Derek Alan Oldridge, M.D., Ph.D.
Assistant Professor of Pathology and Laboratory Medicine
Assistant Director, Immunogenetics Laboratory, Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104
Email:
oldridged@chop.edu
oldridged@chop.edu
Education:
B.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.
Permanent linkB.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.
Description of Clinical Expertise
HistocompatibilityImmunogenetics
Molecular Pathology
Clinical Pathology
Description of Research Expertise
BioinformaticsCancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics
Selected Publications
Shankar N, Kreiger PA, Oldridge DA, Picarsic J, Arnold MA: Digital Pathology and Artificial Intelligence in Pediatric Pathology. Surgical Pathology Clinics Dec 2024 Notes: DOI: 10.1016/j.path.2024.11.006.Yu WW, Barrett JNP, Tong J, Lin MJ, Marohn M, Devlin JC, Herrera A, Remark J, Levine J, Liu PK, Fang V, Zellmer AM, Oldridge DA, Wherry EJ, Lin JR, Chen JY, Sorger P, Santagata S, Krueger JG, Ruggles KV, Wang F, Su C, Koralov SB, Wang J, Chiu ES, Lu CP.: Skin immune-mesenchymal interplay within tertiarylymphoid structures promotes autoimmunepathogenesis in hidradenitis suppurativa. Immunity 57: 2827-2842, Dec 2024.
Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, Nandi A, Anderson S, Han N, Manne S, Kiner E, Sachar C, Lucas M, George S, Yan PK, Kier MW, Laughlin AI, Kothari S, Giles J, Mathew D, Ghinnagow R, Alanio C, Flowers A, Xu W, Tenney DJ, Xu X, Amaravadi RK, Karakousis GC, Schuchter LM, Buggert M, Oldridge D, Minn AJ, Blank C, Weber JS, Mitchell TC, Farwell MD, Herati RS, Huang AC.: Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8(+) T cells. Cancer Cell 42: 1582-1597, Sep 2024.
Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K.: Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. Cell 187(12): 3120-3140, Jun 2024 Notes: doi: 10.1016/j.cell.2024.04.013.
Bandyopadhyay S, Duffy M, Ahn KJ, Pang M, Smith D, Duncan G, Sussman J, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K.: Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging. bioRxiv Mar 2024 Notes: 10.1101/2024.03.14.585083.
Sussman JH*, Oldridge DA*, Yu W*, Chen CH, Zellmer AM, Rong J, Parvaresh-Rizi A, Thadi A, Xu J, Bandyopadhyay S, Sun Y, Wu D, Hunter CE, Brosius S, Ahn KJ, Baxter AE, Koptyra MP, Vanguri RS, McGrory S, Resnick AC, Storm PB, Amankulor NM, Santi M, Viaene AN, Zhang N, Raedt T, Cole K, Tan K.: A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma. bioRxiv Mar 2024 Notes: doi: 10.1101/2024.03.06.583588.
Nabbi A, Beck P, Delaidelli A, Oldridge DA, Sudhaman S, Zhu K, Yang SYC, Mulder DT, Bruce JP, Paulson JN, Raman P, Zhu Y, Resnick AC, Sorensen PH, Sill M, Brabetz S, Lambo S, Malkin D, Johann PD, Kool M, Jones DTW, Pfister SM, Jäger N, Pugh TJ: Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours. Genome Med 15(1), Sep 2023 Notes: doi: 10.1186/s13073-023-01219-x.
Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT.: Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. J Clin Invest 133(10), May 2023.
Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA.: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Sci Immunol 8(83), May 2023 Notes: doi: 10.1126/sciimmunol.ade2335.
Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N.: Human T follicular helper clones seed the germinal center-resident regulatory pool. Sci Immunol 8(82), Apr 2023 Notes: doi: 10.1126/sciimmunol.ade8162.