Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

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Mingyao Li, Ph.D.

Associate Professor of Biostatistics in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology

Contact information
University of Pennsylvania School of Medicine
Department of Biostatistics and Epidemiology
213 Blockley Hall, 423 Guardian Drive
Philadelphia, PA 19104
Office: 215-746-3916
Fax: 215-573-4865
B.S. (Mathematics)
Nankai University, China, 1996.
M.S. (Mathematics)
Nankai University, China, 1999.
M.S. (Biostatistics)
University of Michigan, 2002.
Ph.D. (Biostatistics)
University of Michigan, 2005.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
Mingyao Li is an Assistant Professor of Biostatistics. Her main research area is statistical genetics. In particular, she is interested in developing statistical methods and computational tools for identifying and characterizing genetic variants that influence susceptibility to complex diseases.

Her methodological work includes identifying SNPs responsible for a linkage signal by joint modeling of linkage and association, developing unified statistical framework for association analysis of sibship data and unrelated cases and controls, and developing variance-components linkage and association analysis methods for non-normally distributed quantitative traits.

Much of her recent research is focused on evaluating and improving power for genome-wide association studies. Results from her methodological research will directly benefit genetic studies of cardiovascular disease and related traits.

Selected Publications

Wang X., Zhu X., Qin H., Cooper R., Ewens W., Li C., Li M.* : Adjustment for local ancestry in genetic association analysis of admixed populations. Bioinformatics 27: 670-677, 2011 Notes: * Corresponding author.

Cappola T.P., Matkovich S.J., Wang W., Van Booven D., Li M., Wang X., Qu L., Reilly M.P., Hakonarson H., Nerbonne J.M., Dorn G.W. 2nd: A loss-of-function heart failure risk variant in CLCNKA implicates the cardio-renal axis. Proceedings of the National Academy of Sciences 108: 2456-2461, 2011.

Lettre G., Palmer C.D., Young T., Ejebe K., Allayee H., Benjamin E.J., Bennett F., Bowden D.W., Chakravarti A., Dreisbach A., Farlow D.N., Folsom A.R., Fornage M., Forrester T., Fox E., Haiman C.A., Hartiala J., Hazen S.L., Heckbert S.R., Henderson B.E., Hirschhorn J.N., Keating B., Kritchevsky S.B., Larkin E., Li M., Liu Y., McKenzie C.A., Meigs J.B., Meng Y.A., Mosley T.H., Newman A.B., Newton-Cheh C.H., Paltoo D.N., Papanicolaou G.J., Post W.S., Psaty B.M., Qasim A.N., Qu L., Rader D.J., Redline S., Reilly M.P., Reiner A.P., Rich S.S., Rotter J.I., Rudock M.E., Shrader P., Siscovick D., Tang W.H.W., Taylor H.A., Tracy R.P., Vasan R.S., Waters K.M., Wilks R., Wilson J.G., Fabsitz R.R., Gabriel S.S., Kathiresan S., Boerwinkle E.: Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: The NHLBI CARe Project. PLoS Genetics 7: e1001300, 2011.

CARDIoGRAM Consortium: Novel genetic loci affecting risk of coronary artery disease. Nature Genetics 6: 333-338, 2011.

Zhao J., Bradfield J.P., Li M., Zhang H., Mentch F.D., Wang K., Sleiman P.M., Kim C.E., Glessner J.T., Frackelton E.C., Chiavacci R.M., Berkowitz R.I., Zemel B.S., Hakonarson H., Grant S.F.A.: BMD-associated variation at the Osterix locus is correlated with pediatric BMI in females. Obesity 19: 1311-1314, 2011.

Haas E.J., Zaoutis T.E., Prasad P., Li M., Coffin S.E.: Risk factors and outcomes for vancomycin-resistant enterococcus bloodstream infection in children. Infection Control and Hospital Epidemiology 31: 1038-1042, 2010.

He J., Wang K., Edmondson A.C., Rader D.J., Li C., Li M.*: Gene-based interaction analysis by incorporating external linkage disequilibrium information. European Journal of Human Genetics 19: 164-172, 2011 Notes: * Corresponding author, first author is Dr. Li's PhD student.

Reilly M.*, Li M.*, He J., Ferguson J.F., Stylianou I.M., Mehta N.N., Burnett M.S., Devaney J.M., Knouff C.W., Thompson J.R., Horne, B.D., Stewart A.F., Assimes T.L., Wild P.S., Allayee H., Linsel- Nitschke P., Patel R.S., Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Martinelli N., Girelli D., Quyyumi A.A., Anderson J.L., Erdmann J., Hall A.S., Schunkert H., Quertermous T., Blankenberg S., Hazen S.L., Roberts R., Kathiresan S, Samani N.J., Epstein S.E., Rader D.J.: Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377: 383-392, 2011 Notes: *Co-first authors.

Zhao J., Schug J., Li M., Kaestner K., Grant S.F.A.: Disease-associated loci are significantly over-represented among genes bound by TCF7L2 in vivo Diabetologia 53: 2340-2346, 2010.

Song P.X.-K., Li M., Yuan Y.: Rejoinder: Joint regression analysis for discrete longitudinal data. Biometrics 67: 1670-1671, 2011.

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Last updated: 04/21/2015
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