Ruth McCarrick-Walmsley
Research Specialist
University of Pennsylvania
Hometown
Wheaton, MD
Education
B.A Biology, University of Virginia, Charlottesville, VA
Areas of Special Interest
Development and Characterization of SHED (Stem cells from Human Exfoliated Deciduous teeth) cell lines for use as a model system in investigations of the molecular basis of FOP and drug efficacy.
Assessment of the role of COP (Circulating Osteogenic Progenitor) cells in the progression of FOP lesions.
Development of in vitro and in vivo assays for the assessment of candidate drugs.
Development, curation, and analysis of patient and control plasma samples for the assessment of biomarker correlation with FOP flare-up status, severity of expression, and, ultimately, drug efficacy.
Publications
Wang, H., C. Lindborg, J-H. Kim, R. McCarrick-Walmsley, L. Mangiavini, J. Groppe, E.M. Shore, E. Schipani, F.S. Kaplan, R.J. Pignolo (2016). Targeting the response to cellular hypoxia diminishes heterotopic ossification by normalizing BMP signaling. J. Bone Min. Res. 31, 1652-1665.
Suda RK, Billings PC, Egan KP, Kim JH, McCarrick-Walmsley R, Glaser DL, Porter DL, Shore EM, Pignolo RJ. Circulating osteogenic precursor cells in heterotopic bone formation. Stem Cells. 2009 Sep;27(9):2209-19.
Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T.Inhibition of p300/CBP by early B-cell factor. Mol Cell Biol 2003 Jun;23(11):3837-46.
Sloan SR, Shen CP, McCarrick-Walmsley R, Kadesch T. Phosphorylation of E47 as a potential determinant of B-cell-specific activity. Mol Cell Biol. 1996 Dec;16(12):6900-8.
Henthorn P, McCarrick-Walmsley R, Kadesch T. Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. Nucleic Acids Res. 1990 Feb 11;18(3):677.
Henthorn P, McCarrick-Walmsley R, Kadesch T.Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor. Nucleic Acids Res. 1990 Feb 11;18(3):678.
Nussbaum, R.L., McCarrick-Walmsley, R., Lesko, J.G., Airhart, S.D., Ledbetter, D.H. Thymidylate synthase-deficient Chinese hamster cells: a selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X Expression. Am. J. Hum. Genet. 37: 1192-1205, 1985.