Neil R. Malhotra, M.D.

faculty photo
Associate Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Department: Neurosurgery

Contact information
Chief of Neurosurgery - HUP
Vice Chairman for Operations

Associate Professor and Program Director, Neurological Surgery
Director, EpiLog Quality Improvement Initiative
Co-Director, Restorative Spinal Research Laboratory

3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3487
Fax: 215-349-5534
Lab: 215-662-6137 (Brigitte Britt)
Education:
BA (High Distinction Scholar)
University of Virginia, 1997.
MD (Doctor of Medicine)
University of Virginia, 2002.
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Description of Research Expertise

As Co-Director of the Translational Spinal Research Laboratory, Dr. Malhotra develops restorative approaches to treat disc degeneration. His novel approaches have led to multiple awards and research grants. Through his work, Dr. Malhotra hopes to reduce the need for spinal surgery and offer better treatments for disc degeneration.

Dr. Malhotra's clinical research focuses on disparities in care. Whether studying spinal chordoma outcomes or the impact of household income, gender, or race on clinical outcomes, Dr. Malhotra leverages his expertise with the electronic health record. Dr. Malhotra founded, and leads, the EpiLog project. The EpiLog team of McKenna statistical fellows and Frazier scholars work to uncover disparities in medical outcomes. Where possible, the lab develops approaches to eliminate avoidable differences in outcome.

Description of Clinical Expertise

Dr. Malhotra is chief of neurosurgery at HUP and serves as a departmental vice chairman as well as associate program director. He is an associate professor of neurological and orthopedic surgery. He oversees strategic initiatives to enhance the quality of patient care.

Dr. Malhotra has published more than 120 articles and book chapters related to his clinical and research work.

From a clinical standpoint, Dr. Malhotra provides expertise in the care of brain and spine neurological disorders. His clinical goals focus on optimizing quality of life as well as life expectancy for disorders of the nervous system. He takes particular interest in the development of advanced approaches to brain and spinal lesion treatment (such as meningioma) and spinal column reconstruction and en bloc tumor resection (as with chordoma). Further he treats spinal degenerative disorders such as cervical and lumbar disc herniation and spondylolisthesis. He has developed endoscopic and robotic approaches for spinal degenerative disorders and cancers.

Selected Publications

Goel NJ, Agarwal P, Mallela AN, Abdullah KG, Ali ZS, Ozturk AK, Malhotra NR, Schuster JM, Chen HI: Liver disease is an independent predictor of poor 30-day outcomes following surgery for degenerative disease of the cervical spine. Spine J 19(3):448-460, March 2019.

Dimentberg R, Sinha S, Glauser G, Caplan IF, Schuster JM, McClintock SD, Yoon J, Marcotte PJ, Ali Z, Malhotra NR: Short-Term Impact of Bracing in Multi-Level Posterior Lumbar Spinal Fusion. International Journal of Spine Surgery 2020 Notes: In press.

Glauser G, Sharma N, Beatson N, Dimentberg R, Savarese F, Gagliardi M, Grady MS, Malhotra NR: Surgical CPT Coding Discrepancies: Analysis of Surgeons and Employed Coders. Am J Med Qual 22;1062860620959440, September 2020.

Farooqi A, Dimentberg R, Shultz K, McClintock SD, Malhotra NR: Absence of Gender Disparity in 30-Day Morbidity and Mortality After Supratentorial Brain Tumor Resection. World Neurosurg 27;S1878-8750(20)31915-X, August 2020.

Detchou DK, Dimentberg R, Vaughan KA, Kolster R, Braslow BM, Malhotra NR: Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy. World Neurosurg 10;143:319-324, August 2020.

Zhang C, Gullbrand S, Schaer TP, Boorman S, Elliott DM, Chen W, Dodge GR, Mauck RL, Smith LJ*, Malhotra NR*: Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats. Tissue Eng Part 27,1-2; Epub ahead of print, August 2020.

Blue R, Yang AI, Zhou C, De Ravin E, Teng CW, Arguelles GR, Huang V, Wathen C, Miranda SP, Marcotte P, Malhotra NR, Welch WC, Lee JYK: Telemedicine in the Era of Coronavirus Disease (COVID-19): A Neurosurgical Perspective. World Neurosurg 139:549-557, July 2020.

Gutierrez A, Su YS, Vaughan KA, Miranda S, Chen HI, Petrov D, Malhotra NR, Schuster JM: Penetrating Spinal Column Injuries (pSI): An Institutional Experience with 100 Consecutive Cases in an Urban Trauma Center. World Neurosurg 138:e551-e556, June 2020.

Blue, R., Detchou, DK., Dimentberg, R., Shultz, K., Spadola, M., McClintock, SD., Malhotra, NR: The Influence of Household Income on Survival Following Posterior Fossa Tumor Resection at a Large Academic Medical Center. J Neurol Surg B Skull Base-in press. In press: Lower household income is associated with increased mortality in both the 90-day window and total follow-up period, 2020.

Spadola M, Farooqi A, Dimentberg R, Blue R, Shultz K, McClintock SD, Malhotra NR: The Effect of Household Income on Outcomes Following Supratentorial Meningioma Resection. Clin Neurol Neurosurg 17;195:106031, June 2020.

Blue R, Dimentberg R, Detchou DK, Glauser G, Shultz K, McClintock SD, Malhotra NR: The Impact of Household Economics on Short-Term Outcomes in a Posterior Fossa Tumor Population. Cureus 12(7):e8968, July 2020.

Dimentberg R, Caplan IF, Winter E, Glauser G, Goodrich S, McClintock SD, Hume EL, Malhotra NR: Prediction of Adverse Outcomes Within 90 Days of Surgery in a Heterogeneous Orthopaedic Surgery Population. Journal Healthc Qual Epub ahead of print, August 2020.

