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Qin Laboratory

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Qin Laboratory
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Wang, H.#, Yao, L.#, Zhong, L.#, Fang, J.#, He, Q., Busch, T., Cengel, K., and Qin, L. Marrow adipogenic lineage precursors (MALPs) facilitate bone marrow recovery after chemotherapy. #: these authors contributed equally to this work. Bone In press.

Lu, J., He, Q., Wang, H., Yao, L., Duffy, M., Guo, H., Braun, C., Zhou, Y., Liang, Q., Lin, Y., Bandyopadhyay, S., Tan, K., Choi, Y., Liu, S., and Qin, L. Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice. Bone Res. In press.

Bandyopadhyay, S., Duffy, M., Ahn, K.J., Sussman JH, Pang, M., Smith, D., Duncan, G., Zhang, I., Huang, J., Lin, Y., Xiong, B., Imtiaz, T., Chen, C., Thadi, A., Chen, C., Xu, J., Reichart, M., Martinez, Z., Diorio, C., Pillai, V., Snaith, O., Oldridge, D., Bhattacharyya, S., Maillard, I., Carroll, M., Nelson, C., Qin, L.*, and Tan, K*. Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic Imaging. *: co-corresponding authors. (2024) Cell. 187: 3120-3140.

Li, J.#, Gui, T.#, Yao, L., Guo, H., Lin, Y., Lu, J., Fang, J., Duffy, M., Zgonis, M., Mauck, R., Dyment, N., Zhang, Y., Scanzello, C., Seale, P., and Qin, L. Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis. #: these authors contributed equally to this work. (2024) J Bone Miner Res. 39: 161-176.
Tang, S.^#, Yao, L.^#, Ruan, J., Kang, J., Cao, Y., Nie, X., Lan, W., Zhu, Z., Han, W., Liu, Y., Tian, J., Seale, P., Qin, L.^*, Ding, C^*. Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology. ^#: these authors contributed equally to this work. *: co-corresponding authors. (2024) Sci Transl Med. 16: eadf4590.
Yao, L., Zhong, L., Wei, Y., Gui, T., Wang, L., Ahn, J., Boerckel, J., Rux, D., Mundy, C., Qin, L.*, and Pacifici, M*. Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy. *: co-corresponding authors. (2023) Elife. 12: e89822.
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin. Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone. (2023) Elife 12, e82112
Gui, T.^#, Wei, Y.^#, Luo, L., Li, J., Zhong, L., Yao, L., Beier, F., Nelson, C.L., Tsourkas, A., Liu, S., Enomoto-Iwamoto, M., Yu, F., Cheng, Z., Qin, L. Activating EGFR signaling attenuates osteoarthritis development following loading injury in mice. ^#: these authors contributed equally to this work (2022). J Bone Miner Res. 37(12), 2498-2511.
Gui, T.^#, Luo, L.^#, Chhay, B., Zhong, L., Wei, Y., Yao, L., Yu, W., Li, J., Nelson, C.L., Tsourkas, A., Qin, L.^*, and Cheng, Z.* Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy. ^#: these authors contributed equally to this work. *: co-corresponding authors. (2022) Biomaterials. 283, 121437.
Zhong, L.^#, Yao, L.^#, Holdreith, N., Yu, W., Gui, T., Miao, Z., Elkaim, Y., Li, M., Gong, Y., Pacifici, M., Maity, A., Busch, T.M., Jeong, K.S., Cengel, K., Seale, P., Tong, W., and Qin, L. Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.^#: these authors contributed equally to this work. (2022) JCI Insight. 7 (7): e150323.
Wei, Y.^#, Ma., X.^#, Sun, H., Gui, T., Li, J., Yao, L., Zhong, L., Yu, W., Han, B., Nelson, C.L., Han, L., Beier, F., Enomoto-Iwamoto, M., Ahn, J., and Qin, L. EGFR signaling is required for maintaining adult cartilage homeostasis and attenuating osteoarthritis progression. ^#: these authors contributed equally to this work. (2022) J Bone Miner Res. 37 (5), 1012-1023.
Wang, L.^#, Yao, L.^#, Duan, H., Yang, F., Lin, M., Zhang, R., He, Z., Ahn, J., Fan, Y., Qin, L.*, and Gong, Y*. Plasminogen regulates bone fracture repair by promoting the functions of periosteal mesenchymal progenitors. ^#: these authors contributed equally to this work. *: co-corresponding authors. (2021) J Bone Miner Res. 36 (11), 2229-2242.
Wei, Y.^#, Sun, H.^#, Gui, T.^#, Yao, L., Zhong, L., Yu, W., Heo S., Han, L., Dyment, N., Liu, S., Zhang, Y., Koyama, E., Long, F., Zgonis, M., Mauck, R., Ahn, J., and Qin, L. The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair. ^#: these authors contributed equally to this work. (2021) Elife. 10: e62917.
Yao, L., Tichy, E.D., Zhong, L., Mohanty, S., Wang, L., Ai, E., Yang, S., Mourkioti, F., and Qin, L. Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. (2021) J. Bone Miner. Res.
Wei, Y., Yan, L., Luo, L., Gui, T., Jang, B., Amirshaghaghi, A., You, T., Tsourkas, A., Qin, L., and Cheng, Z. Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression. (2021) Sci. Adv. 7(15): eabe6374.
