Dyment Laboratory

Xi Jiang, M.S., M.D.

Lab Manager / Senior Researcher
University of Pennsylvania


Zhenzhou, China


MD, Medicine. Henan Medical University, China

MS,  Histology. Henan Medical University, China

Areas of Special Interest

Tendon/ligament biology, histology, and tissue engineering


  1. Dyment NA, Jiang X, Chen L, Hong SH, Adams D, Ackert-Bicknell C, Shin DG, Rowe DW, Hight-Throughput, Multi-Image Cryohistology of Mineralized Tissues. 2016. Jove, Issue 115; doi: 10.3791/54468
  2. Utreja A, Dyment NA, Yadav S, Villa MM, Li Y, Jiang X, Nanda R, Rowe DW, Cell and matrix response of temporomandibular cartilage to mechanical loading. Osteoarthritis Cartilage. 2015. doi: 10.1016/j.joca.2015.08.010. PMID: 26362410.
  3. Dyment NA, Hagiwara Y, Jiang X, Huang J, Adams DJ, Rowe DW, Response of knee fibrocartilage to joint destabilization. Osteoarthritis and Cartilage 02/2015; 23(6). DOI:10.1016/j.joca. 2015.01.017 • 4.17
  4. Hagiwara Y, Dyment NA, Jiang X, Huang J, Adams DJ, Rowe DW. Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair. J Orthop Res. 2015; 33(7): 948-956. PMID: 25639792.
  5. Hurley MM, Adams DJ, Wang L, Jiang X, Burt PM, Du E, Xiao L, Accelerated Fracture Healing in Transgenic Mice Overexpressing an Anabolic Isoform of Fibroblast Growth Factor 2. Journal of Cellular Biochemistry 08/2015; DOI:10.1002/jcb.25308 • 3.26
  6. Krishnan L, Priddy L, Esancy C. Li M, Stevens H, Jiang X, Tran L, Rowe D, Guldberg R, Hydrogel-based delivery of rhBMP-2 improves healing of large bone defects compared with autograft. Clinical Orthpaedics and Related Research 04/2015; 473(9). DOI:10.1007/s11999-015-4312-z
  7. Krishnan L, Priddy LB, Esancy C, Li MT, Stevens HY, Jiang X, Tran L, Rowe DW, Guldberg RE. Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft. Clin Orthop Relat Res. 2015 Sep;473(9):2885-97.doi: 10.1007/s11999-015-4312-z. PubMed PMID: 25917422; PubMed Central PMCID: PMC4523508.
  8. Xin X, Jiang X, Wang L, Stover ML, Zhan S, Huang J, Goldberg AJ, Liu Y, Kuhn L, Reichenberger EJ1, Rowe DW1, Lichtler AC. A potential translational approach for bone tissue engineering through endochondral ossification. Conf Proc IEEE Eng Med Biol Soc. 2014:3925-8. doi: 10.1109/EMBC.2014.6944482.
  9. Xin X, Jiang X, Wang L, Stover ML, Zhan S, Huang J, Goldberg AJ, Liu Y, Kuhn L, Reichenberger EJ, Rowe DW, Lichtler AC. A Site-Specific Integrated Col2.3GFP Reporter Identifies Osteoblasts Within Mineralized Tissue Formed In Vivo by Human Embryonic Stem Cells. Stem Cells Transl Med. 2014 Oct; 3(10):1125-37. doi: 10.5966/sctm.2013-0128. Epub 2014 Aug 13.
  10. Xia Z, Yu X, Jiang X, Brody H Rowe DW, Wei M, Fabrication and Characterization of Biomimetic Collagen-Apatite Scaffolds with Tunable Structures for Bone Tissue Engineering. Acta biomaterialia 04/2013; 9(7). DOI:10.1016/j.actbio.2013.03.038 • 6.03
  11. Yu, X., Wang, L, Peng, F., Jiang, X., Xia, Z., Huang, J., Rowe, D. and Wei, M. 2013. The Effect of Fresh Bone Marrow Cells on Reconstruction of Calvarial Defect Combined with Osteoprogenitor Cells and Collagen/Apatite Scaffold. J. Tiss. Engr. Reg. Med. 7: 974-83  PMID: 22473786
  12. Mikael PE, Xin X, Urso M, Jiang X, Wang L, Barnes B, Lichtler AC, Rowe DW, Nukavarapu SP. A potential translational approach for bone tissue engineeringthrough endochondral ossification. Conf Proc IEEE Eng Med Biol Soc.2014; 2014:3925-8. doi: 10.1109/EMBC.2014.6944482. PubMed PMID: 25570850.
  13. Kuhn L., Liu, Y, Boyd N, Dennis J, Jiang X, Xin X, Wang L, Aguila H, Rowe, DW, Lichtler, A. and Goldberg, J. Developmental engineering of bone using human embryonic stem cell-derived mesenchymal cells. Tissue Eng Part A. 2013. PMID: 23952622
  14. Chaubey A, Grawe B, Meganck JA, Dyment N, Inzana J, Jiang X, Connoley, C., Aead, H., Rowe, D., Kenter, K., Goldstein, S.A. and Butler, D.  Structural and biomechanical responses of osseous healing: a novel murine nonunion model. J Orthop Traumatol. 2013. 14(4):247-257. PMID: 23989900.
