Ulf H Beier, MD
Adjunct Associate Professor of Pediatrics (Nephrology)
Department: Pediatrics
Graduate Group Affiliations
Contact information
The Children's Hospital of Philadelphia
Abramson Research Center, Room 916-C
3615 Civic Center Boulevard
Philadelphia, PA 19104
Abramson Research Center, Room 916-C
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: (215) 590 2449
Lab: (267) 426 5407
Lab: (267) 426 5407
Email:
beieru@email.chop.edu
beieru@email.chop.edu
Publications
Education:
Dr. med.
Christian Albrechts University of Kiel, Germany, 2004.
MD
Christian Albrechts University of Kiel, Germany, 2004.
Permanent linkDr. med.
Christian Albrechts University of Kiel, Germany, 2004.
MD
Christian Albrechts University of Kiel, Germany, 2004.
Description of Research Expertise
T cell metabolismTransplant Immunology
Regulatory T cells
Selected Publications
Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Dent SYR, Hancock WW: GCN5 and PCAF have complementary roles in Foxp3+ T-regulatory cells and their dual loss leads to lethal autoimmunity. Cancers (Basel) 11(4): 554, April 2019.Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB: Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Science Translational Medicine 11(1): eaat1500, February 2019.
Lieber Arnon D, Beier Ulf H, Xiao Haiyan, Wilkins Benjamin J, Jiao Jing, Li Xinmin S, Schugar Rebecca C, Strauch Christopher M, Wang Zeneng, Brown J Mark, Hazen Stanley L, Bokulich Nicholas A, Ruggles Kelly V, Akimova Tatiana, Hancock Wayne W, Blaser Martin J: Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB journal 33(1): 1098-1109, Jan 2019.
Chadha S, Wang L, Hancock WW, Beier UH: Sirtuin-1 in Immunotherapy: A Janus-headed target. Journal of Leukocyte Biology 106(2): 337-343, Jan 2019.
Mandapathil M, Beier UH, Graefe H, Kröger B, Hedderich J, Maune S, Meyer JE.: Differential chemokine expression patterns in tonsillar disease. Acta Otorhinolaryngol Ital. 38: 316-322, August 2018.
Wang L, Beier UH, Akimova T, Dahiya S, Han R, Samanta A, Levine MH, Hancock WW: Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation. Am J Transplant 18(7): 1596-1603, Jul 2018.
Ulf H Beier, William J Quinn, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Wayne W Hancock, Evgeniy B Eruslanov, Joshua D Rabinowitz, Joseph A Baur: Nicotinamide adenine dinucleotide (NAD) oxidation preserves T cell function under lactic acidosis characteristic of the tumor microenvironment (TME). J Immunol 200(1 Supplement): 177.4-177.4, May 2018.
Ulf H Beier, William J Quinn, Jing Jiao, Tara TeSlaa, Satinder Dahiya, Zhonglin Wang, Matthew H Levine, Wayne W Hancock, Joshua D Rabinowitz, Joseph A Baur: Immunosuppression reverse engineered from cancer: Reducing nicotinamide adenine dinucleotide (NAD) impairs effector T cell function through glycolysis. J Immunol 200(1 Supplement): 55.27-55.27, May 2018.
Tatiana Akimova, Tianyi Zhang, Ulf H Beier, Jing Jiao, Joshua M Diamond, Jason D Christie, Rebecca A Simmons, Wayne W Hancock: Obesity-driven IL-18 inhibits the suppressive function of FOXP3+ T-regulatory (Treg) cells. J Immunol 200(1 Supplement): 66.52-166.52, May 2018.
Dahiya S, Wang L, Beier UH, Han R, Hancock WW.: HDAC10 Targeting Regulates Foxp3 Promoter, Enhances T-regulatory (Treg) Function and Suppresses Autoimmune Colitis. J Immunol 200(1 Supplement), May 2018.