Soslowsky Laboratory

Snehal Shetye, Ph.D.

Senior Researcher / Lab Manager
University of Pennsylvania

Hometown

Fort Collins, CO

Education

PhD, Mechanical Engineering, Colorado State University
MS, Mechanical Engineering, Colorado State University
BE, Mechanical Engineering, University of Pune

Areas of Special Interest

Mechanical Response of Ligaments and Tendons, Cervical Spine Mechanics, Spinal Cord Mechanics

Book Chapters

  1. Troyer KL, Shetye SS, Puttlitz CM, “Viscoelasticity of Load-Bearing Soft Tissues: Constitutive Formulation, Numerical Integration, and Computational Implementation”, In “Computational Bioengineering”, CRC Press/Taylor & Francis, 2015
  2. SS Shetye, KS Miller, JE Hsu, and LJ Soslowsky, “Materials in Tendon and Ligament Repair”, In Comprehensive Biomaterials II, Elsevier, 2017

Publications

  1. Rajapakse CS, Farid AR, Kargilis DC, Jones BC, Lee JS, Johncola AJ, Batzdorf AS, Shetye SS, Hast MW, Chang G. “MRI-based assessment of proximal femur strength compared to mechanical testing.” Bone. 2020 Jan 8:115227. doi: 10.1016/j.bone.2020.115227.
  2. Hong AL, Ispiryan M, Padalkar MV, Jones BC, Batzdorf AS, Shetye SS, Pleshko N, Rajapakse CS, “MRI-derived bone porosity index correlates to bone composition and mechanical stiffness.” Bone Rep. 2019 Jun 26;11:100213. doi: 10.1016/j.bonr.2019.100213.
  3. Kamalitdinov TB, Fujino K, Shetye SS, Jiang X, Ye Y, Rodriguez AB, Kuntz AF, Zgonis MH, Dyment NA. “Amplifying Bone Marrow Progenitors Expressing α-Smooth Muscle Actin Produce Zonal Insertion Sites During Tendon-to-Bone Repair.” J Orthop Res. 2020 Jan;38(1):105-116. doi: 10.1002/jor.24395.
  4. Soltero-Rivera M, Elliott MI, Hast MW, Shetye SS, Castejon-Gonzalez AC, Villamizar-Martinez LA, Stefanovski D, Reiter AM, “Fracture Limits of Maxillary Fourth Premolar Teeth in Domestic Dogs Under Applied Forces”, Frontiers in Veterinary Science, Jan 2019, 30;5:339
  5. Mengcun Chen, Snehal S. Shetye, Julianne Huegel, Corinne N. Riggin, Daniel J. Gittings, Courtney A. Nuss, Stephanie N. Weiss, Andrew F. Kuntz, and Louis J. Soslowsky, “Biceps Detachment Preserves Joint Function in a Chronic Massive Rotator Cuff Tear Rat Model” American Journal of Sports Medicine, 2018
  6. DS Choi, SS Shetye, JJ Tucker, J Huegel, LJ Soslowsky, “Simvastatin does not adversely affect Achilles tendon properties in a diet induced hypercholesterolemia rat model” Muscles, Ligaments & Tendons Journal, Apr-Jun 2018, Vol. 8 Issue 2, p199-205. 7p.
  7. Zhang K, Hast MW, Izumi S, Usami Y, Shetye S, Akabudike N, Philp NJ, Iwamoto M, Nissim I, Soslowsky LJ, Enomoto-Iwamoto M. “Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.” Am J Sports Med. 2018 Jul;46(9):2222-2231.
  8. Govindaraju P, Todd L, Shetye S, Monslow J, Puré E. “CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing.” Matrix Bio. 2018 Jun 9 pii: S0945-053X(18)30127-6.
  9. Sierra LJ, Brown AG, Barilá GO, Anton L, Barnum CE, Shetye SS, Soslowsky LJ, Elovitz MA. “Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice.” PLoS One. 2018 Jan 18;13(1):e0191524
