Shore Laboratory

Nadine Grossmann

Ph.D. candidate

Hometown: Berlin, Germany

Education:

  • Currently a last-year visiting Ph.D. candidate from the Department of Chemistry and Biochemistry at the Freie Universität Berlin (FUB) and the grad school Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin (BSRT)
  • Master of Science in Molecular Medicine, Georg-August-Universität Göttingen, Germany
  • Bachelor of Science in Biology, University of Basel, Switzerland

Areas of special interest:

  • Age-dependent formation of heterotopic ossification and tissue regeneration in the ultra-rare disease Fibrodysplasia Ossificans Progressiva (FOP)
  • Vascular alterations in FOP
  • BMP signaling pathway and molecular mechanism underlying FOP

Publications:

  • Ipek Ilgin Gönenc, Nursel H. Elcioglu, Carolina Alexandra Martinez, Nadine Großmann, Inka Praulich, Janine Altmüller, Silke Kaulfuß, Yun Li, Peter Nürnberg, Peter Burfeind, Gökhan Yigit and Bernd Wollnik (2022). Phenotypic spectrum of BLM- and RMI1- related Bloom syndrome. Clinical Genetics, 101(5-6):559-564. https://doi.org/10.1111/cge.14125

Achievements & Awards:

  • 2019 – present:  Graduate student, BSRT
  • 2023:                    2nd place poster presentation, Orthopaedic Research Day, University of Pennsylvania
  • 2023:                    Lab exchange grant, BSRT
  • 2022:                    3rd place poster presentation, 13th International BMP Conference
  • 2022:                    Travel grant, Frauenförderung FUB
  • 2022:                    Research grant, Pharmaceutical company
  • 2022:                    Winter School on Scientific Innovation and Translational Research, EURORDIS
  • 2021:                    Summer School on Medicine Research and Development, EURORDIS
  • 2021:                    Scholarship, Dahlem Research School
  • 2020:                    Honorary mention, former federal president of Germany Horst Köhler
  • 2019:                    Scholarship, BSRT
  • 2019:                    GxP Training, Pharmaakademie
  • 2019:                    Jeannie Peeper Inspiring Leadership Award, International FOP Association

Presentations:

Oral

2022

  • Patient engagement explained: Insights from a patient, a patient association and a pharmaceutical company. Webinar Voisin Consulting Life Sciences, virtual
  • FOP – When muscles turn to bone. Landestagung MNU Landesverband Berlin-Brandenburg, virtual

2021

  • FOP – When muscles become bone. Natürlich-Seminar series NatLab student laboratory of the Department of Biology, Chemistry, and Pharmacy at Freie Universität Berlin, virtual
  • FOP: When muscles become bone. „Echt oder Fake“-Show Wissensstadt Berlin, Science Entertainment show BesserWissen e.V., Berlin, Germany
  • Signal transduction: The cellular sender-receiver model. Annual symposium FOP Germany, virtual
  • Ph.D. program Biochemistry. Girl’s Day, virtual

2020

  • Speech about FOP. Eva Luise Köhler Forschungspreisverleihung, Berlin, Germany

2019

  • The role of the receptor ACVR1 in the inner wall of blood vessels. Annual symposium FOP Germany, Valbert, Germany

2017

  • Identification of a potential biomarker to predict flare-ups in patients with FOP. Annual symposium FOP Stichting Nederlands

 

Poster

2023

  • Fibrodysplasia Ossificans Progressiva Mutant ACVR1 has reduced GS domain serine/threonine requirement in a zebrafish BMP signalling assay. Orthopaedic Research Day, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2022

  • Comparative analysis of BMP signaling in uECFCs and pECFCs reveals age-dependent expression of ALK3. 13th International BMP Conference, Dubrovnik, Croatia

2020

  • Investigation of the endothelial BMP/Activin A signaling pathway in the rare disease Fibrodysplasia Ossificans Progressiva (FOP). Annual BSRT PhD Symposium, Berlin, Germany

2019

  • Disease models to study the vascular role of ACVR1 in the context of FOP. Annual BSRT PhD Symposium, Berlin, Germany
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