Shore Laboratory

What's New in the Shore Laboratory

September 2019

Congratulations to to Robyn and Lexy for 2019 ASBMR meeting presentations and travel awards:

  • Allen, R., E.M. Shore, M.C. Mullins. Multiple Modalities of Signaling by FOP Mutant BMP Receptor in the Developing Zebrafish. American Society for Bone and Mineral Research 2019 Annual Meeting; Orlando, FL, September 20-23, 2019.
  • Stanley, A., E. Tichy, F. Mourkioti, E.M. Shore. Aberrant muscle tissue repair by mutant ACVR1 FOP progenitor cells. American Society for Bone and Mineral Research 2019 Annual Meeting; Orlando, FL, September 20-23, 2019.

Congratulations to Niambi Brewer and Robyn Allen for receiving Endocrine Fellows Foundation (EFF) Awards to attend the 13th EFF/ASBMR Fellows Forum on Metabolic Bone Diseases.

 

August 2019:

Congratulations to Dr. Sun Peck as she begins her faculty position at Vanderbilt University on September 1!

*Welcome to Research Specialist Doug Roberts!

 

July 2019:

Congrats to Robyn Allen for her poster presentation at the Society of Developmental Biology Conference, Boston, MA: Allen, R.S., Shore, E.M. and Mullins, M.C. FOP-Acvr1 Signals by Multiple Modalities in the Developing Zebrafish.

 

June 2019:

*Welcome to Andrea Clause for summer research through the NIH/Boehringer Ingelheim Summer Veterinary Scholars Program.

*Welcome to summer students Eileen Zhang, Claire Tse, and Elsa Pheif!

Congrats to all for our accepted manuscript:

  • Ware, A.D., N. Brewer, E. McCarthy, E.M. Shore, and A.W. James. Differential vascularity in genetic and non-genetic heterotopic ossification. International J. Surg. Pathology.

 

May 2019:

***Congratulations to new PhD Alexandra Stanley on her graduation from Penn’s Cell and Molecular Biology Graduate program!

*And welcome to Lexy as a post-doctoral fellow.

Congratulations to Lexy Stanley for her accepted manuscript:

  • Stanley, A., S. Heo, R.L. Mauck, F. Moukioti, and E.M. Shore.   Elevated BMP and mechanical signaling through YAP1/RhoA poises FOP mesenchymal progenitors for osteogenesis. J. Bone Miner. Res. 

 

April 2019:

***Congratulations to Lexy Stanley for her Thesis Defense on April 22, 2019!

Congratulations to all for our manuscript on FOP in a cat:

  • Casel, M., J.B. Engiles, M. Zakosek, A. Berkowitz, Y. Porat-Mosenco, W. Mai, K. Wurzburg, M. Xu, R. Allen, P.A. ODonnell, P.S. Henthorn, K. Thompson, E.M. Shore (2019). Identification of the identical human mutation in ACVR1 in two cats with fibrodysplasia ossificans progressiva. Vet Pathol. 56(4), 614-618.

 

Congrats to all –

  • Guvec, Z., V. Tasic, D. Plaseska-Karanfilska, M. Dimishkovska, N. Laban, Z. Bozinovski, M. Kostovski, A. Saveski, M. Polenakovic, O.W. Towler, E.M. Shore, F.S. Kaplan (2019). Severe digital malformations in a rare variant of fibrodysplasia ossificans progressiva. Amer. J. Med. Genet. 179A, 1310-1314. (accepted April 1, 2019; online published April 22, 2019; print publication April 2019) PMID: 31012264. Selected for Cover Image.

 

February 2019:

Sun Peck was selected as a Finalist at the Orthopaedic Research Society 2019 Annual Meeting, Spine Section Award for her podium presentation:

  • Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O’Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ. Lithium treatment improves vertebral trabecular bone architecture in mucopolysaccharidosis I dogs during postnatal growth. Austin, TX, February 2, 2019. Congrats!

Congrats to Sun for her manuscript:

  • De Silva B, Adhikari B, Allen A, Peck SH, Lee SY. Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels. Biochim Biophys Acta Mol Basis Dis. 1865(2):322-328.

 

January 2019:

Congrats to Lexy Stanley for her poster presentation and BGS travel grant for the Cellular Plasticity: Reprogramming, Regeneration, and Metaplasia Keystone Meeting, January 27-31, 2019, in Keystone, Colorado:

  • Stanley, A., S.J. Heo, R.L. Mauck, F. Mourkioti, and E.M. Shore. Elevated YAP1/RhoA Signaling Poises FOP Mesenchymal Progenitors for Osteogenesis.
  •  

Sun Peck was selected as a 2019 American Society of Bone and Mineral Research John Haddad Young Investigator to attend and present her work at the Advances in Mineral Metabolism (AIMM) 2019 conference.

Congrats to Robyn Allen for her poster "Novel BMP-pSmad1/5 signaling interactions in a zebrafish model of FOP" at the Institute for Regenerative Medicine Retreat. Philadelphia, PA, USA. January 30, 2019.

Congratulations to Julia and Lexy for their published manuscript:

  • Haupt, J. A. Stanley, C.M. McLeod, B.D. Cosgrove, A.L. Culbert, L. Wang, F. Mourkioti, R.L. Mauck, E.M. Shore (2019). ACVR1 R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. Molec. Biol. Cell. 30(1), 17-29.

 

Goodbye to Azadeh Timnak, who is leaving the lab and for a Scientist position at Liquid Biotech USA.

 

December 2018

Fred Kaplan received the Grand Hamdan International Award for Medical Sciences. Congratulations!

