Sun H. Peck, Ph.D.
Postdoctoral Researcher
University of Pennsylvania
Hometown
Plano, Texas
Education
Ph.D. (Chemical Biology) Harvard University, 2011
M.S. (Chemistry) University of Pennsylvania, 2005
B.A. (Biochemistry, Music) University of Pennsylvania, 2005
Areas of Special Interest
- Elucidation of the molecular mechanisms of failed bone formation in Mucopolysaccharidosis VII
- Investigation of developmental signals underlying embryonic nucleus pulposus formation
- Development of cell-based disc regeneration therapies
Publications
De Silva B, Adhikari B, Allen A, Peck SH, Lee SY. Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels. (2019) Biochim Biophys Acta Mol Basis Dis. 1865(2):322-328.
Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ. Effects of hypoxia and TGF-β pretreatment on survival and matrix producing capability of mesenchymal stem cells. (2019) Cartilage. (In minor revisions)
Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Zhang Y, Smith HE, Malhotra NR, Smith LJ. Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. (2018) J Orthop Res. 36(10):2771-2779.
Riester SM, Lin Y, Wang W, Cong L, Ali AM, Peck SH, Smith LJ, Currier B, Clark M, Huddleston P, Krauss W, Yaszemski MJ, Morrey ME, Abdel MP, Bydon M, Qu W, Larson AN, van Wijnen AJ, Nassr A. RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues. (2018) J Orthop Res. 36(5):1356-1369.
Peck SH, McKee KK, Tobias JW, Malhotra NR, Harfe BD, Smith LJ. Whole transcriptome analysis of notochord-derived cells during embryonic formation of the nucleus pulposus using RNA-Seq. (2017) Sci Rep. (1):10504. doi: 10.1038/s41598-017-10692-5
Peck SH, Casal ML, Malhotra NR, Ficicioglu C, Smith LJ. Pathogenesis and Treatment of Spine Disease in the Mucopolysaccharidoses. (2016) Mol Genet Metab. 118(4):232-43.- Publication figure selected as cover art for the Aug 2016 edition of Molecular Genetics and Metabolism.
Peck SH, O’Donnell PJM, Kang JL, Malhotra NR, Dodge GR, Pacifici M, Shore EM, Haskins ME, Smith LJ. Delayed Hypertrophic Differentiation of Epiphyseal Chondrocytes Contributes to Failed Secondary Ossification in Mucopolysaccharidosis VII Dogs. (2015) Mol Genet Metab. 116(3): 195-203.
Moharir A, Peck SH, Budden T, Lee SY. The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5. (2013) PLOS ONE 8(9): e74299. doi:10.1371/journal.pone.0074299
Peck SH, Chen I, Liu DR. Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells. (2011) Chem Biol. 18(5): 619-30.- Publication featured in BioTechniques: Dorman N. A Cut Above. (2011) BioTechniques 51:79.
Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D. A de novo protein binding pair by computational design and directed evolution. (2011) Mol Cell. 42(2):250-60.
Patents
"Ligand-Dependent Protein Splicing" (Small-Molecule-Triggered Inteins) Liu DR, Buskirk AR, Peck SH. US Patent #7192739, #7541450, and other patent(s) pending.
