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Michael S. Parmacek, M.D.
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Frank Wister Thomas Professor of Medicine
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Member, Graduate Group in Cell Biology and Molecular Biology, Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine
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Member, University of Pennsylvania Strategic Planning Committee for Cardiac Clinical Services, University of Pennsylvania Health System
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Member, Strategic Planning CV Biology Working Group I Committee, University of Pennsylvania School of Medicine
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Member, Academic Review Committee, University of Pennsylvania School of Medicine
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Member, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine and School of Engineering and Applied Science
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Member, Task Force on Incentivizing Entrepreneurialism, Department of Medicine, University of Pennsylvania School of Medicine
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Member, Robert Wood Johnson Clinical Scholars Programs, Perelman School of Medicine University of Pennsylvania
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Member, Basic Science Chairs, Perelman School of Medicine, University of Pennsylvania
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Member, Board of Directors, Clinical Practices of the University of Pennsylvania
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Member, Finance Committee, Clinical Practices of the University of Pennsylvania
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CHIBE-Roybal Internal and Exteral Advisory Boards, University of Pennsylvania
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Chair, Department of Medicine, University of Pennsylvania Health System
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Member, Executive Committee, Clinical Practices of the University of Pennsylvania
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Member, Department of Surgery Chair Search Committee, University of Pennsylvania Perelman School of Medicine
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Chair, Search Committee for Chair of Department of Emergency Medicine , University of Pennsylvania Perelman School of Medicine
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PSOM Dean's Advisory Committee, University of Pennsylvania, Perelman School of Medicine
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Chair, CPUP Finance Committee, Penn Medicine
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Co-Chair, CPUP Access Committee, University of Pennsylvania, Perelman School of Medicine
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Member, Penn Medicine Managed Care and Contracting Committee, University of Pennsylvania, Perelman School of Medicine
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Member, Penn Medicine Medical Group (PMMG) Executive Committee, University of Pennsylvania, Perelman School of Medicine
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Member, CPUP Funds Flow 5.0 Committee, University of Pennsylvania, Perelman School of Medicine
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Member, PMMG Restructure Working Group, University of Pennsylvania, Perelman School of Medicine
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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6th Floor, South Pavilion
48 Perelman Center for Advanced Medicine
Philadelphia, PA 19104
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48 Perelman Center for Advanced Medicine
Philadelphia, PA 19104
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Office: 215-662-2402
32 Fax: 215-349-8232
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32 Fax: 215-349-8232
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Publications
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Links
9a Search PubMed for articles
8b Cell and Molecular Biology Graduate Group
8e Penn Health Profile
69 Parmacek Lab (MCRC)
80 Cardiovascular Division Faculty
64 Penn Cardiovascular Institute
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9a Search PubMed for articles
8b Cell and Molecular Biology Graduate Group
8e Penn Health Profile
69 Parmacek Lab (MCRC)
80 Cardiovascular Division Faculty
64 Penn Cardiovascular Institute
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Education:
21 9 B.S. 1f (Biology/Psychology) c
29 Tufts University, 1977.
21 9 M.D. c
3f Northwestern University Medical School, 1981.
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Permanent link21 9 B.S. 1f (Biology/Psychology) c
29 Tufts University, 1977.
21 9 M.D. c
3f Northwestern University Medical School, 1981.
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31 Director, Cardiovascular Institute
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21 Research Interests
4a Transcriptional programs that regulate cardiovascular development
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65 Key Words: smooth muscle cell, cardiac myocyte, GATA, myocardin, transcription, notch
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26 Description of Research
4f9 The Parmacek laboratory examines the molecular and genetic programs that regulate heart and vascular development with particular focus on defining the molecular programs regulating development, differentiation and survival of vascular smooth muscle cells and cardiac myocytes. The Parmacek laboratory utilizes a variety of experimental methodologies including the generation and characterization of genetically-engineered mouse and embryonic stem (ES) cell models to elucidate the function(s) of critical transcription factors and transcriptional co-activators in the cardiovascular system. The Parmacek laboratory cloned and/or characterized the function of the GATA-4/5/6 subfamily of cardiovascular transcription factors and the Myocardin/MKL-1/MKL-2 family of transcriptional coactivators. These data provided unanticipated insights into how cells populating the cardiovascular system transduce signals regulating development and response to hemodynamic stress. While fundamentally important at a basic level, this research has provided insights into the pathogenesis of cardiovascular diseases including atherosclerosis, aortic aneurysm and dissection, heart failure and congenital heart disease.
