Liu Laboratory

Bone Imaging, Biomechanics, Biology, and Bioengineering Journal Club

November 19th, 2020

Ishizuya (1997), “Parathyroid Hormone Exerts Disparate Effects on Osteoblast Differentiation Depending on Exposure Time in Rat Osteoblastic Cells”, J Clin Invest

November 5th, 2020

Wang et. al. (2019), “A Noel Osteogenic Cell Line That Differentiates into GFP-Tagged Osteocytes and Forms Mineral With a Bone-Link Lacunocanalicular Structure", J Bone Miner Res

October 8th, 2020

Miller et. al., (2020), “Effect of Abaloparatide vs. Placebo on New Vertebral Fractures in Postmenopausal Women with Osteoporosis: A Randomized Clinical Trial, JAMA

September 17th, 2020

Arit et. al, (2020), “Effects of Abaloparatide and Teriparatide on Bone Resorption and Bone Formation in Female Mice”, Bone Rep

August 27th, 2020

Shen et. al. (2020), “Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading”, J Bone Miner Res

August 20th, 2020

Dole et. al. (2020), “TGFβ Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic”, J Bone Miner Res

August 13th, 2020

Newton et. al. (2018), “Nondestructive, Indirect Assessment of the Biomechanical Properties of the Rat Intervertebral Disc Using Contrast-Enhanced µCT”, JOR

Marcella et. al. (2008), “The role of the nucleus pulposus in neutral zone human lumbar intervertebral disc mechanics”, J Biomech

July 31st, 2020

Maridas et. al. (2019), “Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton”, FASEB

July 9th, 2020

Zhong et. al. (2020), “Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment”, eLife

May 7th, 2020

Takai et. al. (2004), “Osteocyte Viability and Regulation of Osteoblast Function in a 3D Trabecular Bone Explant Under Dynamic Hydrostatic Pressure”, J Bone Miner Res

Chan et. al. (2009), “A Trabecular Bone Explant Model of Osteocyte–Osteoblast Co-Culture for Bone Mechanobiology” Cell Mol Bioeng

April 30th, 2020

Misof et. al. (2020), “No evidence for alteration in early secondary mineralization by either alendronate, teriparatide or combination of both in transiliac bone biopsy samples from postmenopausal osteoporotic patients”, Bone Rep

April 16th, 2020

Kusumbe et. al. (2014), “Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone”, Nature

April 2nd, 2020

Xiao et. al. (2020), “Mechanics and Biology Interact in Intervertebral Disc Degeneration: A Novel Composite Mouse Model”, Calcif. Tissue Int.

March 26th, 2020

Zannit et. al. (2019), “Proliferation and Activation of Osterix-Lineage Cells Contribute to Loading-Induced Periosteal Bone Formation in Mice”, J Bone Miner Res Plus

November 21st, 2019

Mazur et. al. (2019), “Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis”, Nat. Bone

November 14th, 2019

Jahn et. al. (2017), “Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo”, J Bone Miner Res

November 7th, 2019

Moffat et. al. (2008), “Characterization of the structure-function relationship at the ligament-to-bone interface”, PNAS

Spalazzi et. al. (2013), “Quantitative Mapping of Matrix Content and Distribution across the Ligament-to-Bone Insertion, PloS one

October 31st, 2019

Zwick et. al. (2018), “Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation”, Nat. Commun.

October 24th, 2019

Kir et. al. (2016), “PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer”, Cell Metab.

October 18th, 2019 

Lotinun et. al. (2019), “Cathepsin K–deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression”, J Clin Invest

September 12th, 2019 

Cosman et. al. (2019), "Standard vs Cyclic Teriparatide and Denosumab Treatment for Osteoporosis: A Randomized Trial", J Bone Miner Res

Leder et. al. (2019), "Fracture and Bone Mineral Density Response by Baseline Risk in Patients Treated With Abaloparatide Followed by Alendronate: Results From the Phase 3 ACTIVExtend Trial" J Bone Miner Res

June 5th, 2019 

Literature review and discussion of axial compression loading models to study bone mechanobiology

May 22nd, 2019

Dempster et al. (2018), “Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis from Baseline to 3 Months in the AVA Study.”, J Bone Miner Res

Dempster et al. (2018), “Longitudinal Effects of Teriparatide or Zoledronic Acid on Bone Remodeling- and Remodeling- Based Formation in the SHOTZ Study.” J Bone Miner Res

May 15th, 2019

Gregor et al. (2013), “The role of adipocyte XBP1 in metabolic regulation during lactation.” Cell Reports

Costa et al. (2019), “Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents.” Bone

April 23rd, 2019

Calvi et al. (2001), “Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.” J Clin Inv