Winter E, Dimentberg R, Haldar D, Glauser G, Caplan IF, Shultz K, McClintock SD, Chen HI, Yoon JW, Malhotra NR: Predicting Short Term Outcomes Following Supratentorial Tumor Surgery. Clinical Neurology and Neurosurgery 196:106016, September 2020.

Miranda SP, Glauser G, Wathen C, Blue R, Dimentberg R, Welch WC, Grady MS, Schuster JM, Malhotra NR: Incorporating Telehealth to Improve Neurosurgical Training During the COVID-19 Pandemic. World Neurosurg 139:728-731, July 2020.

Winter E, Haldar D, Glauser G, Caplan IF, Shultz K, McClintock SD, Chen HI, Yoon J, Malhotra NR: The LACE+ Index as a Predictor of 90-Day Supratentorial Tumor Surgery Outcomes. Neurosurgery nyaa225 Epub ahead of print, June 2020.

Caplan IF, Winter E, Glauser G, Goodrich S, McClintock SD, Milby AH, Hume EL, Malhotra NR: Composite Score for Prediction of 30-Day Orthopaedic Surgery Outcomes. J Orthop Res 38(10):2189-2196, April 2020.

Haldar D, Glauser G, Winter E, Goodrich S, Shultz K, McClintock SD, Malhotra NR: Assessing the Role of Patient Race in Disparity of 90-Day Brain Tumor Resection Outcomes. World Neurosurg 139:e663-e671, July 2020.

Haldar D, Glauser G, Schuster JM, Winter E, Goodrich S, Shultz K, Brem S, McClintock SD, Malhotra NR: The Role of Race in Short Term Outcomes for 1700 Consecutive Patients Undergoing Brain Tumor Resection. J Healthc Qual Epub ahead of print, June 2020.

Kvint S, Malhotra NR, Cox M, Mondschein JI, Pukenas BA, Bagley LJ : Giant Iliac Artery Pseudoaneurysm Mimicking Postoperative Fluid Collection and Diskitis. World Neurosurg 136:253-257, April 2020.

Glauser G, Wathen C, Miranda SP, Blue R, Dimentberg R, Welch WC, Lee JYK, Malhotra NR: Implementation and Workflow of a Telehealth Clinic in Neurosurgery During the COVID-19 Pandemic. World Neurosurg 139:373-375, July 2020.

Glauser G, Dimentberg R, Shultz K, McClintock SD, Malhotra NR: Survival Disparity Based on Household Income in 1,970 Patients Following Brain Tumor Surgery. World Neurosurg 143:e112-e121, July 2020.

Glauser G, Winter E, Caplan IF, Goodrich S, McClintock SD, Srinivas SK, Malhotra NR: Composite Score for Outcome Prediction at 30 Days in Gynecologic Surgery Patients. J Healthc Qual Epub ahead of print, March 2020.

Glauser G, Winter E, Caplan IF, Goodrich S, McClintock SD, Srinivas SK, Malhotra NR: Predictive Index for 90 Day Postoperative Outcomes Following Gynecologic Surgery. Am J Manag Care. The results of this study suggest that the LACE+ index is suitable as a prediction model for important patient outcomes in a gynecologic surgery population. 26(7):303-309, July 2020.

Glauser G, Sharma N, Kritikos ME, Malhotra NR, Choudhri O: Intradural Extramedullary Solitary Fibrous Tumors of the Spinal Cord. Asian J Neurosurg 15(1):204-209, January 2020.

Glauser G, Osiemo B, Goodrich S, McClintock SD, Weber KL, Levin LS, Malhotra NR: Assessment of Short-Term Patient Outcomes Following Overlapping Orthopaedic Surgery at a Large Academic Medical Center. J Bone Joint Surg Am 102(8):654-663, April 2020.

Zhang C, Gullbrand SE, Schaer TP, Khai Lau Y, Jiang Z, Dodge GR, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration. J Orthop Res 10.1002/jor.24639, February 2020.

Haldar D, Glauser G, Winter E, Dimentberg R, Goodrich S, Schultz K, Grady MS, McClintock SD, Malhotra NR: The Effect of Race on Short-Term Pituitary Tumor Outcomes. World Neurosurg 137:e447-e453, February 2020.

Glauser G, Goodrich S, McClintock SD, Dimentberg R, Guzzo TJ, Malhotra NR: Evaluation of Short-term Outcomes Following Overlapping Urologic Surgery at a Large Academic Medical Center. Urology. Nonconcurrent overlapping surgery is not associated with adverse outcomes in a large, matched urologic surgery population across 1 academic health system. 138:30-36, April 2020.

Glauser G, Winter E, Caplan IF, Haldar D, Goodrich S, McClintock SD, Guzzo TJ, Malhotra NR: The LACE+ Index as a Predictor of 90-Day Urologic Surgery Outcomes. World J Urol 38(11):2783-2790, November 2020.

Sullivan PZ, Albayar A, Ramayya AG, McShane B, Marcotte P, Malhotra NR, Ali ZS, Chen HI, Janjua MB, Saifi C, Schuster J, Grady MS, Jones J, Ozturk AK: Association of spinal instability due to metastatic disease with increased mortality and a proposed clinical pathway for treatment. J Neurosurg Spine 14;1-8, February 2020.

Winter E, Glauser G, Caplan I, Goodrich S, McClintock SD, Kovach SJ, Fonsnot J, Serletti J, Malhotra NR: The LACE+ Index as a Predictor of 30-Day Patient Outcomes in a Plastic Surgery Population: A Coarsened Exact Match Study. Plast Reconstr Surg 146(3):296e-305e, September 2020.

Winter E, Glauser G, Caplan IF, Goodrich S, McClintock SD, Kovach SJ, Fosnot J, Serletti JM, Malhotra NR : LACE+ Index as a Predictor of 90-Day Plastic Surgery Outcomes. Am J Manag Care 26(4):e113-e120, April 2020.