  10. Ramo NL, Shetye SS, Streijger F, Lee JHT, Troyer KL, Kwon BK, Cripton P, Puttlitz CM. “Comparison of In-Vivo and Ex-Vivo Viscoelastic Behavior of the Spinal Cord.” Acta Biomaterialia 2017 S1742-7061(17)30790-0
  11. Ramo N, Shetye SS, Puttlitz CM. “Damage Accumulation Modeling and Rate Dependency of Spinal Dura Mater.”, ASME J of Medical Diagnostics, 2017 Nov. 1(1)
  12. Gadomski BC, Shetye SS, Hindman BJ, Dexter F, Santoni BG, Todd MM, Traynelis VC, From RP, Fontes RB, Puttlitz CM. “Intubation biomechanics: validation of a finite element model of cervical spine motion during endotracheal intubation in intact and injured conditions.” J Neurosurg Spine. 2017 Oct 20:1-13.
  13. Robinson KA, Sun M, Barnum CE, Weiss SN, Huegel J, Shetye SS, Lin L, Saez D, Adams SM, Iozzo RV, Soslowsky LJ, Birk DE. “Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons.” Matrix Biol. 2017 Dec;64:81-93.
  14. Barnum CE, Fey JL, Weiss SN, Barila G, Brown AG, Connizzo BK, Shetye SS, Elovitz MA, Soslowsky LJ. “Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy.” J Biomech Eng. 2017 Jun 1;139(6).
  15. Johnston JM, Connizzo BK, Shetye SS, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. “Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and mechanical healing in tendons.” J Orthop Res. 2017 Apr 7.
  16. Pulos N, Yoon RS, Shetye SS, Hast MW, Liporace F, Donegan DJ, "Anteroinferior 2.7-mm versus 3.5-mm palting of the clavicle: A biomechanical study", Injury, 2016 Aug;47(8)1642-6
  17. Maulucci CM, Sansur CA, Singh V, Cholewczynski A, Shetye SS, McGilvray K, Puttlitz CM, “Cortical bone facet spacers for cervical spine decompression: effect on intervertebral kinetics and foraminal area”, Journal of Neurosurgery – Spine
  18. Wray S, Mimran R, Vadapalli S, Shetye SS, McGilvray K, Puttlitz CM, “Pedicle screw placement in the lumbar spine: effect of trajectory and screw design on acute biomechanical purchase”, Journal of Neurosurgery – Spine
  19. Zheng L, Li K, Shetye SS, Zhang X, “Integrating dynamic stereo-radiography and surface-based motion data for subject-specific musculoskeletal dynamic modeling”, J Biomech. 2014 Sep 22;47(12):3217-21.
  20. Shetye SS, Deault M, Puttlitz CM, “Biaxial response of ovine spinal cord dura mater”, J Mech Behav Biomed Mater. 2014 Jun;34:146-53
  21. Shetye SS, Troyer KL, Streijger F, Lee, JHT, Kwon BK, Cripton P, Puttlitz CM. “Nonlinear viscoelastic characterization of the porcine spinal cord.” Acta Biomaterialia, 2014 Feb;10(2):792-7
  22. Troyer KL, Shetye SS, Puttlitz CM. “Experimental characterization and finite element implementation of soft tissue nonlinear viscoelasticity.” J Biomech Eng 2012 Nov; 134 (11):114501
  23. Leahy PD, Smith BJ, Easton KL, Kawcak CE, Shetye SS, Puttlitz, CM. “Correlation of Mechanical Properties within the Equine Third Metacarpal with Trabecular Bending and Multi-Density Micro-Computed Tomography Data.” Bone 2010 Apr; 46(4):1108-13
  24. Shetye SS, Malhotra K, Ryan SD, Puttlitz CM. “Determination of Mechanical Properties of Canine Carpal Ligaments.” American Journal of Veterinary Research 70(8):1026-30, 2009