 

November 2018:

Congratulations to Robyn and Niambi for PCMD poster awards:

Robyn Allen received an honorable mention award at the Penn Center for Musculoskeletal Disorders Annual Symposium; Philadelphia, PA, November 7, 2018 for: Allen, R. A., E. M. Shore, M. C. Mullins. Novel BMP-Smad1/5 signaling interactions revealed in a zebrafish model of FOP

Niambi Brewer received a 3rd Prize at the PCMD Scientific Symposium; Philadelphia PA, November 7, 2018 for: Brewer, N., Fong, J.T., Zhang, D., Kaplan, F.S., Pignolo, R.J., Shore, E.M. Gnas inactivation alters adipose tissue properties during progression to heterotopic ossification.

 

October 2018:

We’re in our newly renovated lab!

Congrats to Niambi Brewer for her 1st place poster award for the Genetics and Epigenetics Program at the CAMB Graduate Group Symposium; October 5, 2018: Brewer, N., Fong, J.T., Zhang, D., Kaplan, F.S., Pignolo, R.J., Shore, E.M. Gnas inactivation alters adipose tissue properties during progression to heterotopic ossification.

Congratulations to Sun for her manuscript: Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Zhang Y, Smith HE, Malhotra NR, Smith LJ. Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. J Orthop Res. 36(10):2771-2779.

 

September 2018:

Congratulations to Eileen Shore for selection as an ASBMR Fellow, Inaugural Class of 2018.

Congratulations to Niambi and Lexy for presentations and Rare Bone Disease Alliance Young Investigator Recognition Awards at the Rare Bone Disease Alliance Conference:

  • Brewer, N. J.T. Fong, D. Zhang, F.S. Kaplan, R.J. Pignolo, E.M. Shore. Gnas inactivation alters adipose tissue properties during progression to heterotopic ossification.  Rare Bone Disease Alliance: Mechanistic and Therapeutic Advances in Rare Skeletal Diseases Conference, September 26-27, 2018.
  • Stanley, A. E. Tichy, F. Moukioti, E.M. Shore. Aberrant muscle tissue repair by mutant ACVR1 FOP muscle stem cells – implications for heterotopic ossification. Rare Bone Disease Alliance: Mechanistic and Therapeutic Advances in Rare Skeletal Diseases Conference, September 26-27, 2018.

Congratulations to all for presentations at the 2018 ASBMR meeting:

  • Brewer, N. J.T. Fong, D. Zhang, F.S. Kaplan, R.J. Pignolo, E.M. Shore. Gnas inactivation alters adipose tissue properties during progression to heterotopic ossification.  2018 American Society for Bone and Mineral Research Annual Meeting; Montreal, Canada. Selected for Oral Presentation.
  • Wentworth, K., T. Moody, K. Taylor, N. Brewer, F. Kaplan, R. Pignolo, E. Shore, E. Hsiao. Identifying genetic modifiers in patients with mild fibrodysplasia ossificans progressiva using whole exome sequencing. 2018 American Society for Bone and Mineral Research Annual Meeting; Montreal, Canada. Selected for Plenary Poster Presentation.
  • Stanley, A. E. Tichy, F. Moukioti, E.M. Shore. Aberrant muscle tissue repair by mutant ACVR1 FOP muscle stem cells – implications for heterotopic ossification. 2018 American Society for Bone and Mineral Research Annual Meeting; Montreal, Canada. Selected for Plenary Poster Presentation.
  • Peck, S., Y.K. Lau, J. Bendigo, M. Lin, T. Arginteanu, J. Bagel, P. O’Donnell, N. Malhotra, P. Klein, E. Shore, M. Casal, L. Smith. Lithium-mediated effects on vertebral bone formation in mucopolysaccharidosis I dogs during postnatal growth. 2018 American Society for Bone and Mineral Research Annual Meeting; Montreal, Canada.
  • Yang, Y., R. Xu, X. Zhou, E. Shore, F. Kaplan. Loss of Gs signaling induces osteoblast differentiation in soft tissues of POH patients and during normal cranial bone development by activating Hedgehog signal. 2018 American Society for Bone and Mineral Research Annual Meeting; Montreal, Canada.
  • Cheng, C., M.R. Convente, N. Fleming, Y. Zhang, A. Kalra, C.M. Elkins, E.M. Shore, D.S. Perrien. Macrophages and TNF regulate fibroproliferation and muscle degradation preceding heterotopic ossification in an ALK2R206H model of fibrodysplasia ossificans progressiva. 2018 American Society for Bone and Mineral Research Annual Meeting; Montreal, Canada.

Additional congratulations to –

  • Lexy Stanley who received an Endocrine Fellows Foundation (EFF) Award to attend the 12th EFF/ASBMR Fellows Forum on Metabolic Bone Diseases.
  • Niambi Brewer who received an ASBMR Young Investigator Award for her work which was selected for oral presentation.

Congratulations to Niambi Brewer for her F31 predoctoral grant award from the NIH: NIH Ruth L. Kirschstein-NRSA Postdoctoral F31 Award: Regulation of Cell Fate Decisions in Heterotopic Ossification

*Welcome to post-bac student Lucus Gong.

Special congratulations to Robyn and Tom on their wedding!

 

August 2018:

*Welcome Azadeh Timnak as a new Postdoctoral Researcher in the lab.

Goodbye to Amber Hamilton – we wish you all the best as you begin Medical School at Cornell.

Sun Peck presented a poster at the 15th International Symposium on MPS and Related Diseases; San Diego, CA, August 2018. Peck SH, Lau YKA, Bendigo JR, Lin M, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra NR, Shore EM, Casal ML, Smith LJ. Effects of lithium treatment on bone turnover in mucopolysaccharidosis I dogs during postnatal growth.

