Kyong-Mi Chang, MD
Professor of Medicine (Gastroenterology)
Associate Dean for Research at Crescenz VAMC, Philadelphia, University of Pennsylvanina Perelman School of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Corporal Michael J. Crescenz VAMC &
University of Pennsylvania Perelman School of Medicine
3900 Woodland Avenue
Philadelphia, PA 19104
University of Pennsylvania Perelman School of Medicine
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Lab: (215) 823-5800 ext 6730
Lab: (215) 823-5800 ext 6730
Publications
Links
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Penn Medicine Liver Diseases Program
Primary Work Website
Corporal Michael J. Crescenz VA Medical Center
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Penn Medicine Liver Diseases Program
Primary Work Website
Corporal Michael J. Crescenz VA Medical Center
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
Permanent linkA.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
Description of Research Expertise
Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection. As the Co-PI of a VA Merit award using the VA's Million Veterans Program (MVP), Dr. Chang is also conducting population-based genomic analyses of cardiometabolic disorders including NAFLD and liver disease progression to cirrhosis and HCC. Finally, Dr. Chang participates in VA-funded clinical and translational research involving patients with COVID-19.Description of Clinical Expertise
Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic liver disease (e.g. HBV, HCV, NAFLD). She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.Description of Other Expertise
Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research (e.g. via VA Career Development Award, Merit Review, Cooperative Studies Program and MVP research). She is committed to mentoring VA-based researchers both locally and nationally.Selected Publications
Smith JL, Tcheandjieu C, Dikilitas O, Iyer K, Miyazawa K, Hilliard A, Lynch J, Rotter JI, Chen YI, Sheu WH, Chang KM, Kanoni S, Tsao P, Ito K, Kosel M, Clarke SL, Schaid DJ, Assimes TL, Kullo IJ.: Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization. Circ Genom Precis Med Feb 2024.Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, et al.: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature 2024.
Ghouse J, Sveinbjörnsson G, Vujkovic M, Seidelin AS, Gellert-Kristensen H, Ahlberg G, Tragante V, Rand SA, Brancale J, Vilarinho S, Lundegaard PR, Sørensen E, Erikstrup C, Bruun MT, Jensen BA, Brunak S, Banasik K, Ullum H; DBDS Genomic Consortium; Verweij N, Lotta L, Baras A; Regeneron Genetics Center; Mirshahi T, Carey DJ; Geisinger-Regeneron DiscovEHR Collaboration; VA Million Veteran Program; Kaplan DE, Lynch J, Morgan T, Schwantes-An TH, Dochtermann DR, Pyarajan S, Tsao PS; Estonian Biobank Research Team; Laisk T, Mägi R, Kozlitina J, Tybjærg-Hansen A, Jones D, Knowlton KU, Nadauld L, Ferkingstad E, Björnsson ES, Ulfarsson MO, Sturluson Á, Sulem P, Pedersen OB, Ostrowski SR, Gudbjartsson DF, Stefansson K, Olesen MS, Chang KM, Holm H, Bundgaard H, Stender S.: Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. Nat Genet 2024.
Scorletti E, Saiman Y, Jeon S, Schneider CV, Buyco DG, Lin C, Himes BE, Mesaros CA, Vujkovic M, Creasy KT, Furth EE, Billheimer JT, Hand NJ, Kaplan DE, Chang KM, Tsao PS, Lynch JA, Dempsey JL, Harkin J, Bayen S, Conlon D, Guerraty M, Phillips MC, Rader DJ, Carr RM.: A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice. JHEP Rep 6: 100902, Oct 2023.
Manning A, Sevilla-González M, Smith K, Wang N, Jensen A, Litkowski E, Kim H, DiCorpo D, Westerman K, Cui J, Liu CT, Yu C, McNeil J, Lacaze P, Chang KM, Tsao P, Phillips L, Goodarzi M, Sladek R, Rotter J, Dupuis J, Florez J, Merino J, Meigs J, Zhou J, Raghavan S, Udler M.: Heterogeneous effects on type 2 diabetes and cardiovascular outcomes of genetic variants and traits associated with fasting insulin. Res Sq 19: rs.3.rs-3317661, Sept 2023.
Yarmolinsky J, Bouras E, Constantinescu A, Burrows K, Bull CJ, Vincent EE, Martin RM, Dimopoulou O, Lewis SJ, Moreno V, Vujkovic M, Chang KM, Voight BF, Tsao PS, Gunter MJ, Hampe J, Pellatt AJ, Pharoah PDP, Schoen RE, Gallinger S, Jenkins MA, Pai RK; PRACTICAL consortium; VA Million Veteran Program; Gill D, Tsilidis KK: Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis. Diabetologia 66(8), August 2023.
Schneider CV, Li T, Zhang D, Mezina AI, Rattan P, Huang H, Creasy KT, Scorletti E, Zandvakili I, Vujkovic M, Hehl L, Fiksel J, Park J, Wangensteen K, Risman M, Chang KM, Serper M, Carr RM, Schneider KM, Chen J, Rader DJ.: Large-scale identification of undiagnosed hepatic steatosis using natural language processing. EClinicalMedicine 62, Aug 2023.
Hsu CC, Gopalakrishna H, Mironova M, Lee MH, Chen CJ, Yang HI, Wiese M, Chang KM, Wright EC, Abijo T, Feld JJ, Kaplan DE.: Risk of Hepatocellular Carcinoma After Spontaneous Clearance of Hepatitis C Virus and in Noncirrhosis Chronic Hepatitis C Patients With Sustained Virological Response: A Systematic Review. Clin Infect Dis 77, Aug 2023.
Ross JM, Sugimoto JD, Timmons A, Adams J, Deardoff K, Korpak A, Liu C, Moore K, Wilson D, Bedimo R, Chang KM, Cho K, Crothers K, Garshick E, Gaziano JM, Holodniy M, Hunt CH, Isaacs SN, Le E, Jones BE, Shah JA, Smith NL, Lee JS, EPIC Investigators: Early Outcomes of SARS-CoV-2 Infection in a Multisite Prospective Cohort of Inpatient Veterans. Open Forum Infect Dis 10(7), June 2023.
Feld JJ, King WC, Ghany MG, Chang KM, Terrault N, Perrillo RP, Khalili M, Hinerman AS, Janssen H, Lok AS; Hepatitis B Research Network (HBRN).: Characteristics of Older Patients With Immunotolerant Chronic Hepatitis B Virus Infection. Clin Gastroenterol Hepatol June 2023.