David C. Fajgenbaum, MD, MBA, MSc, FCPP

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania (HUP)
Division of Medical Genetics
5th Floor Silverstein, Suite S05094
3400 Spruce Street
Philadelphia, PA 19104
Fax: 877-991-9674
Lab: 215-614-0936
BS (Human Sciences with Distinction, Magna Cum Laude)
Georgetown University, Washington, DC, 2007.
MSc (Public Health)
University of Oxford, Oxford, UK, 2008.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2013.
MBA (Health Care Management Program)
Wharton School of Business, University of Pennsylvania, 2015.
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Description of Other Expertise

David Fajgenbaum, MD, MBA, MSc, FCPP, is an Assistant Professor of Medicine in the Division of Translational Medicine & Human Genetics at the University of Pennsylvania, the Co-Founder & Executive Director of the Castleman Disease Collaborative Network (CDCN), Associate Director, Patient Impact of the University of Pennsylvania's Orphan Disease Center, and Senior Fellow of the Leonard Davis Institute for Health Economics.

Dr. Fajgenbaum leads the Castleman Research Program at Penn as PI of 18 translational research studies, including an international natural history study and the first-ever NIH R01 grant studying iMCD. His published research has changed the way idiopathic multicentric Castleman disease (iMCD) is researched and treated. He is also an iMCD patient himself, who is in his longest remission ever thanks to a precision treatment that he identified, which had never been used before for iMCD.

Dr. Fajgenbaum co-founded the CDCN in 2012 to accelerate research and treatments for Castleman disease through a 'Collaborative Network Approach,' a business-inspired approach to biomedical research, which has become a bluprint for other rare diseases.

Dr. Fajgenbaum is also the Co-Founder of the National Students of AMF Support Network, a non-profit organization dedicated to supporting grieving college students. AMF has reached 3,000+ students on 200+ college campuses nationwide. He co-authored "We Get It: Voices of Grieving College Students and Young Adults," a book for grieving college students and those who wish to support them.

Dr. Fajgenbaum’s work has been highlighted by the New York Times, Science, Today Show, Reader's Digest, Forbes Magazine (2015 30 Under 30 Healthcare list), College of Physicians of Philadelphia (inducted as a Fellow in 2016), Everylife Foundation (2016 RareVoice: Federal Advocacy Award from Rare Disease Legislative Advocates), Global Genes (2015 RARE Champion of Hope: Science award by Global Genes), and the University of Colorado (2013 Distinguished Service Award).

Dr. Fajgenbaum received his MBA from The Wharton School, where he was awarded the Joseph Wharton Award, Core Value Leadership Award, Kissick Scholarship, Eilers Health Care Management Award, Mandel Fellowship, and Commencement Speaker. Dr. Fajgenbaum earned his MD from the Raymond & Ruth Perelman School of Medicine at the University of Pennsylvania, where he was a 21st Century Gamble Scholar. He studied for an MSc in Public Health from the University of Oxford as the 2007 Joseph L. Allbritton Scholar. He received a BS in Human Sciences with Distinction from Georgetown University, where he was USA Today Academic All-USA First Team.

Description of Research Expertise

Dr. Fajgenbaum holds expertise related to Castleman disease and other hematologic, oncologic and inflammatory diseases. He is also an expert regarding orphan and hematology/oncology drug development, translational research, health care/social entrepreneurship, health policy/public health, bereavement, college student mental health and non-profit development.

Selected Publications

Sheila K. Pierson, Aaron J. Stonestrom, Dustin Shilling, Jason Ruth, Christopher S. Nabel, Amrit Singh, Yue Ren, Katie Stone, Hongzhe Li, Frits van Rhee, David C. Fajgenbaum: Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease. American Journal of Hematology. 2018 [epub ahead of print]

Eric Oksenhendler, David Boutboul, David C. Fajgenbaum, Adrien Mirouse, Claire Fieschi, Marion Malphettes, Laetitia Vercellino, Véronique Meignin, Laurence Gérard, Lionel Galicier: The full spectrum of Castleman Disease: 273 patients studied over 20 years. British Journal of Hematology. 180(2): 206-216, 2018.