Awards
Feb 2019, Finalist, Orthopaedic Research Society 2019 Annual Meeting Spine Section Award
Jan 2019, Selected as American Society of Bone and Mineral Research John Haddad Young Investigator Awardee
Sept 2018, University of Pennsylvania Biomedical Postdoc Program Travel Award
Aug 2018, Elected as chair for 2020 Gordon Research Seminar on Musculoskeletal Biology and Bioengineering
Aug 2018, Discussion Leader, 2018 Gordon Research Seminar on Musculoskeletal Biology and Bioengineering, Andover, NH
Jun 2018, Best Podium Presentation Award, University of Pennsylvania Department of Orthopaedic Surgery Research Symposium
Aug 2017, Co-author, 2nd Place Podium Presentation Award, 2017 David W. Smith Workshop on Malformations and Morphogenesis
May 2017, NIH Ruth L. Kirschstein-NRSA Postdoctoral F32 Award (1F32AR071298-01) - Impaired BMP Signaling and Failed Bone Formation in Mucopolysaccharidosis VII
Mar 2017, Orthopaedic Research Society 2017 Annual Meeting - Spine Section Award - Finalist
Nov 2016, Philadelphia Spine Research Symposium - 2nd Place Poster Presentation Award
Nov 2016, Penn Center for Musculoskeletal Disorders Symposium - Poster Presentation Award
Nov 2015, Penn Center for Musculoskeletal Disorders Symposium - 1st Place Poster Presentation Award, Molecular Profiling - 3rd Place Poster Presentation Award, Molecular Profiling
Nov 2015, ORS PSRS 3rd International Spine Research Symposium - 1st Place Poster Presentation Award, Disease Mechanisms and Pathobiology - 1st Place Podium Presentation Award, Cell and Molecular Biology
Nov 2014, Penn Center for Musculoskeletal Disorders Symposium - Poster Presentation Award
Oct 2014, Philadelphia Spine Research Symposium - Podium Presentation Award
Sept 2014, The Brody Family Medical Trust Fund Postdoctoral Fellowship - Finalist
2008, Joseph R. Levenson Memorial Teaching Prize for Excellence in Education, Harvard University - Finalist
2006-07, Derek Bok Center for Teaching and Learning, Harvard University - Certificate of Distinction in Teaching
2005, University of Pennsylvania - Helix Prize for outstanding undergraduate research and academic record
2001-05, Roy and Diana Vagelos Program in the Molecular Life Sciences, University of Pennsylvania - Science Scholar
Leadership/Service
2018-2020 Chair, 2020 Gordon Research Seminar on Musculoskeletal Biology and Bioengineering
2018-present American Society of Bone and Mineral Research Early Stage Investigator Subcommittee
Abstracts
Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O’Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ. Lithium treatment improves vertebral trabecular bone architecture in mucopolysaccharidosis I dogs during postnatal growth. Orthopaedic Research Society Annual Meeting, Austin, TX. February 2019. (Podium Presentation, ORS Spine Section Award Finalist)
Zhang C, Peck SH, Bendigo JR, Lau YKA, Malhotra NR, Smith LJ. Non-invasive imaging of therapeutic cells delivered percutaneously to the mouse intervertebral disc. Orthopaedic Research Society Annual Meeting, Austin, TX. February 2019. (Poster)
Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O’Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ. Lithium-mediated effects on vertebral bone formation in mucopolysaccharidosis I dogs during postnatal growth. American Society of Bone and Mineral Research Annual Meeting, Montreal, Canada. September 2018. (Poster)
Peck SH, Lau YKA, Bendigo JR, Lin M, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra NR, Shore EM, Casal ML, Smith LJ. Effects of lithium treatment on bone turnover in mucopolysaccharidosis I dogs during postnatal growth. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster)
Smith LJ, Peck SH, Lin G, Lau YKA, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra Nr, Casal ML. Effects of enzyme replacement therapy on skeletal disease in mucopolysaccharidosis VII dogs: preliminary findings. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster)
Casal ML, Lin G, Peck SH, Smith LJ. Long-term natural history study of dogs with mucopolysaccharidosis type I. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster)
Peck SH, Lau YA, Kang JL, Matalon DR, Lin M, Bagel JH, O’Donnell PA, Fitzgerald CA, Molony CM, Malhotra NR, Shore EM, Casal ML, Smith LJ. Impaired bone formation in mucopolysaccharidosis VII dogs during postnatal growth is associated with lower serum levels of bone-specific alkaline phosphatase. WORLD Symposium, Lysosomal Diseases Network, San Diego, CA. February 2018. (Late-Breaking Poster)
