Michael Silverman, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104
Education:
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.
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Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Graft-vs-host disease

Selected Publications

Tanca A, Palomba A, Fraumene C, Manghina V, Silverman M, Uzzau S.: Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice. mSphere 3(5): doi: 10.1128, October 2018.

Dixit A, Alexandrescu S, Boyer D, Graf, EH, Vargas SO, Silverman M: Mycoplasma hominis empyema in an 18 year-old stem cell and lung transplant recipient: Case report and review of the literature. J Pediatric Infect Dis Soc 6(4): 173-176, November 2017.

Silverman M, Kua L, Tanco A, Pala M, Palomba A,Tanes C, Bittenger K, Uzzau S, Benoist C, and Mathis D: Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny. Proceedings of the National Academy of Sciences 114(36): 9671-9676, September 2017.

Alessandro Tanca, Valeria Manghina, Cristina Fraumene, Antonio Palomba, Marcello Abbondio, Massimo Deligios, Michael Silverman, Sergio Uzzau: Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Frontiers in Microbiology 8(391): doi: 10.3389, March 2017 Notes: ecollection 2017.

Michael A Silverman, Liza Konnikova, Jeffrey Gerber: Impact of antibiotics on necrotizing enterocolitis and antibiotic-associated diarrhea. Gastroenterology Clinics of North America 46(1): 61-76, March 2017.

Silverman MA, Misasi J, Smole S, Feldman HA, Cohan AB, Santagata S, McManus M, Ahmed AA: Pediatric Eastern Equine encephalitis in Massachussettes and New Hampshire, 1970-2010. Emerging Infectious Diseases 19(2): 194-201, February 2013.

Kambayashi T, Larosa DF, Silverman MA, Koretzky GA: Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunol Rev 232(1): 99-114, November 2009.

Michael Aaron Silverman: "SLP-76: Complex regulation of FcepsilonRI signaling in mast cells" Dissertations available from ProQuest. (eds.). January 2007 Notes: Paper AAI3260992. 
http://repository.upenn.edu/dissertations/AAI3260992.

Olenchock BA, Guo R, Silverman MA, Wu JN, Carpenter JH, Koretzky GA, Zhong XP.: Impaired degranulation but enhanced cytokine production after FcepsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med 205(5): 1471-80, May 2006.

Silverman MA, Shoag J, Wu J, Koretzky GA: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol 26(5): 1826-38, March 2006.

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Last updated: 11/15/2018
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