Melanie Ruffner, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children’s Hospital of Philadelphia
Division of Allergy and Immunology
3401 Civic Center Blvd.
Wood Building, 3rd floor
Philadelphia, PA 19104
Office: 2155902549
Fax: 2155906849
Lab: 2155904685
B.S. (Biomedical Engineering)
Johns Hopkins University, 2003.
Ph.D. (Bioengineering)
University of Pittsburgh, 2009.
M.D. (Medicine)
University of Pittsburgh, 2011.
M.S. (Translational Research)
University of Pennsylvania, 2020.
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Selected Publications

Ruffner MA, Juste L, Muir AB: Medical Management of Eosinophilic Esophagitis in Pediatric Patients. Pediatr Clin North Am 68(6): 1191-1204, Dec 2021.

Ruffner MA, Cotton C, Dellon ES: Post-treatment gene scores support histologic and endoscopic response thresholds in eosinophilic esophagitis American College of Gastroenterology Annual Meeting, Las Vegas, NV October 2021.

Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni C, Sullivan KE, Spergel JS: RNA sequencing identifies global transcriptional changes in peripheral CD4 + cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Clin Transl Immunology 10(7): e1314, July 2021.

Ruffner MA, Brown-Whitehorn TF, Spergel JM: CON: Peripheral intravenous access should always be secured before initiating food protein-induced enterocolitis syndrome oral food challenge. Ann Allergy Asthma Immunol 126(5): 462-463, May 2021.

Benitez AJ, Bittinger K, Tanes C, Hofstaedter CE, Kim DK, Gross J, Ruffner MA, Albenberg L, Spergel JM, Muir AB. : Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis. Allergy 76(5): 1549-1552, May 2021.

Ruffner MA*, Hu A*, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K. *contributed equally: Conserved interferon signature in adult and pediatric eosinophilic esophagitis. Journal of Immunology 206(6): 1361-1371, Mar 2021.

Ruffner MA, Carroll MC, Meline M, Sullivan KE, Spergel JM, Sleiman PM: Integrative analysis of eosinophilic esophagitis genome-wide association study single nucleotide polymorphisms. AAAAI 2021 Annual Meeting Feb 2021.

Ruffner MA, Spergel JM, Cianferoni A, Brown-Whitehorn TF: Reply to "Oral food challenge protocol for food protein-induced enterocolitis syndrome: time for a change?" JACI In Practice 8(8): 2843-2844, Sep 2020

Chiang AWT, Duong LD, Shoda T, Nhu QM, Ruffner M, Hara T, Aaron B, Joplin E, Manresa M, Abonia JP, Dellon E, Hirano I, Gonsalves N, Gupta S, Furuta G, Rothenberg ME, Lewis NE, Muir AB, Aceves SS; CEGIR Investigator Group.: Type 2 immunity and age modify gene expression of COVID19 receptors in eosinophilic GI disorders. J Pediatr Gastrerol Nutr Dec 2020.

Ruffner MA, Carroll MC, Meline M, Sullivan KE, Spergel JM, Sleiman PM: Analysis of Genetic Variation, Gene and Protein Expression in Eosinophilic Esophagitis. Midatlantic Bioinformatics Conference Nov 2020.

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Last updated: 11/09/2021
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