Jonni S. Moore, Ph.D.

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-6853
Fax: (215) 898-4227
B.A. (Biology)
University of Virginia, Charlottesville, 1972.
Ph.D. (Microbiology)
Thomas Jefferson University, Philadelphia, 1984.
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Description of Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently she has focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, Parker Institute for Cancer Immunotherapy
Mona Kumar, MD, Neurology

Selected Publications

Urtishak KA, Wang L, Culikovic-Krajiacic B, Davenport J, Porazzi P, Vincent T, Teachey D, Tasian S, Moore J, Seif A, Jin S, Barrett J, Robinson B, Chen I-M, Harvey R, Carroll M, Carroll A, Herrera N, Devidas M, Dryer Z, Hilden J, Hunger S, Willman C, Borden K, Felix C. : Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene 38: 2241, 2019.

Yu L, Silin S, Wang L, Dulmage K, Bhagwat N, Yee S, Sen M, Pletcher C, Moore J, Saksena S, Dixon E,Carpenter E.: An integrated enrichment system to facilitate isolation and mononuclear characterization of single cancer cells from whole blood. Cytometry A. Wiley, 93(12): 1226, 2018.

Bhagwat N, Dulmage K, Pletcher CH, Wang L, DeMuth W, Sen M, Balli D, Yee S, Sa S, Tong F, Yu L, Moore JS, Stanger BZ, Dixon EP, Carpenter EL: An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters. Scientific Reports 8: 5035, 2018.

Mark I. Greene, Jonni S. Moore: "Peter C. Nowell (1928-2016)" Science 355(Issue 6328): 913, March 2017.

WT Rogers, L Zhang, S Welden, B Krieger, M Rickels, JS Moore, ER Mohler, III: Vascular Health Profile Predicts Cardiovascular Outcomes in Patients with Diabetes. Cytometry Part B. Wiley, 92B, 2017.

Nolan, JP and Moore, J: Extracellular Vesicles: Great Potential, Many Challenges. Cytometry Part B 90B: 324-325, May 2016.

Takeshita J, Mohler E, Krishnamoorthy P, Moore J, Rogers W, Zhang L, Gelfand J, Mehta N. : Endothelial Cell-, Platelet-, and Monocyte/Macrophage-Derived Microparticles are Elevated in Psoriasis Beyond Cardiometabolic Risk Factors. J Am Heart Association 2014.

Kurtzman N, Zhang L, French B, Jonas R, Bantly A, Rogers WT, Moore JS, Rickels M, Mohler ER III: Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus. Cytometry Part B: Clinical Cytometry in press, 2013.

Curtis A.M., Edelberg J., Jonas R., Rogers W.T., Moore J.S., Wajihuddin S., Mohler E.R. III: Endothelial Microparticles; Sophisticated Vesicles Modulating Vascular Function. Vascular Medicine in press, 2013.

Urtishak KA, Edwards AY, Wang LS, Hudome A, Robinson BW, Barrett JS, Cao K, Cory L, Moore JS, Bantly AD, Yu QC, Chen IM, Atlas SR, Willman CL, Kundu M, Carroll AJ, Heerema NA, Devidas M, Hilden JM, Dreyer ZE, Hunger SP, Reaman GH, Felix CA : Potent Obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia. Blood 121(14): 2689-2703. Blood 121(14): 2689-2703, 2013.

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Last updated: 07/03/2019
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