Mark Anthony Sellmyer, MD, PhD
Assistant Professor of Radiology
Active, Pennsylvania Hospital – Dept. of Radiology, Division of Nuclear Medicine
Active, Penn Presbyterian Medical Center – Dept. of Radiology, Division of Nuclear Medicine
Active, Chester County Hospital – Dept. of Radiology
Attending, Hospital of the University of Pennsylvania – Dept. of Radiology, Division of Nuclear Medicine
member, Chemistry and Biology Interfaces Program (T32 Trainer)
member, Abramson Cancer Center
member, Institute for Translational Medicine and Therapeutics
Co-Director , Center for Translational Chemical Biology, University of Pennsylvania
Director, UPenn, Small Animal Imaging Facility, NMI sub-core
Director, UPenn, The PET Center
Department: Radiology
Graduate Group Affiliations
Contact information
University of Pennsylvania
Perelman School of Medicine
Department of Radiology
3400 Spruce St., 1 Silverstein, Ste. 130
Philadelphia, PA 19104
Perelman School of Medicine
Department of Radiology
3400 Spruce St., 1 Silverstein, Ste. 130
Philadelphia, PA 19104
Office: 617-543-6546
Lab: 215-573-3212
Lab: 215-573-3212
Publications
Links
Search PubMed for articles
Sellmyer Lab Webpage
Sellmyer Lab Twitter Feed
Codirector of the Center for Translational Chemical Biology
Search PubMed for articles
Sellmyer Lab Webpage
Sellmyer Lab Twitter Feed
Codirector of the Center for Translational Chemical Biology
Education:
BS (Chemistry)
Massachusetts Institute of Technology , 2004.
MD
Stanford Medical School, 2012.
PhD (Chemical and Systems Biology)
Stanford Medical School, 2012.
Permanent linkBS (Chemistry)
Massachusetts Institute of Technology , 2004.
MD
Stanford Medical School, 2012.
PhD (Chemical and Systems Biology)
Stanford Medical School, 2012.
Description of Clinical Expertise
Nuclear RadiologyCancer Imaging and Therapy
Infection and Inflammation
Description of Research Expertise
Molecular ImagingChemical Biology
Synthetic Biology
Radiology
Nuclear Imaging and Therapy
Selected Publications
Lee, I. K., Sharma, N., Noguera-Ortega, E., Liousia, M., Baroja, M. L., Etersque, J. M., Pham, J., Sarkar, S., Carreno, B. M., Linette, G. P., Pure, E., Albelda, S. M., Sellmyer, M. A.: A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy. Mol Ther 31(12): 3564-3578, Nov 2023.Etersque, J. M., Lee, I. K., Sharma, N., Xu, K., Ruff, A., Northrup, J. D., Sarkar, S., Nguyen, T., Lauman, R., Burslem, G. M., Sellmyer, M. A.: Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun 14(1): 7071, Nov 2023.
Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA: Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clin Cancer Res 28(24): 5330-5342, Dec 2022.
Edwards KJ, Chang B, Babazada H, Lohith K, Park DH, Farwell MD, Sellmyer MA: Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation. Cancer Immunol Res 10(9): 1084-1094, Sept 2022.
Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. The Journal of Clinical Investigation 132(18): e156679, Mar 2023 Notes: doi: 10.1172/JCI156679.
Mankoff DA, Sellmyer MA: PET of Fibroblast-Activation Protein for Breast Cancer Diagnosis and Staging. Radiology 302(1): 48-49, Jan 2022.
Mark A Sellmyer, Iris K Lee, David A Mankoff: Building the bridge: molecular imaging biomarkers for 21st century cancer therapies. Journal of Nuclear Medicine 62(12): 1672–6, Dec 2021.
Jacome, D. A., Northrup, J. D., Ruff, A. J., Reilly, S. W., Lee, I. K., Blizard, G. S., Sellmyer, M. A.: A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions. ACS Chem Biol 16(1): 52-57, Jan 2021.
Sellmyer Mark A, Richman Sarah A, Lohith Katheryn, Hou Catherine, Weng Chi-Chang, Mach Robert H, O'Connor Roddy S, Milone Michael C, Farwell Michael D: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Molecular therapy : the journal of the American Society of Gene Therapy 28(1): 42-51, Jan 2020.