Nicole Maloney Belle, MD, PhD

faculty photo
Assistant Professor of Medicine (Gastroenterology)
Department: Medicine
Graduate Group Affiliations

Contact information
Perelman Center for Advanced Medicine
7 South Pavilion
Philadelphia, PA 19104
Office: 215-349-8222
Education:
BA (Bachelor of Arts)
New York University, 2005.
MD, PhD (Doctor of Medicine, Doctor of Philosophy)
Washington University School of Medicine, 2013.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

My long-term research interest is in the molecular pathways that facilitate cross talk between intestinal epithelial cells and the immune system in order to modulate the outcomes of infections, inflammatory processes and cancer. Specifically, my laboratory focuses on understanding how the epithelial layer repairs itself after injury, how epithelial cells prevent deleterious changes that lead to tumorigenesis in the face of chronic inflammation and how epithelial cells influence the immune landscape.

Selected Publications

Lucas M Ethgen, Christopher Pastore, Cailu Lin, Danielle R Reed, Li-Yin Hung, Bonnie Douglas, Dominic Sinker, De'Broski R Herbert, Nicole M Belle : A Trefoil factor 3- Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection. Mucosal Immunology February 2024.

Nicole Belle, Christopher Pastore, Lucas Ethgen, De'Broski Herbert: LINGO2 expression on T cells promote anti-helminth immunity. DDW 2022 2022.

Zullo, K.M, Douglas, B., Maloney N., Yingbiao J, Yun W, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wenjie W, Somsouk M, Hung L.Y., Lengner C, Kohanksi M.H., Cohen N.A and D. R. Herbert: LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Scand J. Gastroenterology 56(7): 791-805, July 2021.

Nicole M Belle, Christopher Pastore, Erin Jean and De'Broski R Herbert: LINGO2 expression on T cells selectively promotes anti-helminth immunity. Virtual Immunology May 2021 Notes: Accepted for poster presentation.

Nicole Belle: Model System Has Answered Critical Questions. GI & Hepatology News June 2020.

Nicole M Belle, Erin Jean, Joon Park and De’broski Herbert: T cell expression of the transmembrane receptor, LINGO2 controls helminth induced colitis. Mucosal Immunology Course & Symposium January 2020 Notes: Accepted Poster Presentation.

Belle NM, Ji Y, Wei Y, Park J, Srivatsa S, Hung LY, Young T, Herbine K, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR: TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nature Communications 10(1): 4408, Sep 2019.

Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW: Essential cell autonomous role for interferon regulatory factor 1 in interferon-γ-mediated inhibition of norovirus replication in macrophages. J. Virol 86(23): 12655-64, Dec 2012.

Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW : Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma. Cell Host Microbe 11(4): 397-09, Apr 2012.

Hwang S, Maloney NS, Thackray LB, Virgin HW: ATG5 is required for interferon γ to control murine norovirus replication. Autophagy Keystone, Whistler, BC March 2011 Notes: Poster presentation.

back to top
Last updated: 03/11/2024
The Trustees of the University of Pennsylvania