Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mitchell A. Lazar, MD, PhD

Sylvan H. Eisman Professor of Medicine
Department: Medicine

Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104-5160
Office: (215) 898-0198
Fax: (215) 898-5408
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
Stanford Univerity, 1982.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.

I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).

Selected Publications

Gerhart-Hines Z, Lazar MA.: Rev-erbα and the circadian transcriptional regulation of metabolism. Diabetes Obes Metab. Suppl 1: 12-6, Sept 2015 Notes: doi: 10.1111/dom.12510. PMID:26332963[PubMed - in process] PMCID: PMC4562061 [Available on 2016-09-01]

Fang B, Lazar MA.: Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in Liver. Cold Spring Harb Symp Quant Biol. Page: pii: 027508. [Epub ahead of print] Sept 2015 Notes: PMID: 26370410

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.: MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab Sept 2015 Notes: pii: S1550-4131(15)00460-X. doi: 10.1016/j.cmet.2015.09.003. [Epub ahead of print]

Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, Voight BF, Lazar MA.: Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell 162(1): 33-44, Jul 2015 Notes: doi: 10.1016/j.cell.2015.06.025. PMID: 26140591

Lim HW, Uhlenhaut NH, Rauch A, Weiner J, Hübner S, Hübner N, Won KJ, Lazar MA, Tuckermann J, Steger DJ.: Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo. Genome Res. 25(6): 836-44, Jun 2015 Notes: doi: 10.1101/gr.188581.114. Epub 2015 May 8.

Cohen DM, Won KJ, Nguyen N, Lazar MA, Chen CS, Steger DJ.: ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis. Elife Jun 2015 Notes: doi: 10.7554/eLife.06821. PMID: 26111340.

Yuxiang Zhang, Bin Fang, Matthew J. Emmett, Manashree Damle, Zheng Sun, Dan Feng, Sean M. Armour, Jarrett R. Remsberg, Jennifer Jager, Raymond E. Soccio, David J. Steger, Mitchell A. Lazar : Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science 348(6242): 1488-92, Jun 2015.

Gerhart-Hines Z, Lazar MA.: Circadian metabolism in the light of evolution. Endocr Rev. 36(3): 289-304, Jun 2015 Notes: doi: 10.1210/er.2015-1007. Epub 2015 Apr 30.

Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P.: PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes Dev. 29(3): 298-307, Feb 2015.

Jang JC, Chen G, Wang SH, Barnes MA, Chung JI, Camberis M, Le Gros G, Cooper PJ, Steel C, Nutman TB, Lazar MA, Nair MG.: Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. PLoS Pathog. 11(1:e1004579), Jan 2015 Notes: doi: 10.1371/journal.ppat.1004579. eCollection 2015 Jan.

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Last updated: 09/24/2015
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