Peck SH, Bendigo JR, Dodge GR, Mauck RL, Malhotra NR, Smith LJ. Donor-Dependent Effects on the Survival and Extracellular Matrix Producing Capacity of Mesenchymal Stem Cells following Hypoxia and TGF-β Conditioning. Orthopaedic Research Society Annual Meeting, New Orleans, LA. March 2018. (Poster)
Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Smith H, Malhotra NR, Smith LJ. Quantitative magnetic resonance imaging correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. Orthopaedic Research Society Annual Meeting, New Orleans, LA. March 2018. (Poster)
Peck SH, McKee KK, Malhotra NR, Harfe BD, Smith LJ. Growth Factor and Extracellular Matrix Expression and Localization during Nucleus Pulposus Formation. Orthopaedic Research Society Annual Meeting, San Diego, CA. March 2017. (Podium, ORS Spine Section Award Finalist)
Peck SH, Bendigo JR, Gullbrand SE, Tobias JW, Dodge GR, Mauck RL, Malhotra NR, Smith LJ. Effects of Hypoxia and TGF-ß Exposure during Monolayer Expansion on the Survival and Matrix Producing Capacity of Mesenchymal Stem Cells. Orthopaedic Research Society Annual Meeting, San Diego, CA. March 2017. (Poster)
Peck SH, Kang JL, Bendigo JR, O’Donnell P, Fitzgerald CA, Bagel J, Malhotra NR, Shore EM, Casal ML, Smith LJ. Rescuing Chondrocyte Hypertrophic Differentiation Potential and Exploring Therapeutic Approaches for Enhancing Bone Formation in Mucopolysaccharidosis VII Dogs. Orthopaedic Research Society Annual Meeting, San Diego, CA. March 2017. (Poster)
Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Smith HE, Malhotra NR, Smith LJ. Comparison of Quantitative Imaging Techniques for Detecting Degenerative Changes in a Mouse Caudal Intervertebral Disc Injury Model. Philadelphia Spine Research Symposium, Philadelphia, PA. November 2016. (Late Breaking Poster)
Peck SH, Bendigo JR, Gullbrand SE, Tobias JW, Dodge GR, Mauck RL, Malhotra NR, Smith LJ. Effects of Hypoxia and TGF-ß Exposure during Monolayer Expansion on the Survival and Matrix Producing Capacity of Mesenchymal Stem Cells. Philadelphia Spine Research Symposium, Philadelphia, PA. November 2016. (Podium)
Peck SH, Kang JL, Bendigo JR, O’Donnell P, Fitzgerald CA, Bagel J, Malhotra NR, Shore EM, Casal ML, Smith LJ. Rescuing Chondrocyte Hypertrophic Differentiation Potential and Exploring Therapeutic Approaches for Enhancing Bone Formation in Mucopolysaccharidosis VII Dogs. Philadelphia Spine Research Symposium, Philadelphia, PA. November 2016. (Poster)
Peck SH, McKee KK, Malhotra NR, Harfe BD, Smith LJ. Growth Factor and Extracellular Matrix Expression and Localization during Nucleus Pulposus Formation. Philadelphia Spine Research Symposium, Philadelphia, PA. November 2016. (Poster, Poster Presentation Award)
Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Smith HE, Malhotra NR, Smith LJ. Comparison of Quantitative Imaging Techniques for Detecting Degenerative Changes in a Mouse Caudal Intervertebral Disc Injury Model. Philadelphia Spine Research Symposium, Philadelphia, PA. November 2016. (Poster)
Peck SH, Kang JL, Pacifici M, Dodge GR, Malhotra NR, Haskins ME, Shore EM, Smith LJ. Impaired Chondrocyte Hypertrophic Differentiation Potential is Associated with Abnormal Glycosaminoglycan Accumulation in Mucopolysaccharidosis VII Dogs. American Society of Bone and Mineral Research Annual Meeting, Atlanta, GA. September, 2016. (Poster)
Peck SH, McKee KK, Malhotra NR, Tobias JW, Mauck RL, Harfe BD, Smith LJ. Whole-Transcriptome Profiling of Notochord-Derived Cells during Embryonic Nucleus Pulposus Formation. Orthopaedic Research Society Annual Meeting, Orlando, FL. March 2016. (Podium)
Peck SH, Shore EM, Malhotra NR, Tobias JW, Pacifici M, Haskins ME, Smith LJ. Impaired Wnt Signaling Contributes to Delayed Chondrocyte Differentiation in Mucopolysaccharidosis VII Dogs. Orthopaedic Research Society Annual Meeting, Orlando, FL. March 2016. (Poster)
Peck SH, Kang JL, Chiaro JA, Malhotra NR, Casal ML, Haskins ME, Smith LJ. Progression of Vertebral Bone Disease in Mucopolysaccharidosis VII Dogs from Birth to Skeletal Maturity. Orthopaedic Research Society Annual Meeting, Orlando, FL. March 2016. (Poster)
Peck SH, Kang JL, Dodge GR, Malhotra NR, Haskins ME, Smith LJ. Aberrant Glycosaminoglycan Accumulation and Sulfation in Epiphyseal Cartilage in Mucopolysaccharidosis VII. Orthopaedic Research Society Annual Meeting, Orlando, FL. March 2016. (Poster)
