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Kim A. Sharp, Ph.D
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Associate Professor of Biochemistry and Biophysics
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Chair, Graduate Group in Biochemistry and Molecular Biophysics
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Department: Biochemistry and Biophysics
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Graduate Group Affiliations
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Contact information
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805A Stellar Chance Labs
3b 422 Curie Boulevard
Philadelphia, PA 19104-6059
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3b 422 Curie Boulevard
Philadelphia, PA 19104-6059
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Office: (215) 573-3506
34 Fax: (215) 898-4217
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Email:
SHARPK@MAIL.MED.UPENN.EDU
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SHARPK@MAIL.MED.UPENN.EDU
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Publications
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Education:
21 e BSc.Hons. 17 (Biophysics) c
29 Leeds University, 1978.
21 a Ph.D. 16 (Chemistry) c
37 University of British Columbia, 1985.
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Permanent link21 e BSc.Hons. 17 (Biophysics) c
29 Leeds University, 1978.
21 a Ph.D. 16 (Chemistry) c
37 University of British Columbia, 1985.
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19 Current Research:
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52 1. Calculation of protein-ligand binding energies and association kinetics
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35 2. Simulation of proteins in reverse micelles
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2f 3. Simulation of viral genome packaging
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46 4. Computational methods to describe and analyze protein shape.
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Description of Research Expertise
161 The goal of my research is to gain a detailed understanding at the molecular and physical chemical level of how proteins bind and recognize other proteins, drugs, ligands and nucleic acids. Theoretical and computational methods used include Poisson-Boltzmann electrostatics, Molecular and Brownian Dynamics, and Monte Carlo simulations.8
19 Current Research:
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52 1. Calculation of protein-ligand binding energies and association kinetics
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35 2. Simulation of proteins in reverse micelles
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2f 3. Simulation of viral genome packaging
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46 4. Computational methods to describe and analyze protein shape.
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b3 Luo, H., Sharp, K. A.: "On the calculation of absolute binding free energies". PNAS 99: 10399-10404, 2002.
a7 Gallagher, K., Sharp, K. A.: "A new angle on the hydrophobic effect". JACS 125: 9863-60, 2003.
11a Chin, K. Sharp, K A. Honig, B. Pyle, A M.: Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function. Nature Structural Biology 6(11): 1055-61, Nov 1999.
bd Brooijmans, N., Sharp, K. A., Kuntz, I. D.: "The stability of macromolecular complexes". Proteins 48: 645-653, 2002.
a2 Daber, R., K. Sharp and M. Lewis: One is Not Enough. J. Mol. Biol. 392: 1133-1144, 2009.
fb Coleman, Ryan G. Sharp, Kim A.: Travel depth, a new shape descriptor for macromolecules: application to ligand binding. Journal of Molecular Biology 362(3): 441-58, Sep 22 2006.
136 Prabhu, Ninad V. Panda, Manoranjan. Yang, Qingyi. Sharp, Kim A.: Explicit ion, implicit water solvation for molecular dynamics of nucleic acids and highly charged molecules. Journal of Computational Chemistry 29(7): 1113-30, May 2008.
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Selected Publications
bb Kuntz, I. D., K. Chen, K. Sharp and P. Kollman.: “The maximal affinity of ligands.” PNAS 96: 9997-10002, 1999.b3 Luo, H., Sharp, K. A.: "On the calculation of absolute binding free energies". PNAS 99: 10399-10404, 2002.
a7 Gallagher, K., Sharp, K. A.: "A new angle on the hydrophobic effect". JACS 125: 9863-60, 2003.
11a Chin, K. Sharp, K A. Honig, B. Pyle, A M.: Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function. Nature Structural Biology 6(11): 1055-61, Nov 1999.
bd Brooijmans, N., Sharp, K. A., Kuntz, I. D.: "The stability of macromolecular complexes". Proteins 48: 645-653, 2002.
a2 Daber, R., K. Sharp and M. Lewis: One is Not Enough. J. Mol. Biol. 392: 1133-1144, 2009.
fb Coleman, Ryan G. Sharp, Kim A.: Travel depth, a new shape descriptor for macromolecules: application to ligand binding. Journal of Molecular Biology 362(3): 441-58, Sep 22 2006.
136 Prabhu, Ninad V. Panda, Manoranjan. Yang, Qingyi. Sharp, Kim A.: Explicit ion, implicit water solvation for molecular dynamics of nucleic acids and highly charged molecules. Journal of Computational Chemistry 29(7): 1113-30, May 2008.
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