Ulf H Beier, MD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Abramson Research Center, Room 916-C
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: (215) 590 2449
Lab: (267) 426 5407
Education:
MD
Christian Albrechts University of Kiel, Germany, 2004.
Dr. med.
Christian Albrechts University of Kiel, Germany, 2004.
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Description of Research Expertise

T cell metabolism
Transplant Immunology
Regulatory T cells

Selected Publications

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Dent SYR, Hancock WW: GCN5 and PCAF have complementary roles in Foxp3+ T-regulatory cells and their dual loss leads to lethal autoimmunity. Cancers (Basel) 11(4): 554, April 2019.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB: Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Science Translational Medicine 11(1): eaat1500, February 2019.

Lieber Arnon D, Beier Ulf H, Xiao Haiyan, Wilkins Benjamin J, Jiao Jing, Li Xinmin S, Schugar Rebecca C, Strauch Christopher M, Wang Zeneng, Brown J Mark, Hazen Stanley L, Bokulich Nicholas A, Ruggles Kelly V, Akimova Tatiana, Hancock Wayne W, Blaser Martin J: Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB journal 33(1): 1098-1109, Jan 2019.

Chadha S, Wang L, Hancock WW, Beier UH: Sirtuin-1 in Immunotherapy: A Janus-headed target. Journal of Leukocyte Biology 106(2): 337-343, Jan 2019.

Mandapathil M, Beier UH, Graefe H, Kröger B, Hedderich J, Maune S, Meyer JE.: Differential chemokine expression patterns in tonsillar disease. Acta Otorhinolaryngol Ital. 38: 316-322, August 2018.

Wang L, Beier UH, Akimova T, Dahiya S, Han R, Samanta A, Levine MH, Hancock WW: Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation. Am J Transplant 18(7): 1596-1603, Jul 2018.

Ulf H Beier, William J Quinn, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Wayne W Hancock, Evgeniy B Eruslanov, Joshua D Rabinowitz, Joseph A Baur: Nicotinamide adenine dinucleotide (NAD) oxidation preserves T cell function under lactic acidosis characteristic of the tumor microenvironment (TME). J Immunol 200(1 Supplement): 177.4-177.4, May 2018.

Ulf H Beier, William J Quinn, Jing Jiao, Tara TeSlaa, Satinder Dahiya, Zhonglin Wang, Matthew H Levine, Wayne W Hancock, Joshua D Rabinowitz, Joseph A Baur: Immunosuppression reverse engineered from cancer: Reducing nicotinamide adenine dinucleotide (NAD) impairs effector T cell function through glycolysis. J Immunol 200(1 Supplement): 55.27-55.27, May 2018.

Tatiana Akimova, Tianyi Zhang, Ulf H Beier, Jing Jiao, Joshua M Diamond, Jason D Christie, Rebecca A Simmons, Wayne W Hancock: Obesity-driven IL-18 inhibits the suppressive function of FOXP3+ T-regulatory (Treg) cells. J Immunol 200(1 Supplement): 66.52-166.52, May 2018.

Dahiya S, Wang L, Beier UH, Han R, Hancock WW.: HDAC10 Targeting Regulates Foxp3 Promoter, Enhances T-regulatory (Treg) Function and Suppresses Autoimmune Colitis. J Immunol 200(1 Supplement), May 2018.

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Last updated: 02/19/2021
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