Anne Rentoumis Cappola, MD, ScM

faculty photo
Professor of Medicine (Endocrinology, Diabetes and Metabolism)
Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA
Fellow, Institute on Aging, University of Pennsylvania School of Medicine
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Executive Director, Penn Medical Communication Research Institute
Director, Division of Geroscience, Gerontology, and Geriatrics, Institute on Aging, University of Pennsylvania School of Medicine
Department: Medicine

Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 746-6391
Fax: (215) 898-5408
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
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Description of Research Expertise

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism and Director of the Penn Medical Communication Research Institute (PMCRI). She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies defining cutoffs for thyroid dysfunction in older men and women; the role of thyroid hormone treatment in cardiovascular disease, hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Selected Publications

Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Benseñor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Del Giovane C: Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. Eur J Endocrinol 187(5): S35-S46, Sept 2022.

Brown RT, Diaz-Ramirez LG, Boscardin WJ, Cappola AR, Lee SJ, Steinman MA: Changes in the hierarchy of functional impairment from middle age to older age. J Gerontol A Biol Sci Med Sci 77(8): 1577-1584, Aug 2022.

Orwig DL, Abraham DS, Hochberg MC, Gruber-Baldini A, Guralnik JM, Cappola AR, Golden J, Hicks GE, Miller RR, Resnick B, Shardell M, Sterling RS, Magaziner J: Sex differences in recovery across multiple domains among older adults with hip fracture. J Gerontol A Biol Sci Med Sci 77(7): 1463-1471, Jul 2022.

Friedman AB, Chen AT, Wu R, Coe NB, Halpern S, Hwang U, Kelz R, Cappola AR: Evaluation and disposition of older adults presenting to the emergency department with abdominal pain. J Am Geriatr Soc 70(2): 501-511, Feb 2022.

Syrogiannouli L, Wildisen L, Meuwese C, Bauer DC, Cappola AR, Gussekloo J, Den Elzen W, Trompet S, Westendorp RG, Jukema JW, Ferrucci L, Ceresini G, Åsvold BO, Chaker L, Peeters RP, Imaizumi M, Ohishi W, Vaes B, Völzke H, Sgarbi JA, Walsh JP, Dullaart RP, Bakker SJ, Iacoviello M, Rodondi N, Del Giovane C: Incorporating baseline outcome data in individual participant data meta-analysis of non-randomized studies. Front Psychiatry 13: 774251, Feb 2022.

Gregson CL, Madanhire T, Rehman A, Ferrand RA, Cappola AR, Tollman S, Mokoena T, Mickelsfield LK, Wade AN, Fabian J: Osteoporosis, rather than sarcopenia, is the predominant musculoskeletal disease in rural South Africa where HIV prevalence is high: a cross-sectional study. J Bone Miner Res 37(2): 244-255, Feb 2022.

van Vliet NA, van Heemst D, Almeida OP, Åsvold BO, Aubert CE, Bae JB, Barnes LE, Bauer DC, Blauw GJ, Brayne C, Cappola AR, Ceresini G, Comijs HC, Dartigues JF, Degryse JM, Dullaart RPF, van Eersel MEA, den Elzen WPJ, Ferrucci L, Fink HA, Flicker L, Grabe HJ, Han JW, Helmer C, Huisman M, Ikram MA, Imaizumi M, de Jongh RT, Jukema JW, Kim KW, Kuller LH, Lopez OL, Mooijaart SP, Moon JH, Moutzouri E, Nauck M, Parle J, Peeters RP, Samuels MH, Schmidt CO, Schminke U, Slagboom PE, Stordal E, Vaes B, Völzke H, Westendorp RGJ, Yamada M, Yeap BB, Rodondi N, Gussekloo J, Trompet S for the Thyroid Studies Collaboration: Association of thyroid dysfunction with cognitive function: an individual participant data analysis. JAMA Intern Med 181(11): 1440-1450, Nov 2021.

Shardell M, Cappola AR, Guralnik JM, Hicks GE, Kritchevsky SE, Simonsick EM, Ferrucci L, Semba RD, Shaffer NC, Harris T, Eiriksdottir G, Godnason V, Cotch MF, Orwoll E, Ensrud KE, Cawthon PM: Sex-specific 25-hydroxyvitamin D threshold concentrations for functional outcomes in older adults: PRoject on Optimal VItamin D in Older adults (PROVIDO). Am J Clin Nutr 114(1): 16-28, Jul 2021.

Wade AN, Crowther NJ, Abrahams-Gessel S, Berkman L, George JA, Gómez-Olivé FX, Manne-Goehler J, Salomon JA, Wagner RG, Gaziano TA, Tollman SM, Cappola AR: Concordance between fasting plasma glucose and HbA1c in the diagnosis of diabetes in Black South African adults: a cross-sectional study. BMJ Open 11(6): e046060, Jun 2021.

Cappola AR, Schriver ER, Mowery DL, Wollack C, Ives CT, Gonzales R, Cappella JN: Effect of targeted messaging on return to in-person visits during the COVID-19 pandemic: a randomized clinical trial. JAMA Netw Open 4(6): e2115211, Jun 2021.

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Last updated: 09/05/2023
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