Caplan IF, Glauser G, Goodrich S, Chen HI, Lucas TH, Lee JYK, McClintock SD, Malhotra NR: Undiagnosed obstructive sleep apnea as a predictor of 90-day readmission for brain tumor patients. World Neurosurg 134:e979-e984, February 2020.

Glauser G, Malhotra NR: The Importance of Confirming Anecdotal Experience: Assessing Overlapping Surgery. World Neurosurg 130: 557-558, October 2019.

Peck SH, Tobias JW, Shore EM, Malhotra NR, Haskins ME, Casal ML, Smith LJ: Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII. Bone 128: 115042, November 2019.

Claeson AA, Vresilovic EJ, Showalter BL, Wright AC, Gee JC, Malhotra NR, Elliott DM: Human Disc Nucleotomy Alters Annulus Fibrosus Mechanics at Both Reference and Compressed Loads. J Biomech Eng 141(11): 1110011–11100112, November 2019.

Caplan, IF., Zadnik, P., Glauser, G., O’Rourke, DM., Kung, D., Choudhri, O., Osiemo, B., Goodrich, S., McClintock, SD., Malhotra, NR: Predicting 30-90-day Readmission in a Brain Tumor Population with the LACE+ Index. American Association of Neurological Surgeons 2019.

Agarwal, P., Ramayya, AG., Osiemo, B., Goodrich, S., Glauser, G., McClintock, SD., Chen, HI., Schuster, JM., Grady, MS., Malhotra, NR: Association of Overlapping Neurosurgery with Patient Outcomes at a Large Academic Medical Center. American Association of Neurological Surgeons 2019.

Caplan IF, Zadnik P, Glauser G, Ali ZS, O’Rourke DM, Kung DK, Choudhri O, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index as a predictor of 30-day readmission in a brain tumor population. American Association of Neurological Surgeons 2019.

Glauser, G., Agarwal, P., Ramayya, AG., Chen, HI., Lee, JYK., Schuster, JM., Osiemo, B., Goodrich, S., Smith, LJ., McClintock, SD., Malhotra, NR: Association of Surgical Overlap During Wound Closure with Patient Outcomes Amongst Neurological Surgery Patients at a Large Academic Medical Center. American Association of Neurological Surgeons Annual Meeting April 2019.

Caplan IF, Sullivan PZ, Glauser G, Choudhri O, Kung D, O’Rourke DM, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index fails to predict 30-90 day readmission for supratentorial craniotomy patients: A retrospective series of 238 surgical procedures. Clin Neurol Neurosurg 182:79-83, July 2019.

Glauser, G., Osiemo, B., Goodrich, S., McClintock, SD., Vollmer, C., DeMatteo, R., Malhotra, NR: Association of Overlapping, Non-Concurrent, Surgery with Patient Outcomes at a Large Academic Medical Center: A Coarsened Exact Matching Study. American Surgical Association 139th Annual Meeting April 2019.

Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Preconditioning Enhances Bone Marrow-Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment. Cartilage 11;1947603519841675, April 2019.

Caplan IF, Sinha S, Osiemo B, McClintock SD, Schuster JM, Smith H, Glauser G, Sharma N, Ozturk AK, Ali ZS, Malhotra, NR: The Utility of Cervical Spine Bracing As a Postoperative Adjunct to Multilevel Anterior Cervical Spine Surgery. Int J Spine Surg 14(2):151-157, April 2020.

Sinha S, Caplan IF, Schuster JM, Piazza M, Glauser G, Sharma N, Welch WC, Osiemo B, McClintock SD, Ozturk AK, Malhotra NR: Evaluation of lumbar spine bracing as a postoperative adjunct to single-level posterior lumbar spine surgery. Asian J Neurosurg 15(2):333-337, May 2020.

Arginteanu, T., Glauser, G., Smith, LJ., Pasha, S., DeTurck, D., Malhotra, NR: Quantifying Scoliosis Severity using Differential Geometry. Spine-In review 2019.

Caplan IF, Glauser G, Goodrich S, Chen HI, Lucas TH, Lee JYK, McClintock SD, Malhotra NR: Undiagnosed obstructive sleep apnea as a predictor of 30-day readmission for brain tumor patients. J Neurosurg 19;1-6, July 2019.

Glauser G, Winter E, Caplan IF, Goodrich S, McClintock SD, Guzzo TJ, Malhotra NR: The LACE+ Index as a Predictor of 30 Day Patient Outcomes in a Urologic Surgery Population: A Coarsened Exact Match Study. Urology 134:109-115, September 2019.

Glauser G, Caplan IF, Winter E, Goodrich S, McClintock SD, Atluri P, Malhotra NR: Evaluation of the LACE+ Index for Short-Term Cardiac Surgery Outcomes: A Coarsened Exact Match Study. Ann Thorac Surg 110(1):173-182, July 2020.

Glauser G, Piazza M, Berger I, Osiemo B, McClintock SD, Winter E, Chen HI, Ali ZS, Malhotra NR: The Risk Assessment and Prediction Tool (RAPT) for Discharge Planning in a Posterior Lumbar Fusion Population. Neurosurgery. Preoperative RAPT score is a highly predictive tool in lumbar fusion patients for discharge disposition. 1;86(2):E140-E146, February 2020.

Glauser G, Goodrich S, McClintock SD, Szeto WY, Atluri P, Acker MA, Malhotra NR: Association of overlapping cardiac surgery with short-term patient outcomes. J Thorac Cardiovasc Surg S0022-5223(20)30028-3, January 2020.

