Anne Rentoumis Cappola, MD, ScM
Professor of Medicine (Endocrinology, Diabetes and Metabolism)
Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA
Fellow, Institute on Aging, University of Pennsylvania School of Medicine
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Executive Director, Penn Medical Communication Research Institute
Director, Division of Geroscience, Gerontology, and Geriatrics, Institute on Aging, University of Pennsylvania School of Medicine
Department: Medicine
Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 573-5634
Fax: (215) 898-5408
Fax: (215) 898-5408
Publications
Links
Search PubMed for articles
Division of Endocrinology, Diabetes, and Metabolism Faculty
School of Medicine Faculty
Search PubMed for articles
Division of Endocrinology, Diabetes, and Metabolism Faculty
School of Medicine Faculty
Education:
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
M.D.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
Permanent linkB.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
M.D.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
Description of Research Expertise
Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism and Exeutive Director of the Penn Medical Communication Research Institute (PMCRI). She is an Associate Editor for the Journal of the American Medical Association (JAMA).Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies defining cutoffs for thyroid dysfunction in older men and women; the role of thyroid hormone treatment in cardiovascular disease, hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.
Selected Publications
Baretella O, Blum MR, Abolhassani N, Alwan H, Wildisen L, Del Giovane C, Tal K, Moutzouri E, Åsvold BO, Cappola AR, Gussekloo J, Iacoviello M, Iervasi G, Imaizumi M, Weiler S, Razvi S, Sgarbi JA, Völzke H, Brown SJ, Walsh JP, Vaes B, Yeap BB, Dullaart RPF, Bakker SJL, Kavousi M, Ceresini G, Ferrucci L, Aujesky D, Peeters RP, Bauer DC, Feller M, Rodondi N: Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex. J Clin Endocrinol Metab 110(5): e1315-e1322, Apr 2025.Wade AN, Guare L, Hayat M, Straub P, Gao Z, Medici M, Teumer A, Davis LK, Ramsay M, Ritchie MD, Cappola AR: Strength of genetic associations with thyroid stimulating hormone values differs between populations with similarity to African and European reference populations. Thyroid 35(2): 131-142, Feb 2025.
Wu RR, Adjei-Poku MN, Kelz RR, Peck GL, Hwang U, Cappola AR, Friedman AB: Trends in visits, imaging, and diagnosis for emergency department abdominal pain presentations in the United States, 2007-2019. Acad Emerg Med 32(1): 20-31, Jan 2025.
Barasch E, Gottdiener J, Buzkova P, Cappola AR, Shah S, DeFilippi C, Gardin J, Kizer JR: Association of thyroid dysfunction in individuals ≥ 65 years of age with subclinical cardiac abnormalities. J Clin Endocrinol Metab 109(10), Sep 2024.
Seedat F, Tollman SM, Twine W, Cappola AR, Wade AN: Double malnutrition and associated factors in a middle-aged and older, rural South African population. BMC Nutr 10(1): 84, Jun 2024.
Armbruster RR, Kumar D, Benyard B, Jacobs P, Khandavilli A, Liu F, Nanga RPR, McCormack S, Cappola AR, Wilson N, Reddy R: Personalized and muscle specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy. Nat Commun 15(1): 5387, Jun 2024.
Hwang S, Reddy S, Wainwright K, Schriver E, Cappola AR, Mowery D: Using natural language processing to extract and classify symptoms among patients with thyroid dysfunction. Stud Health Technol Inform 310: 614-618, Jan 2024.
Teumer A, Sterenborg R, Steinbrenner I, Li Y, Bujnis M, Naito T, Marouli E, Galesloot T, Babajide O, Andreasen L, Astrup A, Åsvold BO, Bandinelli S, Beekman M, Beilby J, Bork-Jensen J, Boutin T, Brody J, Brown S, Brumpton B, Campbell P, Cappola AR, Ceresini G, Chaker L, Chasman D, Concas MP, de Almeida RC, Cross S, Cucca F, Deary I, Kjaergaard A, Tcheugui JE, Ellervik C, Eriksson J, Ferrucci L, Freudenberg J, Fuchsberger C, Gieger C, Giulianini F, Gögele M, Graham S, Grarup N, Gunjača I, Hansen T, Harding B, Harris S, Haunsø S, Hayward C, Hui J, Ittermann T, Jukema JW, Kajantie E, Kanters J, Kårhus L, Kiemeney L, Kloppenburg M, Kühnel B, Lahti J, Langenberg C, Lapauw B, Leese G, Li S, Liewald D, Linneberg A, Lominchar J, Luan J, Martin N, Matana A, Meima M, Meitinger T, Meulenbelt I, Mitchell B, Møllehave L, Mora S, Naitza S, Nauck M, Netea-Maier R, Noordam R, Nursyifa C, Okada Y, Onano S, Papadopoulou A, Palmer C, Pattaro C, Pedersen O, Peters A, Pietzner M, Polasek O, Pramstaller P, Psaty B, Punda A, Ray D, Redmond P, Richards JB, Ridker P, Russ T, Ryan K, Olesen M, Schultheiss U, Selvin E, Siddiqui M, Sidore C, Slagboom PE, Sorensen T, Soto-Perdre E, Spector T, Spedicati B, Srinivasan S, Starr J, Stott D, Tanaka T, Torlak V, Trompet S, Tuhkanen J, Uitterlinden A, van den Akker E, van den Eynde T, van der Klauw M, van Heemst D, Verroken C, Visser WE, Vojinovic D, Völzke H, Waldenberger M, Walsh J, Wareham N, Weiss S, Willer C, Wilson S, Wolffenbuttel B, Wouters H, Wright M, Yang Q, Zemunik T, Zhou W, Zhu G, Zöllner S, Smit J, Peeters R, Köttgen A, Medici M: Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications Nat Commun 15(1): 888, Jan 2024.
Xu Y, Derakhshan A, Hysaj O, Wildisen L, Ittermann T, Pingitore A, Abolhassani N, Medici M, Kiemeney LALM, Riksen NP, Dullaart RPF, Trompet S, Dörr M, Brown SJ, Schmidt B, Führer-Sakel D, Vanderpump MPJ, Muendlein A, Drexel H, Fink HA, Ikram MK, Kavousi M, Rhee CM, Bensenor IM, Azizi F, Hankey GJ, Iacoviello M, Imaizumi M, Ceresini G, Ferrucci L, Sgarbi JA, Bauer DC, Wareham N, Boelaert K, Bakker SJL, Jukema JW, Vaes B, Iervasi G, Yeap BB, Westendorp RGJ, Korevaar TIM, Völzke H, Razvi S, Gussekloo J, Walsh JP, Cappola AR, Rodondi N, Peeters RP, Chaker L; Thyroid Studies Collaboration: The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis. Lancet Diab Endocrinol 11(10): 743-754, Oct 2023.
Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Benseñor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Del Giovane C: Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. Eur J Endocrinol 187(5): S35-S46, Sept 2022.