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McKay Orthopaedic Research Laboratory

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Soslowsky Laboratory

Jeremy Eekhoff, PH.D.

Lab Manager/Research Specialist

University of Pennsylvania

Hometown

Holland, MI

Education

PhD, Biomedical Engineering, Washington University in St. Louis
MS, Biomedical Engineering, Washington University in St. Louis
BS, Mechanical Engineering, Kettering University

Book Chapters

  1. Zellers, JA, Eekhoff JD, Tang SY, Hastings MK, Lake, SP. The effect of diabetes on collagen cross-linking and the resulting tendon tissue mechanics. In The Science, Etiology and Mechanobiology of Diabetes and Its Complications (eds. Gefen, A), (Elsevier, 2021). doi: 10.1016/B978-0-12-821070-3.00009-X.

Publications

  1. Tamburro MK, Bonilla KA, Shetye SS, Leahy TP, Eekhoff JD, Kim MS, Petucci C, Tobias JW, Farber DC, Soslowsky LJ. Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon. J Orthop Res. 2025 Mar.
  2. Darrieutort-Laffite C, Weiss SN, Nuss CA, Newton JB, Eekhoff JD, Soslowsky LJ. Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May Not. Ann Biomed Eng. 2025 Mar.
  3. Newton JB, Weiss SN, Nuss CA, Darrieutort-Laffite C, Eekhoff JD, Birk DE, Soslowsky LJ. Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties. J Orthop Res. 2024 Nov.
  4. Darrieutort-Laffite C, Beach ZM, Weiss SN, Eekhoff JD, Soslowsky LJ. Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging. J Orthop Res. 2023 Oct.
  5. Zellers JA, Edalati M, Eekhoff JD, McNish R, Tang SY, Lake SP, Mueller MJ, Hastings MK, Zheng J. Quantative MRI predicts tendon mechanical behavior, collagen composition, and organization. J Orthop Res. 2023 Oct.
  6. Eekhoff JD, Abraham JA, Schott HR, Solon LF, Ulloa GE, Zellers JA, Cannon PC, Lake SP. Fascicular elastin within tendon contributes to the magnitude and modulus gradient of the elastic stress response across tendon type and species. Acta Biomater. 2023 Jun.
  7. Zellers JA, Eekhoff JD, Walk RE, Hastings MK, Tang SY, Lake SP. Human Achilles tendon mechanical behavior is more strongly related to collagen disorganization than advanced glycation end-products content. Sci Rep. 2021 Dec 17.
  8. Eekhoff JD, Iannucci LE, Lake SP. Shear mechanosensing drives tendon adaptation. Nat Biomed Eng. 2021 Dec 5.
  9. Eekhoff JD, Steenbock H, Berke IM, Brinckmann J, Yanagisawa H, Wagenseil JE, Lake SP. Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus. J Mech Behav Biomed Mater. 2021 Jan.
  10. Hill JR, Eekhoff JD, Brophy RH, Lake SP. Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions. J Orthop Res. 2020 Nov.
  11. Eekhoff JD, Lake SP. Three-dimensional computation of fibre orientation, diameter and branching in segmented image stacks of fibrous networks. J R Soc Interface. 2020 Aug;17.
  12. Silva MJ, Eekhoff JD, Patel T, Kenney-Hunt JP, Brodt MD, Steger-May K, Scheller EL, Cheverud JM. Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice. J Bone Miner Res. 2019 Apr.
  13. Eekhoff JD, Fang F, Lake SP. Multiscale mechanical effects of native collagen cross-linking in tendon. Connect Tissue Res. 2018 Sep.
  14. Eekhoff JD, Fang F, Kahan LG, Espinosa G, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP. Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration. J Biomech Eng. 2017 Nov 1.
  15. Wynkoop A, Ndubaku O, Fras A, Walter N, Eekhoff J, Atkinson T. Ankle fracture patterns in drivers are associated with femoral fracture, higher BMI, and advanced age. Traffic Inj Prev. 2016 Jul 3.