Sun Peck was elected to be the chair for the 2020 Gordon Research Seminar on Musculoskeletal Biology and Bioengineering; Andover, NH.

Congratulations to all authors:

  • Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A. (2018). Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement. Nat Rev Endocrinol. 14, 476-500.

We didn’t want it to happen, but finally goodbye to Ruth and wishing her all the best in Colorado.

 

June 2018:

Congratulations to Lexy Stanley for oral presentation selection at the University of Pennsylvania Department of Orthopaedic Surgery Research Day Symposium, June 1, 2018: Aberrant muscle tissue repair by FOP muscle stem cells – implications for heterotopic ossification.

Congratulation to Sun Peck for a Best Podium Presentation Award at the University of Pennsylvania Department of Orthopaedic Surgery Research Symposium; Philadelphia, PA, June 1, 2018. Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O’Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ. Lithium-mediated effects on vertebral bone formation in mucopolysaccharidosis I dogs during postnatal growth.

*Welcome to the students who will be in the lab with us this summer: Njoh Takem, Eileen Zhang and Kelly Li.

 

May 2018:

Congratulations to Robyn Allen for the Best Oral presentation award at the University of Pennsylvania Cell and Developmental Biology Department Retreat for her presentation: "Novel BMP-Smad1/5 signaling interactions in a zebrafish model of FOP".

Congrats to Robyn Allen for her poster presented at the Mid-Atlantic Regional Society for Developmental Biology meeting. Charlottesville, VA, May 31, 2018. Allen, R. A., E. M. Shore, M. C. Mullins. Novel BMP-Smad1/5 signaling interactions revealed in a zebrafish model of FOP.

Congratulations to Sun for her manuscript:  

  • Riester SM, Lin Y, Wang W, Cong L, Ali AM, Peck SH, Smith LJ, Currier B, Clark M, Huddleston P, Krauss W, Yaszemski MJ, Morrey ME, Abdel MP, Bydon M, Qu W, Larson AN, van Wijnen AJ, Nassr A. RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues. J Orthop Res. 36(5):1356-1369.

 

April 2018:

Congratulations to all authors of manuscripts in the special issue on Rare Bone Diseases in Bone (editors: Kaplan, Pignolo, Shore) including:

  • Haupt, J., M. Xu, and E.M. Shore (2018). Variable signaling activity by FOP ACVR1 mutations. Bone 109, 232-240.
  • Wang, H., E.M. Shore, R.J. Pignolo, and F.S. Kaplan (2018). Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP). Bone 109, 218-224.
  • Ramaswamy, G., J. Fong, N. Brewer, H. Kim, D. Zhang, Y. Choi, F.S. Kaplan, and E.M. Shore (2018). Ablation of Gsa signaling in osteoclast progenitor cells adversely affects skeletal bone maintenance. Bone 109, 86-90.
  • Mucha, B.E., M. Hashiguchi, J. Zinski, E.M. Shore, and M.C. Mullins (2018). Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish. Bone 109, 225-231.
  • Amalfitano, M., B. Fyfe, S.V. Thomas, K.P. Egan, M. Xu, A.G. Smith, F.S. Kaplan, E.M. Shore, and R.J. Pignolo (2018). A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings. Bone 109, 56-60.

 

February 2018:

Sun Peck presented a late-breaking poster at the WORLD Symposium for Lysosomal Diseases Network; San Diego, CA: Peck SH, Lau YA, Kang JL, Matalon DR, Lin M, Bagel JH, O’Donnell PA, Fitzgerald CA, Molony CM, Malhotra NR, Shore EM, Casal ML, Smith LJ. Impaired bone formation in mucopolysaccharidosis VII dogs during postnatal growth is associated with lower serum levels of bone-specific alkaline phosphatase.

Congratulations to Michael for his published manuscript and cover image!

  • Convente, M.R., S.A. Chakkalakal, E. Yang, R.J. Caron, D. Zhang, T. Kambayashi, F.S. Kaplan, and E.M. Shore. Depletion of mast cells and macrophages impairs heterotopic ossification in an Acvr1R206H mouse model of fibrodysplasia ossificans progressiva. JBMR 33(2), 269-282.

 

January 2018:

Congrats to all for accepted manuscripts:

  • Amalfitano, M., B. Fyfe, S.V. Thomas, K.P. Egan, M. Xu, A.G. Smith, F.S. Kaplan, E.M. Shore, and R.J. Pignolo. A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings. Bone, published online January 7, 2018
  • Mucha, B.E., M. Hashiguchi, J. Zinski, E.M. Shore, and M.C. Mullins. Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish. Bone, published online January 4, 2018.

Congrats to Niambi and Will for their presentations at Gordon Research Conference and Gordon Research Seminar on Bones and Teeth, Galveston, TX; January 2018:

  • Niambi Brewer won the 1st place poster award. Brewer, N., J.T. Fong, D. Zhang, F.S. Kaplan, R.J. Pignolo, and E.M. Shore. Post-natal deletion of Gnas alters adipose tissue properties during progression of heterotopic ossification. – Congratulations!
  • Towler, O.W., F.S. Kaplan, and E.M. Shore. Regulation of phalangeal joint development by ACVR1 in fibrodysplasia ossificans progressiva.

Congratulations to Lexy Stanley: Stanley, A., E. Tichy, J. Haupt, F. Mourkioti, and E.M. Shore. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Penn Institute for Regenerative Medicine Retreat, Philadelphia, PA; January 2018. Selected for oral presentation

 

November 2017:

Publication congratulations!

