What's New

Paper Accepted for Publication - Smith/Malhotra Lab
December 12, 2023
Congratulations to Chenghao Zhang and co-authors on their paper entitles "Single cell RNA sequencing reveals emergent notochord-derived cell subpopulations in the postnatal nucleus pulposus" for publication in the Federation of American Societies for Experimental Biology Journal.

Paper Accepted for Publication - Smith/Malhotra Lab
March 9, 2023
Congratulations to Rahul Gawri and co-authors on their paper entitled "Dose-dependent effects of enzyme replacement therapy on skeletal disease progression in mucopolysaccharidosis VII dogs" for publication in Molecular Therapy-Methods & Clinical Development.

2023 ORS Spine Section Poster Award - Karthikeyan Rajagopal
January 14, 2023
Congratulations to Karthikeyan Rajagopal on receiving a Spine Section Poster Award at the 2023 ORS Annual meeting.

Paper Accepted for Publication - Smith/Malhotra Lab
January 4, 2023
Congratulations to Chenghao Zhang and co-authors on their paper entitled "Proteomics identifies novel biomarkers of synovial joint disease in a canine model of mucopolysaccharidosis I" for publication in Molecular Genetics and Metabolism.

Paper Accepted for Publication - Smith/Malhotra Lab
October 18, 2021
Congratulations to Adrian Lau and co-authors on their paper entitled "Effects of lithium administration on vertebral bone disease in Mucopolysaccharidosis I dogs" for publication in Bone.

Paper Accepted for Publication - Smith/Malhotra Lab
June 15, 2021
Congratulations to Sun Peck and co-authors on their paper entitled "Progression of Vertebral Bone Disease in Mucopolysaccharidosis VII Dogs from Birth to Skeletal Maturity" accepted for publication in Molecular Genetics and Metabolism.

R01 Grant Award - Smith/Malhotra Lab
February 18, 2021
Congratulations to the lab on receiving a new 5-year R01 grant from the NIH entitled “Neutralizing the degenerate disc microenvironment to enhance the efficacy of therapeutic stem cells”.

Paper Accepted for Publication - Smith/Malhotra Lab
December 15, 2020
Congratulations to Zhirui Jiang and co-authors on their paper entitled "Epiphyseal Cartilage Canal Architecture and Extracellular Matrix Remodeling in Mucopolysaccharidosis VII Dogs at the Onset of Postnatal Growth" accepted for publication in Connective Tissue Research.

Paper Accepted for Publication - Smith/Malhotra Lab
September 28, 2020
Congratulations to Zhirui Jiang and co-authors on their review paper entitled "Failures of Endochondral Ossification in the Mucopolysaccharidoses" accepted for publication in Current Osteoporosis Reports.

Paper Accepted for Publication - Smith/Malhotra Lab
August 12, 2020
Congratulations to Chenghao Zhang and co-authors on their paper "Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats" accepted for publication in Tissue Engineering: Part A.

Paper Accepted for Publication - Smith/Malhotra Lab
August 6, 2020
Congratulations to Zhirui Jiang and co-authors on their paper "Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth" accepted for publication in the Journal of Anatomy

2020 Engineering Outstanding Research Award - Adrian Lau
May 15, 2020
Congratulations to Adrian Lau for receiving Engineering Outstanding Research Award and graduating with a Master in Biotechnology degree.

Paper Accepted for Publication - Smith/Malhotra Lab
February 19, 2020
Congratulations to Chenghao Zhang and co-authors on the acceptance of their paper "Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration" for publication in Journal of Orthopaedic Research.

2020 ORS New Investigator Recognition Awards - Chenghao Zhang
February 11, 2020
Congratulations to Chenghao Zhang for receiving a New Investigator Recognition Award at the 2020 Orthopaedic Research Society Meeting in Phoenix!

Lisa Dean Moseley Foundation Grant Award - Smith/Malhotra Lab
September 6, 2019
Congratulations to the lab on being awarded a 2 year grant from the Lisa Dean Moseley Foundation to develop an in utero mesenchymal stem cell therapy for mucopolysaccharidoses.

Paper Accepted for Publication - Smith/Malhotra Lab
August 20, 2019
Congratulations to Sun Peck and co-authors on the acceptance of their paper "Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII" for publication in Bone.