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2c Rotation Projects for 2012-13
58 1. Characterization of the function of MKL2/MRTF-B in the heart and vasculature
7b 2. Examine the molecular basis of myocardin function in the heart and in visceral and vascular smooth muscle cells
7c 3. Characterization of mice harboring a conditional mutation in the lineage-restricted transcription factors GATA-6
74 4. Examine the role of Notch signaling and Notch-regulated genes during angiogenesis and in the vasculature
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1e Lab personnel:
2f Jian Li, MD - Senior Research Scientist
39 John Huang MD, PhD - Postdoctoral Research Fellow
30 Xiaohong Zhu - Senior Research Technician
26 29
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Description of Research Expertise
35 Chair, Department of Medicine31 Director, Cardiovascular Institute
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21 Research Interests
4a Transcriptional programs that regulate cardiovascular development
8
65 Key Words: smooth muscle cell, cardiac myocyte, GATA, myocardin, transcription, notch
8
26 Description of Research
4f9 The Parmacek laboratory examines the molecular and genetic programs that regulate heart and vascular development with particular focus on defining the molecular programs regulating development, differentiation and survival of vascular smooth muscle cells and cardiac myocytes. The Parmacek laboratory utilizes a variety of experimental methodologies including the generation and characterization of genetically-engineered mouse and embryonic stem (ES) cell models to elucidate the function(s) of critical transcription factors and transcriptional co-activators in the cardiovascular system. The Parmacek laboratory cloned and/or characterized the function of the GATA-4/5/6 subfamily of cardiovascular transcription factors and the Myocardin/MKL-1/MKL-2 family of transcriptional coactivators. These data provided unanticipated insights into how cells populating the cardiovascular system transduce signals regulating development and response to hemodynamic stress. While fundamentally important at a basic level, this research has provided insights into the pathogenesis of cardiovascular diseases including atherosclerosis, aortic aneurysm and dissection, heart failure and congenital heart disease.
8
2c Rotation Projects for 2012-13
58 1. Characterization of the function of MKL2/MRTF-B in the heart and vasculature
7b 2. Examine the molecular basis of myocardin function in the heart and in visceral and vascular smooth muscle cells
7c 3. Characterization of mice harboring a conditional mutation in the lineage-restricted transcription factors GATA-6
74 4. Examine the role of Notch signaling and Notch-regulated genes during angiogenesis and in the vasculature
8
1e Lab personnel:
2f Jian Li, MD - Senior Research Scientist
39 John Huang MD, PhD - Postdoctoral Research Fellow
30 Xiaohong Zhu - Senior Research Technician
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140 Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek MS: Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature. Development (Cambridge, England) 139(19): 3531-42, Oct 2012.
120 Rong L, Liu J, Qi Y, Graham AM, Parmacek MS, Li S: GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation. Molecular Biology of the Cell 23(18): 3754-63, Sep 2012.
b6 Rader DJ, Parmacek MS: Secreted miRNAs suppress atherogenesis. Nature Cell Biology 14(3): 233-5, Feb 29 2012.
169 Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD Jr, Dedhar S, Parmacek MS, Gerszten RE: Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circulation Research 109(6): 616-28, Sep 2011.
116 Huang J, Lu MM, Cheng L, Li J, Zhu X, Stout A, Chen M, Li J, Parmacek MS: Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci USA(106), 18734-18739, 2009.
9e Parmacek MS, Epstein JA: Cardiomyocyte Renewal. N Engl J Med 2(361): 86-8, July 2009.
14b Zhang Z, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo F, Whitsett JA, Parmacek MS, Morrisey EE: A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nature Genetics 40(7): 862-70, July 2008.
12d Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS: Myocardin regulates smooth muscle cell contractile genes required for closure of the ductus arteriosus. J Clin Invest 118(2): 515-25, Feb 2008.
12f Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS: Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci USA 104(41): 16275-80, Oct 2007.
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Selected Publications
124 Huang J, Elicker J, Bowens N, Liu X, Cheng L, Cappola TP, Zhu X, Parmacek MS: Myocardin regulates BMP10 expression and is required for heart development. The Journal of Clinical Investigation 122(10): 3678-91, Oct 2012.140 Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek MS: Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature. Development (Cambridge, England) 139(19): 3531-42, Oct 2012.
120 Rong L, Liu J, Qi Y, Graham AM, Parmacek MS, Li S: GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation. Molecular Biology of the Cell 23(18): 3754-63, Sep 2012.
b6 Rader DJ, Parmacek MS: Secreted miRNAs suppress atherogenesis. Nature Cell Biology 14(3): 233-5, Feb 29 2012.
169 Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD Jr, Dedhar S, Parmacek MS, Gerszten RE: Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circulation Research 109(6): 616-28, Sep 2011.
116 Huang J, Lu MM, Cheng L, Li J, Zhu X, Stout A, Chen M, Li J, Parmacek MS: Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci USA(106), 18734-18739, 2009.
9e Parmacek MS, Epstein JA: Cardiomyocyte Renewal. N Engl J Med 2(361): 86-8, July 2009.
14b Zhang Z, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo F, Whitsett JA, Parmacek MS, Morrisey EE: A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nature Genetics 40(7): 862-70, July 2008.
12d Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS: Myocardin regulates smooth muscle cell contractile genes required for closure of the ductus arteriosus. J Clin Invest 118(2): 515-25, Feb 2008.
12f Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS: Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci USA 104(41): 16275-80, Oct 2007.
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