  • Wang, H., E.M. Shore, R.J. Pignolo, and F.S. Kaplan (2018). Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressive (FOP). Bone; accepted November 18; online November 21, 2017
  • Ramaswamy, G., J. Fong, N. Brewer, H. Kim, D. Zhang, Y. Choi, F.S. Kaplan, and E.M. Shore. Ablation of Gsa signaling I osteoclast progenitor cells adversely affects skeletal bone maintenance. Bone; accepted November 23; published online November 26, 2017

Niambi Brewer presented a poster at the Penn Center for Musculoskeletal Disorders Annual Symposium; Philadelphia, PA, November 15, 2017. Brewer, N., J.T. Fong, D. Zhang, F.S. Kaplan, R.J. Pignolo, E.M. Shore. Postnatal deletion of Gnas in mice induces heterotopic ossification in subcutaneous tissues caused by aberrant expression of BMP signaling and enhanced collagen deposition in the extracellular matrix.

Will Towler presented a poster and won a 1st place poster award at the Penn Center for Musculoskeletal Disorders Annual Symposium; Philadelphia, PA, November 15, 2017. Towler, O.W., F.S. Kaplan, and E.M. Shore. Regulation of phalangeal joint development by ACVR1 in fibrodysplasia ossificans progressiva.

Lexy Stanley presented a poster and won a 2nd place poster award at the Penn Center for Musculoskeletal Disorders Annual Symposium; Philadelphia, PA, November 15, 2017. Stanley, A., E. Tichy, J. Haupt, F. Mourkioti, and E.M. Shore. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells.

 

October 2017:

Congrats to all for recent publications!

  • Loro, E., G. Ramaswamy, A. Chandra, W-J. Tseng, M.K. Mishra, E.M. Shore and T.S. Khurana (2017). IL15ra is required for osteoblast function and bone mineralization. Bone 103. 20-30.

Congratulations to Michael for his accepted manuscript:

  • Convente, M.R., S.A. Chakkalakal, E. Yang, R.J. Caron, D. Zhang, T. Kambayashi, F.S. Kaplan, and E.M. Shore. Depletion of mast cells and macrophages impairs heterotopic ossification in an Acvr1R206H mouse model of fibrodysplasia ossificans progressiva. JBMR

Congrats to Julia and Meiqi for their accepted manuscript:

  • Haupt, J., M. Xu, and E.M. Shore. Variable signaling activity by FOP ACVR1 mutations. Bone

Good-bye to John Fong who departed the lab for a Technical Account Manager position at GenScript and to Haitao Wang who is now a Senior Research Investigator in Dr. Bob Pignolo’s lab at Mayo Clinic.

 

September 2017:

John Fong was selected to participate in the Eleventh Endocrine Fellows Forum on Metabolic Bone Diseases; Denver, CO; September 6-7, 2017. Fong, J.T., N. Brewer, D. Zhang, F.S. Kaplan, R.J. Pignolo, E.M. Shore. Postnatal deletion of Gnas in mice induces heterotopic ossification in subcutaneous tissues caused by aberrant expression of BMP signaling and enhanced collagen deposition in the extracellular matrix.

Congratulations to Will Towler for selection for an ASBMR Young Investigator's Award and Plenary Poster presentation at American Society for Bone and Mineral Research Annual Meeting; Denver, CO, September 8-11, 2017. Towler, O.W., F.S. Kaplan, and E.M. Shore. Regulation of phalangeal joint development by ACVR1 in fibrodysplasia ossificans progressiva.

Niambi Brewer presented a poster at the University of Pennsylvania Genetics Department Retreat. Bear Creek, PA. September 11-13, 2017. Brewer, N., J.T. Fong, G. Ramaswamy, and E.M. Shore (2017). Regulation of cell fate decisions in heterotopic ossification.

Congratulations to Lexy Stanley for her F31 predoctoral grant award from the NIH: NIH Ruth L. Kirschstein-NRSA Postdoctoral F31 Award: Intersection of Upregulated BMP Signaling & Cellular Mechanotransduction in FOP.

 

August 2017:

Congrats to Sun Peck for her 2nd place Podium Presentation Award: Matalon DR, Peck SH, Can Ficicioglu, Bhoj E, Lulis L, Lin M, Bendigo JR, O’Donnell P, Fitzgerald CA, Bagel JH, Malhotra NR, Shore EM, Casal ML, Smith LJ. David W. Smith Workshop on Malformations and Morphogenesis, Stowe, VT.

 

July 2017:

Robyn Allen presented a poster at the International Society for Developmental Biology Conference entitled “Novel BMP-pSmad1/5 signaling interactions in a zebrafish model of FOP". Minneapolis, MN, USA.

 

June 2017:

Congratulations to Will Towler for oral presentation selection at the University of Pennsylvania Department of Orthopaedic Surgery Research Day Symposium, June 2, 2017.

Congrats to Lexy Stanley for her poster at the Gordon Myogenesis Conference in Il Ciocco, Italy: Stanley, A., J. Haupt, M. Convente, E. Tichy, F. Mourkioti, and E.M. Shore. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells – implications for heterotopic ossification. Gordon Research Conference and Gordon Research Seminar on Myogenesis, Lucca Barga), Italy.

*Welcome to the students who will be in the lab with us this summer: Njoh Takem, Megan Martucci, Mishel Figueroa, Kelly Li and Adam Jacob.

 

May 2017:

Congratulations to Sun Peck for her F32 postdoctoral grant award from the NIH: NIH Ruth L. Kirschstein-NRSA Postdoctoral F32 Award: Impaired BMP Signaling and Failed Bone Formation in Mucopolysaccharidosis VII.