Glauser G, Osiemo B, Goodrich S, McClintock SD, Vollmer C, DeMatteo R, Malhotra NR: Association of Overlapping, Non-Concurrent, Surgery with Patient Outcomes at a Large Academic Medical Center: A Coarsened Exact Matching Study. Annals of Surgery 270(4):620-629, October 2019.

Hitti FL, McShane BJ, Yang AI, Rinehart C, Albayar A, Branche M, Malhotra NR, Janjua MB, Ali ZS, Schuster JM, Ozturk AK: Predictors of Failure of Nonoperative Management Following Subaxial Spine Trauma and Creation of Modified Subaxial Injury Classification System. World Neurosurg 122:e1359-e1364, February 2019.

Ramayya AG, Glauser G, Mcshane B, Branche M, Sinha S, Kvint S, Buch V, Abdullah KG, Kung DK, Chen HI, Malhotra NR, Ozturk AK: Factors Predicting Ventriculostomy Revision at a Large Academic Medical Center. World Neurosurg 123:e509-e514, March 2019.

Petrov D, Spadola M, Berger C, Glauser G, Mahmoud A, O’Malley B, Malhotra NR: Novel Approach using Ultrasonic Bone Curettage and TransOral Robotic Surgery for En Bloc Resection of Cervical Spine Chordomas. J Neurosurg Spine 1;1-6, March 2019.

Ali ZS, Flanders TM, Ozturk AK, Malhotra NR, Leszinsky L, McShane BJ, Gardiner D, Rupich K, Chen HI, Schuster J, Marcotte PJ, Kallan MJ, Grady MS, Fleisher LA, Welch WC: Enhanced recovery after elective spinal and peripheral nerve surgery: pilot study from a single institution. J Neurosurg Spine 30(4) Epub ahead of print, January 2019.

Glauser G, Ali ZS, Gardiner D, Ramayya AG, Pessoa R, Grady MS, Welch WC, Zager EL, Sim E, Haughey V, Wells B, Restuccia M, Tait G, Fala G, Malhotra NR: Assessing the utility of an IoS application in the perioperative care of spine surgery patients: the NeuroPath Pilot study. Mhealth 5:40, September 2019.

Caplan IF, Sullivan PZ, Kung D, O’Rourke DM, Choudhri O, Glauser G, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index as a predictor of 30-day readmission in a brain tumor population. World Neurosurg 127:e443-e448, July 2019.

Jivraj I, Liu GT, Sharma N, Glauser G, Grady MS, Malhotra NR: Resolution of Papilledema associated with Chiari I Malformation with Ventriculoperitoneal Shunting Asian J Neurosurg 14(2):598-601, April 2019.

Caplan IF, Sinha S, Schuster JM, Piazza M, Glauser G, Osiemo B, McClintock SD, Welch WC, Sharma N, Ozturk AK, Malhotra NR: The Utility of Cervical Spine Bracing as a Postoperative Adjunct to Single-Level Anterior Cervical Spine Surgery. Asian J Neurosurg 14(2):461-466, June 2019.

Glauser G, Agarwal P, Ramayya AG, Chen HI, Lee JYK, Schuster JM, Osiemo B, Goodrich S, Smith LJ, McClintock SD, Malhotra NR: Association of Surgical Overlap During Wound Closure with Patient Outcomes Amongst Neurological Surgery Patients at a Large Academic Medical Center. Neurosurgery 85(5):E882-E888, November 2019.

Agarwal P, Ramayya AG, Osiemo B, Goodrich S, Glauser G, McClintock SD, Chen HI, Schuster JM, Grady MS, Malhotra NR: Association of Overlapping Neurosurgery with Patient Outcomes at a Large Academic Medical Center. Neurosurgery 85(6):E586, June 2020.

Ramayya AG, Chen HI, Marcotte PJ, Brem S, Zager EL, Osiemo B, Piazza M, Sharma N, McClintock SD, Schuster JM, Ali ZS, Connolly P, Heuer GG, Grady MS, Kung DK, Ozturk AK, O’Rourke DM, Malhotra NR: Assessing variability in surgical decision making among attending neurosurgeons at an academic center. J Neurosurg 31;1-7, May 2019.

Berger I, Piazza M, Sharma N, Glauser G, Osiemo B, McClintock SD, Lee JYK, Schuster JM, Ali ZS, Malhotra NR: Evaluation of the Risk Assessment and Prediction Tool for Post-Operative Disposition Needs After Cervical Spine Surgery. Neurosurgery 85(5):E902-E909, November 2019.

Malhotra NR, Piazza M, Demoor R, McClintock SD, Hamilton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Maloney E, Smith LJ, Grady MS: Impact of Reduced Pre-incision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study. Annals of Surgery 271(4):774-780, April 2020.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Zhang Y, Smith HE, Smith LJ*, Malhotra NR*: Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. J Orthop Res 36(10):2771-2779, October 2018.

Piazza M, Sharma N, Osiemo B, McClintock S, Missimer E, Gardiner D, Maloney E, Callahan D, Smith JL, Welch W, Schuster J, Grady MS, Malhotra NR: Initial Assessment of the Risk Assessment and Prediction Tool in a Heterogeneous Neurosurgical Patient Population. Neurosurgery 85(1):50-57, July 2019.

Nayak NR, Richard CE, Martinez-Lage M, Smith H, Malhotra N: Synovial-Type Giant Cell Tumors of the Axial Spine. J Neurosurg Sci 61(1):106-109, February 2017.

Kvint S, Malhotra NR, Cox M, Mondschein JI, Pukenas BA, Bagley LJ: Giant Iliac Artery Pseudoaneurysm Mimicking Postoperative Fluid Collection and Discitis. World Neurosurg December 2019.

Christian Terwiesch: Cobotics in Surgery-En Bloc Resection of Spinal Cancers. Sirius XM: Wharton Business Radio May 2018.

