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Daniel J. Licht, MD

Daniel J. Licht, MD

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Associate Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology

Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Clinical Expertise

My clinical expertise is in the neurological care for children who are critically ill. I am the neurology liaison to the cardiac intensive care unit and am a consult attending for the Neonatal, Pediatric and Cardiac intensive care units. My special interests are the neurologic complications in the care of congenital cardiac disease and I am also an expert in pediatric stroke and founding member of the pediatric stroke team at CHOP.

As a consequence of caring for critically ill children, I am also a palliative care provider and attending on the Pediatric Advanced Care Team at CHOP. The PACT team is a multidisciplinary palliative care team with a directive to provide symptom relief at the end of life, with a goal of achieving the best quality of life in the face of terminal illness.

My interests in congenital malformations including congenital heart defects and congenital diaphragmatic hernia, have recently led me to the relatively new field of Fetal Neurology. I am currently the only neurologist to perform Fetal Neurology consults to optimize the care for infants with congenital malformations.

Selected Publications

Busch David R, Rusin Craig G, Miller-Hance Wanda, Kibler Kathy, Baker Wesley B, Heinle Jeffrey S, Fraser Charles D, Yodh Arjun G, Licht Daniel J, Brady Kenneth M: Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest. Biomedical optics express 7(9): 3461-3470, Sep 2016.

Kirschen Matthew P, Dori Yoav, Itkin Maxim, Licht Daniel J, Ichord Rebecca, Vossough Arastoo: Cerebral Lipiodol Embolism after Lymphatic Embolization for Plastic Bronchitis. The Journal of pediatrics 176: 200-3, Jun 2016.

Hawks Charlotte, Jordan Lori C, Gindville Melissa, Ichord Rebecca N, Licht Daniel J, Beslow Lauren A: Educational Placement After Pediatric Intracerebral Hemorrhage. Pediatric neurology 61: 46-50, May 2016.

Jalali Ali, Jones Gerard F, Licht Daniel J, Nataraj C: Application of Mathematical Modeling for Simulation and Analysis of Hypoplastic Left Heart Syndrome (HLHS) in Pre- and Postsurgery Conditions. BioMed research international 2015: 987293, Oct 2015.

Busch David R, Lynch Jennifer M, Winters Madeline E, McCarthy Ann L, Newland John J, Ko Tiffany, Cornaglia Mary Anne, Radcliffe Jerilynn, McDonough Joseph M, Samuel John, Matthews Edward, Xiao Rui, Yodh Arjun G, Marcus Carole L, Licht Daniel J, Tapia Ignacio E: Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome. Sleep 39(1): 209-16, Aug 2015.

Fogel Mark A, Li Christine, Wilson Felice, Pawlowski Tom, Nicolson Susan C, Montenegro Lisa M, Diaz Berenstein Laura, Spray Thomas L, Gaynor J William, Fuller Stephanie, Keller Marc S, Harris Matthew A, Whitehead Kevin K, Clancy Robert, Elci Okan, Bethel Jim, Vossough Arastoo, Licht Daniel J: Relationship of cerebral blood flow to aortic-to-pulmonary collateral/shunt flow in single ventricles. Heart (British Cardiac Society) 101(16): 1325-31, Jun 2015.

Wu J, Awate S P, Licht D J, Clouchoux C, du Plessis A J, Avants B B, Vossough A, Gee J C, Limperopoulos C: Assessment of MRI-Based Automated Fetal Cerebral Cortical Folding Measures in Prediction of Gestational Age in the Third Trimester. AJNR. American journal of neuroradiology 36(7): 1369-74, Jun 2015.

McCarthy Ann L, Winters Madeline E, Busch David R, Gonzalez-Giraldo Ernesto, Ko Tiffany S, Lynch Jennifer M, Schwab Peter J, Xiao Rui, Buckley Erin M, Vossough Arastoo, Licht Daniel J: Scoring System for Periventricular Leukomalacia in Infants with Congenital Heart Disease. Pediatric research 78(3): 304-9, May 2015 Notes: We developed and validated an observational scale for rating white matter injury in this population of infants with severe congenital heart surgery. This is a first step for a multicenter collaborative trial.

Starling Rebecca M, Shekdar Karuna, Licht Dan, Nadkarni Vinay M, Berg Robert A, Topjian Alexis A: Early Head CT Findings Are Associated With Outcomes After Pediatric Out-of-Hospital Cardiac Arrest. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 16(6): 542-8, Apr 2015.

Naim Maryam Y, Gaynor J William, Chen Jodi, Nicolson Susan C, Fuller Stephanie, Spray Thomas L, Dlugos Dennis J, Clancy Robert R, Costa Livia Vianez, Licht Daniel J, Xiao Rui, Meldrum Heather, Abend Nicholas S: Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. The Journal of thoracic and cardiovascular surgery 150(1): 169-80, Apr 2015.

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Last updated: 10/18/2016
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