 

April 2017:

Congrats to Will for his paper publication:

  • Towler, O.W., E.M. Shore, M. Xu, A. Bamford, I. Anderson, R.J. Pignolo, and F.S. Kaplan (2017). The Congenital Great Toe Malformation of Fibrodysplasia Ossificans Progressiva? - A Close Call. Eur. J. Med. Genet. 60, 399-402.

 

March 2017:

*Welcome to Amber Hamilton who joined the lab as Research Specialist.

***Congratulations to Michael Convente on his thesis defense. Michael is now starting new adventures as a Medical Writer at Nucleus Global.

Congratulations to Sun Peck for her poster: Peck SH, Kang JL, Bendigo JR, O’Donnell P, Fitzgerald CA, Bagel J, Malhotra NR, Shore EM, Casal ML, Smith LJ. Rescuing Chondrocyte Hypertrophic Differentiation Potential and Exploring Therapeutic Approaches for Enhancing Bone Formation in Mucopolysaccharidosis VII Dogs. Orthopaedic Research Society Annual Meeting, San Diego, CA. March 2017.

 

December 2016:

Good-bye to Girish Ramaswamy as he begins a Senior Analyst position at Windrose Consulting Group.

 

October 2016:

Congrats to Robyn and Julia for International BMP Conference presentations:

  • Haupt J., Cosgrove B., McLeod C., Culbert A., Mauck R.L., Shore E.M. ACVR1 R206H alters mechanosensing and tissue stiffness during heterotopic ossification. 11th International Bone Morphogenetic Protein (BMP) Conference; Boston, MA, October 26-30, 2016.
  • Allen, R. S., E.M. Shore, M.C. Mullins. Determination of novel BMP-Smad1/5 signaling interactions in fibrodysplasia ossificans progressiva. 11th International Bone Morphogenetic Protein (BMP) Conference; Boston, MA, October 26-30, 2016

 

September 2016:

Congratulations to all for presentations at the 2016 ASBMR meeting:

  • Peck, S., Kang, J., Pacifici, M., Dodge, G., Malhotra, N.R., Haskins, M.E., Shore, E.M., Smith, L.J. Impaired chondrocyte hypertrophic differentiation potential is associated with abnormal glycosaminoglycan accumulation in mucopolysaccharidosis VII dogs. American Society for Bone and Mineral Research Annual Meeting; Atlanta, GA, September 16-19, 2016.
  • Ramaswamy, G., H. Kim, D. Zhang, V. Lounev, J. Wu, Y. Choi, F.S. Kaplan, R.J. Pignolo, E.M. Shore. Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via pCREB and β-Catenin Pathways. American Society for Bone and Mineral Research Annual Meeting; Atlanta, GA, September 16-19, 2016.

 

August 2016:

Haupt J, McLeod C, Cosgrove B., Stanley, A., Culbert, A, Wang, L., Mauck, RL, Shore, EM. The ACVR1R206H FOP mutation alters progenitor cell force sensing and increases lesion stiffness during muscle repair – implications for heterotopic ossification. Gordon Research Conference on Musculoskeletal Biology and Bioengineering. Andover, NH, August 7-12, 2016. Selected for oral presentation.

 

June 2016:

Congratulations to Michael Convente for oral presentation selection at the University of Pennsylvania Department of Orthopaedic Surgery Research Day Symposium, June 7, 2016.

Congrats to all –

  • Han, H., Baubet, V., Boucher, K., Pignolo, R., Kaplan, F., Shore, E., Storm, P., Dahmane, N., Resnick, A. ACVR1-mutant diffuse intrinsic pontine gliomas (DIPGs) acquire aberrant activin-mediated BMP pathway activation. 17th International Symposium on Pediatric Neuro-Oncology; Liverpool, UK, June 12-15, 2016.
  • Loro, E. Ramaswamy, G., Chandra, A., Tseng, W-J., Mishra, M.K., Shore, E.M., Khurana, T.S. Role of Il15rα on musculoskeletal load-adaptation and remodeling. The 2016 New Directions in Biology and Disease of Skeletal Muscle Conference; Orlando, FL, June 29-July 2, 2016.

 

March 2016:

Congratulations to Sun Peck for her oral presentation at the 2016 ORS meeting:

  • Peck, S., Shore, E.M., Malhotra, N.R., Tobias, J.W., Pacifici, M., Haskins, M.E., Smith, L.J. Dysregulated Wnt Signaling Contributes to Delayed Chondrocyte Differentiation in Mucopolysaccharidosis VII Dogs. Orthopaedic Research Society 2016 Annual Meeting; Orlando, FL, March 5-8, 2016. Selected for oral presentation

 

February 2016:

Congratulations to Lexy Stanley for her GRS/GRC presentation:

  • Stanley, A., J. Haupt, E. Tischy, F. Mourkioti, E.M. Shore. Influence of BMP Signaling on the Resident Muscle Stem Cell Population During Skeletal Muscle Regeneration. Gordon Research Conference and Gordon Research Seminar on Bones and Teeth, Galveston, TX

 

November 2015:

PCMD Annual Scientific Symposium:  Congratulations to Michael Convente for winning 1st place for his poster in the Miscellaneous category and to Girish Ramaswamy for his 3rd place poster in the same category.

 

October 2015:

*Welcome to Robyn Allen who is joining our lab for her PhD Thesis research (cosponsors: Mary Mullins and Eileen Shore).

