McKay Orthopaedic Research Laboratory

Our Personnel

Faculty

• Eileen M. Shore, Ph.D.
• Frederick S. Kaplan, M.D.

Research Team

• Nadine Grossmann
• Vitali Y. Lounev, Ph.D.
• Loreilys Mejias Rivera
• Douglas Roberts
• Nava Schein
• Deyu Zhang
• Diego Ocaranza Nunez

Former Lab Members (listed chronologically)

Robyn Allen   CAMB Graduate Student (DSRB), 2015-2019: FOP-ACVR1 Signals by Multiple Modalities in the Developing Zebrafish; PhD thesis defense: November 2019.

Alexandra Stanley, PhD   Postdoc, 2019-2019: ACVR1 R206H and Muscle Stem Cells and Repair

Azadeh Timnak, PhD  Postdoc, 2018-2019: Inflammation and Heterotopic Ossification in FOP Mouse Models

Alexandra Stanley  CAMB Graduate Student (DSRB), 2014-2019: Cellular Mechanotransduction and Skeletal Muscle Regeneration in FOP; PhD thesis defense: April 2019

John Fong, PhD  Postdoc, 2013-2017: A Novel Mouse Model for HO Induction by Gnas Inactivation

Girish Ramaswamy, PhD  Postdoc, 2012-2016: Ablation of Gsa signaling in osteoclast progenitor cells adversely affects skeletal bone maintenance.

Julia Haupt, PhD  Postdoc, 2012-2015: ACVR1 R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification

Michael Convente  CAMB Graduate Student (DSRB), 2010 – 2017: In vivo Consequences of Enhanced BMP Signaling on Non-Bone Tissues; PhD thesis defense: May 2017

Bettina Mucha Le-Ny, PhD  Postdoc/Fellow 2009-2012 BMP Signaling Activity of Variant FOP ACVR1 Mutations in Zebrafish Assay Systems

Jan-Jan Liu, PhD  Postdoc 10/2009 - 2012 GNAS Inactivation in Adipogenic Differentiation

Andria Culbert  CAMB Graduate Student (GT) 4/2009 - 2014 Effects of Altered BMP Receptor Signaling on Cell Differentiation; PhD thesis defense: May 2014

Haitao Wang, PhD  Postdoc 8/2007- 2013 The Roles of Hypoxia in Cell Differentiation

Salin Chakkalakal, PhD  Postdoc 2/2007 - 2015 In vivo Mouse Model of FOP

Shengliang Zhang, MD, PhD  Postdoc 2/2007 –2010 GNAS Expression in Osteogenic Differentiation

Josef Kaplan, PhD  Postdoc 1/2007 –6/2012 Regulation of Osteoblast Differentiation using Gene Knockdown Approaches

Qi Shen, MD, PhD  Postdoc 6/2006 –12/2008 Functional Analysis of the FOP ACVR1 R206H Mutation

Vitali Lounev, PhD  Postdoc 10/2005 -2014? Origin of Cells that Participate in Heterotopic Ossification

Nichelle Adegbite, MD  Postdoc 7/2005 – 6/2006 Clinical Features and Diagnostic Criteria for Progressive Osseous Heteroplasia (POH) and POH-like Syndromes

Michael O’Connell, PhD  Graduate student 10/2004 -10/2006 Heparan Sulfate Proteoglycan Modulation of BMP Signaling in Fibrodysplasia Ossificans Progressiva; PhD thesis defense: September 2006

Gisela Melcon, MD  Postdoc 8/2004 - 7/2005 Microarray Analysis of Differential Gene Expression in FOP

Berangere Saucy, PhD  Postdoc 6/2004 - 1/2006 GNAS-regulated Signaling Pathways

Rishi Gupta  Medical student 1/2004 - 3/2005 The Lineage-Specific Origin of Osteoprogenitor Cells in Skeletal Regeneration

Reem Kanaan, PhD  Postdoc 12/2003 -4/2006 Effects of Inactivating GNAS Mutations on Osteoblast Differentiation

Brett Gibson, MD  Medical student 7/2003 - 6/2004 Cell Lineage Participation in Fracture Healing

Jennifer Fiori, PhD  CAMB Graduate Student (GGR) 7/2002 – 8/2006 The Role of Overexpression BMPRIA on BMP Signaling Pathways; PhD thesis defense: April 2006

Nader Hebela, MD  Medical student 7/2002 - 6/2003 BMPRIA Expression in Peripheral Blood Cells in FOP

Xiangyang Jiao, MD  Postdoc 6/2002 – 6/2005 Novel Treatments of Heterotopic Ossification

Greg Deirmengian, MD  Medical student 6/2001 - 6/2004 The Role of HSPGs in FOP

Richard Scarlett, MD  Medical student 11/2000 - 5/2002 Candidate Gene Analysis in the FOP Linkage Region

Yangguan Wu, PhD  Postdoctoral trainee 8/2000 -12/2002 Angiogenic Pathways in Genetic Disorders of Heterotopic Ossification

Raj Patel, MD  Medical student 7/2000 - 6/2001 Candidate Gene Analysis in the FOP Linkage Region

Jaimo Ahn, MD, PhD  Postdoc 1/2000 - 8/2003 Molecular Genetics of BMP Antagonists

Lourdes Serrano de la Pena, PhD  Postdoc 6/1999 - 2/2003 BMP Receptor Expression in FOP

Stephen Fitzgerald, MD  Medical student 6/1999 - 6/2000 Gs-alpha Protein Expression in POH

David Chang, MD  Medical student 9/1998 - 5/2000 Regulatory DNA Binding Factors for the BMP4 Gene

Sameer Mathur, MD  Medical student 5/1998 - 4/1999 Cbfa1 Gene Expression in POH

Melinda Yin, PhD  Graduate student 1/1998 - 9/1999 Role of Myoblasts in Ectopic Bone Formation

Brian Alverson, MD  Medical student 10/1997 - 10/1998 Heterotopic Bone Formation and Spinal Cord Injury

George Yeh, MD  Medical student 7/1997 - 6/1998 Cbfa1 Gene Expression in a Patient with Osteoma Cutis

David Glaser, MD  Postdoc/resident 7/1996 - 6/1997 BMP4 Gene Expression in FOP

Elizabeth Olmsted, PhD  Postdoc 7/1994 - 10/1998 Molecular Pathogenesis of Heterotopic Ossification in FOP