Wei, Y., Luo, L., Gui, T., Yu, F., Yan, L., Yao, L., Zhong, L., Yu, W., Han, B., Patel, J.M., Liu, J.F., Beier, F., Levin, L.S., Nelson, C., Shao, Z., Han, L., Mauck, R.L., Tsourkas, A., Ahn, J., Cheng, Z., and Qin, L. Targeting cartilage EGFR pathway for osteoarthritis treatment. (2021) Sci. Transl. Med. 13(576): eabb3946.
Yu, W., Zhong, L., Yao, L., Wei, Y., Gui, T., Li, Z., Kim, H., Holdreith, N., Jiang, X., Tong, W., Dyment, N., Liu, X.S., Yang, S., Choi, Y., Ahn, J., and Qin, L. Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. (2021) J. Clin. Invest. 131(2): e140214
Zhong, L., Yao, L., Tower, R.J., Wei, Y., Miao, Z., Park, J., Shrestha, R., Wang, L., Yu, W., Holdreith, N., Huang, X., Zhang, Y., Tong, W., Gong, Y., Ahn, J., Susztak, K., Dyment, N., Li, M., Long, F., Chen, C., Seale, P., and Qin, L. Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. (2020) Elife 9: e54695
Qin, L., and Beier, F. EGFR Signaling: Friend or Foe for Cartilage? (2019) JBMR Plus 3(2): e10177.
Wang, L., Tower, R.J., Chandra, A., Yao, L., Tong, W., Xiong, Z., Tang, K., Zhang, Y., Liu, X.S., Boerckel, J.D., Guo, X., Ahn, J., and Qin, L. Periosteal Mesenchymal Progenitor Dysfunction and Extraskeletally-Derived Fibrosis Contribute to Atrophic Fracture Nonunion. (2019) J. Bone Miner. Res. 34(3): 520-532.
Tong, W., Tower, R.J., Chen, C., Wang, L., Zhong, L., Wei, Y., Sun, H., Cao, G., Jia, H., Pacifici, M., Koyama, E., Enomoto-Iwamoto, M., and Qin, L. Periarticular Mesenchymal Progenitors Initiate and Contribute to Secondary Ossification Center Formation During Mouse Long Bone Development. (2019) Stem Cells 37(5): 677-689.
Wang, L., Jia, H., Tower, R.J., Levine, M.A., and Qin, L. Analysis of short-term treatment with the phosphodiesterase type 5 inhibitor tadalafil on long bone development in young rats. (2018) Am. J. Physiol. Endocrinol. Metab. 315(4): E446-E453.
Jia, H., Ma, X., Wei, Y., Tong, W., Tower, R.J., Chandra, A., Wang, L., Sun, Z., Yang, Z., Badar, F., Zhang, K., Tseng, W.J., Kramer, I., Kneissel, M., Xia, Y., Liu, X.S., Wang, J.H.C., Han, L., Enomoto-Iwamoto, M., and Qin, L. Loading-Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late-Stage Osteoarthritis. (2018) Arthritis Rheumatol 70(2): 230-241.
Chandra, A., Wang, L., Young, T., Zhong, L., Tseng, W.J., Levine, M.A., Cengel, K., Liu, X.S., Zhang, Y., Pignolo, R.J., and Qin, L. Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. (2018) FASEB J. 32(1): 52-62.
Tian, Z., Ma, X., Yasen, M., Mauck, R.L., Qin, L., Shofer, F.S., Smith, L.J., Pacifici, M., Enomoto-Iwamoto, M., and Zhang, Y. Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model. (2018) Am. J. Phys. Med. Rehabil. 97(3): 170-177.
Marcucio, R.S., Qin, L., Alsberg, E., and Boerckel, J.D. Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering. (2017) J. Orthop. Res. 35(11): 2356-2368.
Tong, W., Lu, Z., Qin, L., Mauck, R.L., Smith, H.E., Smith, L.J., Malhotra, N.R., Heyworth, M.F., Caldera, F., Enomoto-Iwamoto, M., and Zhang, Y. Cell therapy for the degenerating intervertebral disc. (2017) Transl. Res. 181: 49-58.
Xu, H., Dahiya, S., Wang, L., Akimova, T., Han, R., Zhang, T., Zhang, Y., Qin, L., Levine, M.H., Hancock, W.W., and Levin, L.S. Utility of IL-2 Complexes in Promoting the Survival of Murine Orthotopic Forelimb Vascularized Composite Allografts. (2018) Transplantation 102(1): 70-78.
Altman-Singles, A.R., Jeong, Y., Tseng, W.J., de Bakker, C.M., Zhao, H., Lott, C., Robberts, J., Qin, L., Han, L., Kim, D.G., and Liu, X.S. Intermittent Parathyroid Hormone After Prolonged Alendronate Treatment Induces Substantial New Bone Formation and Increases Bone Tissue Heterogeneity in Ovariectomized Rats. (2017) J. Bone Miner. Res. 32(8): 1703-1715.
Jia, H., Ma, X., Tong, W., Doyran, B., Sun, Z., Wang, L., Zhang, X., Zhou, Y., Badar, F., Chandra, A., Lu, X.L., Xia, Y., Han, L., Enomoto-Iwamoto, M., and Qin, L. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation. (2016) Proc. Natl. Acad. Sci. U. S. A. 113(50): 14360-14365.
Bugueno, J., Li, W., Salat, P., Qin, L., and Akintoye, S.O. The bone regenerative capacity of canine mesenchymal stem cells is regulated by site-specific multilineage differentiation. (2017) Oral Surg Oral Med Oral Pathol Oral Radiol 123(2): 163-172.
Chandra, A., Lin, T., Young, T., Tong, W., Ma, X., Tseng, W.J., Kramer, I., Kneissel, M., Levine, M.A., Zhang, Y., Cengel, K., Liu, X.S., and Qin, L. Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. (2017) J. Bone Miner. Res. 32(2): 360-372.
Doyran, B., Tong, W., Li, Q., Jia, H., Zhang, X., Chen, C., Enomoto-Iwamoto, M., Lu, X.L., Qin, L., and Han, L. Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis. (2017) Osteoarthritis Cartilage 25(1): 108-117.