Congratulations to all for presentations at the 2015 ASBMR meeting:

  • Ramaswamy, G. Kim, H., Zhang, D., Choi, Y., Kaplan, F.S., Pignolo, R.J., Shore, E.M. Gnas inactivation adversely affects cortical bone quality by altering osteoclast and osteocyte activity during bone remodeling. American Society for Bone and Mineral Research Annual Meeting; Seattle, WA, October 9-12, 2015.
  • Convente, M.R., Yang, E., Chakkalakal, S.A., Zhang, D., Caron, R.J., Perrien, D. S., Kambayashi, T., Kaplan, F.S., Shore, E.M. Targeted Ablation of Macrophages and Mast Cells Impairs Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva. American Society for Bone and Mineral Research Annual Meeting; Seattle, WA, October 9-12, 2015. Selected as a Late Breaking Abstract.

Vieson, M.D, Shore, E.M., Xu, M., Saunders, G.K. Confirmation of FOP in a domestic shorthair kitten by detection of the R206H mutation in the activin receptor 1A/activin-like kinase-2 (ACVR1/ALK2) gene. American College of Veterinary Pathologists (ACVP) 2015 Annual Meeting, Minneapolis, MN; October 17-21, 2015. Selected for oral presentation.

Very special congratulations to Lexy and Anthony on their wedding!

 

August 2015:

Congratulations to Girish Ramaswamy for receiving the Alice L. Jee Young Investigator Award and for his oral presentation "Gnas Maintains Cortical Bone Quality by Regulating Osteoclast and Osteocyte Activity During Bone Remodeling" at the ORS 45th International Sun Valley Workshop: Musculoskeletal Biology in Sun Valley, Idaho, August 2-5, 2015.

Congratulations to Michael Convente who received an Endocrine Fellows Foundation (EFF) Award to attend the Ninth EFF/ASBMR Fellows Forum on Osteoporosis and Metabolic Bone Diseases, October 7-8, 2015.

 

July 2015:

Congrats to Michale Convente for his poster presentation “The Acvr1R206H Mutation Upregulates BMP Signaling and Inflammatory Cytokine Expression in Mast Cells and Macrophages” at the FASEB Summer Research Conference, TGF- Superfamily Signaling in Development and Disease, Snowmass, CO; July 12-16, 2015.

 

June 2015:

*Welcome to Niambi Brewer as she joins the lab for her PhD thesis research.

*Welcome to the students who will be in the lab with us this summer – Alexis McLemore and Jerry Zhu.

Congrats to Will Towler for his poster presentation: “Acvr1, a BMP type I receptor, contributes both to hindlimb development and more generally to joint formation in digits” at the 13th International Limb Development & Regeneration Conference; St. Petersburg, FL, June 28-July 1, 2015.

 

May 2015:

Congratulations to Eileen Shore and Fred Kaplan!  In the email edition of Penn News Today, celebrating the 250th birthday of the Perelman School of Medicine, they were noted in the timeline for 2006:

“Frederick Kaplan, Eileen Shore, and colleagues discovered the genetic mutation that causes FOP”.

 

March 2015:

Good-bye to Julia Haupt, as she departs for her home country of Germany. We’ll miss you!

 

January 2015:

*Welcome to CAMB/GGR rotation student Niambi Brewer!

 

December 2014:

Congratulations to Michael Convente, Haitao Wang, Bob Pignolo, Fred Kaplan and Eileen Shore for their article “The immunological contribution to heterotopic ossification disorders” accepted for publication in Current Osteoporosis Reports.

Congratulations to Bob Pignolo, Girish Ramaswamy, John Fong, Eileen Shore and Fred Kaplan for their review “Progressive osseous heteroplasia: diagnosis, treatment, and prognosis” accepted for publication in the Application of Clinical Genetics.

 

November 2014:

Congratulations to Salin Chakkalakal for his 2nd place poster award in the Histology category at the PCMD Symposium!

Congratulations to Julia Haupt for her 1st place PCMD Symposium poster award in the Biomechanics category!

 

October 2014:

Congrats to Will Towler for his poster presentation at the 2014 Cell and Molecular Biology Graduate Group Symposium.

 

September 2014:

Congratulations to …

  • Julia Haupt who received a 2015 American Society for Bone and Mineral Research Young Investigator Award and for her oral presentation “Altered force sensing and cell-cell adhesion by mutant ACVR1/ALK2 FOP progenitor cells – implications for heterotopic ossification” that was presented at the ASBMR Annual Meeting in Houston, TX.
  • Girish Ramaswamy who received an Endocrine Fellows Foundation (EFF) Award to attend the Eighth EFF/ASBMR Fellows Forum on Metabolic Bone Diseases.
  • Julia Haupt and Salin Chakkalakal for their poster presentations at National Bone Health Alliance/Rare Bone Disease Patient Network Workshop: Mechanistic and Therapeutic Insights into Skeletal Biology Learned from the Study of Rare Bone Diseases.
  • Andria Culbert for her invited oral presentation “Increased Alk2R206H ligand sensitivity accelerates chondrogenic differentiation and promotes heterotopic endochondral ossification” at the Tenth International Bone Morphogenetic Protein Conference in Berlin, Germany.

Congrats to Eileen Shore, Basic Science Program Chair for the 2015 ASBMR Meeting, on a successful program.

 

August 2014:

Good-bye to Andria Culbert as she begins her postdoctoral work at Alliance Pharma.

Good-bye to Carter Lindborg as he leaves to attend Georgetown University Medical School.

 

July 2014:

Congrats to Salin Chakkalakal for his abstract accepted for poster presentation at the ASBMR annual meeting in September.

Congrats to Julia Haupt for her selection as a 2015 ASBMR Young Investigator! She will present her work, conducted in collaboration with Brian Cosgrove and Claire McLeod in the Mauck lab, at the ASBMR annual meeting.

