Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Brian Litt, MD

Professor of Neurology and Professor of Bioengineering
Department: Neurology
Graduate Group Affiliations

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Permanent link
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Description of CVI Expertise

CVI Program Unit(s):
Biotechnology / Nanomedicine / Imaging

CVI Research Description:

1. Predicting cardiac arrhythmias from quantitative analysis of ECG using techniques to predict epileptic seizures.

2. Translating cardiac EP technology to neurological applications.

Selected Publications

Worrell, GA, Gardner, AB, Stead, SM, Hu, SQ, Goerss, S, Cascino, GJ, Meyer, FB, Marsh, R, Litt, B: High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain 131(4): 928-937, Apr 2008.

Blanco JA, Stead M, Krieger A, Viventi J, Marsh WR, Lee KH, Worrell G, Litt B: Unsupervised Classification of High-Frequency Oscillations in Human Neocortical Epilepsy and Control Patients. J Neurophysiology 104(5): 2900-2912, Nov 2010.

Viventi J, Kim DH, Moss J, Kim Y-S, Blanco J, Anetta N, Hicks A, Xiao J, Huang Y, Callans DJ, Rogers JA, Litt B: A Conformal, Bio-interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology. Science Translational Medicine (Cover article) 2(24): 24ra22, 2010.

Kim DH, Lu N, Ghaffari R, Kim YS, Lee S, Xu L, Wu J, Kim RH, Song J, Liu ZJ, Viventi J, de Graff B, Elolampi B, Mansour M, Slepian M, Hwang S, Moss J, Won SM, Huang Y, Litt B, Rogers J: Materials for Multifunctional Balloon Catheters With Capabilities in Cardiac Electrophysiological Mapping and Ablation Therapy. Nature Materials 10(4): 316-23, April 2011.

Blanco JA, Stead M, Krieger A, Stacey W, Maus D, Marsh E, Viventi J, Lee KH, Marsh R, Litt B, Worrell GA: Data mining neocortical high-frequency oscillations in epilepsy and controls. Brain 134(Pt 10): 2948-59, October 2011 Notes: 2011 Sep 8 [Epub ahead of print]

Manning JR, Polyn SM, Baltuch GH, Litt B, Kahana MJ: Oscillatory patterns in temporal lobe reveal context reinstatement during memory search. Proc Natl Acad Sci U S A 108(31): 12893-7, Aug 2011 Notes: Epub 2011 Jul 7.

Viventi J, Kim D-H, Vigeland L, Frechette E, Blanco J, Kim Y-S, Avrin A, Tiruvadi V, Hwang S-W, Chamberlain A, Wulsin D, Davis K, Gelber C, Palmer L, Van der Spiegel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, and Litt B: Flexible, Foldable, Actively Multiplexed, High-Density Electrode Array for Mapping Brain Activity in vivo. Nature Neuroscience 14(12): 1599-605, Nov 2011.

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Last updated: 06/23/2015
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