Albert M. Maguire, MD

faculty photo
F.M. Kirby Professor of Molecular Ophthalmology
Director, Fellowship Program, Vitreoretinal Surgery, University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Princeton University (magna cum laude), 1982.
Harvard University, 1986.
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Description of Research Expertise

Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery

Description of Clinical Expertise

diabetic retinopathy, retinopathy of prematurity, macular degeneration, sickle cell disease, gene therapy, retinal degeneration

Selected Publications

Mowad TG, Willett AE, Mahmoudian M, Lipin M, Heinecke A, Maguire AM, Bennett J, Ashtari M: Compensatory Cross-Modal Plasticity Persists After Sight Restoration. Front Neurosci 12(14): 291, May 2020.

Maguire, Albert M; Russell, Stephen; Wellman, Jennifer A; Chung, Daniel C; Yu, Zi-Fan; Tillman, Amy; Wittes, Janet; Pappas, Julie; Elci, Okan; Marshall, Kathleen A; McCague, Sarah; Reichert, Hannah; Davis, Maria; Simonelli, Francesca; Leroy, Bart P; Wright, J Fraser; High, Katherine A; Bennett, Jean.: Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials. Ophthalmology 126(9): 1273-1285, Sep 2019.

Aleman, Tomas S; Uyhazi, Katherine E; Serrano, Leona W; Vasireddy, Vidyullatha; Bowman, Scott J; Ammar, Michael J; Pearson, Denise J; Maguire, Albert M; Bennett, Jean.: RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function. Investigative Ophthalmology & Visual Science 59(12): 5225-5236, Oct 2018.

Silson, Edward H; Aleman, Tomas S; Willett, Aimee; Serrano, Leona W; Pearson, Denise J; Rauschecker, Andreas M; Maguire, Albert M; Baker, Chris I; Bennett, Jean; Ashtari, Manzar.: Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia. Investigative Ophthalmology & Visual Science 59(8): 3249-3258, Jul 2018.

Song, Ji Yun; Aravand, Puya; Nikonov, Sergei; Leo, Lanfranco; Lyubarsky, Arkady; Bennicelli, Jeannette L; Pan, Jieyan; Wei, Zhangyong; Shpylchak, Ivan; Herrera, Pamela; Bennett, Daniel J; Commins, Nicoletta; Maguire, Albert M; Pham, Jennifer; den Hollander, Anneke I; Cremers, Frans P M; Koenekoop, Robert K; Roepman, Ronald; Nishina, Patsy; Zhou, Shangzhen; Pan, Wei; Ying, Gui-Shuang; Aleman, Tomas S; de Melo, Jimmy; McNamara, Ilan; Sun, Junwei; Mills, Jason; Bennett, Jean.: Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness. Molecular Therapy 26(6): 1581-1593, Jun 2018.

Russell, Stephen; Bennett, Jean; Wellman, Jennifer A; Chung, Daniel C; Yu, Zi-Fan; Tillman, Amy; Wittes, Janet; Pappas, Julie; Elci, Okan; McCague, Sarah; Cross, Dominique; Marshall, Kathleen A; Walshire, Jean; Kehoe, Taylor L; Reichert, Hannah; Davis, Maria; Raffini, Leslie; George, Lindsey A; Hudson, F Parker; Dingfield, Laura; Zhu, Xiaosong; Haller, Julia A; Sohn, Elliott H; Mahajan, Vinit B; Pfeifer, Wanda; Weckmann, Michelle; Johnson, Chris; Gewaily, Dina; Drack, Arlene; Stone, Edwin; Wachtel, Katie; Simonelli, Francesca; Leroy, Bart P; Wright, J Fraser; High, Katherine A; Maguire, Albert M.: Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet 390: 849-860, Aug 2017.

Ashtari, Manzar; Nikonova, Elena S; Marshall, Kathleen A; Young, Gloria J; Aravand, Puya; Pan, Wei; Ying, Gui-Shuang; Willett, Aimee E; Mahmoudian, Mani; Maguire, Albert M; Bennett, Jean.: The Role of the Human Visual Cortex in Assessment of the Long-Term Durability of Retinal Gene Therapy in Follow-on RPE65 Clinical Trial Patients. Ophthalmology 124(6): 873-883, Jun 2017.

Parikh, Rupin N; Traband, Anastasia; Kolomeyer, Anton M; VanderBeek, Brian L; Kim, Benjamin J; Maguire, Albert M; Brucker, Alexander J.: Intravitreal Bevacizumab for the Treatment of Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy. American Journal of Ophthalmology 176: 194-202, Apr 2017.

Aleman, Tomas S; Han, Grace; Serrano, Leona W; Fuerst, Nicole M; Charlson, Emily S; Pearson, Denise J; Chung, Daniel C; Traband, Anastasia; Pan, Wei; Ying, Gui-Shuang; Bennett, Jean; Maguire, Albert M; Morgan, Jessica I W.: Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study. Ophthalmology 124(3): 359-373, Mar 2017.

Ramachandran Pavitra, Lee Vivian, Wei Zhangyong, Song Ji Yun, Casal Giulia, Cronin Therese, Willett Keirnan, Huckfeldt Rachel, Morgan Jessica I W, Aleman Tomas S, Maguire Albert M, Bennett Jean: Evaluation of dose and safety of AAV7m8 and AAV8BP2 in the non-human primate retina. Human gene therapy Oct 2016 Notes: Epub ahead of print.

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Last updated: 02/01/2021
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