Bone Imaging, Biomechanics, Biology, and Bioengineering Journal Club
July 6th, 2023
Wenzheng Wang et al (2022), "Distinct Responses of Modeling- and Remodeling-Based Bone Formation to the Discontinuation of Intermittent Parathyroid Hormone Treatment in Ovariectomized Rats", JBMR. DOI:10.1002/jbmr.4704
Apirl 20th, 2023
Altman et al (2015), "Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography" , Bone. DOI: 10.1016/j.bone.2015.07.037.
April 6th, 2023
Shenghui Lan et al (2013), "3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo microcomputed tomography (μCT)", Bone. DOI: 10.1016/j.bone.2013.05.014.
January 26th, 2023
Wei-ju Tseng et al (2022), "Short Cyclic Regimen With Parathyroid Hormone (PTH) Results in Prolonged Anabolic Effect Relative to Continuous Treatment Followed by Discontinuation in Ovariectomized Rats", JBMR. DOI: 10.1002/jbmr.4495.
Jan 13, 2023
de Bakker et al (2018), "Structural Adaptation in the Rat Tibia Bone Induced by Pregnancy and Lactation Confer Protective Effects Against Future Estrogen Deficiency", JBMR. DOI: 10.1002/jbmr.3559.
Dec 16, 2022
de Bakker et al. (2017), "Adaptations in the Microarchitecture and Load Distribution of Maternal Cortical and Trabecular Bone in Response to Multiple Reproductive Cycles in Rats", JBMR. DOI: 10.1002/jbmr.3084
November 28th, 2022
Wenzheng Wang et al (2021), "Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats", Biomaterials. DOI: 10.1016/j.biomaterials.2021.121015
March 11th, 2022
Wang Q et al. (2013), "Tracking adipogenesis during white adipose tissue development, expansion and regeneration", Nature Medicine. DOI: 10.1038/nm.3324
September 24th, 2021
Alabdulaaly L (2021), "Deletion of the Parathyroid Hormone Receptor in Marrow Adipose Lineage Precursors (MALPs) Prevents Their Negative Regulation of Skeletal Homeostasis", Thesis.
November 19th, 2020
Ishizuya et.al. (1997), “Parathyroid Hormone Exerts Disparate Effects on Osteoblast Differentiation Depending on Exposure Time in Rat Osteoblastic Cells”, J Clin Invest
November 5th, 2020
Wang et. al. (2019), “A Noel Osteogenic Cell Line That Differentiates into GFP-Tagged Osteocytes and Forms Mineral With a Bone-Link Lacunocanalicular Structure", J Bone Miner Res
October 8th, 2020
Miller et. al., (2020), “Effect of Abaloparatide vs. Placebo on New Vertebral Fractures in Postmenopausal Women with Osteoporosis: A Randomized Clinical Trial, JAMA
September 17th, 2020
Arit et. al, (2020), “Effects of Abaloparatide and Teriparatide on Bone Resorption and Bone Formation in Female Mice”, Bone Rep
August 27th, 2020
Shen et. al. (2020), “Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading”, J Bone Miner Res
August 20th, 2020
Dole et. al. (2020), “TGFβ Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic”, J Bone Miner Res
August 13th, 2020
Newton et. al. (2018), “Nondestructive, Indirect Assessment of the Biomechanical Properties of the Rat Intervertebral Disc Using Contrast-Enhanced µCT”, JOR
Marcella et. al. (2008), “The role of the nucleus pulposus in neutral zone human lumbar intervertebral disc mechanics”, J Biomech
July 31st, 2020
Maridas et. al. (2019), “Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton”, FASEB
July 9th, 2020
Zhong et. al. (2020), “Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment”, eLife
May 7th, 2020
Takai et. al. (2004), “Osteocyte Viability and Regulation of Osteoblast Function in a 3D Trabecular Bone Explant Under Dynamic Hydrostatic Pressure”, J Bone Miner Res
Chan et. al. (2009), “A Trabecular Bone Explant Model of Osteocyte–Osteoblast Co-Culture for Bone Mechanobiology” Cell Mol Bioeng
April 30th, 2020
Misof et. al. (2020), “No evidence for alteration in early secondary mineralization by either alendronate, teriparatide or combination of both in transiliac bone biopsy samples from postmenopausal osteoporotic patients”, Bone Rep
April 16th, 2020
Kusumbe et. al. (2014), “Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone”, Nature
April 2nd, 2020
Xiao et. al. (2020), “Mechanics and Biology Interact in Intervertebral Disc Degeneration: A Novel Composite Mouse Model”, Calcif. Tissue Int.