Candela, M.E., Wang, C., Gunawardena, A.T., Zhang, K., Cantley, L., Yasuhara, R., Usami, Y., Francois, N., Iwamoto, M., van der Flier, A., Zhang, Y., Qin, L., Han, L., and Enomoto-Iwamoto, M. Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints. (2016) PLoS One 11(6): e0156783.
Wang, Y., Dellatore, P., Douard, V., Qin, L., Watford, M., Ferraris, R.P., Lin, T., and Shapses, S.A. High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice. (2016) Nutr. Res. 36(7): 742-750.
Shi, P., Chen, E.Y., Cs-Szabo, G., Chee, A., Tannoury, C., Qin, L., Lin, H., An, S., An, H.S., and Zhang, Y. Biglycan Inhibits Capsaicin-Induced Substance P Release by Cultured Dorsal Root Ganglion Neurons. (2016) Am. J. Phys. Med. Rehabil. 95(9): 656-662.
Zhu, H., Xie, F., Luo, X., Qin, L., Sherry Liu, X., Scott Levin, L., and Li, Q. Orthotopic forelimb allotransplantation in the rat model. (2016) Microsurgery 36(8): 672-675.
Lin, T., Tong, W., Chandra, A., Hsu, S.Y., Jia, H., Zhu, J., Tseng, W.J., Levine, M.A., Zhang, Y., Yan, S.G., Liu, X.S., Sun, D., Young, W., and Qin, L. A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats. (2015) Bone Res 3: 15028.
Altman, A.R., Tseng, W.J., de Bakker, C.M.J., Chandra, A., Lan, S., Huh, B.K., Luo, S., Leonard, M.B., Qin, L., and Liu, X.S. Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography. (2015) Bone 81: 370-379.
de Bakker, C.M., Altman, A.R., Tseng, W.J., Tribble, M.B., Li, C., Chandra, A., Qin, L., and Liu, X.S. μCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy. (2015) Bone 73: 198-207.
Li, Q., Doyran, B., Gamer, L.W., Lu, X.L., Qin, L., Ortiz, C., Grodzinsky, A.J., Rosen, V., and Han, L. Biomechanical properties of murine meniscus surface via AFM-based nanoindentation. (2015) J. Biomech. 48(8): 1364-1370.
Scanzello, C.R., Markova, D.Z., Chee, A., Xiu, Y., Adams, S.L., Anderson, G., Zgonis, M., Qin, L., An, H.S., and Zhang, Y. Fibronectin splice variation in human knee cartilage, meniscus and synovial membrane: observations in osteoarthritic knee. (2015) J. Orthop. Res. 33(4): 556-562.
Chandra, A., Lin, T., Zhu, J., Tong, W., Huo, Y., Jia, H., Zhang, Y., Liu, X.S., Cengel, K., Xia, B., and Qin, L. PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway. (2015) J. Biol. Chem. 290(1): 157-167.
Altman, A.R., de Bakker, C.M., Tseng, W.J., Chandra, A., Qin, L., and Liu, X.S. Enhanced individual trabecular repair and its mechanical implications in parathyroid hormone and alendronate treated rat tibial bone. (2015) J. Biomech. Eng. 137(1): 011004.
Chandra, A., Lin, T., Tribble, M.B., Zhu, J., Altman, A.R., Tseng, W.J., Zhang, Y., Akintoye, S.O., Cengel, K., Liu, X.S., and Qin, L. PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival. (2014) Bone 67: 33-40.
Zhang, X., Zhu, J., Liu, F., Li, Y., Chandra, A., Levin, L.S., Beier, F., Enomoto-Iwamoto, M., and Qin, L. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. (2014) Bone Res 2: 14015.
