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George Scott Worthen, M.D.

Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
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Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure

CVI Research Description:
As of summer 2007, I have recently arrived at Children's Hospital of Philadelphia (CHOP), having moved from University of Colorado Health Sciences Center of Denver where I was an adult lung disease physician at National Jewish.

I was recruited to CHOP to contribute to the Joseph Stokes Jr. Research Institute's Neonatology Division Research portfolio in the area of lung injury, since my lab has focused on lung inflammation for many years.

We have recently made a knockout of an interesting chemokine, CXCL5, which appears to be expressed in resident cells of the lung heart, and gut (rather than myeloid/DC cells that have taken up residence). It appears that certain inflamatory responses in the lung are attenuated in this mouse, despite the considerable redundancy of chemokine expression. We are interested in the possibility that expression of CXC chemokines by the heart in response to ischemia-reperfusion or infarction contributes to myocardial dysfunction, infarct extension, and remodeling.

We would like to find a group with which to work on this problem - applying insights on neutrophil recruitment to the ischemic heart.

Selected Publications

Nadir Yehya, Hossein Fazelinia, Gladys G Lawrence, Lynn A Spruce, Mark V Mai, G Scott Worthen, Jason D Christie. : Plasma Nucleosomes Are Associated with Mortality in Pediatric Acute Respiratory Distress Syndrome Crit Care Med 2021 Notes: online ahead of print.

Jacob W. Myerson, Priyal N. Patel, Kate Rubey, Nahal Habibi, Landis R, Walsh, Yi-Wei Lee, David C. Luther, Laura T. Ferguson, Michael H. Zaleski, Marco E. Zamora, Oscar A. Marcos-Contreras, Patrick M. Glassman, Ian Johnson, Elizabeth D. Hood, Tea Shuvaeva, Jason V. Gregory, Raisa Y. Kiseleva, Jia Nong, Colin Greineder, Samir Mitragotri, G. Scott Worthen, Vincent M. Rotello, Joerg Lahann, Vladimir R. Muzykantov, Jacob S. Brenner : Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment. 2021 In Press. Nature Nanotechnology 2021 Notes: In Press.

Yasmine Issah, Amruta Naik, Soon Y Tang, Kaitlyn Forrest, Thomas G Brooks, Nicholas Lahens, Katherine N Theken, Mara Mermigos, Amita Sehgal , George S Worthen, Garret A FitzGerald, Shaon Sengupta. : Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates. Elife 10: e61241, 2021.

Paris, AJ, Oved, JH, Wang, P, Dai, N, Worthen, GS: Neutrophils degrade nucleic acids to improve lung repair after injury. Blood 30: 392-93, 2021.

Dimitra Kokkinaki, Sophia Murphy, Alessandro Venosa, Scott Sherrill-Mix, Meghan J. Hotz, Carla Casu, Peggy Zhang, Dorothy E. Loy, Caroline A.G. Ittner, Nuala J. Meyer, Stefano Rivella, Beatrice H. Hahn, G. Scott Worthen, Nilam S. Mangalmurti.: Cell free DNA drives inflammatory anemia via TLR9 by masking the marker of self CD47 on red blood cells. Science Translational Medicine 2021 Notes: In review.

Bellissimo DC, Chen CH, Zhu Q, Bagga S, Lee CT, He B, Wertheim GB, Jordan M, Tan K, Worthen GS, Gilliland DG, Speck NA: Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling. Blood Adv. 24(6): 1145-115, 2020.

Paris, AJ, Hayer, KE, Oved, JH, Avgousti, DC, Toulmin, SA, Zepp, JA, Zacharias, WJ, Katzen, JB, Basil, MC, Kremp, MM, Slamowitz, AR, Jayachandran,S, Sivakumar,A, Wang, P, Dai, N, Frank, DB, Eisenlohr, LC, Cantu, E, Beers, MF, Weitzman, MD, Morissey, EE, Worthen, GS.: Stat3-Bdnf-TrkB signaling promotes alveolar regeneration. Nature Cell Biology 22: 1197-1210, 2020.

Hudock KM, Collins MS, Imbrogno M, Snowball J, Kramer EL, Brewington JJ, Gollomp K, McCarthy C, Ostmann AJ, Kopras EJ, Davidson CR, Srdiharan A, Arumugam P, Sengupta S, Xu Y, Worthen GS, Trapnell BC, Clancy JP: Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 319: L137-L147, 2020.

Liu Y, Perego M, Xiao Q, He Y, Fu S, He J, Liu W, Li X, Tang Y, Li X, Yuan W, Zhou W, Wu F, Jia C, Cui Q, Worthen GS, Jensen EA, Gabrilovich DI, Zhou J.: Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice. J Clin Invest. 129(10): 4261-4275, 2019.

Paris AJ, Guo L, Dai N, Katzen JB, Patel PN, Worthen GS, Brenner J: Using selective lung injury to improve murine models of spatially heterogeneous lung diseases. PLoS One 14(4): e0202456, 2019.

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Last updated: 06/11/2021
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