March 26th, 2020
Zannit et. al. (2019), “Proliferation and Activation of Osterix-Lineage Cells Contribute to Loading-Induced Periosteal Bone Formation in Mice”, J Bone Miner Res Plus
November 21st, 2019
Mazur et. al. (2019), “Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis”, Nat. Bone
November 14th, 2019
Jahn et. al. (2017), “Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo”, J Bone Miner Res
November 7th, 2019
Moffat et. al. (2008), “Characterization of the structure-function relationship at the ligament-to-bone interface”, PNAS
Spalazzi et. al. (2013), “Quantitative Mapping of Matrix Content and Distribution across the Ligament-to-Bone Insertion, PloS one
October 31st, 2019
Zwick et. al. (2018), “Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation”, Nat. Commun.
October 24th, 2019
Kir et. al. (2016), “PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer”, Cell Metab.
October 18th, 2019
Lotinun et. al. (2019), “Cathepsin K–deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression”, J Clin Invest
September 12th, 2019
Cosman et. al. (2019), "Standard vs Cyclic Teriparatide and Denosumab Treatment for Osteoporosis: A Randomized Trial", J Bone Miner Res
Leder et. al. (2019), "Fracture and Bone Mineral Density Response by Baseline Risk in Patients Treated With Abaloparatide Followed by Alendronate: Results From the Phase 3 ACTIVExtend Trial" J Bone Miner Res
June 5th, 2019
Literature review and discussion of axial compression loading models to study bone mechanobiology
May 22nd, 2019
Dempster et al. (2018), “Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis from Baseline to 3 Months in the AVA Study.”, J Bone Miner Res
Dempster et al. (2018), “Longitudinal Effects of Teriparatide or Zoledronic Acid on Bone Remodeling- and Remodeling- Based Formation in the SHOTZ Study.” J Bone Miner Res
May 15th, 2019
Gregor et al. (2013), “The role of adipocyte XBP1 in metabolic regulation during lactation.” Cell Reports
Costa et al. (2019), “Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents.” Bone
April 23rd, 2019
Calvi et al. (2001), “Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.” J Clin Inv
Qiu et al. (2014), “PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate.” J Bone Miner Res
April 17th, 2019
Saini et al. (2013), “Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signalizing in osteocytes regulates anabolic and catabolic skeletal responses to PTH.” J Biol. Chem
Delgado-Calle (2017), “Control of bone anabolism in response to mechanical loading and PTH by distinct mechanisms downstream of the PTH receptor.” J Bone Miner Res
March 6th, 2019
Kar et al. (2013), “Connexin 43 channels protect osteocytes against oxidative stress-induced cell death.” J Bone Miner Res
February 27th, 2019
Sakabe et al. (2018), “Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice.” J Biol. Chem
January 30th, 2019
Hemmatian et al. (2018), “Mechanical loading differentially affects osteocytes in fibulae from lactating mice compared to osteocytes in virgin mice: possible role for lacuna size.” Calci Tissue Int
January 23rd, 2019
Kogawa et al. (2013), “Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.” J Bone Miner Res
January 16th, 2019
Dole et al. (2017), “Osteocyte-intrinsic TGF-B signaling regulates bone quality through perilacunar/canalicular remodeling.” Cell Reports
September 20th, 2018
Herber et al. (2018), “Estrogen signaling in Arcuate Kiss1 neurons suppresses a sex-dependent circuit that promotes dense strong bones in female mice.” bioRxiv
September 6th, 2018
Zhou et al. (2015), “Enhancement of lumbar fusion and alleviation of adjacent segment disc degeneration by intermittent PTH(1-34) in ovariectomized rats.” J Bone Miner Res
Song et al. (2017), “Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats.” Spine
August 22nd, 2018
Laporta et al. (2018), “Serotonin regulates calcium homeostasis in lactation by epigenetic activation of Hedgehog Signaling.” Mol Endocrinol
July 25th, 2018
Weaver et al. (2018), “Peripartum dietary supplementation of a small molecule inhibitor of Tryptophan Hydroxylase 1 compromises infant, but not maternal bone.”