Altman, A.R., Tseng, W.J., de Bakker, C.M., Huh, B.K., Chandra, A., Qin, L., and Liu, X.S. A closer look at the immediate trabecula response to combined parathyroid hormone and alendronate treatment. (2014) Bone 61: 149-157.
Zhang, X., Zhu, J., Li, Y., Lin, T., Siclari, V.A., Chandra, A., Candela, E.M., Koyama, E., Enomoto-Iwamoto, M., and Qin, L. Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through ß-catenin-dependent and -independent pathways. (2013) J. Biol. Chem. 288(45): 32229-32240.
Chandra, A., Lan, S., Zhu, J., Siclari, V.A., and Qin, L. Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression. (2013) J. Biol. Chem. 288(28): 20488-20498.
Lan, S., Luo, S., Huh, B.K., Chandra, A., Altman, A.R., Qin, L., and Liu, X.S. 3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo microcomputed tomography (μCT). (2013) Bone 56(1): 83-90.
Chandra, A., Lan, S., Zhu, J., Lin, T., Zhang, X., Siclari, V.A., Altman, A.R., Cengel, K.A., Liu, X.S., and Qin, L. PTH prevents the adverse effects of focal radiation on bone architecture in young rats. (2013) Bone 55(2): 449-457.
Barnes, V.M., Xu, T., Shimizu, E., Nakatani, T., Jefcoat, S., Vasilov, A., Qin, L., and Partridge, N.C. Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts. (2013) J. Periodontol. 84(11): 1683-1689.
Siclari, V.A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H.D., Shi, S., and Qin, L. Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. (2013) Bone 53(2): 575-586.
Cantley, L., Saunders, C., Guttenberg, M., Candela, M.E., Ohta, Y., Yasuhara, R., Kondo, N., Sgariglia, F., Asai, S., Zhang, X., Qin, L., Hecht, J.T., Chen, D., Yamamoto, M., Toyosawa, S., Dormans, J.P., Esko, J.D., Yamaguchi, Y., Iwamoto, M., Pacifici, M., and Enomoto-Iwamoto, M. Loss of ß-catenin induces multifocal periosteal chondroma-like masses in mice. (2013) Am. J. Pathol. 182(3): 917-927.
Zhu, J., Siclari, V.A., Liu, F., Spatz, J.M., Chandra, A., Divieti Pajevic, P., and Qin, L. Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes. (2012) PLoS One 7(12): e50099.
Usmani, S.E., Pest, M.A., Kim, G., Ohora, S.N., Qin, L., and Beier, F. Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth. (2012) Bone 51(1): 131-141.
Moorthi, A., Saravanan, S., Srinivasan, N., Partridge, N.C., Zhu, J., Qin, L., and Selvamurugan, N. Synthesis, Characterization and Biological Action of Nano-Bioglass Ceramic Particles for Bone Formation. (2012) J. Biomater. Tissue Eng. 2(3): 197-205.
Zhang, X., Siclari, V.A., Lan, S., Zhu, J., Koyama, E., Dupuis, H.L., Enomoto-Iwamoto, M., Beier, F., and Qin, L. The critical role of the epidermal growth factor receptor in endochondral ossification. (2011) J. Bone Miner. Res. 26(11): 2622-2633.
Zhu, J., Shimizu, E., Zhang, X., Partridge, N.C., and Qin, L. EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix. (2011) J. Cell. Biochem. 112(7): 1749-1760.
Zhang, X., Tamasi, J., Lu, X., Zhu, J., Chen, H., Tian, X., Lee, T.C., Threadgill, D.W., Kream, B.E., Kang, Y., Partridge, N.C., and Qin, L. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. (2011) J. Bone Miner. Res. 26(5): 1022-1034.

