Soslowsky Laboratory

Biao Han, PH.D.

Post-doctoral Researcher
University of Pennsylvania

Hometown

Tianjin, China

Education

Ph.D. in Biomedical Engineering, Drexel University, 2020
M.S. in Electrical Engineering, B.S. in Mathematics, University of Bridgeport, 2011
B.S. Mathematics, Nankai University, 2009

Areas of Interest 

Biomechancs, Atomic Force Microscopy, nanoscale rheology, collagen fibril structure, proteoglycans, pericellular matrix

Publications

  1. C. Cui, D.-O. Kim, M.Y. Pack, B. Han, L. Han, Y. Sun, L.-H. Han, 4D printing of self-folding and cell-encapsulating 3D microstructures as scaffolds for tissue-engineering applications. Biofabrication 2020. 12 (4), 045018.
  2. D. R. Chery, B. Han, Q. Li, Y. Zhou, S.-J. Heo, B. Kwok, P. Chandrasekaran, C. Wang, L. Qin, X. L. Lu, D. Kong, M. Enomoto-Iwamoto, R. L. Mauck, and L. Han. Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis. Acta Biomater. 2020. 111: 267-278.
  3. Q. Li, B. Han, C. Wang, W. Tong, Y. Wei, W. Tseng, L.-H. Han, X. S. Liu, M. Enomoto‐Iwamoto, R. L. Mauck, L. Qin, R. V. Iozzo, D. E. Birk, and L. Han. Mediation of Cartilage Matrix Degeneration and Fibrillation by Decorin in Post‐traumatic Osteoarthritis. Arthritis Rheumatol. 2020. 72: 1266-1277.
  4. C. Wang, B. K. Brisson, M. Terajima, Q. Li, B. Han, A. M. Goldberg, X. S. Liu, M. S. Marcolongo, M. Enomoto-Iwamoto, M. Yamauchi, S. W. Volk, and L. Han. Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus, Matrix Biol. 2020. 85-86: 47-67.
  5. B. Han, Q. Li, C. Wang, P. Patel, S. M. Adams, B. Doyran, H. T. Nia, R. Oftadeh, S. Zhou, C. Y. Li, X. S. Liu, X. L. Lu, M. Enomoto-Iwamoto, L. Qin, R. L. Mauck, R. V. Iozzo, D. E. Birk, and L. Han. Decorin regulates the aggrecan network integrity and biomechanical functions of cartilage extracellular matrix. ACS Nano 2019. 13: 11320-11333.
  6. M. Wang, C. Cui, M. M. Ibrahim, B. Han, Q. Li, M. Pacifici, J. T. R. Lawrence, L. Han, and L.-H. Han. Regulating mechanotransduction in three-dimensions using sub-cellular scale, crosslinkable fibers of controlled diameter, stiffness and alignment. Adv. Funct. Mater. 2019. 29: 1808967.
  7. R. Malik, T. Luong, X. Cao, B. Han, N. Shah, L. Han, V. B. Shenoy, P. I. Lelkes, and E. Cukierman. Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer invasion via extracellular signal-regulated kinase 2. Matrix Biol. 2019. 81: 50-69.
  8. T. Zhou, B. Han, H. Qi, Q. Pan, D. Smith, L. Han, and C. Li. Velcro-mimicking adhesive surface based on polymer loop brushes, Nanoscale 2018. 10:18269-18274.
  9. Q. Li, C. Wang, B. Han, F. Qu, H. Qi, C. Y. Li, R. L. Mauck, and L. Han. Impacts of maturation on the micromechanics of the meniscus extracellular matrix. J. Biomech. 2018. 72: 252-257 (Issue Highlight).
  10. B. R. Freedman, A. B. Rodriguez, C. D. Hillin, S. N. Weiss, B. Han, L. Han, and L. J. Soslowsky. Tendon healing affects the multiscale mechanical, structural and compositional response of tendon to quasi-static tensile loading, J. R. Soc. Interface 2018. 15: 20170880.
  11. B. Han, T. Ma, J. H. Vergara, G. R. Palmese, J. Yin, D. Lee, and L. Han. Non-additive impacts of covalent cross-linking on the viscoelastic nanomechanics of ionic polyelectrolyte complexes. RSC Adv. 2017. 7: 53334-53345.
  12. B. Han, H. T. Nia, C. Wang, P. Chandrasekaran, Q. Li, D. R. Chery, H. Li, A. J. Grodzinsky, and L. Han. AFM-nanomechanical test: an interdisciplinary tool that links the understanding of cartilage and meniscus biomechanics, osteoarthritis degeneration, and tissue engineering. ACS Biomater. Sci. Eng. 2017. 3: 2033-2049.
  13. P. Chandrasekaran, B. Doyran, Q. Li, B. Han, T. E. Bechtold, E. Koyama, X. L. Lu, and L. Han. Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation, J. Biomech. 2017. 60: 134-141.
  14. Q. Li, F. Qu, B. Han, C. Wang, H. Li, R. L. Mauck, and L. Han. Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix. Acta Biomater. 2017. 54: 356-366.