July 19th, 2018
Stegen et al. (2018), “Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.” Nature Communications
July 16th, 2018
Wang et al. (2014), “Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system.” J Bone Miner Res
June 27th, 2018
Hyatt et al. (2018), “Lactation has persistent effects on a mother’s metabolism and mitochondrial function.” Nature Scientific Reports
June 21st, 2018
Tokarz et al. (2017), “Hormonal regulation of osteocyte perilacunar and canalicular remodeling in the Hyp Mouse Model of X-linked Hypophosphatemia.” J Bone Miner Res
June 13th, 2018
Ciani et al. (2014), “Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone.” Bone
June 6th, 2018
Wang et al. (2013), “Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system.” J Bone Miner Res
May 30th, 2018
Price et al. (2011), “Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow.” J Bone Miner Res
May 19th, 2018
Wang et al. (2005), “In situ measurement of solute transport in the bone lacunar-canalicular system.” PNAS
May 11th, 2018
Sugiyama et al. (2008), “Mechanical Loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice.” Bone
Warden et al. (2013), “Elevated Mechanical Loading when young provides lifelong benefits to cortical bone properties in female rats independent of a surgically induced menopause.” Endocrinol
April 27th, 2018
Silva et al. (2012), “Tibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Aged Mice” PLos one
Sun et al. (2017), “Evaluation of Loading Parameters for Murine Axial Tibial Loading: Stimulating Cortical Bone Formation While Reducing Loading Duration.” J Ortho Res
April 19th, 2018
Glatt et al. (2007), “Age-Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice.”, J Bone Miner Res.
Willinghamm et al. (2010), “Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice”, Calif Tissue Int
March 5th, 2018
Xiong et al. (2011), “Matrix-embedded cells control osteoclast formation.” Nature Medicine
February 1st, 2018
Ansari et al. (2017), “Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.” J Bone Miner Res.
February 1, 2017
Yihan Li & Chantal de Bakker
Kaya S et al. (2016), "Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue." J Bone Miner Res.
Bjørnerem Å et al. (2016),"Irreversible Deterioration of Cortical and Trabecular Microstructure Associated With Breastfeeding." J Bone Miner Res.
January 11, 2017
Yihan Li & Hongbo Zhao
Relationship between peak microstructure properites and estrogen-deficiency-induced bone loss.Effects of daily or cyclic parathyoid hormone treatment regimens on bone in OVX rats.
September 14, 2016
Chantal de Bakker
Reproduction-Induced Changes in Maternal Trabecular Bone Microarchitecture Confer Protective Effects Against Estrogen Deficiency
August 17, 2016
Hongbo Zhao
Discussion of Compression Test on Lumbar Vertebrae
July 20, 2016
Laurel Leavitt
Discussion of Local Thresholding &Waarsing JH et al. (2004), "An improved segmentation method for in vivo µCT imaging." J Bone Miner Res. 19(10):1640-1650.
July 6, 2016
Meghan Pinezich
Understanding osteocyte modulation of maternal bone tissue mineral and matrix properties using raman and qBEI
April 13, 2016
Wonsae Lee, Yihan Li &Hongbo Zhao
Discussion of MMA embedding and Plastic Microtome protocol
April 6, 2016
Wonsae Lee, Yihan Li & Hongbo Zhao
Discussion of Image Registration Protocol
March 30, 2016
Hongbo Zhao
Wysolmerski JJ, (2013), "Osteocytes remove and replace perilacunar mineral during reproductive cycles." Bone. 54(2):230-236.