Qiu et al. (2014), “PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate.” J Bone Miner Res

April 17th, 2019

Saini et al. (2013), “Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signalizing in osteocytes regulates anabolic and catabolic skeletal responses to PTH.” J Biol. Chem

Delgado-Calle (2017), “Control of bone anabolism in response to mechanical loading and PTH by distinct mechanisms downstream of the PTH receptor.” J Bone Miner Res

March 6th, 2019

Kar et al. (2013), “Connexin 43 channels protect osteocytes against oxidative stress-induced cell death.” J Bone Miner Res

February 27th, 2019

Sakabe et al. (2018), “Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice.” J Biol. Chem

January 30th, 2019

Hemmatian et al. (2018), “Mechanical loading differentially affects osteocytes in fibulae from lactating mice compared to osteocytes in virgin mice: possible role for lacuna size.” Calci Tissue Int

January 23rd, 2019

Kogawa et al. (2013), “Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.” J Bone Miner Res

January 16th, 2019

Dole et al. (2017), “Osteocyte-intrinsic TGF-B signaling regulates bone quality through perilacunar/canalicular remodeling.” Cell Reports

September 20th, 2018

Herber et al. (2018), “Estrogen signaling in Arcuate Kiss1 neurons suppresses a sex-dependent circuit that promotes dense strong bones in female mice.” bioRxiv

September 6th, 2018

Zhou et al. (2015), “Enhancement of lumbar fusion and alleviation of adjacent segment disc degeneration by intermittent PTH(1-34) in ovariectomized rats.” J Bone Miner Res

Song et al. (2017), “Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats.” Spine

August 22nd, 2018

Laporta et al. (2018), “Serotonin regulates calcium homeostasis in lactation by epigenetic activation of Hedgehog Signaling.” Mol Endocrinol

July 25th, 2018

Weaver et al. (2018), “Peripartum dietary supplementation of a small molecule inhibitor of Tryptophan Hydroxylase 1 compromises infant, but not maternal bone.”

July 19th, 2018

Stegen et al. (2018), “Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.” Nature Communications

July 16th, 2018

Wang et al. (2014), “Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system.” J Bone Miner Res

June 27th, 2018

Hyatt et al. (2018), “Lactation has persistent effects on a mother’s metabolism and mitochondrial function.” Nature Scientific Reports

June 21st, 2018

Tokarz et al. (2017), “Hormonal regulation of osteocyte perilacunar and canalicular remodeling in the Hyp Mouse Model of X-linked Hypophosphatemia.” J Bone Miner Res

June 13th, 2018

Ciani et al. (2014), “Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone.” Bone

June 6th, 2018

Wang et al. (2013), “Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system.” J Bone Miner Res

May 30th, 2018

Price et al. (2011), “Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow.” J Bone Miner Res

May 19th, 2018

Wang et al. (2005), “In situ measurement of solute transport in the bone lacunar-canalicular system.” PNAS

May 11th, 2018

Sugiyama et al. (2008), “Mechanical Loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice.” Bone

Warden et al. (2013), “Elevated Mechanical Loading when young provides lifelong benefits to cortical bone properties in female rats independent of a surgically induced menopause.” Endocrinol

April 27th, 2018

Silva et al. (2012), “Tibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Aged Mice” PLos one

Sun et al. (2017), “Evaluation of Loading Parameters for Murine Axial Tibial Loading: Stimulating Cortical Bone Formation While Reducing Loading Duration.” J Ortho Res

April 19th, 2018

Glatt et al. (2007), “Age-Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice.”, J Bone Miner Res.

Willinghamm et al. (2010), “Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice”, Calif Tissue Int

March 5th, 2018

Xiong et al. (2011), “Matrix-embedded cells control osteoclast formation.” Nature Medicine

February 1st, 2018

Ansari et al. (2017), “Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.” J Bone Miner Res.

February 1, 2017

Yihan Li & Chantal de Bakker
Kaya S et al. (2016), "Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue." J Bone Miner Res. 

Bjørnerem Å et al. (2016),"Irreversible Deterioration of Cortical and Trabecular Microstructure Associated With Breastfeeding." J Bone Miner Res.

January 11, 2017

Yihan Li & Hongbo Zhao
Relationship between peak microstructure properites and estrogen-deficiency-induced bone loss.Effects of daily or cyclic parathyoid hormone treatment regimens on bone in OVX rats.

