David John Irwin, MD

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Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
Department: Neurology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Department of Neurology
3400 Spruce Street, 3 W Gates
Philadelphia, Pa 19104
Drew University, 2001.
Drexel University College of Medicine, 2006.
University of Pennsylvania Perelman School of Medicine, 2015.
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Description of Clinical Expertise

My clinical focus is on cognitive neurology and neurodegenerative disease including frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. I have a particular interest in young-onset dementia and the behavioral variant of frontotemporal dementia.

Description of Other Expertise

Research Interests: Neuropathology of Neurodegenerative Disease.

Keywords: Neuropathology, Digital Pathology, Biomarkers, Frontotemporal degeneration, Primary progressive aphasia, Amyotrophic lateral sclerosis, Lewy body disorders, Parkinson's disease, Alzheimer's disease, tau, amyloid-beta, alpha-synuclein, TDP-43.

Research Details: We use novel quantitative approach to histopathological studies to relate postmortem measures of disease to antemortem imaging and biofluid biomarkers to improve the antemortem diagnosis of neurodegenerative disease. Techniques and skills include neuropathology, gross anatomy and microanatomy, immunohistochemistry, digital image analysis, advanced patient classification statistics.

Rotation projects: Quantification of neuron loss and gliosis in neurodegenerative disease, Distribution of TDP-43 pathology across the spectrum of ALS and FTLD-TDP, Distribution of tau and amyloid-beta in non-amnestic Alzheimer's disease patients.

Lab Personnel: Mendy Liang- research assistant, Andrew Williams- research assistant, Lucia Giannini- visiting scholar, David Coughlin- ITMAT fellow, Simon Miller- Penn PURM researcher.

Description of Research Expertise

My research program focuses on the interface of clinical symptoms and underlying neuropathology in neurodegenerative disease. The purpose of this approach is to better identify clinically, pathologically and genetically homogeneous patient populations for inclusion into clinical trials to efficiently study emerging disease modifying treatments that target the pathogenic proteins specific for each neuropathological subtype of disease (e.g. FTLD-associated with tau or TDP-43 protein inclusions).

Selected Publications

Irwin David J, Lleó Alberto, Xie Sharon X, McMillan Corey T, Wolk David A, Lee Edward B, Van Deerlin Viviana M, Shaw Leslie M, Trojanowski John Q, Grossman Murray: Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration. Annals of neurology 82(2): 247-258, Aug 2017.

Irwin David J, Grossman Murray, Weintraub Daniel, Hurtig Howard I, Duda John E, Xie Sharon X, Lee Edward B, Van Deerlin Vivianna M, Lopez Oscar L, Kofler Julia K, Nelson Peter T, Jicha Gregory A, Woltjer Randy, Quinn Joseph F, Kaye Jeffery, Leverenz James B, Tsuang Debby, Longfellow Katelan, Yearout Dora, Kukull Walter, Keene C Dirk, Montine Thomas J, Zabetian Cyrus P, Trojanowski John Q: Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology 16(1): 55-65, Jan 2017.

Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M and Trojanowski JQ: Deep Clinical and Neuropathological Phenotyping of Pick’s Disease. Annals of Neurology 79(2): 272-87, 2016.

Irwin, DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VMY, Grossman M, Trojanowski JQ. : Semi-automated digital image analysis of Pick’s disease and TDP-3 proteinopathy. Journal of Histochemistry & Cytochemistry 64(1): 54-66, Jan 2016.

Irwin DJ, Cohen T, Grossman M, Arnold S, Xie S, Lee V, Trojanowski JQ: Acetylated Tau, a Novel Pathological Signature in Alzheimer’s disease and Other Tauopathies. Brain 135(3): 807-818, 2011.

Irwin DJ, White M, Toledo J, Robinson J, Xie S, Leverenz JB, Montine TJ, Duda J, Hurtig HI, Trojanowski JQ: Neuropathologic substrates of Parkinson’s disease dementia. Ann Neurol 72: 587-598, 2012.

Irwin DJ, McMillian CT, Brettschneider J, Libon DJ, Powers J, Rascovsky K, Toledo JB, Boller A, Bekisz J, Chandrasekaran K, Wood B, Shaw LM, Woo JH, Cook PA, Wolk D, Arnold SE, VanDeerlin V, Elman L, McCluskey L, Lee VMY, Trojanowski JQ, Grossman M: Cognitive decline and reduced survival in C9orf72 expansion Frontotemporal degeneration and Amyotrophic lateral sclerosis. J Neurol Neurosurg Psych 84(2): 163-169, 2013.

Irwin DJ, Abrams JY, Schoenberger LB, Leschek EW, Mills JL, Lee VMY and Trojanowski JQ: Evaluation of potential infectivity of Alzheimer’s disease and Parkinson’s disease proteins in recipients of cadaver-derived human growth hormone. JAMA Neurol 70(4): 462-8, 2013.

Irwin DJ, Lee VMY and Trojanowski JQ: Parkinson’s disease dementia: convergence of alpha synuclein, tau and amyloid-β pathologies. Nat Rev Neurosci 14(9): 626-36, 2013.

Irwin DJ, McMillan CT, Suh E, powers J, Rascovsky K, Wood EM, Toledo JB, Arnold SE, Lee V M.-Y., Van Deerlin V.M., Trojanowski J.Q., and Grossman M. : Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Neurology 83(6): 502-9, 2014.

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Last updated: 11/10/2017
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