Jonni S. Moore, Ph.D.

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-6853
Fax: (215) 898-4227
Education:
B.A. (Biology)
University of Virginia, Charlottesville, 1972.
Ph.D. (Microbiology)
Thomas Jefferson University, Philadelphia, 1984.
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Description of Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently she has focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, Parker Institute for Cancer Immunotherapy
Mona Kumar, MD, Neurology

Selected Publications

Rogers W, Ionita M, Moore J: PanoplyCF: A New R Package for Manifold Learning Clustering via Binning. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstract accepted for poster presentation at CYTO Virtual 2020.

Kumar M, Schmierer M, Silverman E, Kulkarni N, Silvestro E, Schretzenmair R, Sandsmark D, Diaz-Arrastia R, Rogers W, Moore J: Reduction in non-classical monocytes suggest recruitment to CNS after Acute Traumatic Brain Injury. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstracted selected for oral presentation (by Monisha Kumar) at CYTO Virtual 2020.

Ionita M, Jones D, Moore J, Schretenmair R, Wang L-S, Rogers W.: Tailor: Targeting heavy tails in flow cytometry data with fast mixture modeling. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstract selected for oral presentation (by post doc Matei Ionita) at CYTO Virtual 2020.

Rogers W, Ionita M, Moore J. : Fluster: A New R Package for Fingerprint-based Clustering. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Poster accepted for virtual presentation at CYTO Virtual 2020.

Schretzenmair RD, Jones DD, Brake-Silla G, Balderas R, Stall A, Moore JS: FACSymphony A5 Harmonization and Validation for Computational Population Discovery. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstract accepted for poster presentation at CYTO Virtual 2020.

Schretzenmair RD, Brake-Silla G, Jakubowski J, Jones DD, Moore JS. : Robust Measurement of CD279 on Patients Receiving anti-PD-1 Therapy. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: abstract accepted as virtual poster for presentation at CYTO Virtual 2020.

Chislock E, Woodfield G, Graves J, Pan T-C, Pant D, Chen Y, Shih N, Bayne L, Blanchard T, Smith M, Murphy W, Morchauser A, DeMuth W, Pletcher C, Moore J, Yu L, Bornheimer S, , Feldman M, Nayak A, DeMichele A, Chodosh L.: Development of a Flow Cytometry-Based Assay for Clinical Detection and Molecular Characterization of Breast Cancer Disseminated Tumor Cells in Bone Marrow. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstract selected for oral presentation (by Elisabeth Chislock) at CYTO Virtual 2020.

Kumar M, Schmierer M , Silverman E, Kulkarni N, Ballestar S, Silvestro E, Schretzenmair R, Diaz-Arrastia R, Rogers W, Moore JS. : Expression of Extracellular Vesicles after acute Traumatic Brian Injury: A Pilot Flow Cytometry Study. International Society for Extracellular Vesicles (ISEV Virtual) https://www.eventscribe.com/2020/ISEV/posterspeakers.asp?pfp=PresentingAuthor July 2020 Notes: Abstract Selected for poster presentation at ISEV Virtual 2020.

Cossarizza A, Chang HD, Radbruch A, et al: Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European Journal of Immunology 49(10): 1457-1973, 2019.

Urtishak KA, Wang L, Culikovic-Krajiacic B, Davenport J, Porazzi P, Vincent T, Teachey D, Tasian S, Moore J, Seif A, Jin S, Barrett J, Robinson B, Chen I-M, Harvey R, Carroll M, Carroll A, Herrera N, Devidas M, Dryer Z, Hilden J, Hunger S, Willman C, Borden K, Felix C. : Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene 38: 2241, 2019.

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Last updated: 08/24/2020
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