September 14, 2016

Chantal de Bakker
Reproduction-Induced Changes in Maternal Trabecular Bone Microarchitecture Confer Protective Effects Against Estrogen Deficiency

August 17, 2016

Hongbo Zhao
Discussion of Compression Test on Lumbar Vertebrae

July 20, 2016

Laurel Leavitt
Discussion of Local Thresholding &Waarsing JH et al. (2004), "An improved segmentation method for in vivo µCT imaging." J Bone Miner Res. 19(10):1640-1650.

July 6, 2016

Meghan Pinezich
Understanding osteocyte modulation of maternal bone tissue mineral and matrix properties using raman and qBEI

April 13, 2016

Wonsae Lee, Yihan Li &Hongbo Zhao
Discussion of MMA embedding and Plastic Microtome protocol

April 6, 2016

Wonsae Lee, Yihan Li & Hongbo Zhao
Discussion of Image Registration Protocol

March 30, 2016

Hongbo Zhao
Wysolmerski JJ, (2013), "Osteocytes remove and replace perilacunar mineral during reproductive cycles." Bone. 54(2):230-236.

March 23, 2016

Yihan Li
Donnelly E et al.(2010), "Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex." J Biomed Mater Res A. 92(3):1048-1056.

March 16, 2016

Marissa Eppes
Sharma D et al. (2012), "Alterations in the osteocyte lacunar-canalicular microenvironment due to estrogen deficiency." Bone. 51(3):488-497.

March 9, 2016

Wonsae Lee
Hu M and Qin Y-X. (2014), "Dynamic fluid flow stimulation on cortical bone and alterations of the gene expressions of osteogenic growth factors and transcription factors in a rat functional disuse model." Arch Biochem Biophys. 545:154-161.

February 17, 2016

Chantal de Bakker
Ardeshirpour L et al. (2015), " OPG Treatment prevents bone loss during lactation but does not affect milk production or maternal calcium metabolism." Endocrinology. 156(8):2762-2773.

February 10, 2016

Yihan Li
Ozcivici E and Judex S. (2014)," Trabecular bone recovers from mechanical unloading primarily by restoring its mechanical function rather than its morphology." Bone, 67:122-129.

February 3, 2016

Chih-Chiang Chang
Buie HR et al. (2008), "Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice*. " Journal of Bone and Mineral Research, 23(12):2048-2059.

November 24, 2015    

Wei-Ju Tseng & Chih-Chiang Chang    
Tu X et al. (2012) "Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading" Bone. 50:209-217.

November 17, 2015

Wei-Ju Tseng    
Warden SJ et al. (2013) "Reduced Gravitational Loading Does Not Account for the Skeletal Effect of Botulinum Toxin-Induced Muscle Inhibition Suggesting a Direct Effect of Muscle on Bone." Bone. 54:98-105.

November 10, 2015  

Hongbo Zhao    
Roschger P et al. (2010), "Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)." J Bone Miner Res. 25(1):48-55.

October 27, 2015    

Yihan Li    
Mandair GS and Morris MD (2015), "Contributions of Raman spectroscopy to the understanding of bone strength." Bonekey Rep. 4:620.

October 13, 2015    

Wonsae Lee    
Gunness-Hey M et al. (1989), "Loss of the anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats." Bone. 7(6):447-452. 

Bala Y et al. (2010), "Time sequence of secondary mineralization and microhardness in cortical and cancellous bone from ewes." Bone. 46(4):1204-1212.

Cohen A et al. (2015), "Bone Density after Teriparatide Discontinuation in Premenopausal Idiopathic Osteoporosis." J Clin Endocrinol Metab.
May 27, 2015    Yihan Li    Zysset PK et al. (1999), "Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur." J Biomech. 32(10):1005-1012.

Hoffler CE et al. (2005), "An application of nanoindentation technique to measure bone tissue Lamellae properties." J Biomech Eng. 127(7):1046-1053.

Wolfram U et al. (2010), "Rehydration of vertebral trabecular bone: Influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral levels." Bone. 46(2):348-354.

March 4, 2015  

Youwen Yang    
Introduction of RT-PCR and qPCR

February 18, 2015  

Yihan Li    
Introduction of Raman Spectroscopy

February 11, 2015  

Chih-Chiang Chang    
Introduction of FTIR

February 5, 2015    

Wei-Ju Tseng    
Introduction of Atomic Force Microscopy

January 21, 2015    

Wei-Ju Tseng & Yihan Li    
Schwiedrzik J et al. (2014), "In situ micropillar compression reveals superior strength and ductility but an absence of damage in lamellar bone." Nat Mater. 13(7):740-747.

July 24, 2014    

Wei-Ju Tseng    
Tu X et al. (2012) "Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading." Bone. 50:209-217.