March 23, 2016
Yihan Li
Donnelly E et al.(2010), "Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex." J Biomed Mater Res A. 92(3):1048-1056.
March 16, 2016
Marissa Eppes
Sharma D et al. (2012), "Alterations in the osteocyte lacunar-canalicular microenvironment due to estrogen deficiency." Bone. 51(3):488-497.
March 9, 2016
Wonsae Lee
Hu M and Qin Y-X. (2014), "Dynamic fluid flow stimulation on cortical bone and alterations of the gene expressions of osteogenic growth factors and transcription factors in a rat functional disuse model." Arch Biochem Biophys. 545:154-161.
February 17, 2016
Chantal de Bakker
Ardeshirpour L et al. (2015), " OPG Treatment prevents bone loss during lactation but does not affect milk production or maternal calcium metabolism." Endocrinology. 156(8):2762-2773.
February 10, 2016
Yihan Li
Ozcivici E and Judex S. (2014)," Trabecular bone recovers from mechanical unloading primarily by restoring its mechanical function rather than its morphology." Bone, 67:122-129.
February 3, 2016
Chih-Chiang Chang
Buie HR et al. (2008), "Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice*. " Journal of Bone and Mineral Research, 23(12):2048-2059.
November 24, 2015
Wei-Ju Tseng & Chih-Chiang Chang
Tu X et al. (2012) "Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading" Bone. 50:209-217.
November 17, 2015
Wei-Ju Tseng
Warden SJ et al. (2013) "Reduced Gravitational Loading Does Not Account for the Skeletal Effect of Botulinum Toxin-Induced Muscle Inhibition Suggesting a Direct Effect of Muscle on Bone." Bone. 54:98-105.
November 10, 2015
Hongbo Zhao
Roschger P et al. (2010), "Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)." J Bone Miner Res. 25(1):48-55.
October 27, 2015
Yihan Li
Mandair GS and Morris MD (2015), "Contributions of Raman spectroscopy to the understanding of bone strength." Bonekey Rep. 4:620.
October 13, 2015
Wonsae Lee
Gunness-Hey M et al. (1989), "Loss of the anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats." Bone. 7(6):447-452.
Bala Y et al. (2010), "Time sequence of secondary mineralization and microhardness in cortical and cancellous bone from ewes." Bone. 46(4):1204-1212.
Cohen A et al. (2015), "Bone Density after Teriparatide Discontinuation in Premenopausal Idiopathic Osteoporosis." J Clin Endocrinol Metab.
May 27, 2015 Yihan Li Zysset PK et al. (1999), "Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur." J Biomech. 32(10):1005-1012.
Hoffler CE et al. (2005), "An application of nanoindentation technique to measure bone tissue Lamellae properties." J Biomech Eng. 127(7):1046-1053.
Wolfram U et al. (2010), "Rehydration of vertebral trabecular bone: Influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral levels." Bone. 46(2):348-354.
March 4, 2015
Youwen Yang
Introduction of RT-PCR and qPCR
February 18, 2015
Yihan Li
Introduction of Raman Spectroscopy
February 11, 2015
Chih-Chiang Chang
Introduction of FTIR
February 5, 2015
Wei-Ju Tseng
Introduction of Atomic Force Microscopy
January 21, 2015
Wei-Ju Tseng & Yihan Li
Schwiedrzik J et al. (2014), "In situ micropillar compression reveals superior strength and ductility but an absence of damage in lamellar bone." Nat Mater. 13(7):740-747.
July 24, 2014
Wei-Ju Tseng
Tu X et al. (2012) "Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading." Bone. 50:209-217.
July 15, 2014
Allison Altman
Warden SJ et al. (2013) "Reduced Gravitational Loading Does Not Account for the Skeletal Effect of Botulinum Toxin-Induced Muscle Inhibition Suggesting a Direct Effect of Muscle on Bone." Bone. 54:98-105.
June 23, 2014
Chantal de Bakker
Amugongo SK et al. (2014) "Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass." Osteoporosis Int. 25:1735- 1750.
February 18, 2014
Allison Altman
Rhee Y et al. (2013), "Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes." J Biological Chemistry. 288(41):29809-29820.