Conference Abstracts

  1. Eekhoff JD, Zellers JA, Lake SP. Elastic fiber content and distribution in human tendon varies by tendon type and tendon compartment (Poster presentation). 68th Annual Orthopaedic Research Society Meeting, Tampa, FL, 2022.
  2.  Eekhoff JD, Abraham JA, Lake SP. Elastase treatment differentially affects murine Achilles and tibialis anterior tendon mechanics (Poster presentation). 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
  3. Zellers JA, Eekhoff JD, Walk R, Hastings MK, Tang SY, Lake SP: Collagen organization – but not glycation state – predicts mechanical behavior in human Achilles tendon (Poster presentation). 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
  4. Zellers JA, Edalati M, Tang SY, Lake SP, Eekhoff JD, Walk R, Zheng J, Hastings MK: Diffusion tensor imaging reveals collagen content and organization in ex vivo human Achilles tendon (Poster presentation). 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
  5. Eekhoff JD, Steenbock H, Brinckmann J, Lake SP. Malformed elastic fibers induce a tendon-specific increase in elastic modulus in fibulin-5 knockout mice (Pre-recorded lightning talk). Summer Biomechanics, Bioengineering, and Biotransport Conference, Virtual, 2020.
  6. Zellers JA, Eekhoff JD, Walk R, Tang SY, Hastings MK, Lake SP. Relationship of advanced glycation end-product accumulation with posterior tibialis tendon mechanics (Poster presentation). American Physical Therapy Association Combined Sections Meetings, Denver, CO, 2020.
  7. Zellers JA, Eekhoff JD, Walk R, Tang SY, Hastings MK, Lake SP. Accumulation of advanced glycation end-products is associated with impaired energy storage of the human posterior tibialis tendon (Poster presentation). 66th Annual Orthopaedic Research Society Meeting, Phoenix, AZ, 2020.
  8. Eekhoff JD, Lake, SP. The role of elastic fibers in tendon mechanics (Invited podium presentation). International Symposium on Ligaments and Tendons, Phoenix, AZ, 2020.
  9. Zellers JA, Eekhoff JD, Walk R, Tang SY, Hastings MK, Lake SP. Posterior tibialis material properties and accumulation of advanced glycation endproducts in individuals with diabetes mellitus (ePoster presentation). American Orthopaedic Foot & Ankle Society Annual Meeting, Chicago, IL, 2019.
  10. Zellers JA, Edalati M, Eekhoff JD, Lake SP, Zheng J, Hastings MK. Posterior tibialis tendon appearance on diffusion tensor imaging and ex vivo material properties (ePoster presentation). American Orthopaedic Foot & Ankle Society Annual Meeting, Chicago, IL, 2019.
  11. Eekhoff JD, Lake SP. Comparative biomechanics across the hierarchical length scales of tendon (Invited podium presentation). Joint XXVII Congress of the International Society of Biomechanics and 43rd Annual Meeting of the American Society of Biomechanics, Calgary, Canada, 2019.
  12. Eekhoff JD, Lake SP. Functional elastic fibers are necessary for mechanical integrity of tendon: Insights from elastin haploinsufficient and fibulin-5 knockout murine models (Podium presentation). Elastin, Elastic Fibers and Microfibrils Gordon Research Conference, Manchester, NH 2019.
  13. Abraham JA, Eekhoff JD, Lake SP. Elastase treatment increases and accelerates stress relaxation in tendon (Poster presentation). Summer Biomechanics, Bioengineering, and Biotransport Conference, Seven Springs, PA, 2019. BS-level paper competition finalist.
  14. Eekhoff JD, Lake SP. Automated fiber orientation estimation in three dimensional images (Poster presentation). Summer Biomechanics, Bioengineering, and Biotransport Conference, Seven Springs, PA, 2019.
  15. Eekhoff JD, Lake SP. Dysregulated elastic fiber assembly alters tendon mechanics in fibulin-5 knockout mice (Poster presentation). 65th Annual Orthopaedic Research Society Meeting, Austin, TX, 2019.
  16. Eekhoff JD, Lake SP. Dysregulated elastic fiber assembly alters tendon mechanics in fibulin-5 knockout mice (Poster presentation). Orthopaedic Research Society Tendon Section Conference, Portland, OR, 2018.
  17. Eekhoff JD, Lake SP. Elastin quantity in tendon is dependent on species and specific tendon function (Podium presentation). 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
  18. Eekhoff JD, Fang F, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP. Elastin contributes to stiffness and structural reorganization in functionally distinct mouse tendons (Poster presentation). 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2018.

 

Jeremy joined the McKay Orthopedic Research Laboratory in January 2022. He enjoys woodworking, playing banjo and trumpet, reading, and hiking.

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