Vitali Y. Lounev, Ph.D.
Senior Research Investigator
University of Pennsylvania
Hometown
Minsk, Belarus
Education
MAPC (Multipotent Adult Progenitor Cells) Training Program, Stem Cell Institute, University of Minnesota, Minneapolis, MN, 2004 Ph.D., Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia, 1989M.S., Belarusian State University, Minsk, Belarus, 1981
Areas of Special Interest
Origin of cells that participate in heterotopic ossification
Peer-Reviewed Publications
Ramaswamy, G., H. Kim, D. Zhang, V. Lounev, J.Y. Wu, Y. Choi, F.S. Kaplan, R.J. Pignolo, and E.M. Shore (2017). Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways. Scientific Reports 7, 45140; doi:10.1038/srep45140.
Culbert, A.L., S.A. Chakkalakal, M.R. Convente, V.Y. Lounev, F.S. Kaplan, and E.M. Shore (2013). Fibrodysplasia (Myositis) Ossificans Progressiva, Chapter 24; pp. 375-393. Genetics of Bone Biology and Skeletal Disease. R.V. Thakker, M.P. Whyte, J.A. Eisman, and T. Igarashi, Editors. Elsevier, New York.
Wang H, Lindborg C, Lounev V, Kim JH, McCarrick-Walmsley R, Xu M, Mangiavini L, Groppe JC, Shore EM, Schipani E, Kaplan FS, Pignolo RJ. Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling. J Bone Miner Res. 2016 Sep;31(9):1652-65.
Kaplan FS, Lounev VY, Wang H, Pignolo RJ, Shore EM. Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis. Ann N Y Acad Sci. 2011 Nov;1237:5-10.
Kan L, Lounev VY, Pignolo RJ, Duan L, Liu Y, Stock SR, McGuire TL, Lu B, Gerard NP, Shore EM, Kaplan FS, Kessler JA. Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem. 2011 Oct;112(10):2759-72.
Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010 Dec;16(12):1400-6. Erratum in: Nat Med. 2011 Apr;17(4):514.
Kaplan FS, Seemann P, Haupt J, Xu M, Lounev VY, Mullins M, Shore EM. Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor, that causes fibrodysplasia ossificans progressiva. Methods Enzymol. 2010;484:357-73.
Lounev VY, Ramachandran R, Wosczyna MN, Yamamoto M, Maidment AD, Shore EM, Glaser DL, Goldhamer DJ, Kaplan FS. Identification of progenitor cells that contribute to heterotopic skeletogenesis. J Bone Joint Surg Am 2009 Mar 1;91(3):652-63.
Kaplan FS, Shen Q, Lounev V, Seemann P, Groppe J, Katagiri T, Pignolo RJ, Shore EM. Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP). J Bone Miner Metab 2008;26(6):521-30.
Markov V., Kusumi K., Tadesse M.G., William D.A., Hall D.M., Lounev V., Carlton A., Leonard J., Cohen R.I., Rappaport E.F., Saitta B. Identification of cord blood-derived mesenchymal stem/stromal cell populations with distinct growth kinetics, differentiation potentials, and gene expression profiles. Stem Cells Dev 2007 Feb;16(1):53-73.
Fidel P.L.Jr., Barousse M., Lounev V., Espinosa T., Chesson R.R., Dunlap K. Local immune responsiveness following intravaginal challenge with Candida antigen in adult women at different stages of the menstrual cycle. Med Mycol 2003 Apr;41(2):97-109.
Fidel PL Jr, Wormley FL Jr, Chaiban J, Chesson RR, Lounev V. Analysis of the CD4 protein on human vaginal T lymphocytes. Am J Reprod Immunol 2001 Apr;45(4):200-4.
Martsev SP, Preygerzon VA, Mel'nikova YI, Kravchuk ZI, Ponomarev GV, Lunev VE, Savitsky AP. Modification of monoclonal and polyclonal IgG with palladium (II) coproporphyrin I: stimulatory and inhibitory functional effects induced by two different methods. J Immunol Methods 1995 Oct 26;186(2):293-304.
Mel'nikova IaI, Lunev VE, Preigerzon VA, Luneva NM, Koshkin SA, Rodionov MA, Martsev SP. Monoclonal antibodies to human spleen ferritin. II. Localization of epitopes and quantitative parameters of antigen binding. Biokhimiia 1993 May;58(5):759-71. Russian.
Lunev VE, Mel'nikova IaI, Koshkin SA, Luneva NM, Cherkesova TS, Vasilevskaia IA, Preygerzon VA, Martsev SP. Monoclonal antibodies to human spleen ferritin. I. Preparation and study of the interaction with isoferritin and apoferritin. Biokhimiia 1993 May;58(5):745-58. Russian.
Bespalov IA, Shiianov PA, Lukashevich LV, Lunev VE, Tribush SS, Gaponova GI, Deev SM. Preparation of single-chained antibodies to human ferritin in Escherichia coli. Mol Biol (Mosk) 1993 Mar-Apr;27(2):451-60. Russian.
Skrivelis VA, Bundulis IuP, Paniutich AV, Voitenok NN, Lunev VE, Nesmeianov VA, Tsimanis AIu, Gren EIa. Localization of an antigenic determinant of recombinant interleukin-2, recognized by monoclonal antibody 13B1. Bioorg Khim 1991 Jun;17(6):725-31. Russian.
Lunev VE, Lukin YuV, Kazennykh NV, Belyaev SV, Zubov VP, Nesmeyanov VA. Latex-agglutination analysis of human recombinant interleukin-2 with monoclonal antibodies. Biomed Sci 1990 Jan;1(1):68-72.
Onoprienko LV, Mikhaleva II, Lunev VE, Nesmeianov VA, Ivanov VT. Synthesis and immunochemical properties of peptides corresponding to sequences 59-72 and 25-36 of human interleukin-2. Bioorg Khim 1989 Jul;15(7):908-21. Russian.
Book Chapters
Andria L. Culbert, Salin A. Chakkalakal, Michael R. Convente, Vitali Y. Lounev, Frederick S. Kaplan and Eileen M. Shore. “Fibrodysplasia (Myositis) Ossificans Progressiva” In R.V. Thakker, M.P. Whyte, J. Eisman, T. Igarashi, eds. Genetics of Bone Biology and Skeletal Disease. Elsevier Science, 2012, pp 375-394.
Awards
Canon Foundation Fellow, 1997