Research Publications, Peer-reviewed Reviews

Zhong, L., Yao, L., Seale, P., and Qin, L. Marrow adipogenic lineage precursor: A new cellular component of marrow adipose tissue. (2021) Best Pract Res Clin Endocrinol Metab. 101518.
Qin, L. and Beier, F. EGFR signaling: friend or foe for cartilage? (2019) JBMR Plus. 3: e10177.
Marcucio, R.S., Qin, L., Alsberg, E., and Boerckel, J.D. Reverse engineering development: crosstalk opportunities between developmental biology and tissue engineering. (2017) J Orthop Res. 35: 2356-2368.
Siclari, V.A., and Qin, L. Targeting the osteosarcoma cancer stem cell. (2010) J. Orthop. Surg. Res. 5: 78.

Book Chapters

Zhong, L., Yao, L., and Qin, L. (2020) A Novel Enzymatic Digestion Approach for Isolation and Culture of Rodent Bone Marrow Mesenchymal Progenitors, 2nd Edition”, Edited by Andre van Wijnen and Marina Ganshina. Part of the Methods in Molecular Biology book series (MIMB, volume 2221)
Tower, R.J. and Qin, L. (2020) Chondrocyte cell fate analysis. Invited chapter in Cartilage development and Disease (edited by Di Chen) in Encyclopedia of Bone Biology, 1^st Edition (Editor in Chief: Mone Zaidi)
Zhu, J., Siclari, V.A. and Qin, L. (2014) Isolating endosteal mesenchymal progenitors from rodent long bones. Invited chapter in “Osteoporosis and Osteoarthritis, Methods in Molecular Biology," Vol. 1226, Edited by Westendorf and van Wijnen, Springer, 19-29.
Qin, L. & Partridge, N.C. (2012) Parathyroid hormone and parathyroid hormone-related protein: normal function, diseases, and emerging therapeutics. Invited chapter in “Bone-Metabolic Functions and Modulators (Topics in Bone Biology).” Vol. 7, Edited by Bronner, Farach-Carson, and Roach. Springer, 1-20.

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