 

Conference Abstracts

  1. Joseph B. Newton, George W. Fryhofer, Snehal S. Shetye, Ashley B. Rodriguez, Andrew F. Kuntz, Louis J. Soslowsky, “Aging Adversely Affects Different Rat Rotator Cuff Tendons Similarly” Summer Biomechanics, Bioengineering and Biotransport Conference, Seven Springs, PA
  2. Ryan J. Leiphart, Snehal S. Shetye, Stephanie N. Weiss, Louis J. Soslowsky, “Decorin, Alone And In Tandem With Biglycan, Alters Viscoelasticity In Aged Tendons” Summer Biomechanics, Bioengineering and Biotransport Conference, Seven Springs, PA
  3. Ashley K. Fung, Snehal S. Shetye, Yihan Li, X. Sherry Liu, Louis J. Soslowsky, “Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon Failure Properties” Summer Biomechanics, Bioengineering and Biotransport Conference, Seven Springs, PA
  4. Kamalitdinov TB, Fujino K, Ye Y, Jiang Xi, Shetye SS, Rodriguez AB, Kuntz AF, Zgonis MH, Dyment NA, “Alpha Smooth Muscle Actin-Expressing Bone Marrow Progenitor Cells Contribute to Tunnel Integration Following ACL Reconstruction” Summer Biomechanics, Bioengineering and Biotransport Conference, Seven Springs, PA
  5. Shetye SS, Hagiwara Y, Rodriguez AB, Zgonis MH, Kuntz AF, Dyment NA. “Anterior Drawer Tests to Quantify the Stability of the human Knee” Trans Orthop Res Soc, Austin, TX, 2019
  6. Yaping Ye; Snehal S. Shetye; Ryan Leiphart; David E. Birk; Louis J. Soslowsky, “Scleraxis Targeted Deletion of Collagen XI Affects Mouse Tendon Mechanical Properties”, Trans Orthop Res Soc, Austin, TX, 2019
  7. Thomas P. Leahy; Benjamin R. Freedman; Wei-Ju Tseng; Snehal S. Shetye; Xiaowei S. Liu; Louis J. Soslowsky, “Estrogen Deficiency and Intermittent Parathyroid Hormone Treatment Affect Regional Achilles Tendon Vessel Microarchitecture” Trans Orthop Res Soc, Austin, TX, 2019
  8. Jaclyn A. Carlson; Jessica M. Johnston; Kelsey A. Bonilla; Snehal S. Shetye; Courtney A. Nuss; Stephanie N. Weiss; Ashley B. Rodriguez; David B. Birk; Louis J. Soslowsky, “Gender Dependent Alterations in the Mechanical Response of Injured Collagen V Haploinsufficient Murine Tendons” Trans Orthop Res Soc, Austin, TX, 2019
  9. Rohit Shinde; Dietrich James Nigh; Sylvia Rhodes; Snehal Shetye; Abhishek Chandra; Robert Pignolo; Chamith Rajapakse, “Feasibility of 3D Printing Musculoskeletal Scaffolds with Varying Tissue Properties”, Trans Orthop Res Soc, Austin, TX, 2019
  10. Beach ZM, Dekhne M, Rodriguez AB, Weiss SN, Shetye SS, Adams TH, Adams SM, Sun M, Birk DE, Soslowsky LJ. “Differential Roles for Decorin and Biglycan in Tendon Aging” Trans Orthop Res Soc, Austin, TX, 2019
  11. Fung AK, Li Y, Leahy TP, Shetye SS, Liu XS, Soslowsky LJ. “Reproduction and Lactation Lead to Long-Term Changes in Supraspinatus Tendon and Humeral Trabecular Bone Properties in a Rat Model” Trans Orthop Res Soc, Austin, TX, 2019.
  12. Fung AK, Shetye SS, de Bakker CM, Li Y, Liu XS, Soslowsky LJ. “Female Rat Supraspinatus Tendon Mechanical Properties Exhibit a Differential Response to Estrogen-Deficiency Depending on Reproductive History” Trans Orthop Res Soc, Austin, TX, 2019.
  13. Leiphart RJ, Shetye SS, Pham H, Weiss SN, Young MF, Soslowsky LJ. “Collagen VI plays an important role in FDL tendon mechanics that is distinct from the role of biglycan” Orthopedic Research Society Annual Meeting, Austin, TX, USA, 2019.
  14. Snehal S. Shetye, Thomas Leahy, Mengcun Chen, Ashley Rodriguez, Louis J. Soslowsky, “Type II Diabetes Impairs the Quasi-Static, Viscoelastic, and Fatigue Response of Rat Supraspinatus Tendons”, ORS Tendon Section Conference 2018 Conference, Discovery to Delivery in Tendon Research: Team Approaches, Portland, OR
  15. Daniel C. Kargilis, Gregory Cheng, Jae S. Lee, Alexander R. Farid, Snehal S. Shetye, Michael Hast, Brandon C. Jones, Chamith S. Rajapakse, “MRI-Based Assessment of Proximal Femur Compared to Direct Mechanical Testing”, American Society of Bone and Mineral Research, 2018 Annual Meeting, Montreal, Canada
