Mohammad Haj Dezfulian, PhD
Assistant Professor of Pathology and Laboratory Medicine
Member, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Member, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
Member, The Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
Haj-Dezfulian Lab Website
Department of Pathology and Laboratory Medicine Profile
The Institute for Immunology and Immune Health Profile
Search PubMed for articles
Haj-Dezfulian Lab Website
Department of Pathology and Laboratory Medicine Profile
The Institute for Immunology and Immune Health Profile
Education:
B.Sc. (Molecular Biology and Genetics)
Tehran University & Chamran University, 2006.
PhD (Molecular Biology and Genetics)
University of Windsor, 2014.
Permanent linkB.Sc. (Molecular Biology and Genetics)
Tehran University & Chamran University, 2006.
PhD (Molecular Biology and Genetics)
University of Windsor, 2014.
Description of Research Expertise
Our laboratory investigates the molecular drivers of immune recognition across autoimmunity, malignancy, and infectious disease. We combine systems immunology with functional genomics and protein engineering to develop high-throughput technologies capable of mapping T cell specificity within patient samples. This engineering-driven approach enables us to elucidate the governing principles of immune specificity and tolerance, ultimately guiding the design of novel immunotherapeutic modalities.Selected Publications
Kohlgruber AC, Dezfulian MH, Sie B, Wang CI, Kula T, Laserson U, Larman HB, Elledge SJ.: High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. Nat Biotechnol no volume(no issue), July 2024 Notes: https://doi.org/10.1038/s41587-024-02248-6.Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell 186(25): 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.
Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4): 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.