Melanie Ruffner, MD, PhD
Assistant Professor of Pediatrics (Allergy/Immunology)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children’s Hospital of Philadelphia
Division of Allergy and Immunology
3615 Civic Center Blvd.
Abramson Research Center, 1202C
Philadelphia, PA 19104
Division of Allergy and Immunology
3615 Civic Center Blvd.
Abramson Research Center, 1202C
Philadelphia, PA 19104
Office: 2155902549
Fax: 2155906849
Lab: 2674253074
Fax: 2155906849
Lab: 2674253074
Publications
Education:
B.S. (Biomedical Engineering)
Johns Hopkins University, 2003.
Ph.D. (Bioengineering)
University of Pittsburgh School of Medicine, 2009.
M.D. (Medicine)
University of Pittsburgh School of Medicine, 2011.
M.S. (Translational Research)
University of Pennsylvania School of Medicine, 2020.
Permanent linkB.S. (Biomedical Engineering)
Johns Hopkins University, 2003.
Ph.D. (Bioengineering)
University of Pittsburgh School of Medicine, 2009.
M.D. (Medicine)
University of Pittsburgh School of Medicine, 2011.
M.S. (Translational Research)
University of Pennsylvania School of Medicine, 2020.
Selected Publications
Ruffner MA*, Shoda T*, Lal M, Mrozek Z, Muir AB, Spergel JM, Dellon ES, Rothenberg ME (*contributed equally): Persistent esophageal changes after histologic remission in eosinophilic esophagitis. J Allergy Clin Immunol 153(4): 1063-1072, Apr 2024.Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM: Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Ann Allergy Asthma Immunol 128(5): 589-593, May 2022.
Tran P, Gober L, Garabedian EK, Fuleihan RL, Puck JM, Sullivan KE, Spergel JM, Ruffner MA: Eosinophilic gastrointestinal disorders in patients with inborn errors of immunity: Data from the USIDNET registry. Front Immunol 13(987895): doi: 10.3389, Sep 2022 Notes: epub.
Ruffner MA*, Hu A*, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K (*contributed equally): Conserved interferon signature in adult and pediatric eosinophilic esophagitis. Journal of Immunology 206(6): 1361-1371, Mar 2021.
Benitez AJ, Bittinger K, Tanes C, Hofstaedter CE, Kim DK, Gross J, Ruffner MA, Albenberg L, Spergel JM, Muir AB: Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis. Allergy 76(5): 1549-1552, May 2021.
Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni C, Sullivan KE, Spergel JS: RNA sequencing identifies global transcriptional changes in peripheral CD4 + cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Clin Transl Immunology 10(7): e1314, July 2021.
Ruffner MA, Song L, Mauer K, Shi L, Wang JX, Muir AB, Spergel JM, Sullivan KE: Toll like receptor 2 stimulation augments esophageal barrier integrity Allergy 74(12): 2449-2460, Dec 2019.
Ruffner MA, Wang KY, Dudley JW, Cianferoni A, Grundemeier R, Spergel JM, Brown-Whitehorn TF, Hill DA: Elevated Allergic Comorbidity in Patients with Food Protein-Induced Enterocolitis. J Allergy Clin Immunol Pract 8(3): 1039-1046, Mar 2020.
Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. : Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract 7(6): 2059-2061, Jul 2019.
Wang KY, Lee J, Cianferoni A, Ruffner MA, Dean A, Molleston JM, Pawlowski NA, Heimall J, Saltzman RW, Ram GS, Fiedler J, Gober LM, Spergel JM, Brown-Whitehorn TF: Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. J Allergy Clin Immunol Pract. 7(2): 444-450, Sept 2018.