Paul M. Titchenell, Ph.D.

faculty photo
Assistant Professor of Physiology
Department: Physiology

Contact information
Institute for Diabetes, Obesity, and Metabolism
Smilow Center for Translational Research
3400 Civic Center Blvd, Building 421
Room: 12-104
Philadelphia, PA 19104
Office: 215-573-1872
Lab: 215-573-1875
Education:
B.S. (Biochemistry and Molecular Biology)
Dickinson College, 2008.
Ph.D. (Physiology)
Pennsylvania State University, 2013.
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Description of Research Expertise

Research Interests:
Molecular mechanisms of insulin signaling and insulin resistance

Keywords:
metabolism, insulin, diabetes, obesity, AKT, mTORC1

Research Details:
My research interests are focused on the regulation of metabolism by hormones and nutrients, with a particular emphasis on a master regulator of organismal anabolic metabolism, insulin. Alterations in insulin action underlie metabolic disease and lead to the development of deadly vascular and neuronal complications. Through the use of various techniques encompassing molecular biology, biochemistry, metabolomics, genome-wide transcriptional techniques and whole-animal physiology, the long-term goals of my research program are to decipher the underlying mechanisms driving metabolic deregulation during disease and identify new therapies that improve metabolic control.

Lab personnel:
Matthew Gavin (Research Specialist)
Natasha Jaiswal Ph.D. (Postdoctoral Researcher)
Jaclyn Welles Ph.D. (Postdoctoral Researcher)
Kahea Uehara (PhD student, BMB graduate group)
Jaimarie Sostre (PhD student, CAMB graduate group)
Dominic Santoleri (PhD student, BMB graduate group)
Anna Garcia Whitlock M.D. (PhD student, CAMB graduate group)
Megan Stefkovich, (PhD student, CAMB graduate group)
Jennifer Guo (Penn undergraduate)

Selected Publications

Garcia Whitlock AE, Sostre-Colón J, Gavin M, Martin ND, Baur JA, Sims CA, Titchenell PM.: Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia. Molecular metabolism 51(101246), Sep 2021.

Sostre-Colón J, Uehara K, Garcia Whitlock AE, Gavin MJ, Ishibashi J, Potthoff MJ, Seale P, Titchenell PM.: Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms. Cell reports 35((7):109128): 109128, May 2021.

Jaimarie Sostre-Colón, Kahealani Uehara, Anna E. Garcia Whitlock, Matthew J. Gavin, Jeff Ishibashi, Matthew J. Potthoff, Patrick Seale and Paul M. Titchenell : Liver Insulin Signaling Regulates Adipose Tissue Thermogenesis Via Circulating Fgf21 And Catecholamine-induced Lipolysis. Insulin100 Apr 2021 Notes: Poster Presentation.

Kahealani Uehara, Jaimarie Sostre-Colón, Matthew Gavin, Paul M. Titchenell: Activation of Hepatic mTORC1 Protects Against NASH via Dual Regulation of VLDL- TAG Secretion and De Novo Lipogenesis. Keystone Symposia NAFLD Feb 2021 Notes: Poster Presentation.

Anna E. Garcia Whitlock, Matthew Gavin, Joseph A. Baur, Carrie A. Sims, Paul M. Titchenell : Inhibition of PKA Signaling in the Liver Prevents Stress-induced Hyperglycemia in Trauma. Association for Academic Surgery and Society of University Surgeons Annual Academic Surgical Congress 2021 Notes: Poster Presentation.

Jaiswal J, Gavin M, Loro E, Sostre-Colon J, Roberson P, Uehara K, Fuentes N, Neinast M, Arany Z, Kimball S, Khurana TS, Titchenell PM: AKT controls protein synthesis and oxidative metabolism via combined mTORC1/FOXO1 signaling to govern muscle physiology. Journal of Cachexia, Sarcopenia and Muscle 2021 Notes: Accepted for Publication.

Shen Yachen, Su Yvonne, Silva Francisco J, Weller Angela H, Sostre-Colón Jaimarie, Titchenell Paul M, Steger David J, Seale Patrick, Soccio Raymond E: Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function. Cell reports 30(9): 3079-3091.e5, Mar 2020.

Zhao Steven, Jang Cholsoon, Liu Joyce, Uehara Kahealani, Gilbert Michael, Izzo Luke, Zeng Xianfeng, Trefely Sophie, Fernandez Sully, Carrer Alessandro, Miller Katelyn D, Schug Zachary T, Snyder Nathaniel W, Gade Terence P, Titchenell Paul M, Rabinowitz Joshua D, Wellen Kathryn E: Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 579(7800): 586-591, Mar 2020.

Garcia Whitlock Anna E, Titchenell Paul M: Glutamine Breakdown as a Potential Metabolic Biomarker for Nonalcoholic Steatohepatitis. Cellular and molecular gastroenterology and hepatology Mar 2020.

Angueira Anthony R, Shapira Suzanne N, Ishibashi Jeff, Sampat Samay, Sostre-Colón Jaimarie, Emmett Matthew J, Titchenell Paul M, Lazar Mitchell A, Lim Hee-Woong, Seale Patrick: Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Cell reports 30(9): 2869-2878.e4, Mar 2020.

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Last updated: 11/18/2021
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