February 12, 2014
Chantal de Bakker
Waarsing JH et al. (2004), "An improved segmentation method for in vivo µCT imaging." J Bone Miner Res. 19(10):1640-1650.
February 5, 2014
Wei-Ju Tseng
Barou O et al., (2002), "Relationships between trabecular bone remodeling and bone vascularization: a quantitative study." Bone. 30(4):604-612.
September 24, 2013
Allison Altman
Rauch F. (2012), "The dynamics of bone structural development during pubertal growth." J Musculoskelet Neuronal Interact. 12(1):1-6.
July 25, 2013
Connie Li & Carina Lott
Chandra A et al. (2013), "PTH prevents the adverse effects of focal radiation on bone architecture in young rats." Bone. 55:449-457.
July 11, 2013
Klyde Breitton
Green JO et al. (2012), "Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year" Osteoporos Int. 23:2313-2320.
June 6, 2013
Mary Beth Tribble
Nickolas TL et al. (2013), "Rapid cortical bone loss in patients with chronic kidney disease" J Bone Miner Res. 28(8):1811-1820.
May 30, 2013
Allison Altman
Allen MR et al. (2008), "Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily Treatment" Calcif Tissue Int 82:354-360.
April 25, 2013
Wei-Ju Tseng
Mekraldi S et al. (2003), "Changes in vasoactive factors associated with altered vessel morphology in the tibial metaphysis during ovariectomy-induced bone loss in rats" Bone, 32:630-641.
April 18, 2013
Beom Kang Huh
Ding W-G et al. (2011), "Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice" Connect Tissue Res. 52(1): 25-29.
March 28, 2013
Klyde Breitton
Arlot ME et al. (2008), "Microarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone" J Bone Miner Res. 23(10):1613-1618.
March 14, 2013
Mary Beth Tribble
Macdonald HM et al. (2011), "Changes in trabecular and cortical bone microarchitecture at peripheral sites associated with 18 months of teriparatide therapy in postmenopausal women with osteoporosis" Osteoporos Int 22:357-362.
March 7, 2013
Chantal de Bakker
Schulte FA et al. (2011), "In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging" Bone 48:433-442.
December 13, 2012
Allison Altman
Green JO et al. (2012), "Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year" Osteoporos Int. 23:2313-2320.
December 6, 2012
Wei-Ju Tseng
Qing H et al. (2012), "Demonstration of Osteocytic Perilacunar/Canalicular Remodeling in Mice During Lactation" J Bone Miner Res. 27(5):1018-1029.
November 8, 2012
Allison Altman
Tang Y et al. (2009), "TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation" Nat. Med. 15:757-765.
November 1, 2012
Allison Altman
Wu XW et al. (2010), "Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling" Cell Stem Cell. 7:571-580.
Kostenuik PJ et al. (2001), "OPG and PTH-(1-34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats" Endocrinology, 142(10):4295-4304.
October 25, 2012
Wei-Ju Tseng
Kim SW et al. (2012), "Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts" J Bone Miner Res. 27(10):2075-2084.
October 18, 2012
Chantal de Bakker
Hayward LNM et al. (2012), "MRT Letter: Contrast-Enhanced Computed Tomographic Imaging of Soft Callus Formation in Fracture Healing" Microscopy Research and Technique, 75:7-14.
September 27, 2012
Allison Altman
Kazakia RJ et al. (2008), "Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: Comparison with synchrotron radiation microcomputed tomography and ash measurements" Med Phys, 35(7):3170-3179.
September 20, 2012
Mimi Luo
Prisby R et al. (2011), "Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites" J Bone Miner Res, 26(11):2583-2596.
September 13, 2012
Beom Kang Huh
Fuchs RK et al. (2008), "Strontium ranelate does not stimulate bone formation in ovariectomized rats" Osteoporos Int, 19(9):1331-1341.
Bain SD et al. (2009), "Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants" Osteoporos Int, 20(8):1417-1428.
July 9, 2012
Allison Altman
Nishiyama KK et al. (2010), "Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration" Bone, 46(1):155-161.