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Gerd A. Blobel, MD, PhD

Gerd A. Blobel, MD, PhD

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Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
316H Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-3988
Fax: (215) 590-4834
Lab: (215) 590-4461
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Description of Research Expertise

Research Interests
higher order chromatin structure, gene expression, epigenetic memory, transcription factors, mitosis, BET proteins, gene therapy

Description of Research
Our lab focuses on the genetic and epigenetic control of hematopoiesis and its disorders. Specifically, we study how tissue-specific transcription factors govern the specification and maintenance of hematopoietic cell lineages. We examine how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity. Our work is leading us deeply into the analysis of chromatin structure, its modifications and organization. For example, we investigate how regulatory elements are spatially organized in the nucleus. We are developing approaches to manipulate higher order chromatin organization as a therapeutic tool for the treatment of diseases affecting the globin genes. For our studies we combine molecular, genomic, biochemical, and imaging approaches with studies in normal and gene targeted mice.

Lab Rotation Projects:
For information about rotation projects please contact me directly.

Lab personnel:
Saurabh Bhardwaj, postdoctoral fellow
Caroline Bartman, graduate student
Vivek Behera, combined degree student
Chris Edwards, postdoctoral fellow
Carolyne Face, technician
Jeremy Grevet, combined degree student
Chris Hsiung, combined degree student
Sarah Hsu combined degree student
Peng Huang, postdoctoral fellow
Kiwon Lee, postdoctoral fellow
Laavanya Sankar, technician
Michael Werner, combined degree student
Hongxin Wang, technician/lab manager
Di Zhang, combined degree student

Selected Publications

Bartman CR, Hsu SC, Hsiung CC, Raj A, Blobel GA: Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping. Molecular Cell(62), 237, 2016.

Lee K, Hsiung CC, Huang P, Raj A, Blobel GA: Dynamic enhancer-gene body contacts during transcription elongation. Genes Dev. 29: 1992, 2015.

Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, Giardine BM, Kadauke S, Campbell AE, Evans P, Hardison RC, Blobel GA.: Functions of BET proteins in erythroid gene expression. Blood 125: 2825, 2015.

Hsiung CC, Morrissey CS, Udugama M, Frank CL, Keller CA, Baek S, Giardine B, Crawford GE, Sung MH, Hardison RC, Blobel GA.: Genome accessibility is widely preserved and locally modulated during mitosis. Genome Research 25: 213, 2015.

Deng W, Rupon JW, Krivega I, Breda L, Motta I, Jahn KS, Reik A, Gregory PD, Rivella S, Dean A, Blobel GA: Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell 158(4): 849, 2014.

Kadauke S, Udugama MI, Pawlicki JM, Achtman JC,Jain DP, Cheng Y, Hardison RC, and Blobel GA: Tissue-specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1. Cell 150: 725, 2012.

Deng W, Lee J, Wang H, Miller J, Reik A, Gregory PD, Dean A, Blobel GA: Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149: 1233, 2012.

Lamonica JM, Deng W, Kadauke S, Campbell AE, Gamsjaeger R, Wang H, Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA: Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. PNAS 108: 159, 2011.

Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA: NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 29: 442, 2010.

Blobel GA, Kadauke S, Wang E, Lau AW, Zuber J, Chou MM, Vakoc CR: A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Molecular Cell 36: 970, 2009.

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Last updated: 05/07/2016
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