Fatemah Behnia, Saeed Elojeimy, Manuela Matesan, David C. Fajgenbaum: Potential value of FDG PET-CT in diagnosis and follow-up of TAFRO syndrome. Annals of Hematology. 96(3): 497-500, 2017.

Li Yu, Meifeng Tu, Jorge Cortes, Zijun Y. Xu-Monette, Roberto N. Miranda, Jun Zhang, Robert Z. Orlowski, Sattva Neelapu, Prajwal C. Boddu, Mary A. Akosile, Thomas S. Uldrick, Robert Yarchoan, L. Jeffrey Medeiros, Yong Li, David C. Fajgenbaum, Ken H. Young: Clinical and pathological characteristics of HIV- and HHV8- negative Castleman disease. Blood. 129(12): 1658-1668, 2017.

Céline Louis, Sandrine Vijgen, Kaveh Samii, Yves Chalandon, Louis Terriou, David Launay, David C. Fajgenbaum, Jörg D. Seebach, Yannick D. Muller: TAFRO Syndrome in Caucasians: A Case Report and Review of the Literature. Frontiers in Medicine. 4: 149, 2017.

David C. Fajgenbaum, Thomas S. Uldrick, Adam Bagg, Dale Frank, David Wu, Gordan Srkalovic, David Simpson, Amy Y. Liu, David Menke, Shanmuganathan Chandrakasan, Mary Jo Lechowicz, Raymond S.M. Wong, Sheila Pierson, Michele Paessler, Jean-François Rossi, Makoto Ide, Jason Ruth, Michael Croglio, Alexander Suarez, Vera Krymskaya, Amy Chadburn, Gisele Colleoni, Sunita Nasta, Raj Jayanthan, Christopher S. Nabel, Corey Casper, Angela Dispenzieri, Alexander Fosså, Dermot Kelleher, Razelle Kurzrock, Peter Voorhees, Ahmet Dogan, Kazuyuki Yoshizaki, Frits van Rhee, Eric Oksenhendler, Elaine S. Jaffe, Kojo S.J. Elenitoba-Johnson, Megan S. Lim: International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease. Blood. 129(12): 1646-1657, 2017.

Noriko Iwaki, David C. Fajgenbaum, Christopher S. Nabel, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Isao Yoshida, Hiroshi Moro, Koji Nikkuni, Kazue Takai, Kosei Matsue, Mitsutoshi Kurosawa, Masao Hagihara, Akio Saito, Masataka Okamoto, Kenji Yokota, Shinichiro Hiraiwa, Naoya Nakamura, Shinji Nakao, Tadashi Yoshino, Yasuharu Sato: Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease. American Journal of Hematology. 91(2): 220-226, 2016.

Amy Y. Liu, Christopher S. Nabel, Brian S. Finkelman, Jason R. Ruth, Razelle Kurzrock, Frits van Rhee, Vera P. Krymskaya, Dermot P. Kelleher, Arthur H. Rubenstein, David C. Fajgenbaum: Idiopathic Multicentric Castleman's Disease: A Systematic Literature Review. The Lancet Haematology. 3(4): 163-175, 2016.

David C. Fajgenbaum, Frits van Rhee, Adnan Nasir, Misha Rosenbach, Jason Reutter: Eruptive Cherry Hemangiomatosis associated with Multicentric Castleman’s Disease: A Case Report and possible Mechanism. JAMA Dermatology. 149(2): 204-208, 2013.

David C. Fajgenbaum, Ben Chesson, Robin Lanzi: Building a Network of Grief Support on College Campuses: A National Grassroots Initiative. The Journal of College Student Psychotherapy. 26(2): 99-120, 2012.

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Last updated: 07/05/2018
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