  16. Shetye SS, Chen M, Rodriguez AR, Soslowsky LJ, “Type II Diabetes Adversely Affects the Viscoelastic and Quasi-Static Properties of Supraspinatus Tendons”, Orthoopaedic Research Society Annual Meeting, New Orleans, LA, 2018
  17. Ashley B. Rodriguez, Snehal S. Shetye, Brianne K. Connizzo, Julianne Huegel, Wei-Ju Tseng, David E. Birk, Louis J. Soslowsky. “Scleraxis Targeted Collagen V Deletion Affects Bone Morphology Due to Altered Skeletal Loading.”, Orthopaedic Society Annual Meeting, New Orleans, LA, 2018. (poster presentation)
  18. Joseph B. Newton, George W. Fryhofer, Snehal S. Shetye, Ashley B. Rodriguez, Andrew F. Kuntz, and Louis J. Soslowsky. “Aging Related Degenerative Mechanical Changes Manifest Earlier in Supraspinatus Tendons”, Orthopaedic Society Annual Meeting, New Orleans, LA, 2018. (poster presentation)
  19. Mengcun Chen, Snehal S. Shetye, Julianne Huegel, Daniel J. Gittings, Courtney A. Nuss, Stephanie N. Weiss, Andrew F. Kuntz, Louis J. Soslowsky. “Biceps detachment alters joint function and tendon mechanical properties in a chronic massive rotator cuff tear rat model” Orthopaedic Society Annual Meeting, New Orleans, LA, 2018. (podium presentation)
  20. Jaclyn A. Carlson, Snehal S. Shetye, Ashley B. Rodriguez, Jessica M. Johnston, Mei Sun, Sheila M. Adams, David E. Birk, Louis J. Soslowsky. “Gender Dependent Alterations in the Mechanical Response of Collagen V Haploinsufficient Murine Tendons”, Orthopaedic Society Annual Meeting, New Orleans, LA, 2018. (poster presentation)
  21. Beach ZM, Robinson KA, Rodriguez AB, Shetye SS, Weiss SN, Adams TH, Adams SM, Sun M, Birk DE, Soslowsky LJ. “Induced Deletion of Biglycan in Mature Tendon Reveals a Surprising Role during Adulthood.” Orthopaedic Society Annual Meeting, New Orleans, LA, 2018. (podium presentation)
  22. Shetye SS, Freedman BR, Fryhofer GW, Riggin CN, Gordon JA, Thomas SJ, Farber DC, Soslowsky LJ. “Structural and In Vivo Function Measures Predict Achilles Tendon Fatigue Mechanics During Healing.” Orthopaedic Society Annual Meeting, San Diego, CA, 2017. (poster presentation)
  23. Benjamin C. Gadomski, Snehal Shetye, Brandon Santoni, Michael Todd, Vincent Traynelis, Ricardo Fontes, Christian Puttlitz. "The Effect of Cervical Spine Injury on Intervertebral Kinetics and Spinal Cord Strain during Direct Laryngoscopy: A Computational Investigation", Orthopaedic Research Society Annual Meeting, San Diego, CA, 2017
  24. Shetye SS, Johnston JM, Connizzo BK, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. "Collagen V Haploinsufficiency Results in Deficient Mechanical and Structural Recovery of Injured Mouse Patellar Tendons", Orthopaedic Research Society Annual Meeting, San Diego, CA, 2017
  25. Robinson, K., Barnum, C., Weiss, S., Huegel, J., Shetye, S., Sun, M., Adams, S., Birk, D., Soslowsky, L., "Conditional deletion of decorin and biglycan in mature mouse tendons results in delayed collagen fiber realignment", Orthopaedic Research Society Annual Meeting, San Diego, CA, 2017
  26. Padalkar MV, Shetye SS, Hast M, Soslowsky LJ, Pleshko N, “NIR Spectroscopic Assessment of Ligament Composition Provides Insight into Regional Differences in Mechanical Properties”, Orthopaedic Research Society Annual Meeting, Orlando, FL, 2016
  27. B.C Gadomski, S.S. Shetye, B.J. Hindman, B.G. Santoni, M.M. Todd, V.C. Traynels, R.B. Fontes, C.M. Puttlitz. "The Role of Cervical Spine Injury Type on Spinal Cord Strain Predictions during Direct Laryngoscopy", Cervical Spine Research Society Annual Meeting, Toronto, Canada, 2016
  28. Samantha Telfer, James Rafferty, PhD, Amanda Cox, Lance Farr, Mario Mendoza, Snehal Shetye, PhD, Christian Puttlitz, PhD, “Comparative Analysis of Human Lumbar and Thoracic Vertebrae Using Micro Computed Tomography (micro-CT) and the Fine Structure Analysis (fineSA®) MRI Technique” American Society of Bone and Mineral Research, 2015 Annual Meeting, Seattle, WA
