Multiple Sclerosis

Divisions and Programs

The Myelin Disorders Biorepository Project (MDBP) is a collaboration between CHOP and over 10 other hospitals and universities around the country which collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects. The MDBP is one of the world’s largest leukodystrophy biorepositories, having enrolled over 3,500 affected individuals since it was launched over a decade ago. Researchers working in the biorepository hope to use these materials to uncover genetic etiologies for various leukodystrophies, develop biomarkers for use in future clinical trials, and better understand the natural history of these disorders. They also seek to use the knowledge gained from these efforts to improve diagnostic tools and expand treatment options available to future patients. Penn is a satellite site for this project, and patients referred to Dr. Orthmann-Murphy's neurogenetics clinic may have the opportunity to participate in the study following evaluation.