Zadnik-Sullivan P, Sanborn M, Smith LJ, Malhotra NR: Spinal Cord and Spinal Column. The Trauma Manual: Trauma and Acute Care Surgery 5th Edition-in press 2018.

Smith LJ, Silverman L, Sakai D, Lotz JC, Le Maitre CL, Malhotra NR, Mauck RL, Buckley CT: Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic. JOR Spine 1(4):e1036, December 2018.

Baker M, Malhotra NR: En Bloc Spondylectomy and Trans Oral Robotic Surgery for Cervical Chordoma. Clinical Briefing August 2018.

McCann AC, Berger C, Mahmoud AF, Kuan EC, Malhotra NR, O'Malley BW Jr: Novel approach using transoral robotic surgery for resection of cervical spine chordoma. Laryngoscope 129(6):1395-1399, November 2018.

Sharma N, Piazza M, Marcotte PJ, Welch W, Ozturk AK, Chen HI, Ali ZS, Schuster J, Malhotra NR: Implications of anesthetic approach, spinal vs general, for the treatment of spinal disc herniation. J Neurosurg Spine 30(1):78-82, November 2018.

Ali ZS, Ma TS, Ozturk AK, Malhotra NR, Schuster JM, Marcotte PJ, Grady MS, Welch WC: Pre-optimization of Spinal Surgery Patients: Development of a Neurosurgical Enhanced Recovery After Surgery (ERAS) Protocol. Clin Neurol Neurosurg 164:142-153, January 2018.

Nayak NR, Piazza M, Milby A, Thawani JP, Smith LJ, Stein SC, Malhotra NR: Surgical Approaches for the Treatment of Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: Results of a Decision Analysis. World Neurosurg 112:e375-e384, April 2018.

Peck SH, McKee KK, Tobias JW, Malhotra NR, Harfe BD, Smith LJ: Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus. Sci Rep 7(1):10504, September 2017.

Hitti FL, Hudgins ED, Chen HI, Malhotra NR, Zager EL, Schuster JM: Intraoperative Navigation Is Associated with Reduced Blood Loss During C1-C2 Posterior Cervical Fixation. World Neurosurg 107:574-578, November 2017.

Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge G, Chen W, Elliott D, Mauck RL, Smith LJ*, Malhotra NR*: Translation of an Injectable Triple-Interpenetrating-Network Hydrogel for Intervertebral Disc Regeneration in a Goat Model. Acta Biomater 60: 201-209, September 2017.

Piazza M, Nayak N, Ali Z, Heuer G, Sanborn M, Stein S, Schuster J, Grady MS, Malhotra NR: Trends in Resident Operative Teaching Opportunities for Treatment of Intracranial Aneurysms. World Neurosurg 103: 194-200, July 2017.

Berger I, Nayak N, Schuster JM, Lee JYK, Stein S, Malhotra NR: Microvascular Decompression Versus Stereotactic Radiosurgery for Trigeminal Neuralgia: A Decision Analysis. Cureus 9(1): e1000, January 2017.

Tong W, Tian Z, Qin L, Motomi EI, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Zhang Y: Cell Therapy for the Degenerating Intervertebral Disc. Transl Res 181: 49-58, March 2017.

Jiang X, Orton M, Feng R, Hossain E, Malhotra NR, Zager EL, Liu R: Chronic Opioid Usage in Surgical Patients in a Large Academic Center. Ann Surg 265(4):722-727, April 2017.

Pisapia JM, Nayak NR, Salinas RD, Macyszyn L, Lee JY, Lucas TH, Malhotra NR, Chen IH, Schuster JM: Navigated Odontoid Screw Placement Using the O-arm. J Neurosurg Spine 26(1):10-18, January 2017.

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo JR, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ: A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration. Osteoarthritis Cartilage 25(1): 146-156, January 2017.

Nayak NR, Bauman JA, Stein SC, Thawani JP, Malhotra NR: Surgical Approaches for the Treatment of Thoracic Disk Herniation: Results of a Decision Analysis. Clin Spine Surg 30(7): 901-908, August 2017.

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Elliott DM, Mauck RL, Chen, Malhotra NR: In Vitro Characterization of a Stem-Cell-Seeded Triple-Interpenetrating-Network Hydrogel for Functional Regeneration of the Nucleus Pulposus. Tissue Eng Part A 20(13-14): 1841-1849, July 2014.

Baker M, Malhotra NR: En Bloc Spondylectomy and TransOral Robotic Surgery for Cervical Chordoma. Clinical Briefing June 2018.

Lorraine L. Janeczko: Statin Shows Promise as Alternative to Surgery for Chronic Brain Bleeds. Reuters Health News August 2018.

Ali ZS, Flanders TM, Ozturk A, Malhotra NR, McShane B, Kallan M, Grady MS, Welch WC: Enhanced Recovery After Surgery (ERAS) decreases postoperative opioid use in elective spinal and peripheral nerve surgery – a single institution,one-year study American Academy of Neurological Surgery Meeting September 2018.

Louisa Shepard: Robot Revolution. Bellwether Magazine 2016 Notes: Dr. Malhotra was interviewed and provided editorial comments.

Syre P, Malhotra NR: Chronic Back Pain and Degenerative Disc Disease. Clinical Decision Support in Spine Surgery. Vaccaro A, Rihn J, Prasad S, Wang M (eds.). Decision Support in Medicine, LLC, 2016.

Syre P, Macyszyn, Nyirjesy S, Millhouse PW, Koerner J, Vaccaro AR, Malhotra NR: Advanced Anterior Cervical Foraminotomy Technique. Spine Surgery: Tricks of the Trade, 3rd ed. Vaccaro AR, Albert T (eds.). Thieme, 2016.

Nayak NR, Stephen JH, Abdullah KG, Stein SC, Malhotra NR: Comparing Utility Scores in Common Spinal Radiculopathies: Results of a Prospective Valuation Study. Global Spine J 6(3): 270-6, May 2016.

