insight 4: e122742, 2019.

Yu CK, Xu T, Assoian RK, Rader DJ: Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators. Arterioscler Thromb Vasc Biol 38: 164-173, 2018.

Bade ND, Xu T, Kamien RD, Assoian RK*, Stebe KJ* (*co-corresponding): Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration. Biophysical Journal 114: 1467-1476, 2018.

Bade ND, Kamien RD, Assoian RK*, Stebe KJ* (*co-corresponding): Curvature and Rho activation differentially control the alignment of cells and stress fibers. Science Advances 3: e1700150, 2017.

Mui KL, Chen CS, Assoian RK: The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces. J Cell Science 129: 1093-1100, 2016.

Liu SL, Bae YH, Yu C, Monslow J, Hawthorne EA, Castagnino P, Branchetti E, Ferrari G, Damrauer SM, Puré E, Assoian RK: Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening. Scientific Reports 5: 17189, 2015.

Bae YH, Mui KL, Hsu BY, Liu SL, Cretu A, Razinia Z, Xu T, Puré E, Assoian RK. : A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling. Science Signaling 7: ra57, 2014.

Kothapalli, D.*, Liu, S.L.*, Bae, Y.H., Monslow, J., Xu, T., Hawthorne, E.A., Castagnino, P., Byfield, F.J., Rao, S., Rader, D.J., Pure, E., Phillips, M.C., Lund-Katz, S., Janmey, P.A., Assoian, R.K.: Cardiovascular protection by apoE and apoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Reports 2: 1259-1271, 2012.

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Last updated: 10/29/2019
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