Drew Weissman, M.D., Ph.D.
380 S University Ave.
Philadelphia, PA 19104
B.A., M.A. (Biochemistry/Enzymology)
Brandeis University, 1981.
M.D. Ph.D. (Immunology/Microbiology)
Boston University, 1987.
Description of Research ExpertiseDr. Weissman's laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. There are three main projects in his laboratory. The first project began through the use of mRNA encoding antigen as a delivery system to load dendritic cells to promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and translation and the development of applications for gene therapy. The second project develops new HIV envelope immunogens that can induce broad responses and cross-reactive neutralizing antibodies. The third project continues previous studies that identified a protein found on DC, macrophages, and epithelial cells that binds HIV envelope with high affinity. The main focus of this project is testing whether this and related molecules function in vivo to promote HIV genital tract infection.
Selected PublicationsLo Michael K, Spengler Jessica R, Welch Stephen R, Harmon Jessica R, Coleman-Mccray Joann D, Scholte Florine E M, Shrivastava-Ranjan Punya, Montgomery Joel M, Nichol Stuart T, Weissman Drew, Spiropoulou Christina F: Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters. The Journal of infectious diseases Nov 2019.
Ravimohan Shruthi, Maenetje Pholo, Auld Sara C, Ncube Itai, Mlotshwa Mandla, Chase William, Tiemessen Caroline T, Vangu Mboyo-Di-Tamba, Wallis Robert S, Churchyard Gavin, Weissman Drew, Kornfeld Hardy, Bisson Gregory P: A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Nov 2019.
Mehta K, Ravimohan S, Pasipanodya JG, Srivastava S, Modongo C, Zetola NM, Weissman D, Ivaturi V, Gumbo T, Bisson GP, Vinnard C: Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study. J Antimicrob Chemother 74(10): 2994-3002, Oct 2019.
Cable Jennifer, Srikantiah Padmini, Crowe James E, Pulendran Bali, Hill Adrian, Ginsberg Ann, Koff Wayne, Mathew Anuja, Ng Tony, Jansen Kathrin, Glenn Gregory, Permar Sallie, Wilson Ian, Weiner David B, Weissman Drew, Rappuoli Rino: Vaccine innovations for emerging infectious diseases-a symposium report. Annals of the New York Academy of Sciences Oct 2019.
Auld SC, Maenetje P, Ravimohan S, Weissman D, Ncube I, Mlotshwa M, Ratsela N, Chase W, Vangu M-D-T, Wallis R, Churchyard G, Kornfeld H, Bisson GP: Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome. Clin Infect Dis Sep 2019.
Awasthi S, Hook LM, Pardi N, Wang F, Myles A, Cancro MP, Cohen GH, Weissman D, Friedman HM: Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes. Sci Immunol 4(39), Sep 2019.
Pardi N, LaBranche CC, Ferrari G, Cain DW, Tombácz I, Parks RJ, Muramatsu H, Mui BL, Tam YK, Karikó K, Polacino P, Barbosa CJ, Madden TD, Hope MJ, Haynes BF, Montefiori DC, Hu S-L, Weissman D: Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques. Mol Ther Nucleic Acids 15: 36-47, Apr 2019.
Parhiz H, Shuvaev VV, Pardi N, Khoshnejad M, Kiseleva RY, Brenner JS, Uhler T, Tuyishime S, Mui BL, Tam YK, Madden TD, Hope MJ, Weissman D, Muzykantov VR: PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake. J Control Release Page: pii: S0168-3659(18)30586-8, Oct 2018.
Foster JB, Choudhari N, Perazzelli J, Storm J, Hofmann TJ, Jain P, Storm PB, Pardi N, Weissman D, Waanders AJ, Grupp SA, Karikó K, Resnick AC, Barrett DM: Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response. Hum Gene Ther Page: 145, Oct 2018.
Pardi N, Parkhouse K, Kirkpatrick E, McMahon M, Zost SJ, Mui BL, Tam YK, Karikó K, Barbosa CJ, Madden TD, Hope MJ, Krammer F, Hensley SE, Weissman D: Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. Nat Commun 9(1): 3361, Aug 2018.