The Penn Epilepsy Center is the best comprehensive center in the region, and one of America’s best. We use a team approach for personalized care and offer the newest medication trials, brain imaging techniques to map seizures only found at Penn, and guarantee same week appointments, and often the same or next day. We offer a transition program to adult care for children & young adults, state of the art minimally invasive epilepsy surgery (Visualase laser ablation, NeuroPace RNS devices, endoscopic epilepsy surgery (only at Penn)) and we are piloting and inventing tomorrow’s therapies. We are one of the world’s leaders in monitoring patients continuously throughout their evaluations, in the operating room and throughout their hospitalizations to prevent complications and “silent” or subclinical seizures.
- Penn Epilepsy Center (internal)
- Center for Neuroengineering and Therapeutics (CN&T)
The Litt laboratory translates NeuroEngineering research directly into patient care. We collaborate broadly across disciplines to invent, develop and test new technologies and apply them to basic and clinical research. While epilepsy is the lab’s core focus, our multidisciplinary efforts span a variety of scientific and clinical areas, including brain-machine interfaces, functional neurosurgery, network and computational neuroscience, movement disorders, intra-operative and ICU monitoring, and a broad array of “brain network” disorders.
The major focus of my laboratory is on developing new age-specific therapies for epilepsy and its comorbidities. We specifically focus on forms of epilepsy that affect the infant and early childhood brain, and have extensive expertise in investigations of human tissue as well as rat and mouse models of early life epilepsy. Our interests have been on hypoxic/ischemic injury and seizures in the perinatal and young postnatal brain. My lab has published expertise in cellular and regional alterations in synaptic proteins and signaling pathways using whole animal, human tissue, and in vitro brain slices and cell cultures. Almost 20 years ago we showed that hypoxia can induce seizures in the neonatal brain and this increased network excitability in adulthood; over the years we have worked to show that AMPARs are involved in this epileptogenesis and that spontaneous seizures are increased in adulthood, confirming this as a model of epileptogenesis
- Coulter Lab
- Davis Lab
- Dichter Lab