Sergei Vinogradov, PhD

faculty photo
Professor of Biochemistry and Biophysics
Member, PENN Institute for Translational Medicine (ITMAT)
Member, Abramson Family Cancer Center
Member, PENN NanoBio Interface Center
Department: Biochemistry and Biophysics

Contact information
1013 Stellar-Chance Bldg.
422 Curie Blvd.
Department of Biochemistry and Biophysics
Philadelphia, PA 19104-6059
Office: 2155737524
M.S. (Chemistry)
Moscow State University, 1988.
Ph.D. (Organic Chemistry)
Moscow State University, 1995.
Permanent link
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Description of Research Expertise

Dr. Vinogradov's research is focused on the development of advanced probes for microscopy and imaging applications. On the fundamental level our interests encompass chemistry of porphyrins and other pyrrolic dyes, energy and electron transfer in multichromophoric systems, spectroscopy and imaging. Essentially, we are a group of synthetic and physical chemists developing new techniques for biomedical research. Over the past years the main focus of the lab has been optical imaging of oxygen in biological systems, including chemistry of imaging probes, phosphorescence lifetime imaging instrumentation, image reconstruction methods and a variety of applications of phosphorescence. Other bio-analytes of interests have been pH and metal ions. Currently the laboratory also pursues interests in optical energy upconversion and magnetic field effects on luminescence in view of their applications in imaging. Dr. Vinogradov collaborates broadly with laboratories across the world whose interests include basic studies of cellular metabolism and applications in neuroscience, stem cell biology, cancer therapy, tissue engineering and ophthalmology.

Selected Publications

Tatiana V. Esipova, Héctor J. Rivera-Jacquez, Bruno Weber, Artëm E. Masunov, Sergei A. Vinogradov: Stabilizing g‑States in Centrosymmetric Tetrapyrroles: Two-Photon-Absorbing Porphyrins with Bright Phosphorescence. J. Phys. Chem. A 121: 6243−6255, 2017.

Tatiana V. Esipova, Héctor J. Rivera-Jacquez, Bruno Weber, Artëm E. Masunov, Sergei A. Vinogradov: Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π‑Extension and Peripheral Substitution. J. Am. Chem. Soc. 138: 15648−15662, 2016.

Esipova, T. V., and Vinogradov, S. A.: Synthesis of Phosphorescent Asymmetrically pi-Extended Porphyrins for Two-Photon Applications. J. Org. Chem. 79: 8812-8825, 2014.

Esipova, T. V., Ye, X. C., Collins, J. E., Sakadzic, S., Mandeville, E. T., Murray, C. B., Vinogradov, S. A.: Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources. PNAS 109(51): 20826-20831, 2012.

Mani, T., Tanabe, M., Yamauchi, S., Tkachenko, N. V., Vinogradov, S. A.: Modulation of Visible Room Temperature Phosphorescence by Weak Magnetic Fields. Journal of Physical Chemistry Letters 3(21): 3115-3119, 2012.

Vinogradov, S.A., Wilson, D.F. : Porphyrin-dendrimers as biological oxygen sensors. Designing dendrimers. Wiley, 2012.

Lecoq, J., Parpaleix, A., Roussakis, E., Ducros, M., Houssen, Y. G., Vinogradov, S. A.*, Charpak, S.*: Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels. Nature Medicine 17(7): 893-U262, 2011.

Finikova, O. S., Lebedev, A. Y., Aprelev, A., Troxler, T., Gao, F., Garnacho, C., Muro, S., Hochstrasser, R. M., Vinogradov, S. A.: Oxygen microscopy by two-photon-excited phosphorescence. ChemPhysChem 9(12): 1673-1679, 2008.

Apreleva, S. V., Wilson, D. F., Vinogradov, S. A.: Tomographic imaging of oxygen by phosphorescence lifetime. Applied Optics 45(33): 8547-8559, 2006.

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Last updated: 04/10/2020
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