Girish Ramaswamy has been selected to attend the EFF/ASBMR Eighth Fellows Forum on Metabolic Bone Diseases – congratulations!

*Welcome to the students who will be in the lab with us this summer – Christine Emery, Kelly Li, Keegan McGuire, Alexis McLemore.

 

June 2014:

Congratulations to Andria Culbert for her 1st place award winning presentation and poster at the 2014 Orthopaedics Research Day Symposium.

*Welcome to Erika Wright-McAfee.

*Welcome to Lexy Stanley as she joins the lab for her PhD thesis research.

 

May 2014:

***Congratulations to new PhD Andria Culbert on her graduation from Penn’s Cell and Molecular Biology Graduate program!

Congratulations to Andria et al. for our published paper in Stem Cells

  • Culbert, A.L., S.A. Chakkalakal, E. Theosmy, T.A. Brennan, F.S. Kaplan, and E.M. Shore (2014). Alk2 regulates early chondrogenic fate in FOP heterotopic endochondral ossification. Stem Cells 32, 1289-1300.

Congratulations to Julia Haupt, Petra Seemann et al. for their paper in Human Molecular Genetics

  • Haupt, J., Deichsel, A., Stange, K., Ast, C., Bocciardi, R. Ravazzolo, R., DiRocco, M., Ferrari, P., Landi, A., Kaplan, F.S., Shore, E.M., Reissner, C., and Seemann, P. (2014). ACVR1 p.Q207E causes classic fibrodysplasia ossifcans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant. Hum Molec Genet 23, 5364-5377.

*Welcome to Jack Suva-Urwin for a month-long lab internship.

 

April 2014:

***Congratulations to Andria Culbert on the successful defense of her PhD thesis “Role of ALK2 Signaling in Chondrogenic Commitment and Heterotopic Endochondral Ossification” on April 1!

 

January 2014:

Congratulations to Girish Ramaswamy for a Young Investigator Award and for his oral presentation “Heterozygous inactivation of Gnas alters skeletal development and bone quality” at the Bones and Teeth Gordon Research Seminar and Gordon Research Conference in Galveston, TX.

Welcome to CAMB/DSRB rotation student Alexandra Stanley.

Congratulations to Salin and Alock on the arrival of their new daughter Shriya on January 5.

 

December 2013:

A report of the ACVR1 mutations in FOP patients in China has been published in Bone

  • Zhang, W., K. Zhang, L. Song, J. Pang, H. Ma, E.M. Shore, F.S. Kaplan and P. Wang (2013). The phenotype and genotype of fibrodysplasia ossificans progressiva in China: a report of 72 cases. Bone 57, 386-391.

Congratulations to Andria Culbert for her paper “ALK2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification” accepted for publication in Stem Cells.

 

November 2013:

Congratulations to Girish Ramaswamy for his selection for an oral presentation the 2014 Bones and Teeth Gordon Research Seminar.

A collaborative study with colleagues Jean Regard and Yingzi Yang at the NIH was published this month in Nature Medicine

  • Regard, J.B., D. Malhotra, J. Gvozdenovic-Jeremic, M. Josey, M. Chen, L.S. Weinstein, E.M. Shore, F.S. Kaplan, and Y. Yang (2013). Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nature Medicine 19, 1505-1512.

 

October 2013:

Congratulations to Andria Culbert and Girish Ramaswamy for their poster presentations at the 2013 ASBMR Annual Meeting in Baltimore, MD:

  • Culbert, A.L., S.A. Chakkalakal, E. Theosmy, L. Wang, E.M. Shore. The BMP type I receptor ALK2 is a key regulator of chondrogenesis. Presented at the American Society for Bone and Mineral Research Annual Meeting; Baltimore, MD, October 4-8, 2013.
  • Ramaswamy G., D. Zhang, F.S. Kaplan, R.J. Pignolo, and E.M. Shore. Heterozygous inactivation of Gnas induces heterotopic ossification and impairs normal skeletal development Presented at the American Society for Bone and Mineral Research Annual Meeting; Baltimore, MD, October 4-8, 2013.

*Welcome to new postdoctoral fellow John Fong.

 

August 2013:

Congrats to all on our paper in the Journal of Clinical Investigation

  • Cairns, D.M., R.J. Pignolo, T. Uchimura, T.A. Brennan, C.M. Lindborg, M. Xu, F.S. Kaplan, E.M. Shore, and L. Zeng (2013). Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. J. Clinical Invest 123, 3624-3633.

Congratulations to Andria and Brian – Happy birthday, Watson! (August 26)

 

July 2013:

Congratulations to Girish and Subashini on their wedding (July 10)!

 

June 2013:

Congratulations to Will Towler on passing his CAMB prelim!

 

May 2013:

Congratulations to Girish Ramaswamy on his Young Investigator Award to attend and present his work “Heterozygous inactivation of Gnas affects early postnatal bone quality” at the AAOS/ORS Bone Quality and Fracture Prevention Research Symposium.

 

April 2013:

Congratulations to Andria Culbert for her selection as a 2013 Cartilage Biology and Pathology Gordon Research Conference Young Investigator and her Outstanding Poster Award for her presentation “Gain-of-function Alk2 mutation enhances chondrocyte differentiation and promotes heterotopic endochondral ossification.”

 

March 2013:

Congratulations to Bettina Mucha-Li Ny for her presentation “Human BMP receptor mutations causing fibrodysplasia ossificans progressiva lead to ligand-independent receptor activation in zebrafish embryos” at the ACMG Annual Clinical Genetics Meeting, Phoenix, AZ.

*Welcome to lab intern Franziska Mühlhoff!

