Derek Alan Oldridge, M.D., Ph.D.
Assistant Professor of Pathology and Laboratory Medicine
Assistant Director, Immunogenetics Laboratory, Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104
Email:
oldridged@chop.edu
oldridged@chop.edu
Education:
B.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.
Permanent linkB.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.
Description of Clinical Expertise
HistocompatibilityImmunogenetics
Molecular Pathology
Clinical Pathology
Description of Research Expertise
BioinformaticsCancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics
Selected Publications
Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT.: Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. J Clin Invest 133(10), May 2023.Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA.: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Sci Immunol 8(83), May 2023.
Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N.: Human T follicular helper clones seed the germinal center-resident regulatory pool. Sci Immunol 8(82), Apr 2023.
Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT.: Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State. bioRxiv Mar 2023.
Alanio C, Verma A, Mathew D, Gouma S, Liang G, Dunn T, Oldridge DA, Weaver J, Kuri-Cervantes L, Pampena MB, Betts MR, Collman RG, Bushman FD, Meyer NJ, Hensley SE, Rader D, Wherry EJ; UPenn COVID Processing Unit: Cytomegalovirus Latent Infection is Associated with an Increased Risk of COVID-19-Related Hospitalization. J Infect Dis 226(3): 463-473, Aug 2022 Notes: doi: 10.1093/infdis/jiac020.
Goel RR, Painter MM, Lundgreen KA, Apostolidis SA, Baxter AE, Giles JR, Mathew D, Pattekar A, Reynaldi A, Khoury DS, Gouma S, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Kc W, Oldridge DA, Erickson RI, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, Drapeau EM, Davenport MP, Hensley SE, Bates P, Greenplate AR, Wherry EJ: Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine. Cell 185(11): 1875-1887, May 2022 Notes: doi: 10.1016/j.cell.2022.04.009.
Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Huang AC, Shi J, Wherry EJ: Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. Immunity 55(3): 557-574, Mar 2022 Notes: doi: 10.1016/j.immuni.2022.02.004.
Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ: Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. Front Immunol 13: 834988, Mar 2022 Notes: doi: 10.3389/fimmu.2022.834988.
Goel RR, Painter MM, Lundgreen KA, Apostolidis SA, Baxter AE, Giles JR, Mathew D, Pattekar A, Reynaldi A, Khoury DS, Gouma S, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Kc W, Oldridge DA, Erickson RI, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, Drapeau EM, Davenport MP, Hensley SE, Bates P, Greenplate AR, Wherry EJ: Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine. bioRxiv Feb 2022 Notes: doi: 10.1101/2022.02.20.481163.
Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ: mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science 374(6572): abm0829, Dec 2021 Notes: doi: 10.1126/science.abm0829.