July 15, 2014    

Allison Altman    
Warden SJ et al. (2013) "Reduced Gravitational Loading Does Not Account for the Skeletal Effect of Botulinum Toxin-Induced Muscle Inhibition Suggesting a Direct Effect of Muscle on Bone." Bone. 54:98-105.

June 23, 2014    

Chantal de Bakker    
Amugongo SK et al. (2014) "Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass." Osteoporosis Int. 25:1735- 1750.

February 18, 2014    

Allison Altman    
Rhee Y et al. (2013), "Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes." J Biological Chemistry. 288(41):29809-29820.

February 12, 2014    

Chantal de Bakker   
Waarsing JH et al. (2004), "An improved segmentation method for in vivo µCT imaging." J Bone Miner Res. 19(10):1640-1650.

February 5, 2014    

Wei-Ju Tseng    
Barou O et al., (2002), "Relationships between trabecular bone remodeling and bone vascularization: a quantitative study." Bone. 30(4):604-612.

September 24, 2013    

Allison Altman    
Rauch F. (2012), "The dynamics of bone structural development during pubertal growth." J Musculoskelet Neuronal Interact. 12(1):1-6.

July 25, 2013    

Connie Li & Carina Lott    
Chandra A et al. (2013), "PTH prevents the adverse effects of focal radiation on bone architecture in young rats." Bone. 55:449-457.

July 11, 2013    

Klyde Breitton    
Green JO et al. (2012), "Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year" Osteoporos Int. 23:2313-2320.

June 6, 2013    

Mary Beth Tribble    
Nickolas TL et al. (2013), "Rapid cortical bone loss in patients with chronic kidney disease" J Bone Miner Res. 28(8):1811-1820.

May 30, 2013    

Allison Altman    
Allen MR et al. (2008), "Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily Treatment" Calcif Tissue Int 82:354-360.

April 25, 2013    

Wei-Ju Tseng    
Mekraldi S et al. (2003), "Changes in vasoactive factors associated with altered vessel morphology in the tibial metaphysis during ovariectomy-induced bone loss in rats" Bone, 32:630-641.

April 18, 2013    

Beom Kang Huh    
Ding W-G et al. (2011), "Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice" Connect Tissue Res. 52(1): 25-29.

March 28, 2013    

Klyde Breitton    
Arlot ME et al. (2008), "Microarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone" J Bone Miner Res. 23(10):1613-1618.

March 14, 2013    

Mary Beth Tribble    
Macdonald HM et al. (2011), "Changes in trabecular and cortical bone microarchitecture at peripheral sites associated with 18 months of teriparatide therapy in postmenopausal women with osteoporosis" Osteoporos Int 22:357-362.

March 7, 2013    

Chantal de Bakker    
Schulte FA et al. (2011), "In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging" Bone 48:433-442.

December 13, 2012    

Allison Altman    
Green JO et al. (2012), "Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year" Osteoporos Int. 23:2313-2320.

December 6, 2012    

Wei-Ju Tseng    
Qing H et al. (2012), "Demonstration of Osteocytic Perilacunar/Canalicular Remodeling in Mice During Lactation" J Bone Miner Res. 27(5):1018-1029.

November 8, 2012    

Allison Altman    
Tang Y et al. (2009), "TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation" Nat. Med. 15:757-765.

November 1, 2012    

Allison Altman    
Wu XW et al. (2010), "Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling" Cell Stem Cell. 7:571-580.

Kostenuik PJ et al. (2001), "OPG and PTH-(1-34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats" Endocrinology, 142(10):4295-4304.

October 25, 2012    

Wei-Ju Tseng    
Kim SW et al. (2012), "Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts" J Bone Miner Res. 27(10):2075-2084.

October 18, 2012    

Chantal de Bakker    
Hayward LNM et al. (2012), "MRT Letter: Contrast-Enhanced Computed Tomographic Imaging of Soft Callus Formation in Fracture Healing" Microscopy Research and Technique, 75:7-14.

September 27, 2012    

Allison Altman    
Kazakia RJ et al. (2008), "Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: Comparison with synchrotron radiation microcomputed tomography and ash measurements" Med Phys, 35(7):3170-3179.

September 20, 2012    

Mimi Luo    
Prisby R et al. (2011), "Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites" J Bone Miner Res, 26(11):2583-2596.

September 13, 2012    

Beom Kang Huh    
Fuchs RK et al. (2008), "Strontium ranelate does not stimulate bone formation in ovariectomized rats" Osteoporos Int, 19(9):1331-1341. 

Bain SD et al. (2009), "Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants" Osteoporos Int, 20(8):1417-1428.

July 9, 2012    

Allison Altman    
Nishiyama KK et al. (2010), "Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration" Bone, 46(1):155-161.

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