Daniel J. Licht, MD

faculty photo
Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology

Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill infants and children. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Clinical Expertise

My clinical expertise is in the neurological care for children who are critically ill infants and children. I am the neurology liaison to the cardiac intensive care unit and am a consult attending for the Neonatal, Pediatric and Cardiac intensive care units. My special interests are the neurologic complications in the care of congenital cardiac disease and I am also an expert in pediatric stroke and founding member of the pediatric stroke team at CHOP.

My interests in congenital malformations including congenital heart defects and congenital diaphragmatic hernia, have recently led me to the relatively new field of Fetal Neurology. I am currently the only neurologist to perform Fetal Neurology consults to optimize the care for infants with congenital malformations.

Selected Publications

Ko TS, Mavroudis CD, Morgan RW, Baker WB, Marquez AM, Boorady TW, Devarajan M, Lin Y, Roberts AL, Landis WP, Mensah-Brown K, Nadkarni VM, Berg RA, Sutton RM, Yodh AG, Licht DJ, Guo W, Kilbaugh TJ.: Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation. Sci Rep 11: 3828, Feb 2021.

Padawer-Curry JA, Jahnavi J, Breimann JS, Licht DJ, Yodh AG, Cohen AS, White BR.: Variability in atlas registration of optical intrinsic signal imaging and its effect on functional connectivity analysis. J Opt Soc Am A Opt Image Sci Vis 38: 245-252, Feb 2021.

Favilla E, Faerber JA, Hampton LE, Tam V, DeCost G, Ravishankar C, Gaynor JW, Burnham A, Licht DJ, Mercer-Rosa L.: Early Evaluation and the Effect of Socioeconomic Factors on Neurodevelopment in Infants with Tetralogy of Fallot. Pediatr Cardiol ediatr Cardiol, 2021.

Cuddapah VA, Dubbs HA, Adang L, Kugler SL, McCormick EM, Zolkipli-Cunningham Z, Ortiz-González XR, McCormack S, Zackai E, Licht DJ, Falk MJ, Marsh ED.: Understanding the phenotypic spectrum of ASXL-related disease: Ten cases and a review of the literature. Am J Med Genet A m J Med Genet A, 2021.

Mavroudis CD, Ko TS, Morgan RW, Volk LE, Landis WP, Smood B, Xiao R, Hefti M, Boorady TW, Marquez A, Karlsson M, Licht DJ, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ.: Epinephrine's effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation. Crit Care 24: 583, Sep 2020.

Beslow LA, Breimann J, Licht DJ, Waldman J, Fallacaro S, Pyeritz RE, Goldmuntz E, Vossough A.: Cerebrovascular Malformations in a Pediatric Hereditary Hemorrhagic Telangiectasia Cohort. Pediatr Neurol 110: 49-54, Sep 2020.

Marquez Alexandra M, Morgan Ryan W, Ko Tiffany, Landis William P, Hefti Marco M, Mavroudis Constantine D, McManus Meagan J, Karlsson Michael, Starr Jonathan, Roberts Anna L, Lin Yuxi, Nadkarni Vinay, Licht Daniel J, Berg Robert A, Sutton Robert M, Kilbaugh Todd J: Oxygen Exposure During Cardiopulmonary Resuscitation Is Associated With Cerebral Oxidative Injury in a Randomized, Blinded, Controlled, Preclinical Trial. Journal of the American Heart Association 9: e015032, Apr 2020.

Busch David R, Baker Wesley B, Mavroudis Constantine D, Ko Tiffany S, Lynch Jennifer M, McCarthy Ann L, Du Pont-Thibodeau Genevieve, Buckley Erin M, Jacobwitz Marin, Boorady Timothy, Mensah-Brown Kobina, Connelly James, Yodh Arjun G, Kilbaugh Todd J, Licht Daniel J: Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient. Pediatric research 88: 925-933, Mar 2020.

Thibault Céline, Naim Maryam Y, Abend Nicholas S, Licht Daniel J, Gaynor J William, Xiao Rui, Massey Shavonne L: A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates. Epilepsia 61(4): 627-635, Mar 2020.

Kirschen MP, Licht DJ, Faerber J, Mondal A, Graham K, Winters M, Balu R, Diaz-Arrastia R, Berg RA, Topjian A, Vossough A.: Association of MRI brain injury with outcome after pediatric out-of-hospital cardiac arrest. Neurology eurology: e719-e731, Feb 2020.

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Last updated: 03/23/2021
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