Daniel J. Licht, MD

faculty photo
Emeritus Professor CE of Neurology
Attending, Neurology ICU Consults, Children's Hospital, Philadelphia
Attending, PACT consults (Palliative Care), Children's Hospital, Philadelphia
Attending, Neuro-Cardiac Care Program, Children's Hospital, Philadelphia
Attending, Fetal Neurology Consults, Children's Hospital, Philadelphia
Professor, Children's National Hospital
Department: Neurology
Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
Fax:
Email: licht@email.chop.edu
Publications

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Links
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 Joseph Stokes Jr. Research Institute Profile
Lab web page with people and projects listed
CHOP Provider Profile
ITMAT Member
Education:
BA (Biochemistry)
New York University, 1984.
 MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill infants and children. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Clinical Expertise

My clinical expertise is in the neurological care for children who are critically ill infants and children. I am the neurology liaison to the cardiac intensive care unit and am a consult attending for the Neonatal, Pediatric and Cardiac intensive care units. My special interests are the neurologic complications in the care of congenital cardiac disease and I am also an expert in pediatric stroke and founding member of the pediatric stroke team at CHOP.

My interests in congenital malformations including congenital heart defects and congenital diaphragmatic hernia, have recently led me to the relatively new field of Fetal Neurology. I am currently the only neurologist to perform Fetal Neurology consults to optimize the care for infants with congenital malformations.

Selected Publications

Johng S, Licht DJ, Hedrick HL, Rintoul N, Linn RL, Gebb JS, Xiao R, Massey SL.: Prenatal Brain Maturation is Delayed in Neonates with Congenital Diaphragmatic Hernia. J Pediatr Sep 2023.

 Jacobwitz M, Irving SY, Moriarty H, Yost J, Vossough A, Licht DJ, Lynch JM.: Predictors of the inability to achieve full oral feeding in postoperative infants with CHD. Cardiol Young Aug 2023.

 Shaw K, Mavroudis CD, Ko TS, Jahnavi J, Jacobwitz M, Ranieri N, Forti RM, Melchior RW, Baker WB, Yodh AG, Licht DJ, Nicolson SC, Lynch JM.: The use of novel diffuse optical spectroscopies for improved neuromonitoring during neonatal cardiac surgery requiring antegrade cerebral perfusion. Front Pediatr 11: 1125985, Jun 2023.

 Forti RM, Hobson LJ, Benson EJ, Ko TS, Ranieri NR, Laurent G, Weeks MK, Widmann NJ, Morton S, Davis AM, Sueishi T, Lin Y, Wulwick KS, Fagan N, Shin SS, Kao SH, Licht DJ, White BR, Kilbaugh TJ, Yodh AG, Baker WB.: Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury. Biomed Opt Express 14: 2432-2448, May 2023.

 Licht DJ, Jacobwitz M, Lynch JM, Ko T, Boorady T, Devarajan M, Heye KN, Mensah-Brown K, Newland JJ, Schmidt A, Schwab P, Winters M, Nicolson SC, Montenegro LM, Fuller S, Mascio C, Gaynor JW, Yodh AG, Gebb J, Vossough A, Choi GH, Putt ME.: Impaired Maternal-Fetal Environment and Risk for Preoperative Focal White Matter Injury in Neonates With Complex Congenital Heart Disease. J Am Heart Assoc 12: e025516, Mar 2023.

 Gaynor JW, Burnham NB, Ittenbach RF, Gerdes M, Bernbaum JC, Zackai E, Licht DJ, Russell WW, Zullo EE, Miller T, Hakonarson H, Clarke KA, Jarvik GP, Calafat AM, Bradman A, Bellinger DC, Henretig FM, Coker ES.: Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease. PLoS One 17: e0277611, Nov 2022.

 Ko TS, Mavroudis CD, Benson EJ, Forti RM, Melchior RW, Boorady TW, Morano VC, Mensah-Brown K, Lin Y, Aronowitz D, Starr JP, Rosenthal TM, Shade BC, Schiavo KL, White BR, Lynch JM, Gaynor JW, Licht DJ, Yodh AG, Baker WB, Kilbaugh TJ.: Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass. Metabolites 12: 737, Aug 2022.

 Goldman-Yassen AE, Shifrin A, Mirsky DM, Vossough A, Licht DJ, Feygin T.: Torcular Dural Sinus Malformation: Fetal and Postnatal Imaging Findings and Their Associations With Clinical Outcomes. Pediatr Neurol 135: 28-37, Jul 2022.

 White BR, Ko TS, Morgan RW, Baker WB, Benson EJ, Lafontant A, Starr JP, Landis WP, Andersen K, Jahnavi J, Breimann J, Delso N, Morton S, Roberts AL, Lin Y, Graham K, Berg RA, Yodh AG, Licht DJ, Kilbaugh TJ.: Low Frequency Power in Cerebral Blood Flow is a Biomarker of Neurologic Injury in the Acute Period after Cardiac Arrest. Resuscitation Jul 2022.

 Moon JK, Lawrence KM, Hunt ML, Davey MG, Flake AW, Licht DJ, Chen JM, Kilbaugh TJ, Gaynor JW, Beiting DP.: Chronic hypoxemia induces mitochondrial respiratory complex gene expression in the fetal sheep brain. JTCVS Open 10: 342-349, May 2022.
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Last updated: 09/20/2023
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