Conference Abstracts

  1. Q. Li, B. Han, C. Wang, X. L. Lu, L. Qin, and L. Han. Differentiated Roles of Decorin and Biglycan in the Progression of Post-Traumatic Osteoarthritis. Orthopaedic Research Society (ORS) 2019, Austin, TX. Trans. Orthop. Res. Soc. 62: 346
  2. Y. Wei, X. Ma, H. Sun, B. Han, L. Han, M. Enomoto-Iwamoto, and L. Qin. The regulatory role of EGFR signaling in adult cartilage homeostasis and osteoarthritis. ORS 2019, Austin, TX. (New Investigator Recognition Award Finalist) Trans. Orthop. Res. Soc. 29: 206
  3. B. Han, Q. Li, C. Wang, P. Patel, H. T. Nia, L. Qin, R. V. Iozzo, and L. Han. Decorin provides molecular linkages to regulate the integrity of aggrecan networks in cartilage. ORS 2019, Austin, TX. Trans. Orthop. Res. Soc. 66: 1260
  4. M. Wang, S. J. Heo, B. Han, L. Han, R. L. Mauck, and L.-H. Han. Hand-spun gelatin noodles provide tunable diameter and elasticity for engineering fibro-cartilaginous tissues. ORS 2019, Austin, TX. Trans. Orthop. Res. Soc. 8: 507
  5. K. Hoxha, C. Wang, B. Han, Q. Li, D. R. Chery, P. Chandrasekaran, H. T. Nia, R. L. Mauck, and L. Han. Heterogeneity and anisotropy in the microscale poroelastic properties of the knee meniscus. ORS 2019, Austin, TX. Trans. Orthop. Res. Soc. 65: 512
  6. Q. Li, B. Han, M. Sun, H. T. Nia, W.-J. Tseng, X. S. Liu, L. Qin, R. V. Iozzo, D. E. Birk, and L. Han Decorin is indispensable to cartilage biomechanical functions in health and osteoarthritis. 8th World Congress of Biomechanics (WCB) 2018. Dublin, Ireland.
  7. C. Wang, Q. Li, S.-J. Heo, S. M. Adams, B. Han, M. Sun, M. Enomoto-Iwamoto, R. L. Mauck, D. E. Birk, and L. Han. Nanostructure and biomechanics of fibrocartilage pericellular matrix: roles of collagen V. 8th WCB 2018. Dublin, Ireland.
  8. D. R. Chery, Q. Li, J. Lu, B. Han, L. Qin, X. L. Lu, M. Enomoto-Iwamoto, and L. Han. Pericellular matrix is highly sensitive to cartilage degeneration in early post-traumatic osteoarthritis. ORS 2018, New Orleans, LA. (Podium, Presenting author: Daphney R. Chery) Trans. Orthop. Res. Soc. 64: 209
  9. B. Han, Q. Li, M. Sun, H. T. Nia, R. Oftadeh, L. Qin, R. V. Iozzo, D. E. Birk, and L. Han. Indispensable roles of decorin in cartilage poroelasticity at the nanoscale. Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C) 2017, Tucson, AZ. (Ph.D. Competition Finalist)
  10. B. Han, Q. Li, M. Sun, H. T. Nia, R. Oftadeh, L. Qin, R. V. Iozzo, D. E. Birk, and L. Han. The roles of decorin in the structure and mechanics of cartilage pericellular matrix during skeletal development. SB3C 2017, Tucson, AZ. (2017 SB3C Diversity Travel Awardee and Ph.D. Competition Finalist)
  11. B. Han, Q. Li, M. Sun, H. T. Nia, R. Oftadeh, B. Doyran, L. Qin, R. V. Iozzo, D. E. Birk, and L. Han. Decorin plays an indispensable role in cartilage poroelasticity at the nanoscale. ORS 2017, San Diego, CA. Trans. Orthop. Res. Soc. 63: 248
  12. D. R. Chery, S. J. Rozans, B. Han, L. Qin, D. E. Birk, R. V. Iozzo, M. Enomoto-Iwamoto, and L. Han. Direct investigation of the roles of decorin in cartilage pericellular matrix via immunofluorescence-guided AFM. ORS 2017, San Diego, CA. Trans. Orthop. Res. Soc. 63: 165

Biao joined the McKay Orthopaedic Research Laboratory in the fall of 2020 and is currently working on the role of type V collagen on tendon fibril structure and mechanics. Besides work, Biao likes to play with mechanical and electronic gadgets and do outdoor activities.

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