Huafeng Wei, MD, PhD

faculty photo
Associate Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
University of Pennsylvania
305 John Morgan Building
3620 Hamilton Walk
Email: huafeng.wei@pennmedicine.upenn.edu
Philadelphia, PA 19104-6112
Office: 215-260-9840
Fax: 215-349-5078
Lab: 215-746-8704
Education:
Diploma (Medicine)
Jining Medical School, Jining, China, 1982.
MD (Medicine)
Tongji Medical University, Wuhan, China, 1988.
PhD (Pharmacology and Toxicology)
George Washington University, Washington, DC, 1996.
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Description of Research Expertise

Basic science: Role of intracellular calcium dysregulation on neuronal apoptosis and neurodegenration, autophagy, synapse and cognitive dysfunction in neurodegenerative diseases, especially in Alzheimer's Disease. Treatment of Alzheimer's disease. Mechanisms of anesthesia mediated dual effects of neuroprotection and neurotoxicity, especially in the developing brains and in Alzheimer's disease.

Clinical science: Clinical use of Supraglottic Jet Oxygenationa and Ventilation (SJOV) to maintain oxygenation/ventilation in patients with respiratory depression or apnea, especially during intravenous propofol infusion or difficult airway management.

Description of Clinical Expertise

General practice of anesthesia, Difficult airway management, Clinical use of Supraglottic Jet Oxygenation and Ventilation (SJOV)

Description of Other Expertise

Taichi (one type of Chinese Kungfu Master. Total six gold medals, five silver medals and two brown model on various international Wushu (Kungfu) competitions.

Selected Publications

Jiang B, Liang S, Liang G, Wei H: Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis? European Review for Medical and Pharmacological Sciences 88: 28-29, Oct 2020 Notes: doi: 10.1016/j.bbi.2020.05.042.

Jiang B, Wei H: Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients. European Review for Medical and Pharmacological Sciences 24(19): 10239-10246, Oct 2020 Notes: doi: 10.26355/eurrev_202010_23248.

Wang J, Shi Y, Yu S, Wang Y, Meng Q, Liang G, Eckenhoff MF, Wei H: Intranasal administration of dantrolene increased brain concentration and duration. PloS one 15(3): e0229156, Mar 2020.

Yun Shi, Lei Zhang, Xue Gao, Jing Zhang, Matan Ben Abou, Ge Liang, Qingcheng Meng, Adrian Hepner, Maryellen F. Eckenhoff, Huafeng Wei: Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. Journal of Alzheimer's Disease 76(4): 1375-1389, May 2020 Notes: DOI 10.3233/JAD-200227

WEI H: New Approaches to Develop Drug Treatment for Alzheimer’s Disease: Targeting Calcium Dysregulation. Current Alzheimer Research 17(4): 311-312, May 2020 Notes: DOI: 10.2174/156720501704200520094610.

Matan Ben Abou, Liang Sun, and Huafeng Wei: Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease Current Alzheimer Research 17(4): 324-328, May 2020 Notes: doi: 10.2174/1567205017666200522204722.

Sun L, Wei H: Ryanodine receptors: A potential treatment target in various neurodegenerative disease. Cellular and Molecular Neurobiology Page: In Press, Aug 2020 Notes: doi: 10.1007/s10571-020-00936-w.

Wang Y, Liang G, Liang S, Mund R, Shi Y, Wei H: Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease. Anesthesiology 132(5): 1062-1079, May 2020.

Liang Sun, Ge Liang, Huafeng Wei: Lithium protects against lipopolysaccharide-induced cytotoxicity in SH-SY5Y cells expressing Alzheimer’s presenilin 1 mutation by ameliorating calcium dysregulation. Alzheimer Association International Conference (AAIC). Alzheimer & Dementia, Jul 2020.

Qin Y, Li LZ, Zhang XQ, Wei Y, Wang YL, Wei HF, Wang XR, Yu WF, Su DS: Supraglottic jet oxygenation and ventilation enhances oxygenation during upper-gastrointestinal endoscopy in patients sedated with propofol: A randomized multicentre clinical trial British Journal of Anaesthesia 119(1): 158-66, Jul 2017.

Xu Z, Liu Z, Zhang Y, Jin C, Shen F, Yu Y, Cheek T, Onuoha O, Liang G, Month R, Atkins J, Tran KM, Wei H: S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study. Acta Anaesthesiol Scand 62(3): 293-303, Mar 2018.

