Description of Research Expertise

Research Interests:
Molecular mechanisms of insulin signaling, insulin resistance, obesity, diabetes and metabolism

Keywords:
metabolism, insulin, diabetes, obesity, AKT, mTORC1

Research Details:
The Titchenell lab studies the molecular control of metabolism with the goal of identifying new therapeutic targets and approaches to treat metabolic diseases such as diabetes, obesity and cancer. Specifically, the Titchenell laboratory focuses on hormone and nutrient signaling with a particular interest in glucose, fat and protein metabolism. The lab employs a host of cutting-edge technologies in biochemistry, molecular biology and organismal physiology to address fundamental questions in physiology and disease. In addition to his own research program, Dr. Titchenell serves as Director of the Rodent Metabolic Phenotyping Core (RMPC) at Penn. The RMPC's mission is to provide state-of-the-art technologies, expertise and services for diabetes, obesity and metabolism researchers. Please visit the RMPC website to learn more about the services that are available: https://www.med.upenn.edu/idom/drc/cores/rodent.html.

Current Lab personnel:
Matthew Gavin (Research Specialist/Lab manager)
Matthew Harris Ph.D. (Postdoctoral Researcher)
Jaclyn Welles Ph.D. (Postdoctoral Researcher)
Dominic Santoleri (PhD student, BMB graduate group)
Anna Garcia Whitlock M.D/Ph.D. (Resident/Fellow)
Megan Stefkovich,(PhD student, CAMB graduate group)
Libby Nunn (PhD student, CAMB graduate group)
Talia Coopersmith (Penn undergraduate-PURM)
Olivia Ong (Penn undergraduate)