  15. Hong, S.H., Jiang, X., Chen, L., Joshi, P., Shin, D-G and Rowe, DW. 2012. Computer-Automated Static, Dynamic and Cellular Bone Histomorphometry. Tissue Science & Engineering. S1:004. doi: 10.4172/2157-7552.S1-004. PubMed PMID: 25019033; PubMed Central PMCID: PMC4090931.
  16. Yu, X., L. Wang, Jiang, X., D. Rowe, and M. Wei, Biomimetic CaP coating incorporated with parathyroid hormone improves the osseointegration of titanium implant. Journal of materials science. Materials in medicine, 2012. 23(9): p. 2177-86. PMID: 22639151
  17. Yu, X, Xia, Z, Wang, L, • Peng, Jiang, X,  Huang, J, • Rowe, DW, • Wei, M. Controlling the structural organization of regenerated bone by tailoring tissue engineering scaffold architecture• Journal of Materials Chemistry 22(19):9721-9730 • APRIL 2012
  18. Grcevic D, Pejda S, Matthews BG, Repic D, Wang L, Li H, Kronenberg MS, Jiang X, Maye P, Adams DJ, Rowe DW, Aguila HL, Kalajzic I. In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells. 2012 Feb;30(2):187-96. doi: 10.1002/stem.780. PubMed PMID: 22083974; PubMed Central PMCID: PMC3560295.
  19. Maye P, Fu Y, Butler DL, Chokalingam K, Liu Y, Floret J, Stover ML, Wenstrup R, Jiang X, Gooch C, Rowe D. Generation and characterization of Col10a1-mcherry reporter mice. Genesis. 2011 May;49(5):410-8. doi: 10.1002/dvg.20733. PubMed PMID: 21328521.
  20. Chen IP, Wang L, Jiang X, Aguila HL, Reichenberger EJ. A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD). Hum Mol Genet. 2011 Mar 1;20(5):948-61.doi: 10.1093/hmg/ddq541. Epub 2010 Dec 13. PubMed PMID: 21149338; PubMed Central PMCID: PMC3033186.
  21. Wang, Y.H., Jiang, J., Zhu, Q., AlAnezi, A.Z., Clark, R.B., Jiang, X., Rowe, D.W., and Nichols, F.C. 2010. Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect Immun. 78:3726-3735. PMID: 20584977. PMC2937457
  22. Ushiku C, Adams DJ, Jiang X, Wang L, Rowe DW. Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. J Orthop Res. 2010 Oct;28(10):1338-47. doi: 10.1002/jor.21105. PubMed PMID: 20839319.
  23. Wang YH, Jiang J, Zhu Q, AlAnezi AZ, Clark RB, Jiang X, Rowe DW, Nichols FC. Porphyromonas gingivalis lipids inhibit osteoblast differebtiation and function. Infect Immun. 2010 78(9): 3726-35. doi: 10.1128/IAI.00225-10. Epub 2010 Jun 28. PubMed PMID: 20584977; PubMed Central PMCID: PMC2937457.
  24. Li H, Jiang X, Delaney J, Franceschetti T, Bilic-Curcic I, Kaliovsky J, Lorenzo JA, Grcevic D, Rowe DW, Kalajzic I. Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine. Am J Pathol. 176(5): 2405-13, 2010. doi: 10.2353/ajpath.2010.090704. Epub 2010 Mar 26. PubMed PMID: 20348238; PubMed Central PMCID: PMC2861105.
  25. O'Rourke J, • Hao Z • Jiang X. The Sympathetic Arterial Innervation and Body Stress. SoM Articles. 27, 2010.
  26. Igwe JC, Jiang X, Paic F, Ma L, Adams DJ, Baldock PA, Pilbeam CC, Kalajzic I. Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity. J Cell Biochem. 2009 Oct 15; 108(3):621-30. doi: 10.1002/jcb.22294. PubMed PMID:19670271; PubMed Central PMCID: PMC2754602.
  27. Salie R, Li H, Jiang X, Rowe DW, Kalajzic I, Susa M. A rapid, nonradioactive in situ hybridization technique for use on cryosectioned adult mouse bone. Calcif Tissue Int. 2008 Sep;83(3):212-21. doi: 10.1007/s00223-008-9154-1. Epub 2008 Sep PubMed PMID: 18762852.
  28. Kalajzic Z, Li H, Wang LP, Jiang X, Lamothe K, Adams DJ, Aguila HL, Rowe DW, Kalajzic I. Use of an alpha-smooth muscle actin GFP reporter to identify anosteoprogenitor population. Bone. 2008 Sep; 43(3): 501-10. doi: 10.1016/j.bone.2008.04.023. Epub 2008 May 10. PubMed PMID: 18571490; PubMedCentral PMCID: PMC2614133.
  29. Liping Xiao • Douglas Adams • Liping Wang • Jiang X• Marja M. Hurley Effects of global knockout or over-expression of fibroblast growth factor-2 in osteoblasts on fracture healing in transgenic mice. Bone 42. Feb 2008
  30. Kalajzic I, Kalajzic Z, Wang L, Jiang X, Lamothe K, San Miguel SM, Aguila HL,Rowe DW. Pericyte/myofibroblast phenotype of osteoprogenitor cell. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):320-2. PubMed PMID: 18094492.
