1e
19
1
49
2
2
18
1b
1d
18
3c
45
1d
2 29
1d
25
Mark Anthony Sellmyer, MD, PhD
78
45
Assistant Professor of Radiology
28
89
3
60
Active, Pennsylvania Hospital – Dept. of Radiology, Division of Nuclear Medicine
94
Active, Penn Presbyterian Medical Center – Dept. of Radiology, Division of Nuclear Medicine
6e
Active, Chester County Hospital – Dept. of Radiology
a1
Attending, Hospital of the University of Pennsylvania – Dept. of Radiology, Division of Nuclear Medicine
75
member, Chemistry and Biology Interfaces Program (T32 Trainer)
55
member, Abramson Cancer Center
74
member, Institute for Translational Medicine and Therapeutics
8a
Co-Director , Center for Translational Chemical Biology, University of Pennsylvania
73
Director, UPenn, Small Animal Imaging Facility, NMI sub-core
56
Director, UPenn, The PET Center
11
Department: Radiology
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
48
4
3
3
1d
48
University of Pennsylvania
23 Perelman School of Medicine
21 Department of Radiology
4b 3400 Spruce St., 1 Silverstein, Ste. 130
Philadelphia, PA 19104
26
23 Perelman School of Medicine
21 Department of Radiology
4b 3400 Spruce St., 1 Silverstein, Ste. 130
Philadelphia, PA 19104
2e
Office: 617-543-6546
3e Lab: 215-573-3212
18
f
3e Lab: 215-573-3212
18
18
Publications
23 a
3
2
29
23 a
Links
a7 Search PubMed for articles
66 Sellmyer Lab Webpage
85 Codirector of the Center for Translational Chemical Biology
63 Sellmyer Lab Twitter Feed
c
4
b
1f
a7 Search PubMed for articles
66 Sellmyer Lab Webpage
85 Codirector of the Center for Translational Chemical Biology
63 Sellmyer Lab Twitter Feed
c
13
Education:
21 7 BS 16 (Chemistry) c
3f Massachusetts Institute of Technology , 2004.
21 7 MD c
30 Stanford Medical School, 2012.
21 8 PhD 29 (Chemical and Systems Biology) c
30 Stanford Medical School, 2012.
c
3
3
3
3
8d
Permanent link21 7 BS 16 (Chemistry) c
3f Massachusetts Institute of Technology , 2004.
21 7 MD c
30 Stanford Medical School, 2012.
21 8 PhD 29 (Chemical and Systems Biology) c
30 Stanford Medical School, 2012.
c
2 29
21
1e
1d
24
5e
22 Cancer Imaging and Therapy
21 Infection and Inflammation
71
18 Chemical Biology
19 Synthetic Biology
11 Radiology
22 Nuclear Imaging and Therapy
e 29
27
Description of Clinical Expertise
22 Nuclear Radiology22 Cancer Imaging and Therapy
21 Infection and Inflammation
71
Description of Research Expertise
22 Molecular Imaging18 Chemical Biology
19 Synthetic Biology
11 Radiology
22 Nuclear Imaging and Therapy
e 29
23
144 Etersque, J. M., Lee, I. K., Sharma, N., Xu, K., Ruff, A., Northrup, J. D., Sarkar, S., Nguyen, T., Lauman, R., Burslem, G. M., Sellmyer, M. A.: Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun 14(1): 7071, Nov 2023.
161 Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA: Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clin Cancer Res 28(24): 5330-5342, Dec 2022.
110 Edwards KJ, Chang B, Babazada H, Lohith K, Park DH, Farwell MD, Sellmyer MA: Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation. Cancer Immunol Res 10(9): 1084-1094, Sept 2022.
236 Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. The Journal of Clinical Investigation 132(18): e156679, Mar 2023 Notes: doi: 10.1172/JCI156679.
d2 Mankoff DA, Sellmyer MA: PET of Fibroblast-Activation Protein for Breast Cancer Diagnosis and Staging. Radiology 302(1): 48-49, Jan 2022.
103 Mark A Sellmyer, Iris K Lee, David A Mankoff: Building the bridge: molecular imaging biomarkers for 21st century cancer therapies. Journal of Nuclear Medicine 62(12): 1672–6, Dec 2021.
139 Jacome, D. A., Northrup, J. D., Ruff, A. J., Reilly, S. W., Lee, I. K., Blizard, G. S., Sellmyer, M. A.: A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions. ACS Chem Biol 16(1): 52-57, Jan 2021.
182 Sellmyer Mark A, Richman Sarah A, Lohith Katheryn, Hou Catherine, Weng Chi-Chang, Mach Robert H, O'Connor Roddy S, Milone Michael C, Farwell Michael D: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Molecular therapy : the journal of the American Society of Gene Therapy 28(1): 42-51, Jan 2020.
2c
7
1d
1f
Selected Publications
192 Lee, I. K., Sharma, N., Noguera-Ortega, E., Liousia, M., Baroja, M. L., Etersque, J. M., Pham, J., Sarkar, S., Carreno, B. M., Linette, G. P., Pure, E., Albelda, S. M., Sellmyer, M. A.: A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy. Mol Ther 31(12): 3564-3578, Nov 2023.144 Etersque, J. M., Lee, I. K., Sharma, N., Xu, K., Ruff, A., Northrup, J. D., Sarkar, S., Nguyen, T., Lauman, R., Burslem, G. M., Sellmyer, M. A.: Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun 14(1): 7071, Nov 2023.
161 Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA: Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clin Cancer Res 28(24): 5330-5342, Dec 2022.
110 Edwards KJ, Chang B, Babazada H, Lohith K, Park DH, Farwell MD, Sellmyer MA: Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation. Cancer Immunol Res 10(9): 1084-1094, Sept 2022.
236 Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. The Journal of Clinical Investigation 132(18): e156679, Mar 2023 Notes: doi: 10.1172/JCI156679.
d2 Mankoff DA, Sellmyer MA: PET of Fibroblast-Activation Protein for Breast Cancer Diagnosis and Staging. Radiology 302(1): 48-49, Jan 2022.
103 Mark A Sellmyer, Iris K Lee, David A Mankoff: Building the bridge: molecular imaging biomarkers for 21st century cancer therapies. Journal of Nuclear Medicine 62(12): 1672–6, Dec 2021.
139 Jacome, D. A., Northrup, J. D., Ruff, A. J., Reilly, S. W., Lee, I. K., Blizard, G. S., Sellmyer, M. A.: A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions. ACS Chem Biol 16(1): 52-57, Jan 2021.
182 Sellmyer Mark A, Richman Sarah A, Lohith Katheryn, Hou Catherine, Weng Chi-Chang, Mach Robert H, O'Connor Roddy S, Milone Michael C, Farwell Michael D: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Molecular therapy : the journal of the American Society of Gene Therapy 28(1): 42-51, Jan 2020.
2c