Paper Accepted for Publication - Smith/Malhotra Lab
March 5, 2019
Congratulations to Sun Peck and co-authors on the acceptance of their paper "Hypoxic preconditioning enhances bone marrow-derived mesenchymal stem cell survival in a low oxygen and nutrient-limited 3D microenvironment." for publication in Cartilage.

2019 ASBMR John Haddad Young Investigator Award - Sun Peck
January 28, 2019
Congratulations to Sun Peck on being awarded an ASBMR John Haddad Young Investigator Award to attend the 2019 AIMM-ASBMR Meeting in Snowmass, Colorado.

Paper Accepted for Publication - Smith/Malhotra Lab
April 24, 2018
Congratulations to Matt Piazza and co-authors on the acceptance of their paper "Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration." for publication in Scientific Reports.

Paper Accepted for Publication - Smith/Malhotra Lab
September 07, 2017
Congratulations to Sun Peck and co-authors on the acceptance of their paper "Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus" for publication in Scientific Reports.

2017 David W. Smith Workshop Award - Dena Matalon
September 05, 2017
Congratulations to Dena Matalon on being awarded second prize at the 2017 David W. Smith Workshop on Malformations and Morphogenesis

R01 Grant Award - Smith/Malhotra Lab
July 28, 2017
Congratulations to the Smith/Malhotra lab on being awarded a new R01 grant from the National Institutes of Health to study the pathogenesis and treatment of bone disease in the mucopolysaccharidoses

Paper Accepted for Publication - Smith/Malhotra Lab
July 20, 2017
Congratulations to Sarah Gullbrand and co-authors on the acceptance of their paper "Translation of an Injectable Triple-Interpenetrating-Network Hydrogel for Intervertebral Disc Regeneration in a Goat Model" into Acta Biomaterialia.

R21 Grant Award - Smith/Malhotra Lab
July 12, 2017
Congratulations to the Smith/Malhotra Lab on being awarded a new R21 grant from the National Institutes of Health to study the regenerative potential of embryonic notochordal disc progenitor cells

ISSLS 2017 Best Paper Award - Sarah Gullbrand
June 09, 2017
Congratulations to Sarah Gullbrand and co-authors on being awarded the best paper prize at the 2017 meeting of the International Society for the Study of the Lumbar Spine in Athens, Greece!

NIH Postdoctoral F32 Award - Sun Peck
May 12, 2017
Congratulations to Sun Peck for receiving the NIH Ruth L. Kirschstein-NRSA Postdoctoral F32 Award for Impaired BMP Signaling and Failed Bone Formation in Mucopolysaccharidosis VII!

CHOP Research Poster Day Winner - Dena Matalon
March 08, 2017
Congratulations to Dena Matalon who was a selected as a winner at the CHOP Research Poster Day within the Labarotary-Based research section.

ORS 2017 Accepted Abstracts - Smith/Malhotra Lab
November 11, 2016
Congratulations to the Smith/Malhotra Lab for having 5 abstracts accepted for podium or poster presentation at the Orthopaedic Research Society Annual Meeting 2017 in San Diego, CA.

2016 PSRS Accepted Abstracts - Smith/Malhotra Lab
October 03, 2016
Congratulations to the Smith/Malhotra Lab for having 6 abstracts accepted for presentation at the 2016 Philadelphia Spine Research Symposium.

Paper Accepted for Publication
August 17, 2016
Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo JR, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ. (2016) "A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration". Osteoarthritis and Cartilage.

Paper Figure Selected as Cover Art - Sun Peck
August 01, 2016
Congratulations to Sun Peck whose paper figure was selected as cover art for the August 2016 edition of Molecular Genetics and Metabolism.

Paper Accepted for Publication
June 06, 2016
Peck SH, Casal ML, Malhotra NR, Ficicioglu C, Smith LJ. (2016) "Pathogenesis and Treatment of Spine Disease in the Mucopolysaccharidoses". Molecular Genetics and Metabolism.

Orphan Diseases Grant - Smith/Malhotra Lab
June 02, 2016
The lab was awarded a new grant from the Penn Orphan Diseases Center to investigate novel treatments for skeletal disease in mucopolysaccharidosis I.

