Maria Ciocca Basil, MD PhD
Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care)
Department: Medicine
Graduate Group Affiliations
Contact information
Smilow Center for Translational Research, Room 11-112
3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104
3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104
Education:
AB (Chemistry)
Princeton University, 2005.
PhD (Cell and Molecular Biology; Cancer Biology)
University of Pennsylvania Perelman School of Medicine, 2014.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2014.
Permanent linkAB (Chemistry)
Princeton University, 2005.
PhD (Cell and Molecular Biology; Cancer Biology)
University of Pennsylvania Perelman School of Medicine, 2014.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2014.
Description of Research Expertise
Human lung BiologyOur laboratory is interested in untangling the molecular mechanisms that regulate cell fate in the distal-most human airways (the respiratory airways) and understanding how the cells in this region are impacted by human diseases, including Chronic Obstructive Pulmonary Disease (COPD).
Selected Publications
Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE.: Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 604(7904): 120-126, Apr 2022 Notes: doi: 10.1038/s41586-022-04552-0.Shiraishi K, Shah PP, Morley MP, Loebel C, Santini GT, Katzen J, Basil MC, Lin SM, Planer JD, Cantu E, Jones DL, Nottingham AN, Li S, Cardenas-Diaz FL, Zhou S, Burdick JA, Jain R, Morrisey EE. : Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate. Cell 186(7): 1478, March 2023.
Crnkovic S, Valzano F, Fließer E, Gindlhuber J, Thekkekara Puthenparampil H, Basil MC, Morley MP, Katzen J, Gschwandtner E, Klepetko W, Cantu E, Wolinski H, Olschewski H, Lindenmann J, Zhao YY, Morrisey EE, Marsh LM, Kwapiszewska G.: Single cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling. JCI Insight 7(20): e153471, Sept 2022.
Guo M, Morley MP, Jiang C, Wu Y, Li G, Du Y, Zhao S, Wagner A, Cakar AC, Kouril M, Jin K, Gaddis N, Kitzmiller JA, Stewart K, Basil MC, Lin SM, Ying Y, Babu A, Wikenheiser-Brokamp KA, Mun KS, Naren AP, Clair G, Adkins JN, Pryhuber GS, Misra RS, Aronow BJ, Tickle TL, Salomonis N, Sun X, Morrisey EE, Whitsett JA, Xu Y: Guided construction of single cell reference for human and mouse lung. Nature Communication 14(1): 4556, July 2023.
Ferguson LT, Hood ED, Shuvaeva T, Shuvaev VV, Basil MC, Wang Z, Nong J, Ma X, Wu J, Myerson JW, Marcos-Contreras OA, Katzen J, Carl JM, Morrisey EE, Cantu E, Villa CH, Mitragotri S, Muzykantov VR, Brenner JS.: Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ- and Cell Type-Targeting of Intravascular Nanocarriers. ACS Nano 16(3): 4666-4683, Mar 2022 Notes: doi: 10.1021/acsnano.1c11374.
Loebel C, Weiner AI, Eiken MK, Katzen JB, Morley MP, Bala V, Cardenas-Diaz FL, Davidson MD, Shiraishi K, Basil MC, Ferguson LT, Spence JR, Ochs M, Beers MF, Morrisey EE, Vaughan AE, Burdick JA: Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres. Adv Mater 34(28): e2202992, Jul 2022 Notes: doi: 10.1002/adma.202202992.
Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Masso-Silva JA, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE; NHLBI LungMAP Consortium.: A census of the lung: CellCards from LungMAP. Dev Cell 57(1): 112-145, Jan 2022 Notes: doi: 10.1016/j.devcel.2021.11.007.
Toulmin SA, Bhadiadra C, Paris AJ, Lin JH, Katzen J, Basil MC, Morrisey EE, Worthen GS, Eisenlohr LC.: Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation. Nat Commun 12(1): 3993, Jun 2021 Notes: doi: 10.1038/s41467-021-23619-6.
Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE: Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus. Science 371(6534): eabc3172, Mar 2021 Notes: doi: 10.1126/science.abc3172.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP.: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nat Commun 11(1): 5640, Nov 2020 Notes: doi: 10.1038/s41467-020-18979-4.