Michael Silverman, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.
Permanent link
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Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Graft-vs-host disease

Selected Publications

Gomes LMF, Mahammed A, Prosser KE, Smith JR, Silverman MA, Walsby CJ, Gross Z, Storr T. : A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation. Chem Sci. 10(6): 1634-1643 Dec. 3 2018.

Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD. : In vivo induction of membrane damage by β-amyloid peptide oligomers. Acta Neuropathol Commun. 6(1): 131, Nov. 29 2018.

Tanca A, Palomba A, Fraumene C, Manghina V, Silverman M, Uzzau S.: Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice. mSphere 3(5): doi: 10.1128, October 2018.

Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ.: Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway. ACS Chem Neurosci. 9(6): 1366-1379, June 20 2018.

Discala SL, Basri D, Vartan CM, Silverman MA. : Use of Topical Morphine to Relieve Painful Pressure Ulcers. Consult Pharm. 33(4): 215-221, April 1 2018.

Dixit A, Alexandrescu S, Boyer D, Graf, EH, Vargas SO, Silverman M: Mycoplasma hominis empyema in an 18 year-old stem cell and lung transplant recipient: Case report and review of the literature. J Pediatric Infect Dis Soc 6(4): 173-176, November 2017.

Silverman M, Kua L, Tanco A, Pala M, Palomba A,Tanes C, Bittenger K, Uzzau S, Benoist C, and Mathis D: Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny. Proceedings of the National Academy of Sciences 114(36): 9671-9676, September 2017.

Alessandro Tanca, Valeria Manghina, Cristina Fraumene, Antonio Palomba, Marcello Abbondio, Massimo Deligios, Michael Silverman, Sergio Uzzau: Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Frontiers in Microbiology 8(391): doi: 10.3389, March 2017 Notes: ecollection 2017.

Michael A Silverman, Liza Konnikova, Jeffrey Gerber: Impact of antibiotics on necrotizing enterocolitis and antibiotic-associated diarrhea. Gastroenterology Clinics of North America 46(1): 61-76, March 2017.

Silverman MA, Misasi J, Smole S, Feldman HA, Cohan AB, Santagata S, McManus M, Ahmed AA: Pediatric Eastern Equine encephalitis in Massachussettes and New Hampshire, 1970-2010. Emerging Infectious Diseases 19(2): 194-201, February 2013.

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Last updated: 05/03/2019
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