Melanie Ruffner, MD, PhD

faculty photo
Assistant Professor of Pediatrics (Allergy/Immunology)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children’s Hospital of Philadelphia
Division of Allergy and Immunology
3615 Civic Center Blvd.
Abramson Research Center, 1202C
Philadelphia, PA 19104
Office: 2155902549
Fax: 2155906849
Lab: 2674253074
B.S. (Biomedical Engineering)
Johns Hopkins University, 2003.
Ph.D. (Bioengineering)
University of Pittsburgh, 2009.
M.D. (Medicine)
University of Pittsburgh, 2011.
M.S. (Translational Research)
University of Pennsylvania, 2020.
Permanent link
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Selected Publications

Ruffner MA*, Shoda T*, Lal M, Mrozek Z, Muir AB, Spergel JM, Dellon ES, Rothenberg ME (*contributed equally): Persistent esophageal changes after histologic remission in eosinophilic esophagitis. J Allergy Clin Immunol 153(4): 1063-1072, Apr 2024.

Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM: Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Ann Allergy Asthma Immunol 128(5): 589-593, May 2022.

Tran P, Gober L, Garabedian EK, Fuleihan RL, Puck JM, Sullivan KE, Spergel JM, Ruffner MA: Eosinophilic gastrointestinal disorders in patients with inborn errors of immunity: Data from the USIDNET registry. Front Immunol 13(987895), Sep 2022 Notes: doi: 10.3389/fimmu.2022.987895.

Ruffner MA*, Hu A*, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K (*contributed equally): Conserved interferon signature in adult and pediatric eosinophilic esophagitis. Journal of Immunology 206(6): 1361-1371, Mar 2021.

Benitez AJ, Bittinger K, Tanes C, Hofstaedter CE, Kim DK, Gross J, Ruffner MA, Albenberg L, Spergel JM, Muir AB: Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis. Allergy 76(5): 1549-1552, May 2021.

Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni C, Sullivan KE, Spergel JS: RNA sequencing identifies global transcriptional changes in peripheral CD4 + cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Clin Transl Immunology 10(7): e1314, July 2021.

Ruffner MA, Song L, Mauer K, Shi L, Wang JX, Muir AB, Spergel JM, Sullivan KE: Toll like receptor 2 stimulation augments esophageal barrier integrity Allergy 74(12): 2449-2460, Dec 2019.

Ruffner MA, Wang KY, Dudley JW, Cianferoni A, Grundemeier R, Spergel JM, Brown-Whitehorn TF, Hill DA: Elevated Allergic Comorbidity in Patients with Food Protein-Induced Enterocolitis. J Allergy Clin Immunol Pract 8(3): 1039-1046, Mar 2020.

Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. : Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract. 7(6): 2059-2061, Jul 2019.

Wang KY, Lee J, Cianferoni A, Ruffner MA, Dean A, Molleston JM, Pawlowski NA, Heimall J, Saltzman RW, Ram GS, Fiedler J, Gober LM, Spergel JM, Brown-Whitehorn TF: Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. J Allergy Clin Immunol Pract. 7(2): 444-450, Sept 2018.

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Last updated: 07/12/2024
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