Yvette I. Sheline, M.D.
University of Pennsylvania
Perelman School of Medicine
3700 Hamilton Walk
Richards Building Rm D307
Philadelphia, PA 19104
Yale University, 1975.
Boston University, 1979.
Description of Research ExpertiseMy overall research goal is to identify brain markers of depression and anxiety treatment response across disorders using structural and functional neuroimaging and to improve strategies for brain neuromodulation.
Funded grants include:
1) "Dimensional connectomics of anxious misery"
By acquiring a broad array of behavioral, neurocognitive and imaging measures multiple investigators will be able to test hypotheses about Negative Valence spectrum disorders in a rich database.
2) "Stress and Inflammation in the Pathophysiology of Late-Life Depression"
3) "Elucidating mechanisms of TMS efficacy in neuropsychiatric disorders"
We are using innovative, complementary studies in non-human primates and humans to identify for the first time causal relationships between non-invasive brain stimulation (transcranial magnetic stimulation, or TMS) and changes in neural activity and behavior.
4) "Non-invasive Neuromodulation Mechanism and Dose/Response Metrics"
A comprehensive assay of brain response to TMS will include TMS probe responses as well as resting fMRI recorded before, during, and after application of neuromodulatory TMS.
5) "Novel neural circuit biomarkers of depression response to computer-augmented CBT"
We are using functional and structural magnetic resonance imaging (MRI) to determine novel neural circuit biomarkers of depression treatment response to cognitive behavioral therapy (CBT) augmented by actigraphy and computerized algorithms.
Selected PublicationsYang, Zhen, Oathes, Desmond, Linn, Kristin, Bruce, Steven D., Satterthwaite, Theodore, A. Cook, Philip K. Satchell, Emma Shou, Haochang Sheline, Yvette: Cognitive Behavioral Therapy Is Associated With Enhanced Cognitive Control Network Activity in Major Depression and Posttraumatic Stress Disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2017.
Fortin, J. P., Cullen, N., Sheline, Y. I., Taylor, W. D., Aselcioglu, I., Cook, P. A., . . . Shinohara, R. T. : Harmonization of cortical thickness measurements across scanners and sites. Neuroimage, 2017.
Satterthwaite, T. D., Cook, P. A., Bruce, S. E., Conway, C., Mikkelsen, E., Satchell, E., . . . Sheline, Y. I. : Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivty. Mol Psychiatry 21(7): 894-902, 2016.
Sheline YI, West T, Yarasheski K, Swarm R, Jasielec MS, Fisher JR, Ficker WD, Yan P, Xiong Z, Frederikson C, Grzelak MV, Chott R, Bateman R, Morris, J, Mintun M, Lee J, Cirrito JR: An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice. Science Translational Medicine 6: 236, 2014.
Sheline YI, Disabato BM, Hranilovich J, Morris C, D’Angelo G, Pieper C, Tofanin T, Taylor WD, MacFall J, Wilkins C, Barch DM, Welsh-Bohmer KA, Steffens DC, Krishnan RR, Doraiswamy PM : Treatment course with antidepressant therapy in late-life depression. American Journal of Psychiatry 169(11): 1185-1193, 2013.
Sheline YI, Raichle ME : Resting state functional connectivity in preclinical Alzheimer's disease. Biological Psychiatry 5: 340-7, 2013.
Sheline YI, Pieper CF, Barch DM, Welsh-Boehmer K, McKinstry RC, MacFall JR, D’Angelo G, Garcia K, Gersing K, Wilkins C, Taylor W, Steffens DC, Krishnan RR, Doraiswamy PM : Support for the Vascular Depression Hypothesis in Late Life Depression: Results from a Two Site Prospective Antidepressant Treatment Trial. Archives of General Psychiatry 67: 277-85, 2010.
Sheline YI, Price JL, Yan Z, Mintun MA : Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proceeding of the National Academy of Sciences USA 107: 111020-5, 2010.
Sheline YI, Raichle ME, Snyder AZ, Morris JC, Head D, Wang S, Mintun MA : Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biological Psychiatry 67: 584-7, 2010.
Sheline YI, Barch DM, Price JL, Rundle MM, Vaishnavi N, Snyder AZ, Mintun MA, Wang S, Coalson RS, Raichle ME : The Default Mode Network and Self-Referential Processes in Depression. Proceeding of the National Academy of Sciences 106: 1942-7, 2009.
Fales CL, Barch DM, Rundle MM, Mintun MA, Snyder AZ, Cohen JD, Mathews J, Sheline YI : Altered Emotional Interference Processing in Affective and Cognitive Control Brain Circuitry in Major Depression. Biological Psychiatry 63: 377-84, 2008.
Mintun MA, LaRossa GN, Sheline YI, Dence CS, Yoon Lee MS, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC : PIB in a Nondemented Population Potential Antecedent Marker of Alzheimer Disease. Neurology. Neurology 67: 446-452, 2006.
Sheline YI, Barch DM, Garcia K, Gersing K, Pieper C, Welsh-Bohmer K, Steffens DC, Doraiswamy PM : Cognitive Function in Late Life Depression: Relationships to Depression Severity, Cerebrovascular Risk Factors and Processing Speed. Biological Psychiatry 60: 58-64, 2006.
Sheline YI, Gado MH, Kraemer HC : Untreated Depression and Hippocampal Volume Loss. American Journal of Psychiatry. American Journal of Psychiatry 160: 1516-1518, 2003.
Sheline YI : 3-D MRI Studies of Neuroanatomical Changes in Unipolar Major Depression: The Role of Stress and Medical Co-morbidity. Biological Psychiatry 48: 791-800, 2000.
Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW : Hippocampal Atrophy in Recurrent Major Depression. Proceedings of the National Academy of Sciences 93: 3908-3913, 1996.