Agarwal P, Burke JF, Abdullah KG, Piazza M, Smith BP, Thawani JP, Malhotra NR: Stab wound to the intramedullary spinal cord: Presurgical and surgical management options for a retained blade to optimize neurological preservation. Surgical Neurol Int 7(Suppl 42): S1096-S1098, December 2016.

Malhotra NR: Degenerative Disc Disease and Low Back Pain. Clinical Decision Support System on Spine Surgery. Vaccaro A, Rihn J, Prasad S, Wang M (eds.) (eds.). Decision Support in Medicine, January 2016.

Gorth DJ, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long-Term Agarose Culture. J Orthop Res 33(5): 747-54, May 2015.

Showalter BL, Elliott DM, Chen W, Malhotra NR: Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery. J Biomech Eng 137(8): 081008, August 2015.

Whitmore RG, Curran JN, Ali ZS, Mummaneni PV, Shaffrey CI, Heary RF, Kaiser MG, Asher AL, Malhotra NR, Cheng JS, Hurlbert J, Smith JS, Magge SN, Steinmetz MP, Resnick DK, Ghogawala Z: Predictive Value of 3-Month Lumbar Discectomy Outcomes in the NeuroPoint-SD. J Neurosurg Spine 23(4): 459-66, October 2015.

Nayak NR, Coats JM, Abdullah KG, Stein SC, Malhotra NR: Tracking Patient-Reported Outcomes in Spinal Disorders. Surg Neurol Int 6(Suppl 19): S490-9, October 2015.

Malhotra NR: Medical Breakthrough: Spinal Surgery Today. XM National Radio-ReachMD August 2011 Notes: Radio Interview with Dr. Lee Freedman. XM National Radio-ReachMD XM167: The Channel for Medical Professionals.

Ellen Czajkowski: Surviving the Knife. A Surgeon Removes a Knife from a Patients Spinal Cord and the Patient Miraculously Walks Again. CBS Eyewitness News 2014 Notes: Dr. Malhotra was interviewed and created figures and images.

Robert Linnehan: Enhanced EMRs May Support Better Treatments and Translational Research. Orthopedics / Spine Surgery Today 2014 Notes: DR. Malhotra was interviewed and provided some editorial comments.

Peck SH, Casal ML, Malhotra NR, Ficicioglu C, Smith LJ: Pathogenesis and Treatment of Spine Disease in the Mucopolysaccharidoses. Featured Cover Article. Mol Genet Metab 118(4): 232-43, August 2016.

Gorth DG, Martin JT, Dodge GR, Malhotra NR, Elliott DM, Mauck RL, Smith LJ: In Vivo Retention and Bioactivity of IL-1ra Microspheres in the Rat Intervertebral Disc: a Preliminary Investigation. J Exp Orthop 1(1): 15, December 2014.

Peck SH, O'Donnell PJ, Kang JL, Malhotra NR, Dodge GR, Pacifici M, Shore EM, Haskins ME, Smith LJ: Delayed Hypertrophic Differentiation of Epiphyseal Chondrocytes Contributes to Failed Secondary Ossification in Mucopolysaccharidosis VII Dogs. Mol Genet Metab 116(3): 195-203, November 2015.

Lewis DJ, Attiah MA, Malhotra NR, Burnett MG, Stein SC: Anterior Surgical Management of Single-Level Cervical Disc Disease: A Cost-Effectiveness Analysis Spine (Phila Pa 1976) 39(25): 2084-92, December 2014.

Malhotra NR: Health-Real Life Drama: Neurosurgeon Saves Spinal Cord and a Patient Walks Again. CBS 3 Television News, Sweeps Week May 2014 Notes: Invited Television Broadcast Interview.

Stein SC, Malhotra NR, Burnett MG: Cost-Effectiveness Analysis. J Neurosurg Spine 20(4): 474, April 2014.

Kelz M, Malhotra NR: The Neurosurgical Operative Experience, a Patients Perspective. WHYY “The Pulse”, Host: Maiken Scott January 2014.

Malhotra NR: Improving Surgical Care of the Spinal Disorders: The Osteoporotic Spine. J Osteopor Phys Act June 2013 Notes: Invited Editorial.

Schuster JM, Malhotra NR: Posterior Thoracic Instrumentation. Youmans Neurological Surgery. Ed 6. Winn HR (Ed) (eds.). Saunders. Philadelphia, PA, USA. Page: 3061-3068, 2011, Page: 3061-3068, October 2011 Notes: Chapter 301.

Malhotra NR, Kosty J, Sanborn M, Bekisz JM, Mooncai TW, Neustein TM, Ou J, Zhu A, Bernstein A, Stein SC: Optimal Approach to Circumferential Decompression and Reconstruction for Thoracic Spine Metastatic Disease. Ann Surg Oncol 21(9): 2864-2872, September 2014.

Nestorovski D, Milby AH, Pallavi G, Smith LJ, Smith HE, Malhotra NR: Combined Treatment Approach for Rare Occipito-Cervical Spinal Lesions: Leiomyosarcoma. J Spine Neurosurg S1(003): EPUB only, July 2013 Notes: doi: 10.4172/2325-9701.S1-003.

Bohman LE, Stephen JH, Ramakrishna R, Schuster JM, Malhotra NR : Postoperative Ambulatory Status Predicts Survival in Patients with Glioblastoma Multiforme. J Spine Neurosurg S1(001): EPUB only, May 2013 Notes: doi:10.4172/2325-9701.S1-001.

Chen HI, Lang SS, Coyne TM, Malhotra NR, Schuster JM: Intramedullary Spinal Sarcoidosis Masquerading as Cervical Stenosis. World Neurosurg 80(6): 375-380, December 2013.