ORS PSRS Podium Award - Sun Peck
November 12, 2015
Congratulations to Sun Peck who was awarded 1st Place for her podium presentation in the category of 'Cell and Molecular Biology' at the ORS PSRS 3rd International Spine Research Symposium in Philadelphia, PA: “Whole-Transcriptome Profiling of Notochord Cells during Embryonic Nucleus Pulposus Formation”.

ORS PSRS Poster Award - Sarah Gullbrand
November 12, 2015
Congratulations to Sarah Gullbrand who was awarded 2nd Place for her poster presentation in the category of 'Preclinical, Animal Models and Clinical' at the ORS PSRS 3rd International Spine Research Symposium in Philadelphia, PA: “Recapitulating the Spectrum of Degenerative Changes to the Intervertebral Disc in a Large Animal Model”.

ORS PSRS Poster Award - Sun Peck
November 12, 2015
Congratulations to Sun Peck who was awarded 1st Place for her poster presentation in the category of 'Disease Mechanisms and Pathobiology' at the ORS PSRS 3rd International Spine Research Symposium in Philadelphia, PA: “Inactivation of Wnt/β-Catenin Signaling Contributes to Failed Vertebral Bone Formation in MPS VII”.

Paper Accepted for Publication
September 25, 2015
Peck SH, O’Donnell PJ, Kang J, Shore EM, Pacifici M, Dodge GR, Haskins ME, Malhotra NR, Smith LJ. (2015) "Delayed Hypertrophic Differentiation of Epiphyseal Chondrocytes Contributes to Failed Bone Formation in Mucopolysaccharidosis VII Dogs". Molecular Genetics and Metabolism.

ORS PSRS Podium Presentation - Sun Peck
September 21, 2015
Congratulations to Sun Peck who was selected for the following podium presentation at the ORS PSRS 3rd International Spine Research Symposium in Philadelphia, PA: “Whole-Transcriptome Profiling of Notochord Cells during Embryonic Nucleus Pulposus Formation”.

ORS PSRS Poster Presentations - Sarah Gullbrand
September 21, 2015
Congratulations to Sarah Gullbrand who was selected for the following poster presentations at the ORS PSRS 3rd International Spine Research Symposium in Philadelphia, PA: “Correlation of Quantitative T2 and T1ρ MRI Parameterswith Mechanics and Biochemical Content in a RabbitIntervertebral Disc Degeneration Model” and “Recapitulating the Spectrum of Degenerative Changes tothe Intervertebral Disc in a Large Animal Model”.

ORS PSRS Poster Presentations - Sun Peck
September 21, 2015
Congratulations to Sun Peck who was selected for the following poster presentations at the ORS PSRS 3rd International Spine Research Symposium in Philadelphia, PA: “Inactivation of Wnt/β-Catenin Signaling Contributes to Failed Vertebral Bone Formation in MPS VII” and “Progression of Vertebral Bone Disease in Mucopolysaccharidosis VII Dogs from Birth to Skeletal Maturity”.

ASBMR Poster Presentation - Sun Peck
September 01, 2015
Congratulations to Sun Peck who was selected for the following poster presentation at the 2015 ASBMR Annual Meeting in Seattle, WA: “Failed Vertebral Bone Formation in Mucopolysaccharidosis VII is Associated with Aberrant Sox9 Regulation and Altered Wnt Signaling”

Paper Accepted for Publication
January 09, 2015
Gorth DG, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ. (2015) "Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long Term Agarose Culture". Journal of Orthopaedic Research.

Poster Presentation - Sun Peck
December 18, 2014
Congratulations to Sun Peck who was selected for the following podium presentation at the 2015 World Symposium on Lysosomal Diseases in Orlando, Florida: "Failed Vertebral Bone Formation in Mucopolysaccharidosis VII Dogs is Associated with Impaired Chondrocyte Hypertrophic Differentiation".

2015 ISSLS Prize - Sarah Gullbrand
December 05, 2014
Congratulations to Sarah Gullbrand who won the 2015 ISSLS prize for her graduate school work at RPI. She will present her paper at the 2015 annual meeting in San Francisco in June.

Paper Accepted for Publication - Smith/Malhotra Lab
April 24, 2018
Congratulations to Matt Piazza and co-authors on the acceptance of their paper "Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus" for publication in Scientific Reports.