Kyong-Mi Chang, MD

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research and mentoring VA/Penn dual-appointed Penn faculty at the CMCVAMC.

Selected Publications

M Vujkovic, JM Keaton, JA Lynch, DR Miller, J Zhou, C Tcheandjieu, JE Huffman, TL Assimes, K Lorenz, X Zhu, AT Hilliard, RL Judy, J Juang, KM Lee, D Klarin, S Pyarajan, J Danesh, O Melander, A Rasheed, NH Mallick, SS Sheikh, S Hameed, IH Qureshi, MH Afzal, U Malik, A Jalal, S Abbas, X Sheng, L Gao, KH Kaestner, K Susztak, YV Sun, SL Duvall, K Cho, JS Lee, JM Gaziano, LS Philips, JB Meigs, PD Reaven, PW Wilson, TL Edwards, DJ Rader, SM Damrauer, CJ O'Donnell, PS Tsao, HPAP Consortium, Regeneron Genetics Center, VA Million Veteran Program, KM Chang*, BF Voight* and D Saleheen*: Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis. Nature Genetics 2020 (in press).

Y Hu, M Graff, J Haussler, S Buysse, SA Bien, R Tao, HM Highland, KK Nishimura, N Zubair, Y Lu, M Verbanck, AT Hilliard, D Klarin, SM Damrauer, YL Ho, PWF Wilson, KM Chang, PS Tsao, K Cho, CJ O'Donnell, TL Assimes, LE Petty, JE Below, O Diklitas, DJ Schaid, ML Kosel, IJ Kullo, LJ Rasmussen-Torvik, GP Jarvik, Q Feng, WQ Wei, EB Larson, FD Mentch, B Almoguera, PM Sleiman, LM Raffield, A Correa, LW Martin, M Daviglus, TC Matise, JL Ambite, CS Carlson, R Do, RJF Loos, LR Wilkens, LL Marchand, C Harman, DO Stram, LA Hindorff, KE North, CL Kooperberg, I Cheng, U Peters: Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) Study. PLOS Genetics 2020 (In press).

C Emdin, M Haas, AV Khera, K Arabam, M Chaffin, D Klarin, G Hindi, L Jiang, WQ Wei, Q Feng, J Karjalainen, A Havulinna, T Kiiskinen, A Bock, D Ardissino, JG Wilson, H Schunkert, R McPherson, H Watkins, R Elosua, M Bown, NJ Samani, U Baber, J Erdmann, N Gupta, J Danesh, D Saleheen, KM Chang, M Vujkovic, B Voight, SM Damrauer, J Lynch, DE Kaplan, M Serper, P Tsao, J Mercader, C Hanis, M Daly, J Denny, S Gabriel, S Kathiresan: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLOS Genetics 2020 (In press).

Ghany MG, Feld JJ, Chang KM, Chan HLY, Lok ASF, Visvanathan K, Janssen HLA: Serum alanine aminotransferase flares in chronic hepatitis B infection: the good and the bad. Lancet Gastroenterology Hepatology Page: 406-417, Apr 2020.

Cornberg M, Lok AS, Terrault NA, Zoulim F; 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty: Berg T, Brunetto MR, Buchholz S, Buti M, Chan HL, Chang KM, Dandri M, Dusheiko G, Feld JJ, Ferrari C, Ghany M, Janssen HLA, Kennedy P, Lampertico P, Liang J, Locarnini S, Maini MK, Mishra P, Papatheodoridis G, Petersen J, Schlottmann S, Wang S, Wedemeyer H.: Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference. Journal of Hepatology and ePub in Hepatology 72(3): 539-557, Mar 2020.

Harris RA, Kranzler HR, Chang KM, Doubeni CA, Gross R: Long-term use of hydrocodone vs. oxycodone in primary care. Drug Alcohol Dependence 205: 207524, Dec 2019.

Klarin D, Busenkell E, Judy R, Lynch J, Levin M, Haessler J, Aragam K, Chaffin M, Haas M, Lindström S, Assimes TL, Huang J, Min Lee K, Shao Q, Huffman JE, Kabrhel C, Huang Y, Sun YV, Vujkovic M, Saleheen D, Miller DR, Reaven P, DuVall S, Boden WE, Pyarajan S, Reiner AP, Trégouët DA, Henke P, Kooperberg C, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, Smith NL, O'Donnell CJ, Tsao PS, Kathiresan S, Obi A, Damrauer SM, Natarajan P; INVENT Consortium; Veterans Affairs’ Million Veteran Program: Genome-wide association analysis of venous thromboembolism identifies new risk loci and geneticoverlap with arterial vascular disease. Nature Genetics 51(11): 1574-1579, November 2019.

H Fang, Q Hui, J Lynch, J Honerlaw, TL Assime, J Huang, M Vujovic, SM Damrauer, S Pyarajan, JM Gaziano, SL DuVall, CJ O’Donnell, K Cho, KM Chang, PWF Wilson, PS Tsao, the VA Million Veteran Program, YV Sun* and H Tang*: Harmonizing genetic ancestry and self-identified race/ethnicity in genome-wide association studies. The American Journal of Human Genetics 105: 1-10, October 2019.

Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkov M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, REaven P, Alba, PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O’Donnell CJ, Kathiresan S, VA Million Veteran Program, Tsao PS, Damrauer SM: Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nature Medicine 25(8), Aug 2019.

Bick AG, Akwo E, Robinson-Cohen C, Lee K, Lynch J, Assimes TL, DuVall S, Edwards T, Fang H, Freiberg SM, Giri A, Huffman JE, Huang J, Hull L, Kember RL, Klarin D, Lee JS, Levin M, Miller DR, Natarajan P, Saleheen D, Shao Q, Sun YV, Tang H, Wilson O, Chang KM, Cho K, Concato J, Gaziano JM, Kathiresan S, O'Donnell CJ, Rader DJ, Tsao PS, Wilson PW, Hung AM, Damrauer SM; VA Million Veteran Program.: Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program. Circulation July 2019.

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Last updated: 03/15/2020
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