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-Outcome Relationship in Neurotrauma Care. J Neurosurg 118(3): 687-93, March 2013.

Macyszyn L, Lega B, Bohman LE, Latefi A, Smith MJ, Malhotra NR, Welch WC, Grady MS: Implementation of a Departmental Picture Archiving and Communication System: a Productivity and Cost Analysis. Neurosurgery 73(3): 528-33, September 2013.

Syre P, Petrov D, Malhotra NR: Management of Upper Cervical Spine Injuries. J Neurosurg Sci 57(3): 219-40, September 2013.

Syre P, Rodriguez-Cruz L, Desai R, Greene KA, Hurst R, Schuster J, Malhotra NR, Marcotte P: Civilian Gunshot Wounds to the Atlantoaxial Spine: a Report of 10 Cases Treated Using a Multidisciplinary Approach. J Neurosurg Spine 19(6): 759-766, December 2013.

Ghogawala Z, Shaffrey CI, Asher AL, Heary RF, Logvinenko T, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Abbed KM, Sciubba DM, Resnick DK: The Efficacy of Lumbar Discectomy and Single-Level Fusion for Spondylolisthesis: Results from the NeuroPoint-SD Registry. J Neurosurg Spine 19(5): 555-63, November 2013.

O'Connell Grace D, Malhotra Neil R, Vresilovic Edward J, Elliott Dawn M: The Effect of Nucleotomy and the Dependence of Degeneration of Human Intervertebral Disc Strain in Axial Compression. Spine (Phila Pa 1976) 36(21): 1765-1771, October 2011.

Mummaneni PV, Whitmore RG, Curran JN, Ziewacz JE, Wadhwa R, Shaffrey CI, Asher AL, Heary RF, Cheng JS, Hurlbert RJ, Douglas AF, Smith JS, Malhotra NR, Dante SJ, Magge SN, Kaiser MG, Abbed KM, Resnick DK, Ghogawala Z: Cost-Effectiveness of Lumbar Discectomy and Single Level Fusion for Spondylolisthesis: Experience with the NeuroPoint SD Registry. Neurosurg Focus 36(6): E3, June 2014.

Malhotra NR, Lotier L, Becker W, Smith LJ: The Neurosurgery Quality Improvement Initiative Supports Precision Medicine, QI, and Research. Epic International Physician Advisory Council September 2014.

Sanborn M, Smith LJ, Malhotra NR: Spinal Cord and Spinal Column. The Trauma Manual: Trauma and Acute Care Surgery 4th Edition. Peitzman AB, Yealy DM, Fabian TC, Rhodes M, Schwab CW (eds.). Lippincott Williams and Wilkins of Wolters Kluwer Health. ISBN-10: 1451116799; ISBN-13: 978-1451116793, December 2012 Notes: Chapter 25.

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-Outcome Relationship in Neurotrauma Care. J Neurosurg December 2012 Notes: Podcast.

Malhotra NR, Whitmore R, Smith LJ, Welch WC, Schuster JM, Marcotte P, Dante S, Arlet V, Brem S, Grady MS: Future Directions in Spine: An Opportunity to Accelerate Quality Improvement. J Spine Neurosurg 1(2): doi: 10.4172.2325-9701.1000e105, October 2012.

Lang SS, Malhotra NR: Interviewing for Pediatric Fellowship: Finding the Right Work-Work Balance. AANS Neurosurgeon 23(1), March 2014.

Sanborn MR, Abdullah K, Smith MJ, Grady MS, Malhotra NR: Improving Core Residency Education: An Argument for Increased Incorporation of Endovascular Surgical Training. AANS Neurosurgeon 21(4), August 2012.

Bohman LE, Malhotra NR: The Value of an “Infolded” Fellowship. AANS Neurosurgeon 21(3), July 2012.

Macyszyn L, Malhotra NR: Counterpoint: The Intensivist is in Charge. AANS Neurosurgeon 21(3), March 2012.

Hwang SW, Malhotra NR, Shaffrey CI, Samdani AF: Intraoperative Neurophysiological Monitoring in Spine Deformity Surgery (Invited Review). Spine Deformity Page: DOI:/10.1016/j.jspd.2012.05.006, September 2012 Notes: Internet-Only Publication

Malhotra NR, Bhomick D, Hardesty D, Whitfield P: Intramedullary Spinal Cord Tumors: Diagnosis, Treatment and Outcomes (Invited Review). Advances in Clinical Neuroscience and Rehabilitation (ACNR) 10(4): 21-26, September 2010.

Lang SS, Chen HI, Koch MJ, Kurash L, McGill-Armento KR, Palella JM, Stein SC, Malhotra NR: Development of an Outpatient Protocol for Lumbar Discectomy. World Neurosurg 82(5): 897-901, November 2014.

Chiaro JA, O'Donnell P, Shore EM, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. J Bone Miner Res 29(12): 2610-2617, December 2014.

Showalter BL, Malhotra NR, Vresilovic EJ, Elliott DM: Nucleotomy Reduces the Effects of Cyclic Compressive Loading with Unloaded Recovery on Human Intervertebral Discs. J Biomech 47(11): 2633-2640, August 2014.

Ali Z, Barkley A, Malhotra NR : Acute Spinal Subdural Hematoma Subsequent To Posterior Lumbar Fusion. J Osteopor Phys 1(1): EPUB only, March 2013 Notes: Case Report. Standard Peer Review Process. doi: 10.4172/2329-9509.1000101.

Lang SS, Schuster JM, Smith LJ, Dwyer-Joyce L, Welch W, Marcotte P, Winkelstein B, Malhotra NR : Hemorrhage into Synovial Cysts as a Cause of Acute Radicular Symptoms. A report of 7 Cases and Review of Literature. J Spine Neurosurg 2(1): EPUB only, December 2012.