Peck SH, Shore EM, Malhotra NR, Tobias JW, Pacifici M, Haskins ME, Smith LJ. Impaired Wnt Signaling Contributes to Delayed Chondrocyte Differentiation in Mucopolysaccharidosis VII Dogs. Penn Center for Musculoskeletal Disorders Symposium, University of Pennsylvania, Philadelphia, PA. November 2015. (Poster, 1st Place Poster Presentation Award)
Peck SH, Shore EM, Malhotra NR, Dodge GR, Casal ML, Pacifici M, Haskins ME, Smith LJ. Failed Vertebral Bone Formation in Mucopolysaccharidosis VII is Associated with Aberrant Sox9 Regulation and Altered Wnt Signaling. Penn Center for Musculoskeletal Disorders Symposium, University of Pennsylvania, Philadelphia, PA. November 2015. (Poster, 3rd Place Poster Presentation Award)
Peck SH, McKee KK, Malhotra NR, Tobias JW, Mauck RL, Harfe BD, Smith LJ. Whole-Transcriptome Profiling of Notochord Cells during Embryonic Nucleus Pulposus Formation. ORS PSRS 3rd International Spine Research Symposium, Philadelphia, PA. November 2015. (Podium, 1st Place Podium Presentation Award)
Peck SH, Shore EM, Malhotra NR, Tobias JW, Pacifici M, Haskins ME, Smith LJ. Inactivation of Wnt/β-Catenin Signaling Contributes to Failed Vertebral Bone Formation in MPS VII. ORS PSRS 3rd International Spine Research Symposium, Philadelphia, PA. November 2015. (Poster, 1st Place Poster Presentation Award)
Peck SH, Kang JL, Chiaro JA, Malhotra NR, Casal ML, Haskins ME, Smith LJ. Progression of Vertebral Bone Disease in Mucopolysaccharidosis VII Dogs from Birth to Skeletal Maturity. ORS PSRS 3rd International Spine Research Symposium, Philadelphia, PA. November 2015. (Poster)
Peck SH, Shore EM, Malhotra NR, Dodge GR, Casal ML, Pacifici M, Haskins ME, Smith LJ. Failed Vertebral Bone Formation in Mucopolysaccharidosis VII is Associated with Aberrant Sox9 Regulation and Altered Wnt Signaling. American Society of Bone and Mineral Research Annual Meeting, Seattle, WA. October 2015. (Poster)
Peck SH, O'Donnell PJM, Chiaro JA, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ. Pinpointing the Earliest Manifestations of Skeletal Disease in Mucopolysaccharidosis Disorders. Orthopaedic Research Society Annual Meeting, Las Vegas, NV. March 2015. (Poster)
Lothstein KE, O'Donnell PJM, Peck SH, Dodge GR, Mauck RL, Malhotra NR, Smith LJ. Preconditioning Stem Cells to Maximize Regenerative Potential in the Challenging Microenvironment of the Intervertebral Disc. Orthopaedic Research Society Annual Meeting, Las Vegas, NV. March 2015. (Poster)
Peck SH, O'Donnell PJM, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ. Failed Vertebral Bone Formation is Associated with Impaired Chondrocyte Hypertrophic Differentiation in Mucopolysaccharidosis VII Dogs. WORLD Symposium, Lysosomal Diseases Network, Orlando, FL. February 2015. (Podium)
Peck SH, O'Donnell PJM, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ. Impaired Chondrocyte Differentiation in Failed Vertebral Bone Formation in Mucopolysaccharidosis VII Dogs. Penn Center for Musculoskeletal Disorders Symposium, University of Pennsylvania, Philadelphia, PA. November 2014. (Poster, Poster Presentation Award)
Lothstein KE, O'Donnell PJM, Peck SH, Dodge GR, Mauck RL, Malhotra NR, Smith LJ. Preconditioning Stem Cells to Maximize Regenerative Potential in the Challenging Microenvironment of the Intervertebral Disc. Philadelphia Spine Research Symposium, Philadelphia, PA. October 2014. (Poster)
Peck SH, O'Donnell PJM, Chiaro JA, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ. Earliest Manifestations of Altered Vertebral Bone Formation in Mucopolysaccharidosis Disorders. Philadelphia Spine Research Symposium, Philadelphia, PA. October 2014. (Podium, Podium Presentation Award)
Chung SH, Liu DR. Molecular evolution of inteins. Chemical Biology Retreat, Harvard University, Cambridge, MA. October 2009. (Poster)
Chung SH, Liu DR. Optimization of the ligand-dependent intein for use in mammalian cells. Chemical Biology Retreat, Harvard University, Cambridge, MA. October 2008. (Podium)
Chung SH, Kwong L, Giasson BI, Trojanowski JQ, Lee VMY. Interactions between β-amyloid and α-synuclein in vitro. Frontotemporal Dementia: Clinical, Genetic, Biomarker, and Pathological Perspectives, Satellite Meeting to 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, PA. July 2004. (Poster)