  29. Shetye SS, Streijger F, Strickland C, Lee J.H.T, Kwon BK, Cripton PA, Shipman PD, Puttlitz CM, “The In Vivo Viscoelastic Response of the porcine Spinal Cord”, Summer Biomechanics, Bioengineering and Biotransport Conference, Snowbird Resort, Utah 2015
  30. Ramo N, Shetye SS, Puttlitz CM, “Damage Accumulation Modeling and Rate Dependency of Spinal Dura Mater”, Summer Biomechanics, Bioengineering and Biotransport Conference, Snowbird Resort, Utah 2015
  31. Shetye SS, Troyer KL, Streijger F, Lee J.H.T, Kwon BK, Cripton PA, Puttlitz CM, “In Vitro Nonlinear Viscoelastic Characterization of the Porcine Spinal Cord”, Proceedings of the ASME 2013 Summer Bioengineering Conference, Sunriver, OR 2013
  32. Shetye SS, Puttlitz CM, “Biaxial Response of Ovine Spinal Cord Dura Mater”, Proceedings of the ASME 2013 Summer Bioengineering Conference, Sunriver, OR 2013
  33. Carey R, Bumstead J, Moloney G, Shetye SS, Harner C, Zhang X, “How Does a Mal-positioned X-Ray Affect Insertion Site Identification?”, Orthopaedic Research Society, San Francisco, CA 2012
  34. Schreiber VM, Shetye SS; Moloney GB, Araujo P, Carey R, Zhang X, Harner CD, “Quantitative Insertion Morphology of the Posterior Meniscal Root in Relation to the Posterior Cruciate Ligament”, Orthopaedic Research Society, San Francisco, CA 2012
  35. Haussler KK, Swedberg A, McGilvray KC, Shetye SS, Turner AS, Puttlitz CM, “Effects of Botox on Spinal Kinematics in an Intervertebral Disc Annulotomy Sheep Model”, Orthopaedic Research Society, Long Beach, CA 2011
  36. Shetye SS, Li K, Tashman S, Zhang X. “Incorporation of Dynamic X-ray Based Knee Kinematics Improves Quadriceps Force Prediction in Musculoskeletal Modeling”, American Society of Biomechanics, Long Beach, CA 2011
  37. Li K, Shetye SS, Tashman S, Zhang X. “Comparing surface-marker based and X-ray based knee joint kinematics during functional activities”, American Society of Biomechanics, Long Beach, CA 2011
  38. Shetye SS, Ryan SD, Ehrhart Nicole, Puttlitz CM. “Novel Endoprosthesis for Limb Sparing of Canine Distal Radius Osteosarcoma Patients - A Modular Approach”, ASME Summer Bioengineering Conference, Farmington, PA 2011
  39. Shetye SS, Puttlitz CM. “Evaluation of a Distal Radius Endoprosthesis Using a Validated Finite Element Model of the Canine Antebrachium.”, Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain, February 24-27, 2010
  40. Shetye SS, Ryan SD, Puttlitz CM. “The Mechanical Underpinning of Clinical Failures in a Distal Radius Endoprosthesis currently used for Canine Limb Sparing.”, Veterinary Orthopedic Society Conference, Breckenridge, Colorado, February 20-27, 2010
  41. Shetye SS, Puttlitz CM. “The Use of a Locking Vs.  Non-Locking Plate in a Distal Radius Endoprosthesis for Canine Limb Sparing”, 18th Annual Symposium on Computational Methods in Orthopaedic Biomechanics, New Orleans, Louisiana, March 5th, 2010
  42. Shetye SS, Lyons AS, Bhattacharjee A, Abjornson C, Puttlitz CM. “Radiographic and Histological Evaluation of a Surface Demineralized Flexible Allograft Chain in an Ovine Vertebra Body Model.” Orthopaedic Research Society, New Orleans, Louisiana, March 6-9, 2010
  43. Shetye SS, Lyons AS, Bhattacharjee A, Abjornson C, Puttlitz CM. “Evaluation of a Surface Demineralized Flexible Allograft Chain in An Ovine Vertebra Body Model..” Spine Arthroplasty Society, New Orleans, Louisiana, April 27-30, 2010
  44. Tichota RG, Puttlitz CM, Lyons AS, Troyer K, Shetye SS, Womack WL, Arslanoglu R, Santoni BG. “A biomechanical study of a limited motion device for lumbar posterior stabilization in an ovine model. Orthopaedic Research Society, Las Vegas, NV, February 22-25, 2009
  45. Shetye SS, Malhotra K, Rodriguez-Canessa G, Ryan SD, Puttlitz CM. “Mechanical Behavior of Canine Antebrachiocarpal Ligaments and its Relation to Collagen Content.” Veterinary Orthopedic Society Conference, Big Sky, Montana, March 8-15, 2008
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