Malhotra NR, Han WM, Beckstein J, Cloyd J, Chen W, Elliott DM: An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc. Spine (Phila Pa 1976) 37(18): E1099-105, August 2012.

Sanborn MR, Thawani JP, Whitmore RG, Shmulevich M, Hardy B, Benedetto C, Malhotra NR, Marcotte P, Welch W, Dante S, Stein SC: Cost-Effectiveness of Confirmatory Techniques for the Placement of Lumbar Pedicle Screws. Neurosurg Focus 33(1): E12, July 2012.

Lega BC, Danish SF, Malhotra NR, Sonnad SS, Stein SC: Choosing the Best Operation for Chronic Subdural Hematoma: a Decision Analysis. J Neurosurg 113(3): 615-21, September 2010.

Malhotra NR, Shaffrey CI: Intraoperative Electrophysiological Monitoring in Spine Surgery (Invited Review). Spine (Phila Pa 1976) 35(25): 2167-79, December 2010.

Wendell LC, Khan A, Raser J, Lang SS, Malhotra NR, Kofke WA, LeRoux P, Park S, Levine JM.: Successful Management of Refractory Intracranial Hypertension from Acute Hyperammonemic Encephalopathy in a Woman with Ornithine Transcarbamylase Deficiency. Neurocrit Care 13(1): 113-117, August 2010.

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate Infusion for Intractable Intracranial Hypertension and its Effect on Brain Oxygenation. Neurosurgery 63(5): 880-886, November 2008.

Boockvar JA, Stiefel M, Malhotra NR, Dolinskas C, Dwyer-Joyce C, LeRoux PD: Dural Cavernous Angioma of the Posterior Sagittal Sinus Surg Neurol 63(2): 178-181, February 2005.

Gaston B, Ratjen F, Vaughan JW, Malhotra NR, Canady RG, Snyder AH, Hunt JF, Gaertig S, Goldberg JB: Nitrogen Redox Balance in the Cystic Fibrosis Airway: Effects of Antipseudomonal Therapy. Am J Respir Crit Care Med 165(3): 387-90, February 2002.

Hunt JF, Erwin E, Palmer L, Vaughan J, Malhotra NR, Platts-Mills TA, Gaston B: Expression and Activity of pH-Regulatory Glutaminase in the Human Airway Epithelium. Am J Respir Crit Care Med 165(1): 101-7, January 2002.

Hunt JF, Fang K, Malik R, Snyder A, Malhotra NR, Platts-Mills TA, Gaston B: Endogenous Airway Acidification. Implications for Asthma Pathophysiology. Am J Respir Crit Care Med 161(3 part 1): 694-699, March 2000.

Malhotra NR, Whitfield P: Review of “The Legacy of Harvey Cushing” Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8(3), November 2008.

Malhotra NR, Thomas P, Grady MS: Injury to the Spine. Trauma: Contemporary Principles and Therapy. Flint L, Meredith JW, Schwalb CW, Trunkey DD, Rue LW, Taheri PA (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 297-304, October 2008 Notes: Chapter 28.

Thomas P, Malhotra NR, Grady MS: Injury to the Spinal Cord. Trauma: Contemporary Principles and Therapy. Flint, L., Meredith, W., Schwalb, W., Taheri, P., Trunkey, D. (Ed.) (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 289-297, October 2008 Notes: Chapter 27.

Malhotra NR, Grady MS: Anterior Cervical Foraminotomy Technique. Spine Surgery: Tricks of the Trade, 2nd ed. Vacaro AR (eds.). Thieme Medical Publishers, Inc. Page: 54-56, October 2009 Notes: Chapter 15.

Lega B, Malhotra NR, Danish S, Stein S: The Best Operation for Chronic Subdural Hematoma: A Decision Analysis (Best Scientific Poster Award / 1st Place). Pennsylvania Neurosurgical Society July 2008.

Espinoza Orías AA, Malhotra NR, Elliott DM: Rat Disc Torsional Mechanics: Effect of Lumbar and Caudal Levels and Axial Compression Load. Spine J 9(3): 204-209, March 2009.

Cloyd JM, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott DM: Material Properties in Unconfined Compression of Human Nucleus Pulposus, Injectable Hyaluronic Acid-Based Hydrogels and Tissue Engineering Scaffolds. Eur Spine J 16(11): 1892-1898, November 2007.

Plaha P, Malhotra NR, Heuer G, Whitfield P: Management of Chronic Subdural Hematoma. Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8(5): 12-15, November 2008.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: An In-Situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. (Society Scientific Paper of the Year Award). Pennsylvania Neurosurgical Society July 2008.

Hunt J, Fang K, Snyder A, Malhotra NR, Gaston BM: Ammonia Depletion in Asthma Diminishes Buffering of Endogenous Airway Acid. Journal of Allergy and Clinical Immunology 105(1): S193, January 2000.

Sinha S, Caplan I, Schuster JM, Sharma N, Piazza M, Welch WC, Ozturk AK, Malhotra NR: The Utility of Lumbar Spine Bracing as a Postoperative Adjunct to Single-level Posterior Lumbar Spine Surgery. Congress of Neurological Surgeons October 2018.

Caplan I, Sinha S, Schuster JM, Piazza M, Welch WC, Sharma N, Ozturk AK, Malhotra NR: The Utility of Cervical Spine Bracing as a Postoperative Adjunct to Single-level Anterior Cervical Spine Surgery. Congress of Neurological Surgeons October 2018.

Malhotra NR, Piazza M, DeMoor R, McClintock SS, Hamiliton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Marcotte PJ, Maloney E, Smith LJ, Grady MS: Compliance with Timing Standards for Pre-incision Antibiotic Prophylaxis and Implications for Surgical Site Infections. Congress of Neurological Surgeons October 2018.

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Last updated: 04/21/2021
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