Michael Silverman, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104
Education:
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.
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Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Graft-vs-host disease, Early life immune system development

Selected Publications

Stephanie Si , Kelley Erickson , Nicholas Evageliou , Michael Silverman , Leslie Kersun : An Usual Presentation of Pneumocystis jirovecii Pneumonia in a Woman Treated With Immune Checkpoint Inhibitor. J Pediatric Hematol Oncol 43(1): 163-164, March 2021.

Robert B Lindell, Michael S Wolf, Alicia M Alcamo, Michael A Silverman, Daniel E Dulek, William R Otto, Timothy S Olson, Carrie L Kitko, Paisit Paueksakon and Kathleen Chiotos: Immune dysregulation due to Toxoplasma gondii reactivation after allogeneic hematopoietic cell transplant: a case series and review of the literature. Frontiers in Pediatrics (Accepted) 2021.

Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M.: Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages. Cell Rep. June 2020.

Mathew S. Kelly and Michael A. Silverman: Microbiome Implications in Transplantation and Oncology. Pediatric Transplant and Oncology Infectious Diseases April 2020.

Fasolino M, Goldman N, Wang W, Cattau B, Zhou Y, Petrovic J, Link VM, Cote A, Chandra A, Silverman M, Joyce EF, Little SC, Kaestner KH, Naji A, Raj A, Henao-Mejia J, Faryabi RB, Vahedi G. : Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression. Immunity. PubMed, Page: 257-274, February 2020.

Si S, Erickson K, Evageliou N, Silverman M, Kersun L.: An Usual Presentation of Pneumocystis jirovecii Pneumonia in a Woman Treated With Immune Checkpoint Inhibitor. Pediatr Hematol Oncol. February 2020.

Denu L, Lubin JB, Douglas B, Tuluc F, Silverman MA: Diet-induced microbial autofluorescence confounds flow cytometry of ex vivo isolated fecal microbes. European Journal of Immunology 2019.

Tanca A, Palomba A, Fraumene C, Manghina V, Silverman M, Uzzau S.: Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice. mSphere 3(5): doi: 10.1128, October 2018.

Dixit A, Alexandrescu S, Boyer D, Graf, EH, Vargas SO, Silverman M: Mycoplasma hominis empyema in an 18 year-old stem cell and lung transplant recipient: Case report and review of the literature. J Pediatric Infect Dis Soc 6(4): 173-176, November 2017.

Silverman M, Kua L, Tanco A, Pala M, Palomba A,Tanes C, Bittenger K, Uzzau S, Benoist C, and Mathis D: Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny. Proceedings of the National Academy of Sciences 114(36): 9671-9676, September 2017.

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Last updated: 08/20/2021
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