Xu Z, Wang Y, Liang G, Liu Z, Ma W, Chu CT, Wei H: Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy. Acta Pharmacol Sin. DOI: 10.1038/s41401-019-0303-z 41(3): 303-310, Mar 2020 Notes: Originally Published: Oct. 23, 2019.

Yao W, Wang T, Jiang B, Gao F, Wang L, Zheng H, Xiao W, Yao Shanglong, Mei W, Chen X, Luo A, Sun L, Cook T, Behringer E, Huitink JM, Wong DT, Lane-Fall M, McNarry AF, McGuire B, Higgs A, Shah A, Patel A, Zuo M, Ma W, Xue Z, Zhang LM, Li W, Wang Y, Hagberg C, O'Sullivan EP, Fleisher LA, Wei H: Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations. British Journal of Anaesthesia 125(1): e28-e37, July 2020 Notes: DOI: 10.1016/j.bja.2020.03.026

Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF: Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology 132(1): 55-68, Jan 2020.

Joseph DJ, Liu C, Peng J, Liang G, Wei H: Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. PloS one 14(10): e0223509, Oct 2019.

Liang H, Hou Y, Sun L, Li Q, Wei H, Feng Y: Supraglottic jet oxygenation and ventilation for obese patients under intravenous anesthesia during hysteroscopy: a randomized controlled clinical trial. BMC Anesthesiol 19(1): 151, Aug 2019.

Hou Y, Liang H, Wei H, Feng Y: WEI nasal jet tube during monitored anaesthesia care for removal of oesophageal foreign body for a patient with fragile cardiopulmonary function. Indian J Anaesth 63(5): 403-405, May 2019.

Liang H, Hou Y, Wei H, Feng Y: Supraglottic jet oxygenation and ventilation assisted fiberoptic intubation in a paralyzed patient with morbid obesity and obstructive sleep apnea: a case report. BMC Anesthesiol 19(1): 40, Mar 2019.

Yang M, Wang Y, Liang G, Xu Z, Chu CT, Wei H: Alzheimer's Disease Presenilin-1 Mutation Sensitizes Neurons to Impaired Autophagy Flux and Propofol Neurotoxicity: Role of Calcium Dysregulation. J Alzheimers Dis 67(1): 137-147, Jan 2019.

Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z: Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg 127(6): 1406-1413, Dec 2018.

Shi Y, Wang Y, Wei H: Dantrolene : From Malignant Hyperthermia to Alzheimer's Disease. CNS Neurol Disord Drug Targets 18(9): 668-676, Jan 2019.

Wang Y, Shi Y, Wei H: Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development. J Alzheimers Dis Parkinsonism 7(5), Aug 2017.

Ren G, Zhou Y, Liang G, Yang B, Yang M, King A, Wei H: General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity. Sci Rep 7(1): 12378, Sep 2017.

Yang M, Wei H: Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation. Neurotoxicol Teratol. 60: 59-62, Mar-Apr 2017.

Qiaoyun L, Ping X, Benjun Z, ZhiYun W, Wei H: Supraglottic jet oxygenation and ventilation saved a patient with 'cannot intubate and cannot ventilate' emergency difficult airway. J Anesth 31(1): 144-147, Feb 2017.

Liang S, Liang G, Li Y, Wei H. : Dantrolene ameliorate glutamate induced cytosolic and mitochondrial calcium increase in iPSCs derived neurons from AD patients Annual Meeting of American Society of Anesthesiologists (ASA) Oct 2020.

Deng X, Vipani M, Liang G, Gouda D, Wang B, Wei H: Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis. BMC Anesthesiology 20: 253, Sep 2020 Notes: https://doi.org/10.1186/s12871-020-01139-y.

Wei H, Jiang B, Behringer EC, Hofmeyer R, Myatra SN, Wong DT, O’ Sullivan E, Hagberg CA, McGuire B, Paker P, Li, J, Pylypenko M, Ma W, Zuo M, Senturk NM, Klein U: Controversial Topics Regarding Airway Management in COVID-19 Patients: Updated Information and International Expert Opinion. British Journal of Anaesthesia 126(361-366), Feb 2021 Notes: doi: 10.1016/j.bja.2020.10.029.

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Last updated: 04/04/2021
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