  31. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD. Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E38-49. Epub 2006 Jan PubMed PMID: 16449303.
  32. J. O'Rourke • Z. Hao • Jiang X., • C. Guo • S. Krueger • S. Dufour • T. Pietri • R. Cone Transgenic Evidence For The Concentration of tPA Expressing Sympathetic Nerves in Arterioles Oct 2006 • Journal of Thrombosis and Haemostasis
  33. Zhifang Hao • Caiying Guo • Jiang X• Susan Krueger • Thomas Pietri • Sylvie Dufour • Robert E. Cone New Transgenic Evidence For A System of Sympathetic Axons Able to Express Tissue Plasminogen Activator (tPA) Within Arterial/Arteriolar Walls Running Head: Systemic Distribution of Sympathetic tPA   Blood
  34. Jiang X, Zana Kalajzic, Peter Maye, Alen Braut, Justin Bellizzi, Mina Mina, and David W. Rowe. Histological Analysis of GFP Expression in Murine Bone. Journal of Histochemistry & Cytochemistry. 53(5): 593-602, 2005
  35. L Wang, Y Liu, Z kalajzic, Jiang X and DW Rowe, Heterogeneity of engrafted bone-lining cels after systemic and local transplantation. Blood Nov 15; 106(10): 3650-7, 2005
  36. I Bilic-Curcic, M Kronenberg, Jiang X, J bellizzi, M Mina, I Marijanovic, EM Gardiner and DW Rowe. Visualizing levels of Osteoblast differentiation by a two-color Promoter-GFP strategy: Type I collagen-GFP cyan and osteocalcin-GFPtpz. Genesis, 43(2):87-98, 2005
  37. I Kalajzic • A Braut • D Guo • Jiang X• M S Kronenberg • M Mina • MA Harris • S E Harris • D W Rowe Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone 35 : 74-82 Aug 2004 • Bone
  38. O'Rourke J, Jiang X, Hao Z, Robert E Cone and Arthur R hand. Distribution of Sympathetic Tissue Plasminogen Activator (tPA) to a Distant Microvasculature. Journal of neuroscience Research. 79:727-733, 2005
  39. Inga Marijanovi? • Jiang X • Mark S Kronenberg • Mary Louise Stover • Ivana Erceg • Alexander C Lichtler • David W Rowe Dual reporter transgene driven by 2.3Col1a1 promoter is active in differentiated osteoblasts Sep 2003 • Croatian Medical Journal
  40. Jiang X, A. R. Hand S, Shen, R. E. Cone and J. O’Rourke. Enhanced Tissue Plasminogen Activator Synthesis by the Sympathetic Neurons That Innervate aging Vessels. Journal of Neuroscience Research. 71: 567-574,2003
  41. Jiang X, Y Wang, A. R. Hand, C. Gillies, R. E. Cone, J Kirk and J. O’Rourke. Storage and Release of Tissue Plasminogen Activator by Sympathetic Axons in Resistance Vessel Walls. Microvascular Reaearch, 64: 438-447,2002
  42. Wang Y, Jiang X, AR Hand, C Gilles, J Kirk, RE Cone and J O’Rourke. Additional evidence that the sympathetic nervous system regulates the vessel wall release of tissue plasminogen activator. Blood Coagul fibrinolysis. 13: 471-481, 2002
  43. Jiang X, Y.Wang, A.R. Hand,C.Gillies, R.E.Cone and J.O’Rourke.   Presence of tissue plasminogen activator (t-PA) in the adventitial sympathetic nerve that innervate small arteries: morphologic evidence for a neural fibrinolysis.  Fibrinolysis & Proteolysis. 14: 35-46, 2000
  44. Peng T, Jiang X, Wang Y, Hand AR. Gillies C, Cone RE, O’Rourke J.       Sympathectomy Decreases and Adrenergic Stimulation Increases the Release of Tissue Plasminogen Activator (t-PA) from Artery Walls: New Functional Evidence for Existence of a Neurovascular Fibrinolytic System. Journal of Neuroscience Research. 57:680-b92, 1999
  45. Zhang JS, Jiang X. Et al. Posterior scleral reinforcement in the treatment of retinal Detachment with macular hole in high myopic patients. Chinese J. Ocul Fundus Dis. 12(4): 214-217, 1996
  46. Jiang X, Zhang XF. Distribution of fibronection in experimental traumatic proliferative Vitroretinopathy. Chinese Journal of Ophthalmology. 31:363-365, 1995
  47. Jiang X,  Zhang XF, et al. An immunohistochemical survey of glial fibrillary acidic protein Diseases. Chinese J. Ocul Fundus. 11:260-362, 1995
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