Congratulations to Fred Kaplan and Eileen Shore on their election to the Rare Disease Research Hall of Fame.

 

December 2012:

Congratulations to Eileen Shore for her election to the American Society of Bone and Mineral Research (ASBMR) Council.

Congratulations to all for our paper on HO in a whale:

  • La Sala, L.F., L.M. Pozzi, D. McAloose, F.S. Kaplan, E.M. Shore, E.J.O. Kompanje, I.F. Sidor, L. Musmeci, M.M. Uhart (2012). Severe soft tissue ossification in a southern right whale (Eubalaena australis). Diseases of Aquatic Organisms 102, 149-156.

 

October 2012:

Congratulations to Julia and Andria for their ASBMR meeting presentations:

  • Haupt, J., A. Deichsel, K. Stange, E. Kajikhina, C. Ast, N. Souidi, F.S. Kaplan, E.M. Shore, P. Seemann. Functional consequences of fibrodysplasia ossificans progressiva-associated mutations ACVR1R206H and ACVR1Q207E in comparison to constitutive active ACVR1Q207D. (Presented at the American Society for Bone and Mineral Research Annual Meeting; Minneapolis, MN, October 12-16, 2012.)
  • Culbert, A.L., S.A. Chakkalakal, R.J. Caron, E.M. Shore. The FOP R206H Alk2 Mutation Enhances BMP-Induced Chondrogenic Differentiation. (Presented at the American Society for Bone and Mineral Research Annual Meeting; Minneapolis, MN, October 12-16, 2012.)

Congrats to Andria Culbert for an ASBMR Young Investigator Travel Grant award for her presentation at the ASBMR Annual Meeting, October 2012. (This award is given to the top Young Investigators at this conference.)

 

August 2012:

Congrats to Shengliang -

Zhang, S. F.S. Kaplan, E.M. Shore (2012). Different roles of Gnas and cAMP signaling during early and late stages of osteogenic differentiation. Hormone Metab. Res. 44, 724-731.

 

July 2012:

Congrats to Bettina for her SBD presentation!

  • Mucha, B.E., J. Zinski, M. Hashiguchi, E.M. Shore, M.C . Mullins. Human BMP receptor mutations causing fibrodysplasia ossificans progressiva lead to ligand-independent receptor activation in zebrafish embryos. (Presented at the Society of Developmental Biology Annual Meeting, July 19-23, 2012.)

 

May 2012:

Congratulations to Lixin Kan and Joe Kitterman and co-authors for their accepted papers in Journal of Neurology:

  • Kan, L., J.A. Kitterman, D. Procissi, S. Chakkalakal, C.Y. Peng, T.L. McGuire, R.E. Goldsby, R.J. Pignolo, E.M. Shore, F.S. Kaplan, and J.A. Kessler (2012). CNS demyelination in fibrodysplasia ossificans progressiva. J. Neurol. 259, 2644-2655.
  • Kitterman, J.A., J.B. Strober, L. Kan, D.M. Rocke, A. Cali, J. Peeper, J. Snow, P.L.R. Delai, R. Morhart, R.J. Pignolo, E. M. Shore, F.S. Kaplan (2102) Neurological symptoms in individuals with fibrodysplasia ossificans progressiva. J. Neurol. 259, 2636-2643.

 

April 2012:

Congrats to all!

  • Zimmer J., S.C. Doelken, D. Horn, J.C. Groppe, E.M. Shore, F.S. Kaplan, P. Seemann (2012). Functional Analysis of Alleged NOGGIN Mutation G92E Disproves Its Pathogenic Relevance. PLoS One. 2012;7(4):e35062.

 

May 2012:

Congrats to all on our recent publications:

  • Hammond, P., M. Suttie, R.C. Hennekam, J. Allanson, E.M. Shore, F.S. Kaplan (2012). The Face Signature of Fibrodysplasia Ossificans Progressiva. Am J. Med. Genet. 158A, 1368-1380.
  • Chakkalakal, S. A., D. Zhang, A.L. Culbert, M.R. Convente, R.J. Caron, A.C. Wright, A.D.A. Maidment, F.S. Kaplan, and E.M. Shore (2012). An Acvr1 R206H knocki-in mouse has fibrodysplasia ossificans progressiva. J. Bone Min. Res. 27, 1746-1756.
  • Liu, J., E. Russell, D. Zhang, F.S. Kaplan, R.J. Pignolo, and E.M. Shore (2012). Paternally inherited Gsa mutation impairs adipogenesis and potentiates a lean phenotype in vivo. Stem Cells 30, 1477-1485.
  • Muglu, J.A., A. Garg, T. Pandiarajan, E.M. Shore, F.S. Kaplan, D. Uchil, and M.J. Dickson (2012). Pregnancy in fibrodysplasia ossificans progressiva. Obstet. Med. 5, 35-38.
  • Kaplan, J., F.S. Kaplan, and E.M. Shore (2012). Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele-specific targeting. Gene Therapy 19, 786-790.
  • Kan, L., V.Y. Lounev, R.J. Pignolo, L. Duan, Y. Liu, S.R. Stock, T.L. McGuire, B. Lu, N.P. Gerard, E.M. Shore, F.S. Kaplan and J.A. Kessler (2011). Substance P signaling mediates BMP-dependent heterotopic ossification. J. Cell. Biochem. 112, 2759-2772.

 

January 2012:

Congratulations to Eileen Shore for being named the Cali and Weldon Professor in Fibrodysplasia Ossificans Progessiva Research – with great appreciation to the Cali and Weldon Families.

 

Congratulations to Lexy!
April 22, 2019
Lexy successfully defended her PhD thesis!

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