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Michael Silverman, MD, PhD
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Assistant Professor of Pediatrics (Infectious Diseases)
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Associate Director, Pediatric Infectious Disease Fellowship, Children's Hospital of Philadelphia
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Director, Immunology, Microbial Medicine Center, Children's Hospital of Philadelphia
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Department: Pediatrics
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Graduate Group Affiliations
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- Immunology 6b
- Cell and Molecular Biology e
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Contact information
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Children's Hospital of Philadelphia
27 Division of Infectious Diseases
39 3615 Civic Center Blvd
Philadelphia, PA 19104
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27 Division of Infectious Diseases
39 3615 Civic Center Blvd
Philadelphia, PA 19104
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Email:
silvermam1@email.chop.edu
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silvermam1@email.chop.edu
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Education:
21 7 BS 14 (Biology) c
2b Cornell University, 1998.
21 c MD, PhD 24 (Medicine and Immunology) c
46 University of Pennsylvania School of Medicine, 2007.
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Permanent link21 7 BS 14 (Biology) c
2b Cornell University, 1998.
21 c MD, PhD 24 (Medicine and Immunology) c
46 University of Pennsylvania School of Medicine, 2007.
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Description of Clinical Expertise
2a Immunocompromised patients71
Description of Research Expertise
ad Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system developmente 29
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ee Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. Microbiome October 2025.
be Michael Silverman and Kathryn Knoop: Setting the table for immune tolerance. Science 389(6761): 684-685, August 2025.
c4 Shenhav L, Azad M, and Silverman MA.: Human Milk as a Microbial Pacemaker. Cell Host and Microbe 33(6): 762-765, June 2025.
160 Natalie A Trigg, Simon K Zhou, Jordan C Harris, Madeline N Lamonica, Molly A Nelson, Michael A Silverman, Taku Kambayashi, Colin C Conine: A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice. Reproduction 169(4): e240204, March 2025.
112 Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. bioRxiv Page: doi: 10.1101/2025.02.20.639370, February 2025.
233 Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with lower risk of neonatal sepsis: a case-control study of hospitalized neonates in Botswana. PLOS Global Public Health 4(12): e0003350, December 2024.
229 Liat Shenhav, Kelsey Fehr, Myrtha E Reyna, Charisse Petersen, Darlene L Y Dai, Ruixue Dai, Vanessa Breton, Laura Rossi, Marek Smieja, Elinor Simons, Michael A Silverman, Maayan Levy, Lars Bode, Catherine J. Field, Jean S Marshall, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Michael G Surette, Meghan B Azad: Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development. Cell 187(19): 5431-5452, September 2024.
13d Jean-Bernard Lubin, Michael A Silverman, Paul J Planet: Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome. Gut Microbes 16(1): 2387875, August 2024.
23b Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana. medRxiv Page: doi: 10.1101/2024.05.28.24308042, May 2024.
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Selected Publications
21a Maryam abedi, Priyandarshini Rai, Yeqiao Zhou, Chengyang Liu, Isabelle Johnson, Aditi Chandra, Maria Fasolino, Susan Rostami, Wei Wang, Zaw Min, Yinjing LI, Ming Yu, Atishay Jay, Vung Lian, Michael Silverman, Klaus Kaestner, Ali Naji, Robert B. Faryabi, Golnaz Vahedi: Joint profiling of gene expression and chromatin accessibility in the pancreatic lymph nodes and spleens in human type 1 diabetes. Science Immunology November 2025 Notes: accepted for publication.ee Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. Microbiome October 2025.
be Michael Silverman and Kathryn Knoop: Setting the table for immune tolerance. Science 389(6761): 684-685, August 2025.
c4 Shenhav L, Azad M, and Silverman MA.: Human Milk as a Microbial Pacemaker. Cell Host and Microbe 33(6): 762-765, June 2025.
160 Natalie A Trigg, Simon K Zhou, Jordan C Harris, Madeline N Lamonica, Molly A Nelson, Michael A Silverman, Taku Kambayashi, Colin C Conine: A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice. Reproduction 169(4): e240204, March 2025.
112 Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. bioRxiv Page: doi: 10.1101/2025.02.20.639370, February 2025.
233 Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with lower risk of neonatal sepsis: a case-control study of hospitalized neonates in Botswana. PLOS Global Public Health 4(12): e0003350, December 2024.
229 Liat Shenhav, Kelsey Fehr, Myrtha E Reyna, Charisse Petersen, Darlene L Y Dai, Ruixue Dai, Vanessa Breton, Laura Rossi, Marek Smieja, Elinor Simons, Michael A Silverman, Maayan Levy, Lars Bode, Catherine J. Field, Jean S Marshall, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Michael G Surette, Meghan B Azad: Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development. Cell 187(19): 5431-5452, September 2024.
13d Jean-Bernard Lubin, Michael A Silverman, Paul J Planet: Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome. Gut Microbes 16(1): 2387875, August 2024.
23b Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana. medRxiv Page: doi: 10.1101/2024.05.28.24308042, May 2024.
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