Avery D Posey, PhD

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Assistant Professor of Pharmacology
Instructor, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine
Research Health Specialist, Corporal Michael J. Crescenz VA Medical Center
Director, Diversity and Inclusion, Center for Cellular Immunotherapy, Perelman School of Medicine, University of Pennsylvania
Department: Systems Pharmacology and Translational Therapeutics

Contact information
PCAM SPE 8-106
3400 Civic Center Blvd.
Philadelphia, PA 19104
B.S. (Bioinformatics and Computational Biology)
University of Maryland, Baltimore County (UMBC), Baltimore, MD, 2005.
B.S. (Biochemistry and Molecular Biology)
University of Maryland, Baltimore County (UMBC), Baltimore, MD, 2005.
PhD (Genetics)
The University of Chicago, Chicago, IL, 2011.
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Selected Publications

Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr: Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell 40: 1470-1487, Dec 2022.

Ferguson ID, Patino-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Vasquez WN, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG III, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr., Mullins RD, Eyquem J, Wells JA, and Wiita AP: The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nature Communications 13(1): 4121, July 2022.

Derosiers N, Aguilar W, DeGaramo DA, Posey AD Jr.: Sweet Immune Checkpoint Targets to Enhance T Cell Therapy. J Immunol 208: 278-285, Jan 2022.

Keane JT, Posey AD Jr.: Chimeric Antigen Receptors Expand the Repertoire of Antigenic Macromolecules for Cellular Immunity. Cells 10: 3356, Nov 2021.

King-Peoples TR, Posey AD Jr.: Splitting signals drives CARs further. Nat Cancer 2(9): 873-875, September 2021.

Bear AS, Blanchard T, Cesare J, Ford MJ, Richman LP, Xu C, Baroja ML, McCuaig S, Costeas C, Gabunia K, Scholler J, Posey AD Jr, O'Hara MH, Smole A, Powell DJ Jr, Garcia BA, Vonderheide RH, Linette GP, Carreno BM.: Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting. Nat Commun 12: 4365, Jul 2021.

Douglas, B., Oyesola, O., Cooper, M.M., Posey, A., Tait Wojno, E., Giacomin, P.R., Herbert, D.R.: Immune System Investigation Using Parasitic Helminths. Annu Rev Immunol 39: 639-665, Apr 2021.

Annabi, N., Baker, M., Boettiger, A., Chakraborty, D., Chen, Y., Corbett, K.S., Correia, B., Dahlman, J., de Oliviera, T., Ertuerk, A., Yanik, M.F., Henaff, E., Huch, M., Iliev, I.D., Jacobs, T., Junca, H., Keung, A., Kolodkin-Gal, I., Krishnaswamy, S., Lancaster, M., Macosko, E., Martinez-Nunez, M.A., Miura, K., Molloy, J., Cruz, A.O., Platt, R.J., Posey, A.D. Jr., Shao, H., Simunovic, M., Slavov, N., Takebe, T., Vandenberghe, L.H., Varshney, R.K., Wang, J.: Voices of biotech research. Nat Biotechnology Mar 2021.

Wellhausen, N., Aguilar, A., Posey, A.D. Jr.: Glycans as Targets and Mediators of T-Cell Immunotherapy. Comprehensive Glycoscience (Second Edition) 5: 508-518, January 2021.

Schwab RD, Bedoya DM, King TR, Levine BL, Posey AD Jr.: Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies. Methods Mol Biol 2086: 203-211, November 2020.

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Last updated: 12/19/2022
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