Lexy Stanley
PhD student, CAMB/DSRB Graduate Program, UPenn
Currently: Postdoctoral fellow, UCSD
Hometown
San Diego, California
Education
B.S. Biology (Human Biology), 2013University of California, San Diego
Areas of Special Interest
Skeletal muscle regeneration, muscle stem cells, fibro/adipogenic progenitor cells, cellular mechanotransduction, BMP signaling
BMP receptor signaling, TGFB receptor signaling, chondrogenic differentiation, retinoic acid receptor (RAR) agonist drug analysis, cellular mechano-sensing of the microenvironment
Peer Reviewed Publication
Stanley A, Heo SJ, Mauck RL, Mourkioti F, Shore EM. Elevated BMP and mechanical signaling through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis. Journal of Bone and Mineral Research. 2019 May 20. doi: 10.1002/jbmr.3760
Stanley A, Shore EM, Mourkioti F. “Defining Skeletal Muscle Progenitor Cells.” Encyclopedia of Tissue Engineering and Regenerative Medicine. 1st ed. Philadelphia; Reference Module in Biomedical Sciences, Elsevier, 2018. 65471-5. Print.
Haupt J, Stanley A, Cosgrove BD, McLeod C, Culbert AL, Wang L, Mauck RL, Shore EM. The ACVR1R206H FOP mutation alters progenitor cell force sensing and increases lesion stiffness during muscle repair – implications for heterotopic ossification. Molecular Biology of the Cell. 2019 Jan 1;30(1):17-29.
Convente M, Stanley A, Towler OW, Brewer N, Kaplan FS, Shore EM. “Fibrodysplasia (Myositis) Ossificans Progressiva.” Genetics of Bone Biology and Skeletal Disease. 2nd ed. Philadelphia: Elsevier, 2017. 523-545. Print.
Kauge E, Roy P, Asselin G, Hu G, Stanley A, Albertson C, Fisher S. The osteoblast specific transcription factor Sp7 limits cranial bone initiation sites and is required for formation of sutures. Developmental Biology. 2016 May 15;413(2):160-72.
Ross J, Busch J, Mintz E, Ng D, Stanley A, Brafman D, Sutton VR, Van den Veyver I, Willert K. A rare human syndrome provides genetic evidence that WNT signaling is required for reprograming of fibroblasts to induced pluripotent stem cells. Cell Reports. 2014 Dec 11;9(5):1770-80.
Pope WH, Bowman CA, Russell DA, Jacobs-Sera D, Asai DJ, Cresawn SG, Jacobs WR, Hendrix RW, Lawrence JG, Hatfull GF; Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science; Phage Hunters Integrating Research and Education; Mycobacterial Genetics Course. Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. Elife. 2015 Apr 28;4:e06416.
Conference Presentations
Stanley A, Tichy E, Foteini Mourkioti, and Shore EM. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Oral presentation at Penn Orthopedic Research Day; 2019 May 5; Philadelphia PA. Won first place in the miscellaneous category.
Stanley A, Heo SJ, Mauck R, Mourkioti F, Shore EM. Elevated YAP1/RhoA Signaling Poises FOP Mesenchymal Progenitors for Osteogenesis. Poster presented at Keystone Conference: Cellular Plasticity and Metaplasia; 2019 January 27-31; Keystone, Colorado.
Stanley A, Tichy E, Haupt J, Foteini Mourkioti, and Shore EM. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Poster presented at American Society for Bone and Mineral Research (ASBMR); 2018 September 25-30; Montreal, Canada. Received a Young Investigator Award.
Stanley A, Tichy E, Foteini Mourkioti, and Shore E. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Oral presentation at Penn Orthopedic Research Day; 2018 May 10; Philadelphia PA.
Stanley A, Tichy E, Haupt J, Convente M, Mourkioti F, and Shore EM. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Poster presented at Institute for Regenerative Medicine Symposium; 2018 January 31; Philadelphia PA.
Stanley A, Tichy E, Haupt J, Mourkioti F, and Shore EM. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Poster presented at: PCMD Symposium; 2017 November 15; Philadelphia PA. Won second place in the miscellaneous category.
Stanley A, Tichy E, Haupt J, Convente M, Mourkioti F, and Shore EM. Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells. Oral presentation and poster presented at: Myogenesis Gordon Research Seminar and Conference; 2017 June 10-16; Il Cicco, Italy.
Stanley A, Haupt J, Cosgrove B, Tichy E, Mourkioti F, and Shore EM Increased force sensing and aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells – implications for heterotopic ossification. Poster presented at: 2016 Penn Center for Musculoskeletal Disorders Annual Symposium; 2016 November 9; Philadelphia, PA.
Stanley A, Haupt J, Tichy E, Mourkioti F, and Shore EM. Influence of BMP Signaling on the Resident Muscle Stem Cell Population During Skeletal Muscle Regeneration. Poster presented at: Bones and Teeth Gordon Research Seminar and Conference; 2016 February 13-14 and Gordon Research Conference; 2016 February 14-19; Galveston, TX. Served as discussion leader.
Awards
1. Young Investigator Award, ASBMR Conference, September 2019
2. Howard Hughes Graduate Training in Medical Science (GTMS) Certificate Recipient, May 2019
3. Oral presentation at Orthopedic Research Day, UPenn (1st place in Miscellaneous category for poster), May 2019
4. Endocrine Fellowship, ASBMR Conference, September 2018
5. Young Investigator Award, ASBMR Conference, September 2018
6. Oral presentation at Orthopedic Research Day, UPenn (2nd place in Miscellaneous category), May 2018
7. NIAMS F31 Individual Training Grant (F31 AR069982), May 2017
8. Oral presentation at Gordon Research Seminar & Conference: Myogenesis, June 2017
9. Predoctoral Training Grant from Penn Muscle Institute (T32 AR053461), May 2017
10. Predoctoral Training Grant in Developmental Biology (T32 HD083185), September 2015