Melina Elpi Marmarelis, MD, MSCE
Associate Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Attending Physician , Hospital of the University of Pennsylvania
Attending Physician , Penn Presbyterian Medical Center
Medical Director of Penn Medicine Mesothelioma and Pleural Program, University of Pennsylvania
PC3I Faculty, Penn Center for Cancer Care Innovation, University of Pennsylvania
Physician Lead -Airways Research Program, University of Pennsylvania
Department: Medicine
Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
10th Floor
Philadelphia, PA 19104
3400 Civic Center Blvd
10th Floor
Philadelphia, PA 19104
Education
BA (Bachelors in Biochemistry and Molecular Biology )
Dartmouth College, 2007.
MD (Medicine)
Harvard Medical School , 2013.
MSCE (Clinical Epidemiology )
University of Pennsylvania , 2019.
Permanent linkBA (Bachelors in Biochemistry and Molecular Biology )
Dartmouth College, 2007.
MD (Medicine)
Harvard Medical School , 2013.
MSCE (Clinical Epidemiology )
University of Pennsylvania , 2019.
Description of Clinical Expertise
Lung cancer and mesothelioma.Description of Research Expertise
Clinical trials in lung cancer in mesothelioma.Selected Publications
X. Wang; A. Martella; A. Watts; E.P. Wileyto; P. Gabriel; A. Montgomery; K. Rendle; M. Marmarelis; C. Aggarwal: P2.092 - Inudge: Integration of Liquid Biopsy Based Next Generation Gene Sequencing in Newly Diagnosed NSCLC - Results From a Prospective Clinical Trial. WCLC 2026 Poster September 2026.W. Wang, D. Huth, C. Davis, X. Wang, D. Cantor, A. Singh, L. Sun, C. D’Avella, D. Dougherty, K. Robinson, R. Cohen, C. Langer, M. Marmarelis, C. Aggarwal: P2.091Real-World Implementation of Tumor-Informed ctDNA MRD Testing in Early-Stage NSCLC: Initial Experience From a Large Academic Center. WCLC 2026 Poster September 2026.
Kleeman SO, Riazat-Kesh Y, Carvajal R, Marmarelis ME, Schadendorf D, Sharon E, Othus M, Robert C, Skoulidis F, Izar B, Maki RG, Janowitz T.: Cancer Chemoimmunotherapy: Time Will Tell. Cancer Immunol Res 14: 1212-1215, Aug 2026.
Barsouk AA, Yaskolko M, Sussman JH, Sun L, Singh AP, Cohen RB, Aggarwal C, Marmarelis ME, Langer CJ.: Poor Performance Status Associated With Inferior Tarlatamab Outcomes in a Large, Multi-institution Real-World Database of Patients With 2L + ES-SCLC. Clin Lung Cancer 27: 50-55, Jul 2026.
Melina E. Marmarelis, Adrienne M. Gilligan, Tomoko Sugihara, Tyler Marquart, Sam Whipple, Yufei Wang, Taylor J Allen-Coyle, Naleen Raj Bhandari, Charu Aggarwal: The Waiting Game: How NGS and Guideline-Concordant-Care Timing Shape Survival in Advanced NSCLC. Cancers 18(14): 2287, July 2026.
Benjamin A. Bleiberg, Dylan G. Scholes, Lauren Reed-Guy, Devaki Dravid, Lova L. Sun, Aditi P. Singh, Roger B. Cohen, Corey J. Langer, Melina E. Marmarelis, Charu Aggarwal: The incremental value of liquid biopsy in the initial evaluation of patients with metastatic non-small cell lung cancer undergoing tissue-based molecular testing. The Journal of Liquid Biopsy 12, June 2026.
Sam O. Kleeman; Yosef Riazat-Kesh; Richard Carvajal; Melina E. Marmarelis; Dirk Schadendorf; Elad Sharon; Megan Othus; Caroline Robert; Ferdinandos Skoulidis; Benjamin Izar; Robert G. Maki; Tobias Janowitz.: Cancer chemo-immunotherapy: time will tell. Cancer Immunology Research June 2026.
Benjamin A. Bleiberg, Lauren Reed-Guy, Roger B. Cohen, Charu Aggarwal, Corey J. Langer, Aditi P. Singh, Melina E. Marmarelis: Carboplatin plus Pemetrexed versus Pemetrexed alone in Advanced Thymoma and Thymic Carcinoma: A Retrospective Cohort Study. Frontiers June 2026.
Bleiberg BA, Scholes DG, Reed-Guy L, Dravid D, Sun LL, Singh AP, Cohen RB, Langer CJ, Marmarelis ME, Aggarwal C.: Erratum to "The incremental value of liquid biopsy in the initial evaluation of patients with metastatic non-small cell lung cancer undergoing tissue-based molecular testing" [J. Liq. Biopsy 12 (2026) 100461] J Liq Biopsy 12: 100472, May 2026.
Cole Friedes, Michelle Iocolano, Nikhil Yegya-Raman, John C Kucharczuk, Taine T V Pechet, Roger B Cohen, Charu Aggarwal, Melina E Marmarelis, William P Levin, Keith A Cengel, Christine A Ciunci, Christopher D'Avella, Aditi P Singh, Christiana W Davis, Corey J Langer, Jeffrey Bradley, Steven J Feigenberg: Real World Radiographic Response Rates and Preoperative Attrition in Patients With Non-Small Cell Lung Cancer (NSCLC) Treated With Neoadjuvant Chemoimmunotherapy. American Journal of Clinical Oncology May 2026.